The study of TIM polymer composite materials thermal conductivity

A recent trend in electronic technology deals with a sharp performance increase within decrease dimensions and mass of devices. High-performance thermal interface materials (TIM) primarily thermal pastes are indispensable to application. A number of filler materials: ceramics (aluminum nitride, silicon carbide, alumina) metals (aluminum, copper) and graphite were considered to apply. The data containing average particles size, specific surface area, and maximal volume and mass fraction for various materials was obtained. The thermal conductivity of samples with aluminum and graphite dramatically exceed values obtained within mathematical models' calculation. The highest thermal conductivity values were obtained for SiC (1.37 W/(m·K)), AlN (1.09 W/(m·K)), C (2.85 W/(m·K)) and Al (1.20 W/(m·K)), that mad the mentioned above materials the most promising for high-performance thermal pastes. © 2019 Author(s)

The study of TIM polymer composite materials thermal conductivity

Support by the Ministry of Education and Science of the Russian Federation is gratefully acknowledged: calculation results (chapter 3.1) were obtained under research project # 3.6064.2017/8.9 and experimental results (chapter 3.2) - under project # 3.10704.2018/11.12

Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response

Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial. The aim of this study is to analyze methadone dosage in responder and nonresponder patients considering pharmacogenetic and pharmacokinetic factors that may contribute to dosage adequacy. Opioid dependence patients (meeting Diagnostic and Statistical Manual of Mental Disorders, [4th Edition] criteria) from a MMT community program were recruited. Patients were clinically assessed and blood samples were obtained to determine plasma concentrations of (R,S)-, (R) and (S)- methadone and to study allelic variants of genes encoding CYP3A5, CYP2D6, CYP2B6, CYP2C9, CYP2C19, and P-glycoprotein. Responders and nonresponders were defined by illicit opioid consumption detected in random urinalysis. The final sample consisted in 105 opioid dependent patients of Caucasian origin. Responder patients received higher doses of methadone and have been included into treatment for a longer period. No differences were found in terms of genotype frequencies between groups. Only CYP2D6 metabolizing phenotype differences were found in outcome status, methadone dose requirements, and plasma concentrations, being higher in the ultrarapid metabolizers. No other differences were found between phenotype and responder status, methadone dose requirements, neither in methadone plasma concentrations. Pharmacokinetic factors could explain some but not all differences in MMT outcome and methadone dose requirements

ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ ЭЛЕКТРИЧЕСКОГО РАЗРЯДА В ЖИДКОСТИ, СОЗДАВАЕМОГО МЕЖДУ ЭЛЕКТРОДАМИ С КОНУСНОЙ ВЫЕМКОЙ

This paper delves into electrical discharge in liquid between cone channel electrodes as applied to a problem of cavity initiation with shock waves focusing. The velocity of the cavitation pocket directed motion has been determined. Curves of the liquid transparency variation at 650 nm wave length have been obtained. Low pressure influence on acoustic signals under shock waves focusing has been evaluated.В работе рассмотрен электрический разряд в жидкости между электродами с конусной выемкой применительно к задаче создания кавитационной полости с фокусировкой ударных волн. Исследована скорость направленного движения кавитационной полости, кривые изменения прозрачности жидкости на длине волны 650 нм, влияние пониженного давления на акустические сигналы при фокусировке ударных волн.У роботі розглянуто електричний вибух у рідині, між електродами з конусним вижолобком стосовно до задачі створення кавітаційної порожнини з фокусуванням ударних хвиль. Досліджена швидкість спрямованого руху кавітаційної порожнини, одержані криві зміни прозорості рідини на довжині хвилі 650 нм, встановлений вплив зниженого тиску на акустичні сигнали при фокусуванні ударних хвиль