Fatal adenoviral necrotizing bronchiolitis case in a post-cardiac surgery intensive care unit

We report a case of a 67 year-old-male patient admitted to the intensive care unit in the post-coronary bypass surgery period who presented cardiogenic shock, acute renal failure and three episodes of sepsis, the latter with pulmonary distress at the 30th post-operative day. The patient expired within five days in spite of treatment with vancomycin, imipenem, colistimethate and amphotericin B. At autopsy severe adenovirus pneumonia was found. Viral pulmonary infections following cardiovascular surgery are uncommon. We highlight the importance of etiological diagnosis to a correct treatment approach

40 Anos da revolução de Abril de 1974

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Nacionalizações e transição socialista na evolução portuguesa (1974-75)

O golpe militar de 25 de Abril de 1974 precipitou uma crise de Estado em Portugal, assinalada pelo reforço dos partidos de esquerda e pelo crescente protagonismo político dos militares do Movimento das Forças Armadas. Num contexto de crise da economia mundial e de radicalização dos conflitos laborais, a força da mobilização colectiva no interior das empresas contribuiu para que a transição democrática assumisse a forma de um processo revolucionário. Implicou também um substancial reforço da intervenção do Estado na esfera económica, por via da nacionalização do sistema financeiro e dos grandes grupos económicos que o controlavam. Este artigo propõe-se interpretar as dinâmicas políticas e sociais que conduziram às nacionalizações, bem como a natureza dos projectos de reestruturação e planificação económica que delas resultaram, inspirados na ideia de uma «via portuguesa para o socialismo». The military coup of 25 April 1974 produced a State crisis in Portugal, marked by the rise of the Left and the growing political commitment of the military of the Armed Forces Movement (MFA). In a context of global economic crisis and radicalization of labour conflicts, the strength of collective mobilization in workplaces contributed to turn the democratic transition into a revolutionary process. It produced a remarkable reinforcement of State intervention over the economy, due to the nationalization of the financial system and of the trusts that controlled it. This article seeks to interpret the political and social dynamics that led to the nationalizations, as well as the nature of the projects of economic planning and restructuring that accompanied them, inspired on the idea of a "Portuguese path towards socialism".publishersversionpublishe

Surviving a transfixing gunshot wound to the head 70 years ago.

Surviving a gunshot wound to the head is a rare event, particularly in the past when medical treatment was much less advanced than it is today. Moreover, the finding of such a case as an identified specimen within a museum collection is even more uncommon. This led us to report on this unique case in this paper as it poses a challenge to forensic anthropology and provides a unique educational oppourtunity. The skull from the Collection at the Cranium Museum in the Department of Morphology and Genetic at the Federal University of São Paulo (UNIFESP) dates back to 1946. For trauma registration the bone location, severity, trauma aetiology, trauma classification, description, callus formation, periosteal reaction, degree and success of repair, and an estimate of the time elapsed since the trauma, were all assessed. To explore the case radiologically a CT scan of the skull was performed. Considering the survival of the patient and the morphology of the wound it is likely that the injury was caused by a small calibre, low-velocity gunshot. The bullet path shows an almost vertical direction on the right side of the individual's splanchno and neurocranium. The path of the projectile is consistent with a suicide attempt, although the possibility of a homicide simulating a suicide cannot be discarded. This case highlights how informative such cases can be to the practice of forensic anthropology

Teratoma of the mediastinum: a case report

Abstract\ud \ud \ud \ud Introduction\ud \ud This case report illustrates a rare case of teratoma of the mediastinum which was continuous to the pericardium and caused extrinsic compression to the right atrium.\ud \ud \ud \ud Case presentation\ud \ud A 22-year-old Caucasian man with no complaints or comorbid conditions presented to our hospital with obliteration of the right cardiophrenic sinus by a mass. A non-invasive investigation demonstrated a tumoral mass which was continuous to the pericardium and caused extrinsic compression to the right atrium. The clinical suspicion was a pericardial or bronchogenic cyst. Surgical and anatomopathologic findings led to the diagnosis of a mature cystic teratoma with atrophic thymic tissue at the external teratoma surface.\ud \ud \ud \ud Conclusion\ud \ud We present an original report of a mature teratoma causing obliteration of the right cardiophrenic sinus with extrinsic heart compression. The diagnosis of this tumor is very difficult through non-invasive investigation

