Periodic sulphur dioxide degassing from the Soufriere Hills Volcano related to deep magma supply

Soufrière Hills Volcano produced prodigious quantities of sulphur dioxide (SO2) gas throughout 1995–2013. An unprecedented, detailed record of SO2 flux shows that high SO2 fluxes were sustained through eruptive pauses and for two years after the end of lava extrusion and are decoupled from lava extrusion rates. Lava extrusion rates have exhibited strong 1- to 2-year cyclicity. Wavelet analysis demonstrates periodicities of c. 5 months and c. 2 years within the SO2 time series, as well as the shorter cycles identified previously. The latter period is similar to the wavelength of cycles in lava extrusion, albeit non-systematically offset. The periodicities are consistent with pressure changes accompanying deformation in a coupled magma reservoir system whereby double periodic behaviour may arise from limited connectivity between two reservoirs. During periods of lava extrusion SO2 is released together with the lava (yielding the c. 2 year period), albeit with some offset. In contrast, when magma cannot flow because of its yield strength, SO2 is released independently from lava (yielding the c. 5 month period). Our results have implications for eruption forecasting. It seems likely that, when deep supply of magma ceases, gas fluxes will cease to be periodic

Tumor-specific expression of αvβ3 integrin promotes spontaneous metastasis of breast cancer to bone

INTRODUCTION: Studies in xenograft models and experimental models of metastasis have implicated several β3 integrin-expressing cell populations, including endothelium, platelets and osteoclasts, in breast tumor progression. Since orthotopic human xenograft models of breast cancer are poorly metastatic to bone and experimental models bypass the formation of a primary tumor, however, the precise contribution of tumor-specific αvβ3 to the spontaneous metastasis of breast tumors from the mammary gland to bone remains unclear. METHODS: We used a syngeneic orthotopic model of spontaneous breast cancer metastasis to test whether exogenous expression of αvβ3 in a mammary carcinoma line (66cl4) that metastasizes to the lung, but not to bone, was sufficient to promote its spontaneous metastasis to bone from the mammary gland. The tumor burden in the spine and the lung following inoculation of αvβ3-expressing 66cl4 (66cl4beta3) tumor cells or control 66cl4pBabe into the mammary gland was analyzed by real-time quantitative PCR. The ability of these cells to grow and form osteolytic lesions in bone was determined by histology and tartrate-resistant acid phosphatase staining of bone sections following intratibial injection of tumor cells. The adhesive, migratory and invasive properties of 66cl4pBabe and 66cl4beta3 cells were evaluated in standard in vitro assays. RESULTS: The 66cl4beta3 tumors showed a 20-fold increase in metastatic burden in the spine compared with 66cl4pBabe. A similar trend in lung metastasis was observed. αvβ3 did not increase the proliferation of 66cl4 cells in vitro or in the mammary gland in vivo. Similarly, αvβ3 is not required for the proliferation of 66cl4 cells in bone as both 66cl4pBabe and 66cl4beta3 proliferated to the same extent when injected directly into the tibia. 66cl4beta3 tumor growth in the tibia, however, increased osteoclast recruitment and bone resorption compared with 66cl4 tumors. Moreover, αvβ3 increased 66cl4 tumor cell adhesion and αvβ3-dependent haptotactic migration towards bone matrix proteins, as well as their chemotactic response to bone-derived soluble factors in vitro. CONCLUSION: These results demonstrate for the first time that tumor-specific αvβ3 contributes to spontaneous metastasis of breast tumors to bone and suggest a critical role for this receptor in mediating chemotactic and haptotactic migration towards bone factors

Seismic characterization of pyroclastic flow activity at Soufrier Hills Volcano, Montserrat, 8 January 2007

A partial dome collapse with concurrent pyroclastic flow (PF) activity occurred at Soufrière Hills Volcano (SHV), Montserrat on 8 January 2007. Pyroclastic density currents were observed to propagate from the Northwest and West sectors of the summit dome into the heads of Tyres Ghaut and Gages Valley, respectively. Between 10:00 and 10:15 UTC pyroclastic flows entered Tyres Ghaut and from there descended into the Belham Valley reaching a distance of about 5 km from the source. Pyroclastic flow activity on the Northwest and West side of the edifice continued at high levels over the following 1.5 h, although run-out distances of individual flows did not exceed 1.5 km. Subsequent observations showed that material had been removed from the lower Northwest side of the dome leaving an amphitheatre-like structure cutting through the old crater rim. The seismic waves excited by the propagation of pyroclastic flows were recorded by the Montserrat Volcano Observatory's network of broadband seismometers. The seismic records show the onset of a continuous signal before 09:30 UTC with gradually increasing amplitudes and spectral energy in the 1–8 Hz band. The signal rapidly increased in amplitude and a characteristic spindle-shaped waveform with broadband energy (1–25 Hz) was observed accompanying large PF that descended along the slopes of the volcano. The main phase was followed by a sequence of individual seismic pulses which correlated well with visual observations of PF. PF are a major hazard at SHV and pose significant risk for the population living in the proximity of the volcano. They can occur with little or no warning and have the potential to reach inhabited areas to the Northwest. The study of the seismic activity associated with the generation and propagation of pyroclastic flows can help to identify characteristic precursory seismic sequences providing valuable information to improve the understanding of the hazards posed by the SHV and to allow better warning to be given to the authorities

