52 research outputs found
Dielectric relaxations of nanocomposites composed of HEUR polymers and magnetite nanoparticles
We investigate the dynamics of nanocomposites composed of hydrophobically modified ethoxylated urethanes (HEUR) and magnetite nanoparticles (MNPs) as dry films. Weemployed dielectric relaxation spectroscopy (DRS) in combination with differential scanning calorimetry (DSC) and thermally stimulated depolarization currents (TSDC).The three techniques reveal a strong heterogeneity of the matrix of the nanocomposites, consisting of (i) a crystalline poly(ethyleneoxide) PEO bulk phase, (ii) an amorphous PEO portion, and (iii) small PEO crystallites which experience different constraints than the PEO bulk phase. TSDC and DRS reveal a very high direct current (DC)-conductivity of the pure matrix, which increases with MNPs concentration. The increase of the DCconductivity is not related to an increase of the segmental mobility, but most likely to the change of the morphology of the hydrophobic domains of the polymer matrix, due to the formation of large MNPs clusters. Indeed, the MNPs neither influence the segmental dynamics of the polymer nor the phase behavior of the polymer matrix. The addition of MNPs slightly increases the activation energy related to the Îł-relaxation of the polymer. This effect might be related to the changes in nano-morphology as demonstrated by the slight increase of the degree of crystallinity. The analysis of the DRS data with the electrical modulus Mââ(Ï) and the derivative Δââder formalism allow us to identify a low-frequency process in addition to the conductivity relaxation. This low-frequency dispersion is also revealed by TSDC. It is most likely related to the Maxwell-Wagner- Sillars relaxation, which typically occurs in systems which feature phase separation. The detailed investigation of the dielectric properties of these novel nanocomposites with increasing MNPs concentration will be useful for their practical application, for example as absorbers of electromagnetic waves
âThere was nothing, just absolute darknessâ: Understanding the needs of those caring for children and young people with complex neurodisability in a diverse UK context: A qualitative exploration in the ENCOMPASS study
This is the final version. Available from Wiley via the DOI in this record.âŻBackground: Children and young people (CYP) with complex neurodisability experience multiple physical, communication, educational and social challenges, which
require complex packages of multidisciplinary care. Part of the holistic care required
includes supporting the families and parents/caregivers. The aim of the wider study
was to introduce a new programme (âUbuntuâ) to parents/caregivers and healthcare
professionals (HCPs) in order to test the feasibility and acceptability of the concept
and content, with the goal of potential adaptation for the UK in mind. Data collection
and analysis uncovered rich data on caregiving journeys, navigation of health services, and perceived service gaps. This paper focuses solely on these topics. Further
papers will report on the feasibility and adaptation data.
Methods: Two rounds of semi-structured interviews were conducted with 12 caregivers of CYP with complex neurodisability and six HCPs from a variety of disciplines,
recruited from a community child health service in London Borough of Newham, UK
in 2020. The interviews included open-ended questions to explore caregiving journeys, experiences of navigating health services and perceived service gaps. Transcripts were analysed using a data-driven inductive thematic analysis.
Results: Three themes were identified that related to the aim of understanding caregivers' experiences and unmet needs relating to current service provision. These
were (1) Caregiver Mental Health, (2) The Information Gap and (3) The Need for
Holistic Support. Mental health difficulties were reported, particularly around the
period of diagnosis. Priority needs included the provision of clear information about
the diagnosis and services offered, opportunities to forge peer support networks and
for services across the community to collaborate.
