Экологический мониторинг почв Муганской степи Азербайджана

Soil-ecological monitoring is a scientific information system for monitoring changes in soil cover, assessing the state of soils, and predicting the impact of natural and anthropogenic factors on them. This monitoring shows the results of undesirable regional and global changes in soil cover and landscape and anthropogenic changes over time. Therefore it is important to study the change in the state of land used for crops in the Mugan Desert, where intensive farming is used and to make timely proposals to resolve these changes. The Mugan Desert is located in the southeastern part of the Kura-Araz lowland. The total area of the Mugan Desert is 455,332.5 ha. The main soils are gray-brown, sierozem-meadow, meadow-sierozem, bog-meadow, and alluvial-meadow soils, which are occupied by crops. These soils were the objects of study of the authors. Soil-ecological monitoring was carried out according to the method of G.V. Dobrovolsky and other scientists. Laboratory analyzes, which were taken from soil samples, were carried out according to generally accepted methods. The authors also collected and processed soil data from stock and literary materials of the period from 1980 to 1985 and the present. The authors found that in three of the four studied soil types over 40 years, an increase in crop-producing power was observed in one - it decreased. The content of humus in gray-brown soils increased by 0.20%, meadow-sierozem - by 0.14%, sierozem-meadow - by 0.12%, and in alluvial-meadow soils the content of humus decreased by 0.17%, nitrogen - by 0.02%, phosphorus - by 0.02%. Based on the analysis, the authors compiled a soil salinity map of the Mugan steppe (M 1: 100,000) and determined that alluvial-meadow soils were mainly subjected to low salinity (+0.19%), gray-brown - medium (+0.29%), meadow-sierozem (+0.67%) and sierozem-meadow soils (+0.44%) - to strong salinity. As a result of comparing our data on soil salinity in the study area with the data of G.Sh. Mamedov (2000), the authors found that the area of saline lands in the Mugan Desert increased from 33.9% to 66.1%, of which the area of weakly saline soils decreased from 24.24% to 10.58%, of moderately saline soils increased from 9.68% to 15.6, and highly saline also increased from 5.33% to 36.4%.Почвенно-экологический мониторинг как научная информационная система контроля изменений почвенного покрова, оценки состояния почв и прогнозирования воздействия на него природных и антропогенных факторов показывает результаты нежелательных региональных и глобальных изменений почвенного покрова и ландшафта, антропогенных изменений во времени. В связи с этим важно изучить изменение состояния земель, используемых под сельскохозяйственными культурами на Муганской равнине, где применяется интенсивное земледелие, и своевременно внести предложения по урегулированию этих изменений. Муганская равнина расположена в юго-восточной части Кура-Аразской низменности, общая площадь которой составляет 455332,5 га. Основными почвами исследуемой территории, занятыми под сельскохозяйственными культурами, являются серо-коричневые, сероземно-луговые, лугово-сероземные, болотно-луговые и аллювиально-луговые. Почвенно-экологический мониторинг проводился по методике Г.В. Добровольского и других ученых, лабораторные анализы взятых почвенных образцов проводились по общепринятым методикам, а также были собраны и обработаны почвенные данные из фондовых и литературных материалов периода 1980–1985 гг. и нынешнего времени. Установлено, что в трех из четырех исследованных типов почв за 40-летний период наблюдалось увеличение плодородия, в одном – его снижение. Содержание гумуса в серо-коричневых почвах увеличилось на 0,20%, лугово-сероземных – на 0,14, сероземно-луговых – на 0,12, а в аллювиально-луговых почвах содержание гумуса уменьшилось на 0,17%, азота – на 0,02, фосфора – на 0,02%. На основе анализа составленной нами карты засоления почв Муганской степи (М 1 : 100000) определено, что аллювиально-луговые почвы в основном подверглись слабому засолению (+0,19%), серо-коричневые – среднему (+0,29%), лугово-сероземные (+0,67%) и сероземно-луговые почвы (+0,44%) – сильному засолению. В результате сравнения собственных данных по засолению почв исследуемой территории с данными Г.Ш. Мамедова (2000 г.) установлено, что площадь засоленных земель на Муганской равнине увеличилась с 33,9 до 66,1%, из них площадь слабозасоленных почв – с 24,24 до 10,58, среднезасоленных – с 9,68 до 15,6, а сильнозасоленных – с 5,33 до 36,4%

Electroproduction, photoproduction, and inverse electroproduction of pions in the first resonance region