Microlite transfer by disaggregation of mafic inclusions following magma mixing at Soufrière Hills Volcano, Montserrat

The Soufrière Hills volcano on Montserrat has for the past 12 years been erupting andesite with basaltic to basaltic–andesite inclusions. The andesite contains a wide variety of phenocryst textures and strongly zoned microlites. Analysis of minor elements in both phenocrysts and microlites allows us to put detailed constraints on their origins. Compositions of clinopyroxene, from overgrowth rims on quartz and orthopyroxene and coarse-grained breakdown rims on hornblende, are identical to those from the mafic inclusions, indicating that these rims form during interaction with mafic magma. In contrast, resorbed quartz and reversely zoned orthopyroxenes form during heating. Microlites of plagioclase and orthopyroxene are chemically distinct from the phenocrysts, being enriched in Fe and Mg, and Al and Ca respectively. However, microlites of plagioclase, orthopyroxene and clinopyroxene are indistinguishable from the compositions of these phases in the mafic inclusions. We infer that the inclusions disaggregated under conditions of high shear stress during ascent in the conduit, transferring mafic material into the andesite groundmass. The mafic component of the system is therefore greater than previously thought. The presence of mafic-derived microlites in the andesite groundmass also means that care must be taken when using this as a starting material for phase equilibrium experiments

Magma hybridisation and diffusive exchange recorded in heterogeneous glasses from Soufriere Hills Volcano, Montserrat

Arc volcanoes commonly show evidence of mixing between mafic and silicic magma. Melt inclusions and matrix glasses in andesite erupted from Soufrière Hills Volcano, Montserrat, include an anomalously K2O‐rich population which shows close compositional overlap with residual glass from mafic inclusions. We suggest that these glasses represent the effects of physical mixing with mafic magma, both during ascent and by diffusive exchange during the formation of mafic inclusions. Many glasses are enriched only in K2O, suggesting diffusive contamination by high‐K mafic inclusion glass; others are also enriched in TiO2, suggesting physical mixing of remnant glass. Some mafic inclusion glasses have lost K2O. The preservation of this K‐rich melt component in the andesite suggests short timescales between mixing and ascent. Diffusive timescales are consistent with independent petrological estimates of magma ascent time

Microlite transfer by disaggregation of mafic inclusions following magma mixing at Soufrière Hills volcano, Montserrat

Abstract The Soufrière Hills volcano on Montserrat has for the past 12 years been erupting andesite with basaltic to basaltic–andesite inclusions. The andesite contains a wide variety of phenocryst textures and strongly zoned microlites. Analysis of minor elements in both phenocrysts and microlites allows us to put detailed constraints on their origins. Compositions of clinopyroxene, from overgrowth rims on quartz and orthopyroxene and coarse-grained breakdown rims on hornblende, are identical to those from the mafic inclusions, indicating that these rims form during interaction with mafic magma. In contrast, resorbed quartz and reversely zoned orthopyroxenes form during heating. Microlites of plagioclase and orthopyroxene are chemically distinct from the phenocrysts, being enriched in Fe and Mg, and Al and Ca respectively. However, microlites of plagioclase, orthopyroxene and clinopyroxene are indistinguishable from the compositions of these phases in the mafic inclusions. We infer that the inclusions disaggregated under conditions of high shear stress during ascent in the conduit, transferring mafic material into the andesite groundmass. The mafic component of the system is therefore greater than previously thought. The presence of mafic-derived microlites in the andesite groundmass also means that care must be taken when using this as a starting material for phase equilibrium experiments

Chlorine variations in the magma of Soufriere Hills Volcano, Montserrat: Insights from Cl in hornblende and melt inclusions

The Soufrière Hills Volcano in Montserrat erupts a Cl-rich, porphyritic andesite. HCl degassing accompanies eruption and is dependent on the growth rate of the lava dome. The magma contains hornblende phenocrysts that show repetitive zoning in most elements, including Cl. On the basis of the zoning data, (Cl/OH) ratios in the melt, calculated from partitioning data, increase rimward through each zone, indicating that the phenocrysts formed under conditions of varying (Cl/OH)m. An empirical relationship between A-site occupancy in the hornblende and temperature implies that crystallisation of each zone is also accompanied by increasing temperature. Each zone ends at a resorption horizon, and crystallisation recommences at lower temperature and (Cl/OH)m. Melt inclusion H2O and Cl contents for the 8th January 2007 explosive eruption can be explained by closed-system degassing with DClfl-m between 5 and 30, or by open-system degassing accompanied by a small amount of crystallisation. However, neither simple closed-system degassing nor convective circulation of magma can explain the positive correlation of (Cl/OH)m with temperature. We suggest that the zoning can be caused by accumulation of CO2-rich vapour in the andesite, probably as a result of mafic magma injection into the chamber. Decreasing H2O fugacity and/or increasing Clm result in increasing (Cl/OH)m while heat transferred with the volatiles causes the rise in temperature. Intermittently, the accumulated fluid is lost to the surface, possibly as a result of renewed eruptive activity. This model requires the CO2-rich fluid to be decoupled from the magma, consistent with previous observations of continuous CO2 emissions at the surface