Conclusions: The delivery of health services for CYP with neurodisability should
encompass the broad needs of the family as well as meeting the clinical needs of
the CYPBarts Charit
Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population
Background
Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the development and progression of colorectal cancer (CRC). However, the link between these compounds and CRC remains unknown. In this cross-sectional study, we investigated the association of CRC diagnosis to PFOA and PFOS blood levels in a large Appalachian population. Methods
Participants were 47,359 adultsââ„â21 years of age and residing in six PFOA-contaminated water districts in the mid-Ohio Valley (Nâ=â47,151 cancer-free adults, 208 cases of primary CRC). All participants completed a comprehensive health survey between 2005 and 2006; serum levels of PFOA, PFOS, and a range of other blood markers were also measured. Medical history was assessed via self report and cancer diagnosis confirmed via chart review. Results
CRC showed a strong inverse, doseâresponse association with PFOS serum levels (odds ratio (OR) adjusted for potential confoundersâ=â0.2, 95% confidence interval (CI) 0.2,0.3) for highest vs. lowest quartile of PFOS, P-trendâ\u3câ0.00001) and a significant, but more modest inverse association with PFOA (adjusted ORâ=â0.6 (CI 0.4, 0.9) for highest vs. lowest quartile, P-trendâ=â0.001). These inverse associations were stronger in those diagnosed within the previous 6 years and resident in the same water district for a minimum of 10â15 years preceding assessment. The relationship between PFOA and CRC was also more pronounced in men and leaner adults, and showed a stronger linear trend at lower exposure levels. Conclusions
In this large cross-sectional study, we found a strong, inverse association between PFOS and likelihood of CRC diagnosis and a significant, although more modest inverse association between PFOA and CRC. If confirmed in prospective investigations, these findings may aid in identifying new strategies for CRC prevention and treatment and inform future studies regarding mechanisms underlying CRC pathogenesis
«La relation de limitation et dâexception dans le français dâaujourdâhui : exceptĂ©, sauf et hormis comme pivots dâune relation algĂ©brique »
Lâanalyse des emplois prĂ©positionnels et des emplois conjonctifs dâ âexceptĂ©â, de âsaufâ et dâ âhormisâ permet dâenvisager les trois prĂ©positions/conjonctions comme le pivot dâun binĂŽme, comme la plaque tournante dâune structure bipolaire. PlacĂ©es au milieu du binĂŽme, ces prĂ©positions sont forcĂ©es par leur sĂ©mantisme originaire dĂ»ment mĂ©taphorisĂ© de jouer le rĂŽle de marqueurs dâinconsĂ©quence systĂ©matique entre lâĂ©lĂ©ment se trouvant Ă leur gauche et celui qui se trouve Ă leur droite. Lâopposition qui surgit entre les deux Ă©lĂ©ments nâest donc pas une incompatibilitĂ© naturelle, intrinsĂšque, mais extrinsĂšque, induite. Dans la plupart des cas (emplois limitatifs), cette opposition prend la forme dâun rapport entre une « classe » et le « membre (soustrait) de la classe », ou bien entre un « tout » et une « partie » ; dans dâautres (emplois exceptifs), cette opposition se manifeste au contraire comme une attaque de front portĂ©e par un « tout » Ă un autre « tout ». De plus, lâinconsĂ©quence induite mise en place par la prĂ©position/conjonction paraĂźt, en principe, tout Ă fait insurmontable. Dans lâassertion « les Ă©cureuils vivent partout, sauf en Australie » (que lâon peut expliciter par « Les Ă©cureuils vivent partout, sauf [quâils ne vivent pas] en Australie »), la prĂ©position semble en effet capable dâimpliquer le prĂ©dicat principal avec signe inverti, et de bĂątir sur une telle implication une sorte de sous Ă©noncĂ© qui, Ă la rigueur, est totalement inconsĂ©quent avec celui qui le prĂ©cĂšde (si « les Ă©cureuils ne vivent pas en Australie », le fait quâils « vivent partout » est faux). NĂ©anmoins, lâanalyse montre quâalors que certaines de ces oppositions peuvent enfin