628 research outputs found
Localization of nod-3, a Gene Conditioning Hypernodulation, and Identification of a Novel Translocation in Pisum sativum L. cv. Rondo
Actions of the braid group, and new algebraic proofs of results of Dehornoy and Larue
This article surveys many standard results about the braid group with
emphasis on simplifying the usual algebraic proofs.
We use van der Waerden's trick to illuminate the Artin-Magnus proof of the
classic presentation of the algebraic mapping-class group of a punctured disc.
We give a simple, new proof of the Dehornoy-Larue braid-group trichotomy,
and, hence, recover the Dehornoy right-ordering of the braid group.
We then turn to the Birman-Hilden theorem concerning braid-group actions on
free products of cyclic groups, and the consequences derived by Perron-Vannier,
and the connections with the Wada representations. We recall the very simple
Crisp-Paris proof of the Birman-Hilden theorem that uses the Larue-Shpilrain
technique. Studying ends of free groups permits a deeper understanding of the
braid group; this gives us a generalization of the Birman-Hilden theorem.
Studying Jordan curves in the punctured disc permits a still deeper
understanding of the braid group; this gave Larue, in his PhD thesis,
correspondingly deeper results, and, in an appendix, we recall the essence of
Larue's thesis, giving simpler combinatorial proofs.Comment: 51`pages, 13 figure
The triennial International Pigment Cell Conference (IPCC)
The International Federation of Pigment Cell Societies (IFPCS) held its XXIII
triennial International Pigment Cell Conference (IPCC) in Denver, Colorado in
August 2017. The goal of the summit was to provide a venue promoting a vibrant
interchange among leading basic and clinical researchers working on
leading-edge aspects of melanocyte biology and disease. The philosophy of the
meeting, entitled Breakthroughs in Pigment Cell and Melanoma Research, was to
deliver a comprehensive program in an inclusive environment fostering
scientific exchange and building new academic bridges. This document provides
an outlook on the history, accomplishments, and sustainability of the pigment
cell and melanoma research community. Shared progress in the understanding of
cellular homeostasis of pigment cells but also clinical successes and hurdles
in the treatment of melanoma and dermatological disorders continue to drive
future research activities. A sustainable direction of the societies creates an
international forum identifying key areas of imminent needs in laboratory
research and clinical care and ensures the future of this vibrant, diverse and
unique research community at the same time. Important advances showcase wealth
and breadth of the field in melanocyte and melanoma research and include
emerging frontiers in melanoma immunotherapy, medical and surgical oncology,
dermatology, vitiligo, albinism, genomics and systems biology, precision
bench-to-bedside approaches, epidemiology, pigment biophysics and chemistry,
and evolution. This report recapitulates highlights of the federate meeting
agenda designed to advance clinical and basic research frontiers from melanoma
and dermatological sciences followed by a historical perspective of the
associated societies and conferences
CRYOGENIC UPPER STAGE SYSTEM SAFETY
NASA s Exploration Initiative will require development of many new systems or systems of systems. One specific example is that safe, affordable, and reliable upper stage systems to place cargo and crew in stable low earth orbit are urgently required. In this paper, we examine the failure history of previous upper stages with liquid oxygen (LOX)/liquid hydrogen (LH2) propulsion systems. Launch data from 1964 until midyear 2005 are analyzed and presented. This data analysis covers upper stage systems from the Ariane, Centaur, H-IIA, Saturn, and Atlas in addition to other vehicles. Upper stage propulsion system elements have the highest impact on reliability. This paper discusses failure occurrence in all aspects of the operational phases (Le., initial burn, coast, restarts, and trends in failure rates over time). In an effort to understand the likelihood of future failures in flight, we present timelines of engine system failures relevant to initial flight histories. Some evidence suggests that propulsion system failures as a result of design problems occur shortly after initial development of the propulsion system; whereas failures because of manufacturing or assembly processing errors may occur during any phase of the system builds process, This paper also explores the detectability of historical failures. Observations from this review are used to ascertain the potential for increased upper stage reliability given investments in integrated system health management. Based on a clear understanding of the failure and success history of previous efforts by multiple space hardware development groups, the paper will investigate potential improvements that can be realized through application of system safety principles
