1,594 research outputs found
Alterations in the antioxidant status of patients suffering from diabetes mellitus and associated cardiovascular complications
In view of the high prevalence of type 2 diabetes mellitus, this study aimed at determining the total plasma antioxidant capacity of type 2 diabetic patients with and without macrovascular complications. The erythrocyte catalase level was also evaluated because of the implication of catalase as a risk factor in diabetes. 90 age-‐, gender-‐ and body mass index-‐matched subjects were used for this study and divided into healthy subjects (Group I, n=30), diabetic patients (Group II, n=30) and diabetic patients with cardiovascular complications (Group III, n=30). Blood samples collected from 90 eligible subjects were analyzed for glucose, HbA1c, urea, creatinine, total cholesterol, triglyceride, HDL and LDL cholesterol levels. Blood antioxidant activity and erythrocyte catalase levels were assessed. The mean antioxidant status values of Groups II and III were found to be significantly lower than that of Group I (p < 0.05). A significant decrease was also observed in the mean catalase level of Groups II and III as compared to Group I (p < 0.05) while a significant increase in fasting blood glucose level, glycated hemoglobin, triglycerides and urea was observed in Groups II and III compared to Group I. These data suggest that the in vivo antioxidant defense was highly compromised in patients with diabetes and associated cardiovascular complications although they were on medication, thereby suggesting the potential contributory beneficial effects of exogenous antioxidants. Furthermore, a reduction in catalase level may suggest the role of increasing hydrogen peroxide concentration in the disease progression.KEY WORDS: Antioxidant; Erythrocyte catalase; Cardiovascular complications; Type 2 diabetes mellitu
Imaging the formation of a p-n junction in a suspended carbon nanotube with scanning photocurrent microscopy
We use scanning photocurrent microscopy (SPCM) to investigate individual
suspended semiconducting carbon nanotube devices where the potential profile is
engineered by means of local gates. In situ tunable p-n junctions can be
generated at any position along the nanotube axis. Combining SPCM with
transport measurements allows a detailed microscopic study of the evolution of
the band profiles as a function of the gates voltage. Here we study the
emergence of a p-n and a n-p junctions out of a n-type transistor channel using
two local gates. In both cases the I-V curves recorded for gate configurations
corresponding to the formation of the p-n or n-p junction in the SPCM
measurements reveal a clear transition from resistive to rectification regimes.
The rectification curves can be fitted well to the Shockley diode model with a
series resistor and reveal a clear ideal diode behavior.Comment: Accepted for publication in Journal or Applied Physics. 4 pages, 3
figure
Optimality criteria without constraint qualications for linear semidenite problems
We consider two closely related optimization problems: a problem of convex Semi-
Infinite Programming with multidimensional index set and a linear problem of Semidefinite Programming. In study of these problems we apply the approach suggested in our recent paper [14] and based on the notions of immobile indices and their immobility orders. For the linear semidefinite problem, we define the subspace of immobile indices and formulate the first order optimality conditions in terms of a basic matrix of this subspace.
These conditions are explicit, do not use constraint qualifications, and have the form of criterion. An algorithm determining a basis of the subspace of immobile indices in a finite number of steps is suggested. The optimality conditions obtained are compared with other known optimality conditions
Evidence for Efimov quantum states in an ultracold gas of cesium atoms
Systems of three interacting particles are notorious for their complex
physical behavior. A landmark theoretical result in few-body quantum physics is
Efimov's prediction of a universal set of bound trimer states appearing for
three identical bosons with a resonant two-body interaction.
Counterintuitively, these states even exist in the absence of a corresponding
two-body bound state. Since the formulation of Efimov's problem in the context
of nuclear physics 35 years ago, it has attracted great interest in many areas
of physics. However, the observation of Efimov quantum states has remained an
elusive goal. Here we report the observation of an Efimov resonance in an
ultracold gas of cesium atoms. The resonance occurs in the range of large
negative two-body scattering lengths, arising from the coupling of three free
atoms to an Efimov trimer. Experimentally, we observe its signature as a giant
three-body recombination loss when the strength of the two-body interaction is
varied. We also detect a minimum in the recombination loss for positive
scattering lengths, indicating destructive interference of decay pathways. Our
results confirm central theoretical predictions of Efimov physics and represent
a starting point with which to explore the universal properties of resonantly
interacting few-body systems. While Feshbach resonances have provided the key
to control quantum-mechanical interactions on the two-body level, Efimov
resonances connect ultracold matter to the world of few-body quantum phenomena.Comment: 18 pages, 3 figure
Efimov physics beyond three particles
Efimov physics originally refers to a system of three particles. Here we
review recent theoretical progress seeking for manifestations of Efimov physics
in systems composed of more than three particles. Clusters of more than three
bosons are tied to each Efimov trimer, but no independent Efimov physics exists
there beyond three bosons. The case of a few heavy fermions interacting with a
lighter atom is also considered, where the mass ratio of the constituent
particles plays a significant role. Following Efimov's study of the (2+1)
system, the (3+1) system was shown to have its own critical mass ratio to
become Efimovian. We show that the (4+1) system becomes Efimovian at a mass
ratio which is smaller than its sub-systems thresholds, giving a pure five-body
Efimov effect. The (5+1) and (6+1) systems are also discussed, and we show the
absence of 6- and 7-body Efimov physics there
