Study on a conceptual model for campus transformation of classical universities in the digital era

This article presents a conceptual management model of campus space 4.0 (CS4.0), in which CS4.0 is viewed as a condition for the transformation of classical universities in the digital era. To create this model, we used the systems approach as well as complexity theory, focusing on the ontological, spatial, axiological, social, psychological, and management aspects. The model not only defines the systems status of CS4.0 and describes the three types of properties inherent in CS4.0. This model also explains why, in the digital era, CS4.0 can become the agent of change for a classical university that has had a long history. This model of CS4.0 will not destroy the university’s cultural identity and academic values; rather, it will serve the interests of all groups within the university community. This conceptual model can be the key to understanding one of the possible management strategies for the development of the classical university in the digital network society at the beginning of the Fourth Industrial Revolution

О ФИЗИОЛОГИЧЕСКОМ СТАТУСЕ НЕКОТОРЫХ СТЕРОИДНЫХ ГЛИКОЗИДОВ РАСТЕНИЙ

The comparative study of the processes of growth, organ formation and physiological and biochemical responses of plants in experiences in vitro and in vivo are carried out under influence steroid glycosides and plant hormones (auxins, gibberellins and cytokinins). The common and specific properties of these connections are revealed. On the strength of these properties, the steroid glycosides are referred to new group steroid phytohormones. The general properties of steroid glycosides are optimization of all the known processes of growth and morphogenesis (intensification of the growth of stems, leaves and roots of wheat, apical dominance in barley and wheat, accelerating germination of freshly harvested potato tubers, the increase of pigment content in the cereals leaves, the cotyledons of pumpkin and amaranth seedlings, the accumulation of biomass in clover plants), attraversa ability and regulation of physiological and biochemical processes of plants. The new plant hormones are hydrophilic conjugate that activates juvenile and volumetric growth, with prolonged activity, high stability and transportability in plants.Изучение процессов роста разных органов и видов растений в опытах in vivo и in vitro, особенностей органо- образования, физиолого-биохимических реакций и функций стероидных гликозидов на фоне известных фитогормонов ауксинов, гиббереллинов и цитокининов позволило выявить как общие, так и специфические свойства этой группы природных регуляторов роста, по совокупности которых они отнесены к новой группе стероидных фитогормонов, имеющих наиболее широкое сходство с ауксином. К общим свойствам стероидных гликозидов можно отнести рост растяжением колеоптилей злаков, интенсификацию роста стеблей, листьев и корней пшеницы, апикальное доминирование у ячменя и пшеницы, ускорение прорастания свежеубранных клубней картофеля, повышение содержания пигментов в листьях злаков, семядолях тыквы и проростках щирицы, накопление биомассы в растениях клевера, т. е. оптимизирование всех известных процессов роста и формообразования, а также аттрагирующую способность и регуляцию физиолого-биохимических процессов растений. Отличительные особенности новых фитогормонов – гидрофильные конъюгаты, активирующие ювенильный и объемный рост, обладающие пролонгированной активностью, высокой стабильностью и транспортабельностью в растениях.

Magnetic-field-dependent zero-bias diffusive anomaly in Pb oxide-n-InAs structures: Coexistence of two- and three-dimensional states

The results of experimental and theoretical studies of zero-bias anomaly (ZBA) in the Pb-oxide-n-InAs tunnel structures in magnetic field up to 6T are presented. A specific feature of the structures is a coexistence of the 2D and 3D states at the Fermi energy near the semiconductor surface. The dependence of the measured ZBA amplitude on the strength and orientation of the applied magnetic field is in agreement with the proposed theoretical model. According to this model, electrons tunnel into 2D states, and move diffusively in the 2D layer, whereas the main contribution to the screening comes from 3D electrons.Comment: 8 double-column pages, REVTeX, 9 eps figures embedded with epsf, published versio

Реологические свойства эпоксидного олигомера, наполненного стеклянными микрошариками

Specific features of the flow of filled and highly filled composites with a filler having monofractional structure (glass microspheres) on the basis of epoxy oligomers were investigated in two modes: at a constant shear rate and at a constant shear stress.Исследованы особенности течения наполненных и высоконаполненных композиций на основе эпоксидного олигомера с наполнителем монофракционного состава (стеклянные микрошарики) в двух режимах: при постоянной скорости сдвига; при постоянном напряжении сдвига

