Isolation and characterization ofmicrosatellitemarkers for Acacia senegal (L.)Willd., amultipurpose arid and semi-arid tree

International audienceAcacia senegal is a multipurpose African tree that improves the soil fertility of degraded areas. The species is exploited mainly for gum arabic, but it also supplies fuel wood and fod- der for animals. Despite its wide distribution in Africa, no microsatellite markers have yet been characterized for this species. In this study, we characterized 11 polymorphic microsatel- lite loci specifically designed for A. senegal and analysed 247 individuals from three popula- tions from Niger. On average, 10.9 alleles per locus were detected and expected heterozygosity ranged from 0.160 to 0.794, showing the ability of the markers to detect genetic diversity in this species

Facing the music or burying our heads in the sand?: Adaptive emotion regulation in mid- and late-life

Psychological defense theories postulate that keeping threatening information out of awareness brings short-term reduction of anxiety at the cost of longer-term dysfunction. By contrast, Socioemotional Selectivity Theory suggests that preference for positively-valenced information is a manifestation of adaptive emotion regulation in later life. Using six decades of longitudinal data on 61 men, we examined links between emotion regulation indices informed by these distinct conceptualizations: defense patterns in earlier adulthood and selective memory for positively-valenced images in late life. Men who used more avoidant defenses in midlife recognized fewer emotionally-valenced and neutral images in a memory test 35-40 years later. Late-life satisfaction was positively linked with mid-life engaging defenses but negatively linked at the trend level with concurrent positivity bias

Evaluating system architectures for driving range estimation and charge planning for electric vehicles

Due to sparse charging infrastructure and short driving ranges, drivers of battery electric vehicles (BEVs) can experience range anxiety, which is the fear of stranding with an empty battery. To help eliminate range anxiety and make BEVs more attractive for customers, accurate range estimation methods need to be developed. In recent years, many publications have suggested machine learning algorithms as a fitting method to achieve accurate range estimations. However, these algorithms use a large amount of data and have high computational requirements. A traditional placement of the software within a vehicle\u27s electronic control unit could lead to high latencies and thus detrimental to user experience. But since modern vehicles are connected to a backend, where software modules can be implemented, high latencies can be prevented with intelligent distribution of the algorithm parts. On the other hand, communication between vehicle and backend can be slow or expensive. In this article, an intelligent deployment of a range estimation software based on ML is analyzed. We model hardware and software to enable performance evaluation in early stages of the development process. Based on simulations, different system architectures and module placements are then analyzed in terms of latency, network usage, energy usage, and cost. We show that a distributed system with cloud‐based module placement reduces the end‐to‐end latency significantly, when compared with a traditional vehicle‐based placement. Furthermore, we show that network usage is significantly reduced. This intelligent system enables the application of complex, but accurate range estimation with low latencies, resulting in an improved user experience, which enhances the practicality and acceptance of BEVs

Huysmans pornographe

La question de l’écriture pornographique est d’autant plus intéressante chez Huysmans que, au-delà du témoignage qu’elle offre quant à la place de l’érotisme dans la littérature de la fin du dix-neuvième siècle, elle est également un critérium inattendu de l’unité de l’œuvre. En effet, si la pornographie est au cœur des pratiques sexuelles et littéraires huysmansiennes, c’est moins sa visibilité explicite qui est à souligner que sa surprenante discrétion dans les romans naturalistes qui ont pourtant fait la réputation sulfureuse de l’auteur. Tout au contraire, ce sont les poèmes du Drageoir aux épices qui donnent les portraits de femmes annonciateurs de ce que l’on retrouvera sous la plume de l’auteur d’À rebours, ambivalents et marqués par le caractère antithétique de l’amour sadique, par la même crudité pornographique que celle des fleurs de Des Esseintes ou le rêve de la Syphilis. Le monde onirique ouvre alors l’espace d’une spiritualisation de l’ordure qui est celui du sadisme de Félicien Rops ou de Gilles de Rais, qui transfigure l’écriture du sexe en écriture de la monstruosité et les noces de la chair en noces spirituelles. Mais le trait le plus marquant est certainement celui de la réflexion sur l’essence même de l’écriture que la question permet à l’auteur converti. Après s’être plu à provoquer le bourgeois, Huysmans s’emploie en effet à scandaliser les bigots par le même langage, faisant basculer le point d’équilibre de sa pornographie de pornê à graphê.

