142 research outputs found
Effects of fossil fuel and total anthropogenic emission removal on public health and climate.
Anthropogenic greenhouse gases and aerosols are associated with climate change and human health risks. We used a global model to estimate the climate and public health outcomes attributable to fossil fuel use, indicating the potential benefits of a phaseout. We show that it can avoid an excess mortality rate of 3.61 (2.96-4.21) million per year from outdoor air pollution worldwide. This could be up to 5.55 (4.52-6.52) million per year by additionally controlling nonfossil anthropogenic sources. Globally, fossil-fuel-related emissions account for about 65% of the excess mortality, and 70% of the climate cooling by anthropogenic aerosols. The chemical influence of air pollution on aeolian dust contributes to the aerosol cooling. Because aerosols affect the hydrologic cycle, removing the anthropogenic emissions in the model increases rainfall by 10-70% over densely populated regions in India and 10-30% over northern China, and by 10-40% over Central America, West Africa, and the drought-prone Sahel, thus contributing to water and food security. Since aerosols mask the anthropogenic rise in global temperature, removing fossil-fuel-generated particles liberates 0.51(±0.03) °C and all pollution particles 0.73(±0.03) °C warming, reaching around 2 °C over North America and Northeast Asia. The steep temperature increase from removing aerosols can be moderated to about 0.36(±0.06) °C globally by the simultaneous reduction of tropospheric ozone and methane. We conclude that a rapid phaseout of fossil-fuel-related emissions and major reductions of other anthropogenic sources are needed to save millions of lives, restore aerosol-perturbed rainfall patterns, and limit global warming to 2 °C
Geothermal Casimir Phenomena
We present first worldline analytical and numerical results for the
nontrivial interplay between geometry and temperature dependencies of the
Casimir effect. We show that the temperature dependence of the Casimir force
can be significantly larger for open geometries (e.g., perpendicular plates)
than for closed geometries (e.g., parallel plates). For surface separations in
the experimentally relevant range, the thermal correction for the
perpendicular-plates configuration exhibits a stronger parameter dependence and
exceeds that for parallel plates by an order of magnitude at room temperature.
This effect can be attributed to the fact that the fluctuation spectrum for
closed geometries is gapped, inhibiting the thermal excitation of modes at low
temperatures. By contrast, open geometries support a thermal excitation of the
low-lying modes in the gapless spectrum already at low temperatures.Comment: 8 pages, 3 figures, contribution to QFEXT07 proceedings, v2:
discussion switched from Casimir energy to Casimir force, new analytical
results included, matches JPhysA versio
Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production
The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic levels of Trp is essential for health and well-being. The liver regulates global Trp supply by the immunosuppressive enzyme tryptophan-2,3-dioxygenase (TDO2), which degrades Trp down the kynurenine pathway (KP). In the current study, we show that isolated primary hepatocytes when exposed to hypoxic environments, extensively rewire their Trp metabolism by reducing constitutive Tdo2 expression and differentially regulating other Trp pathway enzymes and transporters. Mathematical modelling of Trp metabolism in liver cells under hypoxia predicted decreased flux through the KP while metabolic flux through the tryptamine branch significantly increased. In line, the model also revealed an increased accumulation of tryptamines under hypoxia, at the expense of kynurenines. Metabolic measurements in hypoxic hepatocytes confirmed the predicted reduction in KP metabolites as well as accumulation of tryptamine. Tdo2 expression in cultured primary hepatocytes was reduced upon hypoxia inducible factor (HIF) stabilisation by dimethyloxalylglycine (DMOG), demonstrating that HIFs are involved in the hypoxic downregulation of hepatic Tdo2. DMOG abrogated hepatic luciferase signals in Tdo2 reporter mice, indicating that HIF stability also recapitulates hypoxic rewiring of Trp metabolism in vivo. Also in WT mice HIF stabilization drove homeostatic Trp metabolism away from the KP towards enhanced tryptamine production, leading to enhanced levels of tryptamine in liver, serum and brain. As tryptamines are the most potent hallucinogens known, the observed upregulation of tryptamine in response to hypoxic exposure of hepatocytes may be involved in the generation of hallucinations occurring at high altitude. KP metabolites are known to activate the aryl hydrocarbon receptor (AHR). The AHR-activating properties of tryptamines may explain why immunosuppressive AHR activity is maintained under hypoxia despite downregulation of the KP. In summary our results identify hypoxia as an important factor controlling Trp metabolism in the liver with possible implications for immunosuppressive AHR activation and mental disturbances
Casimir forces and non-Newtonian gravitation
The search for non-relativistic deviations from Newtonian gravitation can
lead to new phenomena signalling the unification of gravity with the other
fundamental interactions. Various recent theoretical frameworks indicate a
possible window for non-Newtonian forces with gravitational coupling strength
in the micrometre range. The major expected background in the same range is
