A study on the effectiveness of Guggulu based Karanja Ksharasutra in comparison with Apamarga Ksharasutra in the management of Shalyaja Nadivrana with special reference to Pilonidal Sinus

Shalyaja Nadivrana is an Agantuja variety of Vrana. Nidana Panchaka and treatment is extensively described in Sushruta Samhita - Nidhana and Chikitsa Sthana. Presence of Shalya in the tract is an obstacle to its healing. Management of Nadivrana includes Ksharasutra therapy. The pilonidal sinus is an acquired sinus that develops in young, hirsute men, usually in the intergluteal cleft caused by the intrusion of hair into the skin, causing an abscess and gradually forming a sinus. The study was conducted on 40 randomly assigned patients at SJAUM Hospital, Bengaluru by dividing them into 2 groups - Group A and Group B. These groups were treated with Guggulu-based Karanja Ksharasutra and Apamarga Ksharasutra respectively. Assessment of pain, discharge, LOT, tenderness, and induration in Group A showed 91.67%, 91.3%, 99.9%, 85.19%, 95% and 75.6% improvement and Group B showed 87.5%, 86.96%, 100%, 78.6% and 97.37% improvement respectively. Group A’s overall result was 89.5% and Group B’s overall result was 89.9%. The mean UCT of Group A was 8.3 days/cm and Group B was 7.9 cm/day with p -value <0.05 which is significant. The study showed that the trial drug was as good as the control drug in the management of Shalyaja Nadi Vrana

X-ray periodicities in sources observed by the RXTE ASM

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Physics, 2005.Includes bibliographical references (p. 49-50).The X-ray intensities measured from 230 X-ray sources observed by the RXTE All-Sky Monitor (ASM) were analyzed for periodic behavior. The ASM has been observing sources for nine years in the 1.5-12 keV energy range. In this search, we investigated a frequency range of 5 d⁻¹ to 144 d⁻¹ for periodic modulation. The search was carried out by applying the Fast Fourier Transform on the ASM data and whitening the resulting power density spectrum using a local averaging technique. A power threshold was set to determine the statistical significance of a peak in the power density spectrum. The search verified the orbital frequencies of four known X-ray binaries and also identified four previously unreported periodicities. The 5.7232 d⁻¹ orbital frequency of GX 9+9 was observed for the first time in ASM data, although this modulation had been observed before. The 6.0999 d⁻¹ peak found for XTE J1723-376 has not been reported before and may be an orbital frequency.y Vasudha B. Shivamoggi.S.B

An estimate of the physical distance between two linked markers in Haemophilus influenzae

Using DNA clones, the physical distance between the linked genesnov and str in Haemophilus influenzae was estimated. Although none of the cloned inserts contained both the markers, pJ1-8StrR 13 (insert of 18·7 kb) included str gene at one end and part of nov gene at the other end of the insert. By EcoRI restriction analysis and by Southern hybridization, the distance between the two EcoRI sites, cutting at which inactivates the two genes, was estimated to be 17·7 kb. A single continuous EcoRI fragment (containing 4EcoRI sites within it) carrying both the genes intact would need to be 20·4 kb in size. These estimates were confirmed independently using different clones of novr and strr alleles as probes for hybridization with BamHI-digested chromosomal DNA

A case report: incidental diagnosis of endometrial tuberculosis in cases of abnormal uterine bleeding

Abnormal uterine bleeding (AUB), including heavy menstrual bleeding (HMB), levy a massive burden on society. Here, we discuss about two patients who came to OPD with AUB symptoms for evaluation, but incidentally diagnosed with endometrial tuberculosis. In Case 1, 45-year-old female came with complains of heavy menstrual bleeding for 6 months for 6 months. USG showed adenomyosis. Patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. But on day 7 she developed serous blood-tinged discharge per vaginum. Incidentally, patient endometrial CBNAAT report came positive for MTB, with no resistance to rifampicin. Patient was started on anti-tubercular treatment for 6 months. In Case 2, 43-year-old female came with complaints of HMB with pain abdomen and irregular menses for 3 years. USG shows early changes of Adenomyosis. Patient underwent therapeutic curettage with MIRENA insertion. Endometrial CBNAAT was negative and liquid culture (LJ) was MDR positive. Sensitivity report s/o of isoniazid and rifampicin resistant. Patient was advised monthly close follow up as symptoms were under control. When a routine screening for FGTB by CBNAAT is done for cases of AUB, there are high chances of reporting more cases in a developing nation like India. Hence sending endometrial samples for TB screening in AUB cases can be useful in finding out more cases of genital TB, where their symptoms can be related to TB infection rather than searching for a structural cause that may be is not the cause for the severe symptoms. Due to which mismanagement or unnecessary surgical interventions can be avoided