Emotion in the Common Model of Cognition
Emotions play an important role in human cognition and therefore need to be present in the Common Model of Cognition. In this paper, the emotion working group focuses on functional aspects of emotions and describes what we believe are the points of interactions with the Common Model of Cognition. The present paper should not be viewed as a consensus of the group but rather as a first attempt to extract common and divergent aspects of different models of emotions and how they relate to the Common Model of Cognition
Faith in the Republic: A Frances Lewis Law Center Conversation
This is a spontaneous conversation discussing Hauserwas’ singular political theology in response to Levinson and Tushnet’s constitutional jurisprudence. It developed into a highly interesting debate concerning constitutional faith. This conversation was recorded at Washington and Lee’s Law Center on December 11, 1987
Frontiers in Pigment Cell and Melanoma Research
We identify emerging frontiers in clinical and basic research of melanocyte
biology and its associated biomedical disciplines. We describe challenges and
opportunities in clinical and basic research of normal and diseased melanocytes
that impact current approaches to research in melanoma and the dermatological
sciences. We focus on four themes: (1) clinical melanoma research, (2) basic
melanoma research, (3) clinical dermatology, and (4) basic pigment cell
research, with the goal of outlining current highlights, challenges, and
frontiers associated with pigmentation and melanocyte biology. Significantly,
this document encapsulates important advances in melanocyte and melanoma
research including emerging frontiers in melanoma immunotherapy, medical and
surgical oncology, dermatology, vitiligo, albinism, genomics and systems
biology, epidemiology, pigment biophysics and chemistry, and evolution
Faith in the Republic: A Frances Lewis Law Center Conversation
This is a spontaneous conversation discussing Hauserwas’ singular political theology in response to Levinson and Tushnet’s constitutional jurisprudence. It developed into a highly interesting debate concerning constitutional faith. This conversation was recorded at Washington and Lee’s Law Center on December 11, 1987
Functional diversification of maize RNA polymerase IV and V subtypes via alternative catalytic subunits.
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Integrative analysis of a phase 2 trial combining lenalidomide with CHOP in angioimmunoblastic T-cell lymphoma.
Angioimmunoblastic T-cell lymphoma (AITL) is a frequent T-cell lymphoma in the elderly population that has a poor prognosis when treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy. Lenalidomide, which has been safely combined with CHOP to treat B-cell lymphoma, has shown efficacy as a single agent in AITL treatment. We performed a multicentric phase 2 trial combining 25 mg lenalidomide daily for 14 days per cycle with 8 cycles of CHOP21 in previously untreated AITL patients aged 60 to 80 years. The primary objective was the complete metabolic response (CMR) rate at the end of treatment. Seventy-eight of the 80 patients enrolled were included in the efficacy and safety analysis. CMR was achieved in 32 (41%; 95% confidence interval [CI], 30%-52.7%) patients, which was below the prespecified CMR rate of 55% defined as success in the study. The 2-year progression-free survival (PFS) was 42.1% (95% CI, 30.9%-52.8%), and the 2-year overall survival was 59.2% (95% CI, 47.3%-69.3%). The most common toxicities were hematologic and led to treatment discontinuation in 15% of patients. This large prospective and uniform series of AITL treatment data was used to perform an integrative analysis of clinical, pathologic, biologic, and molecular data. TET2, RHOA, DNMT3A, and IDH2 mutations were present in 78%, 54%, 32%, and 22% of patients, respectively. IDH2 mutations were associated with distinct pathologic and clinical features and DNMT3A was associated with shorter PFS. In conclusion, the combination of lenalidomide and CHOP did not improve the CMR in AITL patients. This trial clarified the clinical impact of recurrent mutations in AITL. This trial was registered at www.clincialtrials.gov as #NCT01553786
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