COMPARATIVE ANALYSIS ON MUSCLE STRENGTH AMONG PATIENTS WHO UNDERWENT ARTHROSCOPIC TENOTOMY OF THE LONG HEAD OF THE BICEPS IN RELATION TO ESTHETIC DEFORMITY

ABSTRACTObjective: To determine whether there was any discrepancy in elbow flexion strength among patients with and without evident clinical deformity resulting from arthroscopic tenotomy on the long head of the biceps. Method: A group of 120 patients who underwent this procedure were evaluated. After applying the exclusion criteria, 89 patients remained in the analysis. Eighteen months after the operation (median), the elbow flexion strength was measured in newtons using a digital dynamometer. Three consecutive measurements were made and the average was used. The dominant and non-dominant sides were compared. Sex, age and mean elbow flexion strength in the operated and contralateral arms of patients with and without apparent clinical deformity were evaluated. Results: The median elbow flexion strength among the patients with evident clinical deformity was 17.78 N for the dominant arm and 20.87 N for the non-dominant arm. The difference was 2.51 N. In the group without evident clinical deformity, the difference was 2.14 N. The median muscle strength in the operated arm was 17.26 N, while the median was 20.06 N in the non-operated arm, thus suggesting that there was a significant loss of muscle strength (p = 0.005). The difference in muscle strength loss between the patients with and without evident deformity was not considered statistically significant (p = 0.977). Conclusion: The patients who underwent arthroscopic tenotomy on the long head of the biceps with or without apparent clinical deformity from distal migration presented similar elbow flexion muscle strength

A vertex detector for the International Linear Collider based on CMOS sensors

The physics programme at the International Linear Collider (ILC) calls for a vertex detector (VD) providing unprecedented flavour tagging performances, especially for c-quarks and τ leptons. This requirement makes a very granular, thin and multi-layer VD installed very close to the interaction region mandatory. Additional constraints, mainly on read-out speed and radiation tolerance, originate from the beam background, which governs the occupancy and the radiation level the detector should be able to cope with. CMOS sensors are being developed to fulfil these requirements. This report addresses the ILC requirements (highly related to beamstrahlung), the main advantages and features of CMOS sensors, the demonstrated performances and the specific aspects of a VD based on this technology. The status of the main R&D directions (radiation tolerance, thinning procedure and read-out speed) are also presented

Small-Scale Readout Systems Prototype for the STAR PIXEL Detector

A prototype readout system for the STAR PIXEL detector in the Heavy Flavor Tracker (HFT) vertex detector upgrade is presented. The PIXEL detector is a Monolithic Active Pixel Sensor (MAPS) based silicon pixel vertex detector fabricated in a commercial CMOS process that integrates the detector and front-end electronics layers in one silicon die. Two generations ofMAPS prototypes designed specifically for the PIXEL are discussed. We have constructed a prototype telescope system consisting of three small MAPS sensors arranged in three parallel and coaxial planes with a readout system based on the readout architecture for PIXEL. This proposed readout architecture is simple and scales to the size required to readout the final detector. The real-time hit finding algorithm necessary for data rate reduction in the 400 million pixel detector is described, and aspects of the PIXEL system integration into the existing STAR framework are addressed. The complete system has been recently tested and shown to be fully functional

PTCH1+/− Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts

Gorlin's or nevoid basal cell carcinoma syndrome (NBCCS) causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. Mutations in the tumor suppressor gene PTCH1 are responsible for this autosomal dominant syndrome. In NBCCS patients, as in the general population, ultraviolet exposure is a major risk factor for BCC development. However these patients also develop BCCs in sun-protected areas of the skin, suggesting the existence of other mechanisms for BCC predisposition in NBCCS patients. As increasing evidence supports the idea that the stroma influences carcinoma development, we hypothesized that NBCCS fibroblasts could facilitate BCC occurence of the patients. WT (n = 3) and NBCCS fibroblasts bearing either nonsense (n = 3) or missense (n = 3) PTCH1 mutations were cultured in dermal equivalents made of a collagen matrix and their transcriptomes were compared by whole genome microarray analyses. Strikingly, NBCCS fibroblasts over-expressed mRNAs encoding pro-tumoral factors such as Matrix Metalloproteinases 1 and 3 and tenascin C. They also over-expressed mRNA of pro-proliferative diffusible factors such as fibroblast growth factor 7 and the stromal cell-derived factor 1 alpha, known for its expression in carcinoma associated fibroblasts. These data indicate that the PTCH1+/− genotype of healthy NBCCS fibroblasts results in phenotypic traits highly reminiscent of those of BCC associated fibroblasts, a clue to the yet mysterious proneness to non photo-exposed BCCs in NBCCS patients

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Rôles de la voie SONIC HEDGEHOG/PATCHED et des interactions dermo-épidermiques dans la prédisposition aux carcinomes basocellulaires chez les patients atteints du syndrome de Gorlin