Pattern of histopathological lesions in lung autopsy

Background: A large number of pathologic conditions involve the lung parenchyma like inflammatory, neoplastic and others. The lungs are also involved in almost all terminal events of cardiovascular disease. Autopsy is an important and most useful way to find out the condition of internal organs and to evaluate any localized lesions or systemic disease and hence determine cause of death. Aims and objectives of study are to identify the histopathological spectrum of lung disease. To find out frequency of various lung pathologies in respect to age and sex.Methods: This study was retrospective and done on 649 cases of medico legal autopsies. The tissue specimens were fixed and processed. Routine paraffin sectioning was done followed by Hematoxylene and eosin (H and E) staining. Special stains were done whenever required. Relevant clinical and postmortem findings, gross and microscopic examination findings were recorded.Results: After thorough histopathological examinations, of total 649 cases, various pulmonary lesions were identified in 348(53.6%) cases while in 301(46.4%) cases no significant pathology was seen. Most commonly affected age group was 30-49 years 43.1% followed by age group of >60years 17.8%. Majority of diseased were male 285 (81.9%). Most common lung pathology found was Edema and congestion in 93 cases (26.72%), chronic venous congestion in 92 cases (26.44%) pneumonia in 65 cases (18.68%) followed by Tuberculosis/Tuberculous pneumonia in 29 cases (8.3%).Conclusions: In our population, the present study reveals that infectious disease are still the most common cause of mortality, despite recent advances in diagnostic technology, the autopsy has remained an important complementary tool for identifying and understanding pathology of disease.

Evaluation of peripheral lymphadenopathy by fine needle aspiration cytology: a one year study at tertiary centre

Background: Lymphadenopathy is common presenting features in various non-neoplastic and neoplastic lesions. Fine needle aspiration cytology (FNAC) is simple, quick, inexpensive and minimally invasive technique that can be used as an outpatient procedure to diagnose them. The present study was undertaken to assess the various causes of lymphadenopathy through FNAC, and to see the distribution of lesions with respect to age and gender. To assess the diagnostic accuracy of lymph node fine needle aspiration (FNA) cytology in various non-neoplastic and neoplastic conditions.Methods: Total 555 cases of the lymph node FNAC were studied from January 2014 to December 2014 in Cytopathology department of Government Medical College, Surat .The cytomorphologic features seen in the aspirates were analyzed and correlated with their etiology.Results: In this study 555 cases of cervical lymphadenopathy were analysed. The age of the patients ranged from 5 months to 90 years of which 60.2% were males and 39.8% were females. Maximum numbers of cases 147(26.4%) were in the age group of 21- 30 years. The most common lesion encountered was tuberculous lymphadenitis 44.8% followed by metastatic tumors 31.3%, reactive lymph node 16.7%, acute lymphadenitis 5.4% and lymphoma 1.8%. Male showed predominance of metastatic carcinoma and lymphoma while chronic reactive hyperplasia and tuberculous lymphadenitis were equally distributed in both male & female.Conclusions: FNAC is safe, rapid and cost effective method in establishing the diagnosis in large number of cases of lymphadenopathy. It can differentiate a neoplastic from a non-neoplastic process and therefore influence patient management preventing patient from being subjected to unnecessary surgery

Fog Computing: Issues, Challenges and Future Directions

In Cloud Computing, all the processing of the data collected by the node is done in the central server. This involves a lot of time as data has to be transferred from the node to central server before the processing of data can be done in the server. Also it is not practical to stream terabytes of data from the node to the cloud and back. To overcome these disadvantages, an extension of cloud computing, known as fog computing, is introduced. In this, the processing of data is done completely in the node if the data does not require higher computing power and is done partially if the data requires high computing power, after which the data is transferred to the central server for the remaining computations. This greatly reduces the time involved in the process and is more efficient as the central server is not overloaded. Fog is quite useful in geographically dispersed areas where connectivity can be irregular. The ideal use case requires intelligence near the edge where ultra-low latency is critical, and is promised by fog computing. The concepts of cloud computing and fog computing will be explored and their features will be contrasted to understand which is more efficient and better suited for real-time application

“EVALUATION OF GALPHIMIA GLAUCA STEM METHANOL EXTRACT FRACTIONS FOR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES”