ĂȘtre dĂ©passĂ©es, dâautres ne le peuvent pas. Câest, respectivement, le cas des relations limitatives et des relations exceptives. La relation limitative, impliquant le rapport « tout » - « partie », permet de rĂ©soudre le conflit dans les termes dâune somme algĂ©brique entre deux sous Ă©noncĂ©s pourvus de diffĂ©rent poids informatif et de signe contraire. Les valeurs numĂ©riques des termes de la somme Ă©tant dĂ©sĂ©quilibrĂ©es, le rĂ©sultat est toujours autre que zĂ©ro. La relation exceptive, au contraire, qui nâimplique pas le rapport « tout » - « partie », nâest pas capable de rĂ©soudre le conflit entre deux sous Ă©noncĂ©s pourvus du mĂȘme poids informatif et en mĂȘme temps de signe contraire : les valeurs numĂ©riques des termes de la somme Ă©tant symĂ©triques et Ă©gales, le rĂ©sultat sera toujours Ă©quivalent Ă zĂ©ro
Dans lÂensemble : marqueur dÂattĂ©nuation
Dans cet article, nous Ă©tudions ladverbial "dans lensemble" qui peut ĂȘtre considĂ©rĂ© comme un marqueur dattĂ©nuation au sens oĂč il modalise la valeur de vĂ©ritĂ© dun Ă©noncĂ©. Cette attĂ©nuation a pour particularitĂ© de sexprimer par le biais dune approximation dont le fonctionnement doit ĂȘtre prĂ©cisĂ©. Dans cette perspective, nous montrons par quels biais cette approximation sĂ©tablit et partant quel processus sĂ©mantico-pragmatique est Ă luvre avec "dans lensemble". Il ressort de notre analyse que cette locution agit comme un modalisateur mettant en perspective les liens existant entre le sujet et le prĂ©dicat dun Ă©noncĂ©, ainsi que les connaissances stĂ©rĂ©otypiques qui y sont associĂ©es. La confrontation de "dans lensemble" avec dautres expressions gĂ©nĂ©ralement donnĂ©es comme Ă©quivalentes nous permet ensuite daffiner lanalyse sĂ©mantique proposĂ©e jusqualors. Cette deuxiĂšme partie fait notamment intervenir les domaines de la gĂ©nĂ©ralitĂ© ("en gĂ©nĂ©ral" / "gĂ©nĂ©ralement"), de lapproximation ("en gros" / "grosso modo" / "globalement") ainsi que les expressions liĂ©es Ă la quantification totale ("au total" / "en bloc"). Cette approche prend en compte les structures syntaxiques dans linterprĂ©tation sĂ©mantique, rendant visibles les principales diffĂ©rences des adverbiaux Ă©tudiĂ©s. Leffet dapproximation les rassemble dans tous les cas, tandis que lattĂ©nuation ne concerne que leurs emplois dadverbes de phrase. Il est Ă©vident quune analyse fine de chacun des adverbiaux pris en compte dans cette Ă©tude, ainsi quune comparaison systĂ©matique permettrait de mettre au jour leurs diffĂ©rences syntactico-sĂ©mantiques et les fonctions particuliĂšres quils peuvent remplir
Women and Peace Negotiations in Cyprus
The integration of a gender agenda in the peace negotiations in Cyprus has been elusive over the five decades. However, it is only since the late 2000s that civil society and international observers have problematized this lack and attempted to address it through various initiatives. These have included local and international efforts to mobilize Cypriot women across the divide around an agenda based on UN Security Council Resolution 1325 (2000) on Women, Peace and Security, which led to the formation of the Gender Advisory Team in 2009. They have also included research efforts by local and international organizations and think tanks to document the extent to womenâs inclusion in the peace process on the island. These efforts eventually led to the setup of the Technical Committee on Gender Equality which is attached to the peace negotiations since 2015, but the impact of which has remained marginal. One of the key problems frustrating the integration of a gender agenda in the peace negotiations remains the fact that despite great advances in both societies north and south of the dividing line in many areas of gender equality, the hard politics relating to the Cyprus conflict and its resolution remain contentious and politically perilous to oppose while also being discursively disconnected from perceptions of âgenderâ and feminist concerns
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