Towards the matter of genetic consulting in various forms of congenital and hereditary eye diseases

Purpose. To evaluate the results in genetic consulting of patients with various forms of congenital and hereditary eyes pathology.Material and methods. The study is based on an analysis of results in genetic consulting and molecular genetic investigations of DNA samples of 18 patients: congenital corneal dystrophy (n=3); congenital cataract (n=11); Norrie disease (n = 4). All patients had a comprehensive ophthalmologic clinical and functional examination according to the forms of pathology. Geneticist physician conducted a genealogical analysis. A study of exons and flanking intronic regions was performed using methods of analysis of amplified fragment length polymorphism, restriction fragments and direct sequencing.Results. The clinical diagnosis of endothelial corneal dystrophy with autosomal recessive mode of inheritance using molecular genetic methods in 2 of the 3 cases was confirmed, and a de novo mutation in the gene SLC4A11 non-described previously was found. In the group with hereditary diseases the lens pathogenic mutations were detected in the GJA3 andGJA8 genes in 2 of 11 cases (18%). Pathogenic mutations in NDP gene were detected only in 2 of 4 family members studied, and its sibling proband, directed to the genetic analysis of patients with a clinical diagnosis Norrie disease. In another of the studied probands the diseasecausing mutation was not reveled, and thus, the molecular genetic diagnosis of Norrie disease was not confirmed.Conclusion. For the first time in the Russian Federation pathogenic mutations in the gene SLC4A11 collagen, previously did not described in the literature, were revealed in patients with congenital endothelial corneal dystrophy, in a patient with congenital cataract in the gene GJA8. The success of genetic consulting depends on the complete genealogical analysis, and the correct determination of the clinical and genetic form of pathology

The Role of Native Language and the Fundamental Design of the Auditory System in Detecting Rhythm Changes

Accepted December 13, 2018Purpose: We investigated whether rhythm discrimination is mainly driven by the native language of the listener or by the fundamental design of the human auditory system and universal cognitive mechanisms shared by all people irrespective of rhythmic patterns in their native language. Method: In multiple experiments, we asked participants to listen to 2 continuous acoustic sequences and to determine whether their rhythms were the same or different (AX discrimination). Participants were native speakers of 4 languages with different rhythmic properties (Spanish, French, English, and German) to understand whether the predominant rhythmic patterns of a native language affect sensitivity, bias, and reaction time in detecting rhythmic changes in linguistic (Experiment 2) and in nonlinguistic (Experiments 1 and 2) acoustic sequences. We examined sensitivity and bias measures, as well as reaction times. We also computed Bayes factors in order to assess the effect of native language. Results: All listeners performed better (i.e., responded faster and manifested higher sensitivity and accuracy) when detecting the presence or absence of a rhythm change when the 1st stimulus in an AX test pair exhibited regular rhythm (i.e., a syllable-timed rhythmic pattern) than when the 1st stimulus exhibited irregular rhythm (i.e., stress-timed rhythmic pattern). This result pattern was observed both on linguistic and nonlinguistic stimuli and was not modulated by the native language of the participant. Conclusion: We conclude that rhythm change detection is a fundamental function of a processing system that relies on general auditory mechanisms and is not modulated by linguistic experience.The authors acknowledge support from Spanish Ministry of Economy and Competitiveness Grant PSI2017-82563-P (awarded to A. G. S.), the “Severo Ochoa” Programme for Centres/Units of Excellence in R&D Grant SEV-2015-490 (BCBL), and the Basque Foundation for Science Grant IKERBASQUE (awarded to A. G. S. and M. O.). D. M. G. was supported by Grant PIA/Basal FB0003 from the Chilean Research Council. L. P. was supported by the Spanish Ministry of Economy and Competitiveness via Juan de la Cierva fellowship

