Resíduos sólidos no Brasil: contexto, lacunas e tendências

The theme of solid waste is in high evidence today, a fact noted by the recent implementation of the European directive, and in Brazil, by the National Solid Waste Policy. Understanding the impact of this policy on the national scientific production is essential to plan new directions and research trends. Through a bibliometric and scientometric studied, this research analyzed the national and global context of the last 20 years and found areas in which research progressed, as municipal solid waste, and essentials gaps to develop more the national state-of-the-art, as solid waste of transport. So, the results of this study are a plausible tool to justify for further research on this topic.O tema resíduos sólidos está em evidência na sociedade moderna, fato observado pela recente implantação da diretiva europeia, e no Brasil, com a criação da Política Nacional de Resíduos Sólidos. Entender o impacto dessa política na produção científica nacional é essencial para traçar novos rumos e tendências de pesquisa. Por meio de um estudo bibliométrico e cientométrico, esta pesquisa traçou o contexto nacional e global dos últimos 20 anos e encontrou áreas em que as pesquisas avançaram, como em resíduos sólidos urbanos, e lacunas essenciais para desenvolver mais o estado-da-arte nacional, como resíduos sólidos do transporte. Assim, os resultados encontrados fazem deste estudo uma ferramenta plausível como justificativa para novas pesquisas no tema.Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Engenharia Civil, Faculdade de Engenharia de Bauru, Bauru, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, CEP 17033360, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Engenharia Civil, Faculdade de Engenharia de Bauru, Bauru, Av. Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, CEP 17033360, SP, Brasi

The PLATO mission

PLATO (PLAnetary Transits and Oscillations of stars) is ESA’s M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2R ) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5%, 10%, 10% for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO‘s target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile towards the end of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases

Insulin modulates leptin-induced STAT3 activation in rat hypothalamus

AbstractInsulin and leptin have overlapping effects in the control of energy homeostasis, but the molecular basis of this synergism is unknown. Insulin signals through a receptor tyrosine kinase that phosphorylates and activates the docking proteins IRSs (insulin receptor substrates), whereas the leptin receptor and its associated protein tyrosine kinase JAK2 (Janus kinase 2) mediate phosphorylation and activation of the transcription factor STAT3 (signal transducer and activator of transcription). Here, we present evidence for the integration of leptin and insulin signals in the hypothalamus. Insulin induced JAK2 tyrosine phosphorylation, leptin receptor phosphorylation which, in the presence of leptin, augmented the interaction between STAT3 and this receptor. Insulin also increased the leptin-induced phosphorylation of STAT3 and its activation. These results indicate that insulin modulates the leptin signal transduction pathway, and may provide a molecular basis for the coordinated effects of insulin and leptin in feeding behavior and weight control