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Analgesia para a sutura artroscópica do manguito rotador: estudo comparativo entre o bloqueio interescalênico do plexo braquial e o bloqueio da bursa subacromial contínuo Management of pain after the rotator cuff arthroscopic suture: comparative study among the interescalenic blockade and the continuous intrabursal infusion

OBJETIVO: Comparar o nível de dor pós-operatória de pacientes submetidos à sutura artroscópica da lesão do manguito rotador (MR) que receberam protocolos diferentes de analgesia pós-operatória. Demonstrar a relação entre dor e o sexo do paciente, a dimensão da lesão suturada e a utilização da capsulotomia interna. Verificar a prevalência dos efeitos colaterais. MÉTODO: Foram analisados três grupos de pacientes operados entre 1º de junho de 2004 e 31 de maio de 2007. O grupo I foi composto pelos pacientes que receberam bloqueio interescalênico com ropivacaína a 0,75%. No grupo II, o mesmo bloqueio foi acrescido de 150µg de clonidina. No grupo III foi administrado um bolus de 30ml de ropivacaína a 0,75% para infiltração dos portais artroscópicos e diretamente no espaço subacromial, seguido de infusão contínua de ropivacaína a 0,2% em bomba de infusão. Os pacientes foram submetidos à medição da escala analógica visual (EAV) com 24 horas após o procedimento. As variáveis estudadas foram: EAV, sexo, tamanho da lesão, necessidade de capsulotomia interna e prevalência dos efeitos colaterais. O estudo avaliou 196 pacientes, dos quais foram excluídos 51, totalizando n = 145 pacientes. O total de pacientes no grupo I foi de 65; no grupo II, de 19; e no grupo III, de 61. RESULTADOS: O índice da EAV médio encontrado no grupo I foi de 3,88 ± 1,737 (3); no grupo II, de 3,8 ± 1,6 (3); e no grupo III, de 1,95 ± 1,6 (2). Houve diferença significativa ao comparar os grupos I e III (p < 0,001) e ao comparar os grupos II e III (p < 0,001), sugerindo menor dor nos pacientes do grupo III. Não houve diferença para a percepção da dor entre os sexos (p = 0,700) e entre os diferentes tamanhos de lesão do MR (p = 0,546). Houve diferença na percepção da dor entre os pacientes submetidos ou não à capsulotomia interna (p = 0,038). Houve redução na prevalência das náuseas e/ou vômitos (p = 0,089) e do prurido (p = 0,092) no grupo III, quando comparado com os grupos I e II. CONCLUSÕES: O protocolo de analgesia pós-operatória com infusão contínua de ropivacaína demonstrou ser superior aos protocolos que utilizam morfina após o término do efeito do bloqueio interescalênico. Não houve distinção na percepção da dor entre os sexos e diferentes tamanhos de lesões suturadas. Houve distinção na percepção da dor entre os pacientes que realizaram ou não a capsulotomia interna. O índice de efeitos colaterais foi semelhante entre os protocolos de analgesia.<br>OBJECTIVE: To compare the level of postoperative pain in patients submitted to arthroscopic suture of a rotator cuff lesion who had different analgesia protocols. To demonstrate the relationship between pain and the gender of the patient, the dimension of the lesion sutured, and the use of internal capsulotomy. To check the prevalence of side effects. METHODS: Three groups of patients operated on between June 01, 2004 and May 31, 2007 were analyzed. Group I comprised patients who received interescalenic blockade with 0.75% ropivacaine. In group II, the same blockade was added with 150 µg of clonidine. In group III, a 30 ml bolus of 0.75% ropivacaine was administered to infiltrate the arthroscopic portals and directly in the subacromial space, followed by a continuous infusion of 0.2% ropivacaine with an infusion pump. The patients were submitted to the medication of the EAV analogue-visual scale 24 hours after the procedure. The variables studied were EAV, gender, size of the lesion, need of internal capsulotomy, and prevalence of side effects. The study evaluated 196 patients, 51 of whom were excluded, thus giving a total " n" = 145 patients. The total of patients in group I was 65, in group II, 19, and in group III, 61. RESULTS: The mean EAV index found for group I was 3.88 ± 1,737 (3); in group II, it was 3.8 ± 1.6 (3), and in group III, 1.95 ± 1.6 (2). There was a significant difference when comparing group I to group III (p < 0.001) and when comparing group II to group III (p < 0.001) suggesting less pain felt by patients in group III. There was no pain perception difference between genders (p = 0.700) and among the different sizes of rotator cuff lesion (p = 0.546). There was a pain perception difference between patients that were and those that were not submitted to internal capsulotomy (p = 0.038). There was reduced prevalence of nausea and/or vomiting (p = 0.089) and of pruritus (p = 0.092) in group III as compared to groups I and II. CONCLUSIONS: The protocol of postoperative analgesia with continuous infusion of ropivacaine showed that it is better than the protocols using morphine after the end of the interescalenic blockade effects. There was no difference in pain perception between the genders and according to different sizes of sutured lesions. There was a difference in pain perception by the patients who had and those who have not had internal capsulotomy. The rate of side effects was similar among the analgesia protocols