Cluster-scaling, chaotic order and coherence in DNA

Different numerical mappings of the DNA sequences have been studied using a new cluster-scaling method and the well known spectral methods. It is shown, in particular, that the nucleotide sequences in DNA molecules have robust cluster-scaling properties. These properties are relevant to both types of nucleotide pair-bases interactions: hydrogen bonds and stacking interactions. It is shown that taking into account the cluster-scaling properties can help to improve heterogeneous models of the DNA dynamics. It is also shown that a chaotic (deterministic) order, rather than a stochastic randomness, controls the energy minima positions of the stacking interactions in the DNA sequences on large scales. The chaotic order results in a large-scale chaotic coherence between the two complimentary DNA-duplex's sequences. A competition between this broad-band chaotic coherence and the resonance coherence produced by genetic code has been briefly discussed. The Arabidopsis plant genome (which is a model plant for genome analysis) and two human genes: BRCA2 and NRXN1, have been considered as examples.Comment: extended. arXiv admin note: substantial text overlap with arXiv:1008.135

Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats

BACKGROUND Hypertension is characterized by a maintained high blood pressure leading to cardiac complications such as left ventricular hypertrophy and fibrosis and an increased risk of heart failure and myocardial infarction. This study investigated the cardiac effects of oral administration of Moringa oleifera (MOI) seed powder in spontaneous hypertensive rats (SHR). METHODS SHR received food containing MOI seed powder (750mg/d, 8 weeks) or normal food. In vivo measurement of hemodynamic parameters by telemetry and cardiac structure and function analysis by echocardiography were performed. Histological studies were performed to determine fibrosis and protein expression. RESULTS MOI treatment did not modify blood pressure in SHR but reduced nocturnal heart rate and improved cardiac diastolic function (reduction of isovolumetric relaxation time and deceleration time of the E wave, increase of ejection volume and cardiac output compared to nontreated SHR). Left ventricular anterior wall thickness, interseptal thickness on diastole, and relative wall thickness were reduced after MOI treatment. Furthermore, we found a significant reduction of fibrosis in the left ventricle of MOI-treated SHR. This antihypertrophic and antifibrotic effect of MOI was associated with increased expression of peroxisome proliferator-activated receptor (PPAR)-α and δ, reduced cardiac triglyceride level, and enhanced plasmatic prostacyclins. CONCLUSIONS Our data show a beneficial effect of MOI on the cardiac structure and function in SHR associated with an upregulation of PPAR-α and δ signaling. This study thus provides scientific rational support for the empirical use of MOI in the traditional Malagasy medicine against cardiac diseases associated with blood pressure overload

Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment

BACKGROUND: Periodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-resistant parasites increases. While monitoring anthelmintic drug efficacy is crucial to inform country control program strategies, different factors must be taken into consideration that influence drug efficacy and make it difficult to standardize treatment outcome measures. We aimed to identify suitable approaches to assess and compare the efficacy of different anthelmintic treatments. METHODOLOGY: We built an individual participant-level database from 11 randomized controlled trials and two observational studies in which subjects received single-agent or combination therapy, or placebo. Eggs per gram of stool were calculated from egg counts at baseline and post-treatment. Egg reduction rates (ERR; based on mean group egg counts) and individual-patient ERR (iERR) were utilized to express drug efficacy and analyzed after log-transformation with a linear mixed effect model. The analyses were separated by follow-up duration (14-21 and 22-45 days) after drug administration. PRINCIPAL FINDINGS: The 13 studies enrolled 5,759 STH stool-positive individuals; 5,688 received active medication or placebo contributing a total of 11,103 STH infections (65% had two or three concurrent infections), of whom 3,904 (8,503 infections) and 1,784 (2,550 infections) had efficacy assessed at 14-21 days and 22-45 days post-treatment, respectively. Neither the number of helminth co-infections nor duration of follow-up affected ERR for any helminth species. The number of participants treated with single-dose albendazole was 689 (18%), with single-dose mebendazole 658 (17%), and with albendazole-based co-administrations 775 (23%). The overall mean ERR assessed by day 14-21 for albendazole and mebendazole was 94.5% and 87.4%, respectively on Ascaris lumbricoides, 86.8% and 40.8% on hookworm, and 44.9% and 23.8% on Trichuris trichiura. The World Health Organization (WHO) recommended criteria for efficacy were met in 50%, 62%, and 33% studies of albendazole for A. lumbricoides, T. trichiura, and hookworm, respectively and 25% of mebendazole studies. iERR analyses showed similar results, with cure achieved in 92% of A. lumbricoides-infected subjects treated with albendazole and 93% with mebendazole; corresponding figures for hookworm were 70% and 17%, and for T. trichiura 22% and 20%. CONCLUSIONS/SIGNIFICANCE: Combining the traditional efficacy assessment using group averages with individual responses provides a more complete picture of how anthelmintic treatments perform. Most treatments analyzed fail to meet the WHO minimal criteria for efficacy based on group means. Drug combinations (i.e., albendazole-ivermectin and albendazole-oxantel pamoate) are promising treatments for STH infections