Interaction effects and phase relaxation in disordered systems

This paper is intended to demonstrate that there is no need to revise the existing theory of the transport properties of disordered conductors in the so-called weak localization regime. In particular, we demonstrate explicitly that recent attempts to justify theoretically that the dephasing rate (extracted from the magnetoresistance) remains finite at zero temperature are based on the profoundly incorrect calculation. This demonstration is based on a straightforward evaluation of the effect of the electron-electron interaction on the weak localization correction to the conductivity of disordered metals. Using well-controlled perturbation theory with the inverse conductance $g$ as the small parameter, we show that this effect consists of two contributions. First contribution comes from the processes with energy transfer smaller than the temperature. This contribution is responsible for setting the energy scale for the magnetoresistance. The second contribution originates from the virtual processes with energy transfer larger than the temperature. It is shown that the latter processes have nothing to do with the dephasing, but rather manifest the second order (in $1/g$) correction to the conductance. This correction is calculated for the first time. The paper also contains a brief review of the existing experiments on the dephasing of electrons in disordered conductors and an extended qualitative discussion of the quantum corrections to the conductivity and to the density of electronic states in the weak localization regime.Comment: 34 pages, 13 .eps figure

Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident

BACKGROUND: Previous studies showed an increased risk of thyroid cancer among children and adolescents exposed to radioactive iodines released after the Chornobyl (Chernobyl) accident, but the effects of screening, iodine deficiency, age at exposure and other factors on the dose-response are poorly understood. METHODS: We screened 11 970 individuals in Belarus aged 18 years or younger at the time of the accident who had estimated (131)I thyroid doses based on individual thyroid activity measurements and dosimetric data from questionnaires. The excess odds ratio per gray (EOR/Gy) was modelled using linear and linear-exponential functions. RESULTS: For thyroid doses \u3c5 \u3eGy, the dose-response was linear (n=85; EOR/Gy=2.15, 95% confidence interval: 0.81-5.47), but at higher doses the excess risk fell. The EOR/Gy was significantly increased among those with prior or screening-detected diffuse goiter, and larger for men than women, and for persons exposed before age 5 than those exposed between 5 and 18 years, although not statistically significant. A somewhat higher EOR/Gy was estimated for validated pre-screening cases. CONCLUSION: 10-15 years after the Chornobyl accident, thyroid cancer risk was significantly increased among individuals exposed to fallout as children or adolescents, but the risk appeared to be lower than in other Chornobyl studies and studies of childhood external irradiation

Results of thrombectomy in lower-extremity ischemia in patients with COVID-19 and respiratory failure of different severity

Aim. To analyze the results of thrombectomy in lower-extremity ischemia in patients with coronavirus disease 2019 (COVID-19) and respiratory failure of different severity.Material and methods. This retrospective, cohort, comparative study for the period from May 1, 2020 to March 1, 2022 included 305 patients with acute lower-extremity ischemia and COVID-19. Depending on the type of oxygen support, three groups of patients were formed: group 1 (n=168) — nasal oxygen insufflation; group 2 (n=92) — non-invasive ventilation (NIV); group 3 (n=45) — artificial ventilation (AV). Thrombectomy was carried out according to the standard technique using Fogarty catheters (3F-6F — depending on the vessel size). After the diagnosis was established before and after the start of surgical treatment, all patients received the following therapy: Unfractionated IV heparin infusion at an initial rate of 1000 U/r, adjusted to maintain the activated partial thromboplastin time at 2-3 times the normal value; 2. Oral acetylsalicylic acid 125 mg; 3. Analgesics.Results. Myocardial infarction and ischemic stroke were not detected in the total sample. The highest number of deaths (group 1: 5,3%, n=9; group 2: 72,8%, n=67; group 3: 100%, n=45; p<0,0001), retrombosis (group 1 : 18,4%, n=31; group 2: 69,5%, n=64; group 3: 91,1%, n=41; p<0,0001) and limb amputations (group 1: 9,5%, n=16; group 2: 56,5%, n=52; group 3: 91,1%, n=41; p<0,0001) was recorded in group 3 patients.Conclusion. In patients receiving mechanical ventilation, COVID-19 have more aggressive course, which is expressed in an increase in laboratory para- meters (C-reactive protein, ferritin, interleukin-6, D-dimer), the severity of pneumonia and location of thrombosis in the tibial arteries. Among patients with COVID-19 receiving mechanical ventilation, the greatest number of rethromboses (91,1%), limb amputations (91,1%), and deaths (100%) are noted, which suggests the expediency of abandoning open thrombectomy in favor of anticoagulant/antiplatelet therapy in this cohort of patients. The development of arterial thrombosis in patients with COVID-19 receiving mechanical ventilation is an indicator of a high risk of death. Open thrombectomy in combination with anticoagulant/antiplatelet therapy is most effective in patients on nasal oxygen insufflation or NIV