The timing of the deglaciation in the Atlantic Iberian mountains: Insights from the stratigraphic analysis of a lake sequence in Serra da Estrela (Portugal)

Understanding the environmental response to the last glacial termination in regions located in transitional climate zones such as the Atlantic Iberian mountains is crucial to estimate potential changes in regions affected by current glacial melting. We present an 8.5 m-long, solid last deglaciation and Holocene chronostratigraphic record including detailed sediment analysis from Lake Peixao, a pro-glacial lake in the Serra da Estrela (Central Portugal). The age-depth model relies on a Bayesian approach that includes 16 AMS C-14 dates and Pb-210-(CS)-C-137 measurements, robustly dating the lake formation at 14.7 +/- 0.32 cal. ka BP. This chronological reconstruction shows an average sedimentation rate of ca. 0.07 cm yr(-1) (15 yr cm(-1)), enabling proxy analyses at decadal timescales. The sediment sequence is composed of five lithological units: (U1) coarse and unsorted fluvioglacial lacustrine deposits; (U2) massive fluvioglacial lacustrine deposits (863-790 cm below surface [bsf]; 14.7 +/- 0.32-13.8 +/- 0.12 cal. ka BP); (U3) water current fluvioglacial lacustrine deposits (790-766 cm bsf; 13.8 +/- 0.12-12.9 +/- 0.29 cal. ka BP); (U4) laminated/banded lacustrine deposits characterized by terrigenous deposits from ice-covered lake periods and episodic events of ice and snow melting (766-752 cm bsf; 12.9 +/- 0.29-11.7 +/- 0.15 cal. ka BP); and (U5) massive muddy lacustrine deposits (752-0 cm bsf; 11.7 +/- 0.15 cal. ka BP-present). The occurrence of U2 to U4 deposits defines the transition from glacial cold (U1) to net warm postglacial conditions (U5). These climate transitions are marked by changes in sediments and the presence of very low sedimentation rate periods, possibly related to the Intra-Allerod Cold Period and the coldest phase of the Younger Dryas. Our results support the previously proposed timing of the retreat of the Serra da Estrela glaciers ca. 13.8 +/- 0.12 cal. ka BP. The robust chronology of Lake Peixao highlights the potential of Iberian pro-glacial lakes for dating deglaciation processes and will lead to unprecedented decadal-to-centennial timescale palaeoclimate reconstructions in this region since the last glacial-interglacial transition.info:eu-repo/semantics/publishedVersio

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models

We herein report the synthesis, antioxidant power and neuroprotective properties of nine homo-bis-nitrones HBNs1–9 as alpha-phenyl-N-tert-butylnitrone (PBN) analogues for stroke therapy. In vitro neuroprotection studies of HBNs1–9 against Oligomycin A/Rotenone and in an oxygen-glucose-deprivation model of ischemia in human neuroblastoma cell cultures, indicate that (1Z,1′Z)-1,1′-(1,3-phenylene)bis(N-benzylmethanimine oxide) (HBN6) is a potent neuroprotective agent that prevents the decrease in neuronal metabolic activity (EC = 1.24 ± 0.39 μM) as well as necrotic and apoptotic cell death. HBN6 shows strong hydroxyl radical scavenger power (81%), and capacity to decrease superoxide production in human neuroblastoma cell cultures (maximal activity = 95.8 ± 3.6%), values significantly superior to the neuroprotective and antioxidant properties of the parent PBN. The higher neuroprotective ability of HBN6 has been rationalized by means of Density Functional Theory calculations. Calculated physicochemical and ADME properties confirmed HBN6 as a hit-agent showing suitable drug-like properties. Finally, the contribution of HBN6 to brain damage prevention was confirmed in a permanent MCAO setting by assessing infarct volume outcome 48 h after stroke in drug administered experimental animals, which provides evidence of a significant reduction of the brain lesion size and strongly suggests that HBN6 is a potential neuroprotective agent against stroke.We would like to thank Soledad Martinez Montero for the excellent technical assistance. This work was supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2015-65586-R to JMC; CTQ2016- 78205-P and CTQ2016-81797-REDC to IF, and NEUROCENTRO-CM S2017/BMD3760 to RMM and DNG), and Camilo José Cela University (UCJC-2018-04) to MJOG. DDI thanks the University of Alcalá and Spanish Ministry of Science, Innovation and Universities for pre-doctoral FPU grants. BCG thanks the Spanish Ministr