Methods are set forth for determining the hadron electromagnetic structure in the sub-$N\bar{N}$-threshold timelike region of the virtual-photon ``mass'' and for investigating the nucleon weak structure in the spacelike region from experimental data on the process $\pi N\to e^+e^- N$ at low energies. These methods are formulated using the unified description of photoproduction, electroproduction, and inverse electroproduction of pions in the first resonance region in the framework of the dispersion-relation model and on the basis of the model-independent properties of inverse electroproduction. Applications of these methods are also shown.Comment: The revised published version; Revtex4, 18 pages, 6 figure

Infrared study of the multiband low-energy excitations of the topological antiferromagnet MnBi2Te4

With infrared spectroscopy, we studied the bulk electronic properties of the topological antiferromagnet MnBi2Te4 with TN≃25K. With the support of band-structure calculations, we assign the intra- and interband excitations and determine the band gap of Eg≈0.17 eV. We also obtain evidence for two types of conduction bands with light and very heavy carriers. The multiband free-carrier response gives rise to an unusually strong increase of the combined plasma frequency, ωpl, below 300 K. The band reconstruction below TN yields an additional increase of ωpl and a splitting of the transition between the two conduction bands by about 54 meV. Our study thus reveals a complex and strongly temperature-dependent multiband low-energy response that has important implications for the study of the surface states and device applications.The work in Fribourg was supported by the Schweizerische Nationalfonds (SNF) through Grant No. 200020-172611. V.K. acknowledges support by the Deutsche Forschungsgemeinschaft (DFG) through Grant No. KA1694/12-1. N.M. acknowledges the support of the Science Development Foundation under the President of the Republic of Azerbaijan (Grant No. E˙IF-BGM-4-RFTF1/2017-21/04/1-M-02). The work at Beijing was supported by the Natural Science Foundation of China (NSFC Grant No. 11734003), the National Key R&D Program of China (Grants No. 2016YFA0300600 and No. 2020YFA0308800), and the Beijing Natural Science Foundation (Grant No. Z190006). Z.W. acknowledges the support from Beijing Institute of Technology Research Fund Program for Young Scholars. B.S. acknowledges the support of the Fundamental Research Funds for the Central Universities, Grant No. 19lgpy260. E.V.C. acknowledges Saint Petersburg State University (Grant No. ID 73028629). Y.M.D. acknowledges the support of the Natural Science Foundation of China (Grant No. 11874206). M.M.O. acknowledges the support by Spanish Ministerio de Ciencia e Innovación (Grant No. PID2019-103910GB-I00).Peer reviewe

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990-2010 time period, with the greatest annualised rate of decline occurring in the 0-9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10-24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10-24 years were also in the top ten in the 25-49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50-74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve

ЭФФЕКТИВНОСТЬ ЗОЛЕДРОНОВОЙ КИСЛОТЫ В ПРОФИЛАКТИКЕ КОСТНЫХ МЕТАСТАЗОВ У ПАЦИЕНТОВ С МЕСТНО-РАСПРОСТРАНЕННЫМ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

The analysis of the performed study has established that zoledronic acid is an effective agent in multimodality therapy for locally advanced prostate cancer (PC) and allows long-term stabilization of bone tissue. In addition, there is evidence for the efficacy of zoledronic acid in preventing bone metastases (BM) and increasing the time to the first BM. The currently accumulated experience with zoledronic acid used in PC permits one to consider its use as standard concomitant therapy.На основании анализа проведенного исследования установлено, что золедроновая кислота является эффективным препаратом в комплексной терапии местно-распространенного рака предстательной железы (РПЖ) и позволяет стабилизировать в течение длительного времени состояние костной ткани. Кроме того, подтверждена эффективность золедроновой кислоты в профилактике костных метастазов (КМ), а также в увеличении времени до появления первого КМ. Накопленный к настоящему времени опыт использования золедроновой кислоты при РПЖ позволяет рассматривать ее назначение как стандартную сопроводительную терапию

Global burden of 87 risk factors in 204 countries and territories, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk-outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk-outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk-outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10.8 million (95% uncertainty interval [UI] 9.51-12.1) deaths (19.2% [16.9-21.3] of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8.71 million (8.12-9.31) deaths (15.4% [14.6-16.2] of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253-350) DALYs (11.6% [10.3-13.1] of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0-9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10-24 years, alcohol use for those aged 25-49 years, and high systolic blood pressure for those aged 50-74 years and 75 years and older. Interpretation Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health : all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