attributable to the Casimir force or variants of it if dielectric materials,
rather than conducting ones, are considered. Here we review the measurements of
the Casimir force performed so far in the micrometre range and how they
determine constraints on non-Newtonian gravitation, also discussing the
dominant sources of false signals. We also propose a geometry-independent
parameterization of all data in terms of the measurement of the constant c. Any
Casimir force measurement should lead, once all corrections are taken into
account, to a determination of the constant c which, in order to assess the
accuracy of the measurement, can be compared with its more precise value known
through microscopic measurements. Although the last decade of experiments has
resulted in solid demonstrations of the Casimir force, the situation is not
conclusive with respect to being able to discover new physics. Future
experiments and novel phenomenological analysis will be necessary to discover
non-Newtonian forces or to push the window for their possible existence into
regions of the parameter space which theoretically appear unnatural.Comment: Also available at http://www.iop.org/EJ/abstract/1367-2630/8/10/23
Thermal corrections to the Casimir effect
The Casimir effect, reflecting quantum vacuum fluctuations in the
electromagnetic field in a region with material boundaries, has been studied
both theoretically and experimentally since 1948. The forces between dielectric
and metallic surfaces both plane and curved have been measured at the 10 to 1
percent level in a variety of room-temperature experiments, and remarkable
agreement with the zero-temperature theory has been achieved. In fitting the
data various corrections due to surface roughness, patch potentials, curvature,
and temperature have been incorporated. It is the latter that is the subject of
the present article. We point out that, in fact, no temperature dependence has
yet been detected, and that the experimental situation is still too fluid to
permit conclusions about thermal corrections to the Casimir effect.
Theoretically, there are subtle issues concerning thermodynamics and
electrodynamics which have resulted in disparate predictions concerning the
nature of these corrections. However, a general consensus has seemed to emerge
that suggests that the temperature correction to the Casimir effect is
relatively large, and should be observable in future experiments involving
surfaces separated at the few micrometer scale.Comment: 21 pages, 9 eps figures, uses iopart.cls. Final version to be
published in New Journal of Physics, contains Conclusion and clarified
remark
Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes
The proinflammatory cytokine TNFα fails to provoke cell death in isolated hepatocytes but has been implicated in hepatocyte apoptosis during liver diseases associated with chronic inflammation. Recently, we showed that TNFα is able to sensitize primary murine hepatocytes cultured on collagen to Fas ligand-induced apoptosis and presented a mathematical model of the sensitizing effect. Here, we analyze how TNFα induces apoptosis in combination with the transcriptional inhibitor actinomycin D (ActD). Accumulation of reactive oxygen species (ROS) in response to TNFR activation turns out to be critical for sustained activation of JNK which then triggers mitochondrial pathway-dependent apoptosis. In addition, the amount of JNK is strongly upregulated in a ROS-dependent way. In contrast to TNFα plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch-mediated cFLIP degradation and predominantly caspase-8 activation is not involved. Time-resolved data of the respective pro- and antiapoptotic factors are obtained and subjected to mathematical modeling. On the basis of these data we developed a mathematical model which reproduces the complex interplay regulating the phosphorylation status of JNK and generation of ROS. This model was fully integrated with our model of TNFα/Fas ligand sensitizing as well as with a published NF-κB-model. The resulting comprehensive model delivers insight in the dynamical interplay between the TNFα and FasL pathways, NF-κB and ROS and gives an example for successful model integration
Packing Density of the Erythropoietin Receptor Transmembrane Domain Correlates with Amplification of Biological Responses
Позиционный электропривод механизма перемещения
Объектом исследования является позиционный асинхронный электропривод механизма горизонтального перемещения груза.
Цель работы – исследовать основные характеристики асинхронного электропривода с трехконтурной системой управления положением вала двигателя.
В процессе исследования проводились выбор асинхронного двигателя для механизма перемещения, расчет параметров двигателя, его статических и динамических характеристик, выбор преобразователя частоты, синтез трехконтурной системы управления следящим электроприводом на базе регулируемого с векторным управлением.The object of the study is a positional asynchronous electric drive mechanism for the horizontal movement of cargo.
The purpose of the work is to investigate the basic characteristics of an asynchronous electric drive with a three-circuit control system for positioning the motor shaft.
In the process of research, the choice of an asynchronous motor for the displacement mechanism, calculation of the engine parameters, its static and dynamic characteristics, choice of a frequency converter, synthesis of a three-circuit control system for a servomotor drive based on an adjustable vector control were made
- …