Socio-Economic support for good health in rural Malawi

Objective: To study the socio-economic support for good health among subsistence farmers in rural Malawi.Design: A cross-sectional survey.Setting: Lungwena, a rural area with 17000 inhabitants in southern Malawi.Participants: Seven hundred and ninety five pregnant women who attended the antenatal clinic at Lungwena Health Centre between June 1995 and September 1996. Interventions: Interviews about socio-economic conditions. Measurements of cultivated land areas and distances between home and the local health centre. Main outcome measures: Proportion of households lacking literate adults, adequate water source and sanitation, easy access to modern health care or food security.Results: Only 14% of the interviewed women could read and write and half of the households had no literate members. Every fifth household was lacking both an access to safe drinking water and a proper sanitary facility. The distance to the health centre was more than 5 kmamong half of the households and only 37% had enough land to grow food for all family members. When other potential means of obtaining food were taken into account, 27% of the households had no food security. Numerous households were lacking more than one socioeconomic prerequisites of good health: three or more were missing from a quarter of the families.Conclusions: Socio-economic prerequisites of health were commonly missing in Lungwena. Subsequent health interventions should strengthen the investments into general poverty alleviation

Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake (vol 80, vol 1021, 2010)

Retraction notice to “Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake” [Biochem. Pharmacol. 80 (2010) 1021–1032].Non peer reviewe

Audio computer-assisted self-interviewing (ACASI) may avert socially desirable responses about infant feeding in the context of HIV

BACKGROUND: Understanding infant feeding practices in the context of HIV and factors that put mothers at risk of HIV infection is an important step towards prevention of mother to child transmission of HIV (PMTCT). Face-to-face (FTF) interviewing may not be a suitable way of ascertaining this information because respondents may report what is socially desirable. Audio computer-assisted self-interviewing (ACASI) is thought to increase privacy, reporting of sensitive issues and to eliminate socially desirable responses. We compared ACASI with FTF interviewing and explored its feasibility, usability, and acceptability in a PMTCT program in Kenya. METHODS: A graphic user interface (GUI) was developed using Macromedia Authorware(® )and questions and instructions recorded in local languages Kikuyu and Kiswahili. Eighty mothers enrolled in the PMTCT program were interviewed with each of the interviewing mode (ACASI and FTF) and responses obtained in FTF interviews and ACASI compared using McNemar's χ(2 )for paired proportions. A paired Student's t-test was used to compare means of age, marital-time and parity when measuring interview mode effect and two-sample Student's t-test to compare means for samples stratified by education level – determined during the exit interview. A Chi-Square (χ(2)test) was used to compare ability to use ACASI by education level. RESULTS: Mean ages for intended time for breastfeeding as reported by ACASI were 11 months by ACASI and 19 months by FTF interviewing (p < 0.001). Introduction of complementary foods at ≤3 months was reported more frequently by respondents in ACASI compared to FTF interviews for 7 of 13 complementary food items commonly utilized in the study area (p < 0.05). More respondents reported use of unsuitable utensils for infant feeding in ACASI than in FTF interviewing (p = 0.001). In other sensitive questions, 7% more respondents reported unstable relationships with ACASI than when interviewed FTF (p = 0.039). Regardless of education level, respondents used ACASI similarly and majority (65%) preferred it to FTF interviewing mainly due to enhanced usability and privacy. Most respondents (79%) preferred ACASI to FTF for future interviewing. CONCLUSION: ACASI seems to improve quality of information by increasing response to sensitive questions, decreasing socially desirable responses, and by preventing null responses and was suitable for collecting data in a setting where formal education is low

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling

Plant gas exchange is regulated by guard cells that form stomatal pores. Stomatal adjustments are crucial for plant survival; they regulate uptake of CO2 for photosynthesis, loss of water, and entrance of air pollutants such as ozone. We mapped ozone hypersensitivity, more open stomata, and stomatal CO2-insensitivity phenotypes of the Arabidopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROTEIN (MAP) KINASE 12 (MPK12). In parallel, we showed that stomatal CO2-insensitivity phenotypes of a mutant cis (CO2-insensitive) were caused by a deletion of MPK12. Lack of MPK12 impaired bicarbonate-induced activation of S-type anion channels. We demonstrated that MPK12 interacted with the protein kinase HIGH LEAF TEMPERATURE 1 (HT1)-a central node in guard cell CO2 signaling-and that MPK12 functions as an inhibitor of HT1. These data provide a new function for plant MPKs as protein kinase inhibitors and suggest a mechanism through which guard cell CO2 signaling controls plant water management.</p

Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling

Author Summary Human activities have increased the concentrations of CO2 and harmful air pollutants such as ozone in the troposphere. These changes can have detrimental consequences for agricultural productivity. Guard cells, which form stomatal pores on leaves, regulate plant gas exchange. To maintain photosynthesis, stomata open to allow CO2 uptake, but at the same time, open stomata lead to loss of water and allow the entrance of ozone. Elevated atmospheric CO2 levels reduce stomatal apertures, which can improve plant water balance but also increases leaf temperature. Using genetic approaches—in which we exploit natural variation and mutant analysis of thale cress (Arabidopsis thaliana)—we find that MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12) and its inhibitory interaction with another kinase, HIGH LEAF TEMPERATURE 1 (HT1) (involved in guard cell CO2 signaling), play a key role in this regulatory process. We have therefore identified a mechanism in which guard cell CO2 signaling regulates how efficiently plants use water and cope with the air pollutant ozone.Peer reviewe

Noble Negation: The Value of Linguistic Spaces in Dante's De vulgari eloquentia

Riassunto: Cominciando dall'intrigante, per il lettore, descrizione del locale del primo Discorso, il De vulgari eloquentia di Dante Alighieri (c. 1304–1305) conduce chi lo legge attraverso una serie di ambigui commenti sui luoghi e spazi (curia, aula) legati al vernacolo illustre. Questo crea nuovi spazi linguistici nell'immaginazione del lettore: cammini paralleli del pensiero, congetture, suspence. Il presente saggio intende sostenere che l'affermazione e susseguente negazione – o denarrazione – dei luoghi, più o meno concreti, trasferisce la discussione di Dante, e ugualmente la lingua discussa, in uno spazio più astratto, dove la formalizzazione del volgare, o vernacolo illustre, si realizza. L'ingegnosa funzione degli spazi alternativi che emerge risulta essere sotto stimata se essi devono essere ridotti puramente al risultato di singole metafore o alla riluttanza di Dante a prendere posizione in una controversia di carattere teologico sull'origine del linguaggio. Una simile variante di narrazione non affermativa rende possibile a Dante di assegnare all'illustre vernacolo un somigliante vuoto ontologico tra l'essere e il non essere come nel caso del riferimento biblico alle prime lingue umane. L'ambiguo spazio che di conseguenza risulta essere creato per il volgare illustre è il luogo dove il volgare può essere soggetto alla razionale investigazione dantesca.</jats:p