The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes

As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6

The relevance of individualization in the choice of methods of testing of physical abilities of students in special medical groups

Alternative methods of testing of students of special medical group.Альтернативные методы тестирования студентов специальной медицинской группы

Impact of technological blockchain paradigm on the movement of intellectual property in the digital space

The article is dedicated to investigate the problem of influence of cutting edge digital technology on the virtual and real legal relations, related to the movement and the turnover of intellectual property. Using the method of analyzing modern definitions of blockchain, and relying on the political-economic theory of social redistribution of wealth, authors define the term blockchain and its principles as a technological paradigm. Authors conclude the fact that blockchain can be used to guarantee intellectual property rights and it should be accepted at the national level. As a mechanism of a trusted environment, blockchain allows to reduce transaction costs and increase the level of commercialization of intellectual property.peer-reviewe

Correction of myopia of primary school pupils at lessons of physical culture

In this paper, methods of myopia correction in primary school pupils by means of adapted games and physical exercises in physical education classes are disclosed.В данной работе раскрываются методы коррекции миопии у младших школьников средствами адаптированных игр и физических упражнений на уроках физической культуры

ХАРАКТЕРИСТИКА КЛИНИЧЕСКОЙ КАРТИНЫ И ЦИТОКИНЫ СЫВОРОТКИ КРОВИ У ПАЦИЕНТОВ С БЕЗЭРИТЕМНОЙ ФОРМОЙ ИКСОДОВОГО КЛЕЩЕВОГО БОРРЕЛИОЗА

Purpose of the study: To investigate the role and clinical inflammatory (IL-17A, IL-23, IL-33) and anti-inflammatory (IL-35) cytokines in patients with of form without erythema of Borrelia infection. Materials and methods: We studied 30 patients with of form without erythema of Lyme borreliosis. The diagnosis was based on epidemiological, medical history, clinical and laboratory, serological data. The blood serum interleukins level was detected from patients at admission to the infectious hospital and on the 10th day of hospitalization, as well as from 30 healthy donors. Groups of investigated persons were matched by sex and age. Blood serum analysis was carried out in the laboratory of directed regulation inter microbe interactions in the exo- and endoecological systems in Kirov State Medical University. Statistical analysis was performed using StatSoft Statistica v 10.0. Results: Patients with form without erythema of Lyme borreliosis oft have lesions of the respiratory system (60,0%), nervous system (53,3%), cardiac disorders (40,0%), rarely – liver disease (26,7%), joints (10,0%). In blood serum of patients with form without erythema at admission and at hospital discharge concentrations of IL-17A, IL-23, IL-33 are authentically higher compared with healthy donors. The content of anti-inflammatory IL-35 in patients with a form without erythema during hospitalization and at discharge is authentically lower than in healthy donors. Conclusion: Patients with form without erythema of Lyme borreliosis have early combined Th1-Th2 immune response (increased content of blood serum IL-23 and IL-33). Elevated concentrations of IL-17A and IL-33 serum in patients with form without erythema indicate the presence of autoimmune or allergic reactions. Patients with form without erythema have inflammatory processes limited moderately by inflammatory reactions on the part of Treg-system (lack of IL-35 production).Цель: изучить клиническую картину и роль провоспалительных (IL-17A, IL-23, IL-33) и противовоспалительных (IL-35) цитокинов у пациентов с безэритемной формой боррелиозной инфекции. Материалы и методы: исследованы 30 пациентов с безэритемной формой Лайм-боррелиоза. Диагноз основывался на эпидемиологических, анамнестических, клинико-лабораторных, серологических данных. Определен уровень интерлейкинов сыворотки крови у больных при поступлении в инфекционный стационар и на 10-е сутки госпитализации, а также у 30 здоровых доноров. Группы исследуемых лиц были сопоставимы по полу и возрасту. Анализ сыворотки крови проводился в лаборатории направленного регулирования межмикробных взаимодействий в экзо- и эндоэкологических системах Кировского государственного медицинского университета. Статистическая обработка данных проводилась с использованием StatSoft Statistica v 10.0. Результаты: при безэритемной форме Лаймборрелиоза часто встречаются поражения дыхательной системы (60,0%), нервной системы (53,3%), нарушения сердечной деятельности (40,0%), реже — патология печени (26,7%), суставов (10,0%). В сыворотке крови пациентов с безэритемной формой при госпитализации и при выписке достоверно увеличены концентрации IL-17A, IL-23, IL-33 по сравнению со здоровыми донорами. Содержание противовоспалительного IL-35 у пациентов с безэритемной формой в периоде госпитализации и при выписке из стационара достоверно ниже показателей здоровых доноров. Заключение: у пациентов с безэритемной формой Лайм-боррелиоза установлен ранний комбинированный Th1-Th2 иммунный ответ (повышенное содержание IL-23 и IL-33 сыворотки крови). Повышенные концентрации сывороточных IL-17A и IL-33 у пациентов с безэритемной формой указывают на наличие аутоиммунных и аллергических реакций. У пациентов с безэритемной формой течение воспалительных процессов умеренно ограничивается противовоспалительными реакциями со стороны Treg-системы (недостаточная продукция IL-35)

Application of modern immunological methods in the diagnosis of tuberculosis in HIV-infected patients

Combination of TB and HIV-infection is still the most nowadays important problem, and it connects not only with steady growth of HIV infection, but with difficulties in TB diagnosis. X-ray lung studies often have unusual nature, clinical symptomatology appears when process are hard and spread. At the same time in global practice IGRAtests applying, to which they belong to SPOT.TB test and QuantiFERON®-TB Gold test, they pay great attention to it, particularly among patients with HIV- infection. In study there were data when 41 patients with lung TB were examined, 56 HIV-positive patients with lung TB and 58 healthy donors. When active TB IGRA-test and test with Diaskin test show comparable same results. Against the backdrop of HIV skin tests (Mantoux test with 2 TE and tests with Diaskin test) it was demonstrated direct dependence of level immunosuppression in contrast to IGRA – tests, that allows to carry out these researches in conditions when standard skin tests do not work

Azoloazines as Perspective Antiglycating Agents for Therapy of Diabetes Complications

This work was supported by Russian Federation Ministry of education and science (grant № 4.6351.2017/8.9) and Russian Foundation for Basic Research (grant № 18-03-00787)

TREATMENT EFFICIENCY OF DRUG SUSCEPTIBLE PULMONARY TUBERCULOSIS

The article describes the study of comparative efficiency of fenazid (isonicotinoilhydrazine-О,N’) ferrous dihydrate sulphate (II) and isoniazid in drug susceptible pulmonary tuberculosis patients.The high treatment efficiency namely significant improvement and improvement was observed in the patients of Group 1 – 84.1% which could be compared to the standard treatment regimen (85-7%) in Group 2. The total number of adverse reactions in the main group was confidently lower – 18.6% against 33.9%, p < 0.05. Hepatotoxic reactions with 2-3 fold increase of alaninetransferase level was registered significantly less (9.3%) in Group 1 compared to the Group treated with isoniazid

Dynamics of СО2 evolution bу plants at low pressure

Dynamics of СО2 evolut:ion at low pressure was studied in barley, maize, реа, wheat and pine seedlings using the gas exchange system with laser photoacoust:ic spectrometer. The СО2 evolut:ion from plant surfaces to environment increased with decreasing air pressure. Simultaneously the changes in act:ivities of phosphoenolpyruvat