Background Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-19, and a novel framework for quantifying optimal child survival. Methods We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (USMR). Scenarios for 2030 represent different potential trajectories, notably including potential effects of the COVID-19 pandemic and the potential impact of improvements preferentially targeting neonatal survival. Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. The first metric is a global optimum and is based on the lowest observed mortality, and the second is a survival potential frontier that is based on stochastic frontier analysis of observed mortality and Healthcare Access and Quality Index. Findings Global U5MR decreased from 71.2 deaths per 1000 livebirths (95% uncertainty interval WI] 68.3-74-0) in 2000 to 37.1 (33.2-41.7) in 2019 while global NMR correspondingly declined more slowly from 28.0 deaths per 1000 live births (26.8-29-5) in 2000 to 17.9 (16.3-19-8) in 2019. In 2019,136 (67%) of 204 countries had a USMR at or below the SDG 3.2 threshold and 133 (65%) had an NMR at or below the SDG 3.2 threshold, and the reference scenario suggests that by 2030,154 (75%) of all countries could meet the U5MR targets, and 139 (68%) could meet the NMR targets. Deaths of children younger than 5 years totalled 9.65 million (95% UI 9.05-10.30) in 2000 and 5.05 million (4.27-6.02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3.76 million [95% UI 3.53-4.021) in 2000 to 48% (2.42 million; 2.06-2.86) in 2019. NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. The global optimum analysis suggests NMR could be reduced to as low as 0.80 (95% UI 0.71-0.86) deaths per 1000 livebirths and U5MR to 1.44 (95% UI 1-27-1.58) deaths per 1000 livebirths, and in 2019, there were as many as 1.87 million (95% UI 1-35-2.58; 37% [95% UI 32-43]) of 5.05 million more deaths of children younger than 5 years than the survival potential frontier. Interpretation Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in neonates and 65 (32%) of 204 countries, mostly in sub-Saharan Africa and south Asia, are not on track to meet either SDG 3.2 target by 2030. Focused improvements in perinatal and newborn care, continued and expanded delivery of essential interventions such as vaccination and infection prevention, an enhanced focus on equity, continued focus on poverty reduction and education, and investment in strengthening health systems across the development spectrum have the potential to substantially improve USMR. Given the widespread effects of COVID-19, considerable effort will be required to maintain and accelerate progress

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations

The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).Funding text 1: This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation. ; Funding text 2: This study was funded by the Bill & Melinda Gates Foundation. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The non-consortium authors have no competing interests . Competing interests for consortium authors is as follows: Robert Ancuceanu reports receiving consultancy or speaker feeds from UCB, Sandoz, Abbvie, Zentiva, Teva, Laropharm, CEGEDIM, Angelini, Biessen Pharma, Hofigal, AstraZeneca, and Stada. Jacek Jerzy Jozwiak reports personal fees from Amgen, ALAB Laboratories, Teva, Synexus, Boehringer Ingelheim, and Zentiva, all outside the submitted work. Kewal Krishan reports non-financial support from UGC Centre of Advanced Study, CAS II, Department of Anthropology, Panjab University, Chandigarh, India, outside the submitted work. Walter Mendoza is a Program Analyst in Population and Development at the United Nations Population Fund-UNFPA Country Office in Peru, which does not necessarily endorse or support these findings. Maarten J Postma reports grants and personal fees from MSD, GSK, Pfizer, Boehringer Ingelheim, Novavax, BMS, Seqirus, Astra Zeneca, Sanofi, IQVIA, grants from Bayer, BioMerieux, WHO, EU, FIND, Antilope, DIKTI, LPDP, Budi, personal fees from Novartis, Quintiles, Pharmerit, owning stock options in Health-Ecore and PAG Ltd, and being advisor to Asc Academics, all outside the submitted work. Jasviner A Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio health, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Focus forward, Navigant consulting, Spherix, Practice Point communications, the National Institutes of Health, the American College of Rheumatology, and Simply Speaking, owning stock options in Amarin, Viking, Moderna, Vaxart pharmaceuticals and Charlotte’s Web Holdings, being a member of FDA Arthritis Advisory Committee, the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arm’s length funding from 12 pharmaceutical companies, and the Veterans Affairs Rheumatology Field Advisory Committee, and acting as Editor and Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, all outside the submitted work. Era Upadhyay has a patent A system and method of reusable filters for anti-pollution mask pending, and a patent A system and method for electricity generation through crop stubble by using microbial fuel cells pending