Objective: This current investigation assesses in vivo central and peripheral analgesic effects and anti-inflammatory properties of fractions obtained from Galphimia glauca (GG) stem methanol extract. Methods: The laboratory models such as Swiss albino mice and Wistar albino rats were employed in the studies. The GG stem methanol extract was subjected to fractionation with solvents such as hexane, chloroform, ethyl acetate, and methanol. Orally, the dose range of 100, 200, and 400 mg/kg was given for 1 day for evaluating analgesic (hotplate test, tail clip test, writhing test, and formalin test) and weekdays for assessing anti-inflammatory activity (carrageenan and cotton pellet test methods), respectively. The experimental studies were further conducted for determining the involvement of central and peripheral receptor actions in the analgesic activity of the extract by prechallenging it with naloxone and acetic acid, respectively. The in vivo anti-inflammatory studies were conducted using carrageenan-induced rat paw edema model and cotton pellet granuloma test. Results: The LD50 of the extract was found to be >2000 mg/kg b.w. The methanol fraction of 400 mg/kg dose exhibited significant (p≤0.001) and dose-dependent analgesic and anti-inflammatory activity. It also exhibited central and peripheral analgesic actions when treated with naloxone and acetic acid, respectively. Conclusion: The results revealed that the stem methanol fraction has more potential in terms of analgesic and anti-inflammatory properties

Quantification and Mapping of Surface Residue Cover for Maize and Soybean Fields in South Central Nebraska

The area cultivated under conservation tillage practices such as no-till and minimal tillage has recently increased in Midwestern states, including Nebraska. This increase, consequently, resulted in changes in some of the impacts of cropping systems on soil, such as enhancing soil and water quality, improving soil structure and infiltration, increasing water use efficiency, and promoting carbon sequestration. However, there are no methods currently available to quantify the percent crop residue cover (CRC) and the area under conservation tillage for maize and soybean at large scales on a continuous basis. This research used Landsat-7 (ETM+) and Landsat-8 (OLI) satellite data to evaluate six tillage indices [normalized difference tillage index (NDTI), normalized difference index 7 (NDI7), normalized difference index 5 (NDI5), normalized difference senescent vegetative index (NDSVI), modified CRC (ModCRC), and simple tillage index (STI)] to map CRC in eight counties in south central Nebraska. A linear regression CRC model showed that NDTI performed well in differentiating the CRC for different tillage practices at large scales, with a coefficient of determination (R2) of 0.62, 0.68, 0.78, and 0.07 for 25 March, 18 April, 28 May, and 6 June 2013 Landsat images, respectively. A minimum NDTI method was then used to spatially map the CRC on a regional scale by considering the timing of planting and tillage implementation. The measured CRC data were divided into training (calibration) and testing (validation) datasets. A CRC model was developed using the training dataset between minimum NDTI and measured CRC with an R2 of 0.89 (RMSD = 10.63%). A 3 × 3 matrix showed an overall accuracy of 0.90 with a kappa coefficient of 0.89. About 26% of the maize area and 15% of the soybean area had more than 70% CRC in south central Nebraska. This research and the procedures presented illustrate that multi-spectral Landsat images can be used to estimate and map CRC (error within 10.6%) on a regional scale and continuous basis using locally developed tillage practice versus crop residue algorithms. Further research is needed to incorporate soil and residue moisture content into the CRC versus tillage index to enhance the accuracy of the models for estimating CRC

Recent advances in noble metal free doped graphitic carbon nitride based nanohybrids for photocatalysis of organic contaminants in water: A review

Extensive contamination of water bodies by textile dyeing industries, organic pollutants and agricultural waste has emerged water pollution as one of the major global environmental crisis. The effect of this gross negligence is posing serious threats to human health therefore today; conserving water resources for the essence of life is of grave concern. Recently, advancements in photocatalytic properties of graphitic carbon nitride (g-C3N4) for wastewater treatment have gained tremendous interest in research. However, pristine g-C3N4 suffers from bottlenecks such as low surface area, rapid recombination of photo-generated electron–hole pairs and insufficient light absorption which thereby, reduces the photocatalytic degradation activity. Hitherto, noble metals have been widely utilized as dopants but are cost ineffective, rarely found and are difficult to recover. In this updated and all-inclusive review we have briefly discussed photocatalysis mechanism, primarily focused on non-precious elemental doping via various synthesis techniques of noble metal free doped g-C3N4 photocatalysts. Typically metal, non-metal, rare earth metal doping and co-doping have been explored, which demonstrates the synergistic behavior of the doped nanocomposites in modulation of electronic structure, broaden the visible light absorption range, enhancement in photocatalytic wastewater remediation ability to obtain maximum pollutant eradication. Summary remarks conclude the review with valuable knowledge of noble metal free doped g-C3N4 photocatalysts for water purification and sheds light on current challenges and crucial issues associated with its commercialization. The future aspect aims at designing of efficient solar light driven photocatalysts for application in various domains i.e. production of H2 and O2, reduction of CO2, practical use of solar cells, treatment of wastewater, air purification and environmental conservatio