5,168 research outputs found

    A novel stepwise micro-TESE approach in non obstructive azoospermia

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    Background: The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by employing a novel stepwise micro-TESE approach in a population of poor prognosis patients with non-obstructive azoospermia (NOA). Methods: Sixty-four poor prognosis NOA men undergoing surgical testicular sperm retrieval for ICSI, from March 2007 to April 2013, were included in this study. Patients inclusion criteria were a) previous unsuccessful TESE, b) unfavorable histology (SCOS, MA, sclerahyalinosis), c) Klinefelter syndrome. We employed a stepwise micro-TESE consisting three-steps: 1) single conventional TESE biopsy; 2) micro-TESE on the same testis; 3) contralateral multiple TESE. Results: SRR was 28.1 % (18/64). Sperm was obtained in both the initial single conventional TESE and in the following micro-TESE. The positive or negative sperm retrieval was further confirmed by a contralateral multiple TESE, when performed. No significant pre-operative predictors of sperm retrieval, including patients’ age, previous negative TESE or serological markers (LH, FSH, inhibin B), were observed at univariate or multivariate analysis. Micro-TESE (step 2) did not improve sperm retrieval as compared to single TESE biopsy on the same testicle (step 1) or multiple contralateral TESE (step 3). Conclusions: Stepwise micro-TESE could represent an optimal approach for sperm retrieval in NOA men. In our view, it should be offered to NOA patients in order to gradually increase surgical invasiveness, when necessary. Stepwise micro-TESE might also reduce the costs, time and efforts involved in surgery

    Calibration of White Dwarf cooling sequences: theoretical uncertainty

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    White Dwarf luminosities are powerful age indicators, whose calibration should be based on reliable models. We discuss the uncertainty of some chemical and physical parameters and their influence on the age estimated by means of white dwarf cooling sequences. Models at the beginning of the white dwarf sequence have been obtained on the base of progenitor evolutionary tracks computed starting from the zero age horizontal branch and for a typical halo chemical composition (Z=0.0001, Y=0.23). The uncertainties due to nuclear reaction rates, convection, mass loss and initial chemical composition are discussed. Then, various cooling sequences for a typical white dwarf mass (M=0.6 Mo) have been calculated under different assumptions on some input physics, namely: conductive opacity, contribution of the ion-electron interaction to the free energy and microscopic diffusion. Finally we present the evolution of white dwarfs having mass ranging between 0.5 and 0.9 Mo. Much effort has been spent to extend the equation of state down to the low temperature and high density regime. An analysis of the latest improvement in the physics of white dwarf interiors is presented. We conclude that at the faint end of the cooling sequence (log L/Lo=-5.5) the present overall uncertainty on the age is of the order of 20%, which correspond to about 3 Gyr. We suggest that this uncertainty could be substantially reduced by improving our knowledge of the conductive opacity (especially in the partially degenerate regime) and by fixing the internal stratification of C and O.Comment: 14 figures, accepted by Ap

    Mindfulness as a protective factor for dissatisfaction in HCWS: The moderating role of mindful attention between climate stress and job satisfaction

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    With the aim of investigating the possible moderating effect of job control and dispositional mindfulness between different sources of organizational stress and job satisfaction, a correlational study was designed involving health care workers (HCWs). The following questionnaires were administered and completed by 237 HCWs: (1) Occupational Stress Indicator (OSI), to measure the sources of stress at work (managerial role, climate power, climate structure, internal relationships), and job satisfaction; (2) Mindfulness Attention Awareness Scale (MAAS) to assess the individual's level of attention to what is taking place in the present; (3) Job Control Scale (JCS) to assess the perceived control at work. Hierarchical regression analyses were used to test the hypothesized relationships between variables; the results showed that, between the different sources of stress, the organizational climate dimension was negatively associated with job satisfaction; moreover, mindfulness attention moderated the relationship between climate stress and job satisfaction; unexpectedly, the interaction between job control and the organizational climate dimension was not significant in affecting job satisfaction. This study can provide useful information for Human Resources Management (HRM) practices regarding job and mental control interventions and empowerment, and possibly offer a new interpretation of the role of attention to what is happening in the present moment and autonomy between climate stressors and occupational satisfaction

    The IARA Model Proved Effective in Emotional Literacy, Characters Strengths Awareness, and Cohesion among Italian Children

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    Literature highlights how education in the twenty-first century begins to advocate multiple new concepts, such as new technology, new pedagogies, interdisciplinary curricula, open learning, etc. Among these concepts, the recognition and awareness about one’s character strengths are demonstrated to improve emotional management and individual/group’s quality of life. We studied three fifth-grade Italian classes using an emerging educational model called IARA to verify if it can truly improve emotional literacy, characters strengths awareness, and cohesion in ten-years children. To demonstrate its efficacy, we used Bloom’s Taxonomy and Sociogrammatic study. We proved that the IARA could be an efficient model to improve one’s character strengths and class milieu awareness

    Thermal Conductivity Enhancement of Al2O3 Nanofluid in Ethylene Glycol and Water Mixture