Square lattice Ising model susceptibility: Series expansion method and differential equation for
In a previous paper (J. Phys. A {\bf 37} (2004) 9651-9668) we have given the
Fuchsian linear differential equation satisfied by , the
``three-particle'' contribution to the susceptibility of the isotropic square
lattice Ising model. This paper gives the details of the calculations (with
some useful tricks and tools) allowing one to obtain long series in polynomial
time. The method is based on series expansion in the variables that appear in
the -dimensional integrals representing the -particle contribution to
the isotropic square lattice Ising model susceptibility . The
integration rules are straightforward due to remarkable formulas we derived for
these variables. We obtain without any numerical approximation as
a fully integrated series in the variable , where , with the conventional Ising model coupling constant. We also
give some perspectives and comments on these results.Comment: 28 pages, no figur
Efficient quantum state transfer in spin chains via adiabatic passage
We propose a method for quantum state transfer in spin chains using an
adiabatic passage technique. Modifying even and odd nearest-neighbour couplings
in time allows to achieve transfer fidelities arbitrarily close to one, without
the need for a precise control of coupling strengths and timing. We study in
detail transfer by adiabatic passage in a spin-1 chain governed by a
generalized Heisenberg Hamiltonian. We consider optimization of the transfer
process applying optimal control techniques. We discuss a realistic
experimental implementation using cold atomic gases confined in deep optical
lattices.Comment: 14 pages, 6 figures, to be published in New J. Phy
Involvement of Mhc Loci in immune responses that are not Ir-gene-controlled
Twenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative response of the cells was determined. Both strains were responders to 28 of 29 antigens. Eight antigens were then used to immunize 11 congenic strains carrying different H-2 haplotypes, and the T-cell proliferative responses of these strains were determined. Again, all the strains responded to seven of the eight antigens. These experiments were then repeated, but this time -antibodies specific for the A (AA) or E (EE) molecules were added to the culture to block the in vitro responsiveness. In all but one of the responses, inhibition with both A-specific and E-specific antibodies was observed. The response to one antigen (Blastoinyces) was exceptional in that some strains were nonresponders to this antigen. Furthermore, the response in the responder strains was blocked with A-specific, but not with E-specific, antibodies. The study demonstrates that responses to antigens not controlled by Irr genes nevertheless require participation of class II Mhc molecules. In contrast to Ir gene-controlled responses involving either the A- or the E-molecule controlling loci (but never both), the responses not Ir-controlled involve participation of both A- and E-controlling loci. The lack of Ir-gene control is probably the result of complexity of the responses to multiple determinants. There is thus no principal difference between responses controlled and those not controlled by Ir genes: both types involve the recognition of the antigen, in the context of Mhc molecules
Privatization and State Capacity in Postcommunist Society
Economists have used cross-national regression analysis to argue that postcommunist economic failure is the result of inadequate adherence liberal economic policies. Sociologists have relied on case study data to show that postcommunist economic failure is the outcome of too close adherence to liberal policy recommendations, which has led to an erosion of state effectiveness, and thus produced poor economic performance. The present paper advances a version of this statist theory based on a quantitative analysis of mass privatization programs in the postcommunist world. We argue that rapid large-scale privatization creates severe supply and demand shocks for enterprises, thereby inducing firm failure. The resulting erosion of tax revenues leads to a fiscal crisis for the state, and severely weakens its capacity and bureaucratic character. This, in turn, reacts back on the enterprise sector, as the state can no longer support the institutions necessary for the effective functioning of a modern economy, thus resulting in deindustrialization. Using cross-national regression techniques we find that the implementation of mass privatization programs negatively impacts measures of economic growth, state capacity and the security of property rights.http://deepblue.lib.umich.edu/bitstream/2027.42/40192/3/wp806.pd
Three-dimensional echocardiography for left ventricular quantification: fundamental validation and clinical applications
One of the earliest applications of clinical echocardiography is evaluation of left ventricular (LV) function and size. Accurate, reproducible and quantitative evaluation of LV function and size is vital for diagnosis, treatment and prediction of prognosis of heart disease. Early three-dimensional (3D) echocardiographic techniques showed better reproducibility than two-dimensional (2D) echocardiography and narrower limits of agreement for assessment of LV function and size in comparison to reference methods, mostly cardiac magnetic resonance (CMR) imaging, but acquisition methods were cumbersome and a lack of user-friendly analysis software initially precluded widespread use. Through the advent of matrix transducers enabling real-time three-dimensional echocardiography (3DE) and improvements in analysis software featuring semi-automated volumetric analysis, 3D echocardiography evolved into a simple and fast imaging modality for everyday clinical use. 3DE provides the possibility to evaluate the entire LV in three spatial dimensions during the complete cardiac cycle, offering a more accurate and complete quantitative evaluation the LV. Improved efficiency in acquisition and analysis may provide clinicians with important diagnostic information within minutes. The current article reviews the methodology and application of 3DE for quantitative evaluation of the LV, provides the scientific evidence for its current clinical use, and discusses its current limitations and potential future directions
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