Interaction of oxidative stress and misfolded proteins in the mechanism of neurodegeneration

Aggregation of the misfolded proteins β-amyloid, tau, huntingtin, and α-synuclein is one of the most important steps in the pathology underlying a wide spectrum of neurodegenerative disorders, including the two most common ones—Alzheimer's and Parkinson's disease. Activity and toxicity of these proteins depends on the stage and form of aggregates. Excessive production of free radicals, including reactive oxygen species which lead to oxidative stress, is proven to be involved in the mechanism of pathology in most of neurodegenerative disorders. Both reactive oxygen species and misfolded proteins play a physiological role in the brain, and only deregulation in redox state and aggregation of the proteins leads to pathology. Here, we review the role of misfolded proteins in the activation of ROS production from various sources in neurons and glia. We discuss if free radicals can influence structural changes of the key toxic intermediates and describe the putative mechanisms by which oxidative stress and oligomers may cause neuronal death

A Method and a Device for Diagnostics of the Functional State of Peripheral Vessels of the Upper Limbs

The article suggests a method and a device for diagnostics of the functional state of peripheral vessels of the upper limbs, which provide identification of angiospastic disorders with a lower probability of falsenegative result, allowing thereby the quality of diagnostics to be improved. The suggested approach is based on combined application of laser Doppler flowmetry and contact thermometry during an occlusion test. The obtained results can be used in various fields of medicine for the development of multifunctional noninvasive diagnostic systems for the diagnosis and prevention of diseases associated with changes in the functional state of peripheral vessels

Opportunities for the analysis of the spatial ecological structure of the mycobiota of macromycetes of a natural-territorial entity (the case of the Botanical Garden of Belgorod University, Belgorod, Russia)

On the basis of direct observations, the general principles of the organization of the mycobiota of the macromycetes of the natural-territorial formation "Botanical Garden" of Belgorod State University (Belgorod, Russian Federation) have been clarified. Based on the clarified principles, a scheme of their spatial ecological organization has been constructed: mycobiota - mycohore (mycocenosis, mycoaggregation) - mycosinium-3 - mycocenocells - mycocell. The obtained results can be used to study the spatial ecological organization of mycobiota macromycetes of other natural-territorial formation

Trans-species relation in communities of pathogenic Polyporaceae on pedunculate oak Quercus robur L

In the process of research phytopathological and mycocenological methods were used As a result of the research, real trans-species relation were revealed in the most common and frequently occurring types of PPF on oak within various communities: Mutually positive type relationships based on the proto-operation were found between Laetiporus sulphureus and Fistulina hepatica. Neutral type relationships were found in between Fistulina hepatica and Fomitiporia robusta, Laetiporus sulphureus and Fomitiporia robust

Integral pattern of bench stability on all adjacent rock of open-pit mine in solid rocks

The article presents the integrated image of bench stability across the entire adjacent pit area on the basis of a probabilistic method to predict the azimuthangular parameters of cracks that limit the potential prisms of the pit bench collapse that are put in the final position, as well as those planned to be set to the limiting contour in the form of a software component as the part of the specialized geoinformation GIS system "Stability

New trophic classification of wood-destroying fungi the case of community of pathogenic polypore fungi types on Pedunculate oak

Based on the generalization of experimental data obtained during the practical study of the trophic specialization of wood-destroying fungi from the commonness of PTH on oak in the oak forests of the south-west of the Central Russian Upland, a new ecotrophic classification has been developed, including the following groups of wood-destroying fungi: biotrophic pathogens, saprotrophic pathogens, pathogenic saprotrophs, non-pathogenic saprotroph

HIERARCHICAL STRUCTURE OF PATHOGENIC POLYPORE FUNGI COMMUNITY ON PEDUNCULATE OAK IN THE OAK FORESTS OF THE SOUTHWEST OF THE CENTRAL RUSSIAN UPLAND

The article deals with the possibilities of typological classification and hierarchical subordination of the communities of pathogenic polypore fungi Polyporaceae s. l., associated with Pedunculate oak Quercus robur L. They allow to propose a schematic-model of the hierarchical structure of the regional community of pathogenic polypore fungi on Pedunculate oak (communities of pathogenic polypore fungi on Pedunculate oak) in the oak forests of the southwest of the Central Russian Upland. Based on studies, conducted in the oak forests of the Belgorod, Shebekinsky, Korochansky, Borisovsky administrative districts of the Belgorod region of the Russian Federation and the territory of Belgorod, 6 types of elementary PQ-mycopathocenosis were distinguished: four types of full-membered and two types of semicomplete. Two groups of types of elementary PQ-mycopathocenosis have been identified. Four-level scheme-model of the hierarchical structure of the regional community of pathogenic polypore fungi was proposed. It allowed not only to systematize information about this community of wooddestroying fungi, taking an active part in modern succession processes, occurring in the oak forests of the foreststeppe, but also to create prognostic models for their formation under different conditions. Keywords: hierarchical structure, community, cenosis, Pathogenic Polypore Fungi on Pedunculate oak, PPF on oak, PPF, PQ -mycopathocenosis, type of PQ -mycopathocenosis, subordination level

Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs

The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases. This paper is devoted to the development and application of the optical non-invasive diagnostic approach for the detection and evaluation of the severity of microcirculatory and metabolic disorders in rheumatic diseases and diabetes mellitus. The proposed methods include the joint use of laser Doppler flowmetry, absorption spectroscopy and fluorescence spectroscopy in combination with functional tests. This technique showed the high diagnostic importance for the detection of disturbances in peripheral microhaemodynamics. These methods have been successfully tested as additional diagnostic techniques in the field of rheumatology and endocrinology. The sensitivity and specificity of the proposed diagnostic procedures have been evaluated.<br/

Assessment of the Size of Rocks in Benchs and Lumpiness of the Blasted Mountain Mass on Pits with Use of Gis Geomix

On the basis of natural researches in career of SC Kovdorsky MCP and computer processing of their results in GIS GEOMIX was developed the photometric method of assessment of blocks (sizes) of breeds in the slope of ledges of a pit, the existing version of this method intended for assessment of lumpiness of mountain mass is improve

Blood flow oscillations as a signature of microvascular abnormalities

Laser Doppler flowmetry (LDF) was utilized for blood ow measurements. Wavelet analysis was used to identify spectral characteristics of the LDF signal in patients with rheumatic diseases and diabetes mellitus. Baseline measurements were applied for both pathological groups. Blood flow oscillations analyses were performed by means of the wavelet transform. Higher baseline perfusion was observed in both pathological groups in comparison to controls. Differences in the spectral properties between the groups studied were revealed. The results obtained demonstrated that spectral properties of the LDF signal collected in basal conditions may be the signature of microvasculature functional state