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    AbstractThe ability of nanofluids that exhibits enhanced thermal performance is acknowledged by researchers through studies since decades ago. However, the observation of thermal properties for nanofluids in water and ethylene glycol based is not fully explored yet. Hence, this paper presents the thermal conductivity of water and ethylene glycol (EG) based Al2O3 nanofluid. The 13 nm sized Al2O3 nanoparticles were dispersed into three different volume ratio of water: EG such as 40:60, 50:50 and 60:40 using a two-step method. The measurement of thermal conductivity was performed using KD2 Pro Thermal Properties Analyzer at working temperatures of 30 to 70 ̊C for volume concentration of 0.5 to 2.0%. The results indicate that the thermal conductivity increases with the increase of nanofluid concentration and temperature. While the percentage of ethylene glycol increase, the range of thermal conductivity decreases due to ethylene glycol properties. The measurement data of the nanofluids give maximum enhancement of thermal conductivity at condition 2.0% volume concentration, temperature of 70 ̊C and for all base fluid

    Study of the maxillary yaw on cone beam computed tomography: a preliminary report and comparison between two different dento‐skeletal malocclusions

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    Objectives: To assess the skeletal and dental maxillary transverse compensation (yaw) on the cone beam computed tomography (CBCT) three-dimensional reconstructed image of the skull in two groups of patients, both clinically affected by a class III malocclusion with deviation of the lower midline.Materials and Methods: An observational retrospective study was designed to analyse differences in two groups of patients, the first one was composed by patients affected by horizontal condylar hyperplasia, the second one by patients affected by dento-skeletal asymmetric class III malocclusion. Each group was composed by 15 patients. Transverse analysis was performed by measuring five landmarks (three bilateral and two uneven) with respect to a mid-sagittal plane; sagittal analysis was performed by measuring the sagittal distance on the mid-sagittal plane between bilateral points. Means were compared through inferential analysis.Results: In the condylar hyperplasia group, all differences between the two sides were not statistically significant, nor for canines' difference (P = .0817), for molars (P = .1105) or for jugular points (.05871). In the class III group, the differences between the two sides were statistically significant for molars (P = .0019) and jugular points (P = .0031) but not for canines (P = .1158). Comparing the two groups, significant differences were found only for incisors' midline deviation (P = .0343) and canine (P = .0177).Conclusion: The study of the yaw on CBCT should be integrated into three-dimensional cephalometry and could help in differentiating the various malocclusion patterns

    QUADRUPLE RESCUE THERAPY AFTER FIRST AND SECOND LINE FAILURE FOR HELICOBACTER PYLORI TREATMENT: COMPARISON BETWEEN TWO TETRACYCLINE-BASED REGIMENS

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    Background & Aims: Antibiotic resistance is the main reason for failure of Helicobacter pylori (H. pylori) treatment. Currently, guidelines recommend a treatment guided by antimicrobial susceptibility testing after two failures. However, microbial culture is not feasible everywhere, and the limited number of effective antibiotics against the bacterium narrows the options; thus a rescue therapy combining antibiotics with a low resistance may be fitting. Methods: Patients who have failed a first-line treatment (either prolonged triple or sequential regimens) and, successively, a levofoxacin-based triple therapy were considered for the study. Subjects underwent urea breath test (UBT), stool antigen test (ST) and endoscopy/histology to confirm the diagnosis. Cytopenia and impaired liver and kidney function were exclusion criteria. Fify-four subjects were randomized 1:1 to two regimens: RMB abeprazole/Rifabutin/Minocycline/Bismuth sub-citrate or MTB Rabeprazole/Tinidazole/ Minocycline/Bismuth sub-citrate both for 10 days. Te results were checked 6 weeks afer the end of therapy with ST/UBT plus endoscopy when indicated. Results: RMB eradicated the bacterium in 21 patients. Two subjects dropped out. Te eradication rate was 77.7% (CI 62.0-93.4%) at intention-to-treat and 84.0% (CI 69.6-98.4%) at per-protocol analysis. MTB was successful in 14 patients (51.9%, CI 33.1-70.7%). No patient withdrew from the treatment for adverse events. Drug-related side effects were reported only in 3 subjects, but in all cases the treatment was carried on. Conclusions: Te association minocycline/rifabutin seems to have a synergic effect and a good therapeutic outcome in patients who have failed at least two previous regimens, although a trial on a large population is needed

    Straining at work and its relationship with personality profiles and individual consequences in healthcare workers (HCWs)

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    Straining is an attenuated form of mobbing, in which the continuity of vexatious actions is not driven by a discriminatory intent. With the objective of testing the possible moderating role of personality in the relationship between perceptions about straining at work and individual consequences, a correlational design research involved 374 healthcare workers (HCWs) from two Italian hospitals. The following questionnaires were administered: (1) Short Negative Acts Questionnaire (S‐NAQ), to assess discriminative actions at work); (2) the Italian version of the Big Five Inventory (BFI‐10 scale), to assess personality factors; (3) Occupational Stress Indicator (OSI), to measure psychological and physical health. Regression analysis and Structural Equation Models (SEM) were computed in order to test the relationships between variables. Perceived straining showed significant correlations with both psychological and physical health. Conscientiousness was inversely proportional to work‐related bullying (WB), as agreeableness was to personal bullying (PB). Emotional stability was negatively correlated with all the three component scales of S‐NAQ: WB, PB, and social bullying. The results seem to confirm that straining perceptions especially elicit, through emotional stability, psychological consequences. As regards the role of emotional stability in risk perceptions, it seems management has to pay thorough attention to personal factors in organizational perceptions and to straining actions
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