Sympatho-Vagal Dysfunction in Patients with End-Stage Lung Disease Awaiting Lung Transplantation

Although the literature demonstrates that cardiac autonomic control (CAC) might be impaired in patients with chronic pulmonary diseases, the interplay between CAC and disease severity in end-stage lung disease has not been studied yet. We investigated the effects of end-stage lung disease on CAC through the analysis of heart rate variability (HRV) among patients awaiting lung transplantation. Forty-nine patients on the waiting list for lung transplantation (LTx; 19 men, age 38 \ub1 15 years) and 49 healthy non-smoking controls (HC; 22 men, age 40 \ub1 16 years) were enrolled in a case-control study at Policlinico Hospital in Milan, Italy. LTx patients were divided into two groups, according to disease severity evaluated by the Lung Allocation Score (LAS). To assess CAC, electrocardiogram (ECG) and respiration were recorded at rest for 10 min in supine position and for 10 min during active standing. Spectral analysis identified low and high frequencies (LF, sympathetic, and HF, vagal). Symbolic analysis identified three patterns, i.e., 0V% (sympathetic) and 2UV% and 2LV% (vagal). Compared to HCs, LTx patients showed higher markers of sympathetic modulation and lower markers of vagal modulation. However, more severely affected LTx patients, compared to less severely affected ones, showed an autonomic profile characterized by loss of sympathetic modulation and predominant vagal modulation. This pattern can be due to a loss of sympathetic rhythmic oscillation and a subsequent prevalent respiratory modulation of heart rate in severely affected patients

Desingularization of vortices for the Euler equation

We study the existence of stationary classical solutions of the incompressible Euler equation in the plane that approximate singular stationnary solutions of this equation. The construction is performed by studying the asymptotics of equation -\eps^2 \Delta u^\eps=(u^\eps-q-\frac{\kappa}{2\pi} \log \frac{1}{\eps})_+^p with Dirichlet boundary conditions and $q$ a given function. We also study the desingularization of pairs of vortices by minimal energy nodal solutions and the desingularization of rotating vortices.Comment: 40 page

Constraining the nature of the 18-min periodic radio transient GLEAM-X J162759.5-523504.3 via multi-wavelength observations and magneto-thermal simulations

We observed the periodic radio transient GLEAM-X J162759.5-523504.3 (GLEAM-X J1627) using the Chandra X-ray Observatory for about 30-ks on January 22-23, 2022, simultaneously with radio observations from MWA, MeerKAT and ATCA. Its radio emission and 18-min periodicity led the source to be tentatively interpreted as an extreme magnetar or a peculiar highly magnetic white dwarf. The source was not detected in the 0.3-8 keV energy range with a 3-sigma upper-limit on the count rate of 3x10^{-4} counts/s. No radio emission was detected during our X-ray observations either. Furthermore, we studied the field around GLEAM-X J1627 using archival ESO and DECam data, as well as recent SALT observations. Many sources are present close to the position of GLEAM-X J1627, but only two within the 2" radio position uncertainty. Depending on the assumed spectral distribution, the upper limits converted to an X-ray luminosity of L_{X}<6.5x10^{29} erg/s for a blackbody with temperature kT=0.3 keV, or L_{X}<9x10^{29} erg/s for a power-law with photon index Gamma = 2 (assuming a 1.3 kpc distance). Furthermore, we performed magneto-thermal simulations for neutron stars considering crust- and core-dominated field configurations. Based on our multi-band limits, we conclude that: i) in the magnetar scenario, the X-ray upper limits suggest that GLEAM-X J1627 should be older than ~1 Myr, unless it has a core-dominated magnetic field or has experienced fast-cooling; ii) in the white dwarf scenario, we can rule out most binary systems, a hot sub-dwarf and a hot magnetic isolated white dwarf (T>10.000 K), while a cold isolated white dwarf is still compatible with our limits.Comment: 17 pages, 9 figures; ApJ accepte

Timing Analysis of the 2022 Outburst of the Accreting Millisecond X-Ray Pulsar SAX J1808.4-3658: Hints of an Orbital Shrinking

We present a pulse timing analysis of NICER observations of the accreting millisecond X-ray pulsar SAX J1808.4-3658 during the outburst that started on 2022 August 19. Similar to previous outbursts, after decaying from a peak luminosity of ≃1 × 1036 erg s-1 in about a week, the pulsar entered a ~1 month long reflaring stage. Comparison of the average pulsar spin frequency during the outburst with those previously measured confirmed the long-term spin derivative of ν˙SD=−(1.15±0.06)×10−15 Hz s-1, compatible with the spin-down torque of a ≈1026 G cm3 rotating magnetic dipole. For the first time in the last twenty years, the orbital phase evolution shows evidence for a decrease of the orbital period. The long-term behavior of the orbit is dominated by an ~11 s modulation of the orbital phase epoch consistent with a ~21 yr period. We discuss the observed evolution in terms of a coupling between the orbit and variations in the mass quadrupole of the companion star

A Very Young Radio-loud Magnetar

The magnetar Swift J1818.0–1607 was discovered in 2020 March when Swift detected a 9 ms hard X-ray burst and a long-lived outburst. Prompt X-ray observations revealed a spin period of 1.36 s, soon confirmed by the discovery of radio pulsations. We report here on the analysis of the Swift burst and follow-up X-ray and radio observations. The burst average luminosity was L burst ~ 2 × 1039 erg s−1 (at 4.8 kpc). Simultaneous observations with XMM-Newton and NuSTAR three days after the burst provided a source spectrum well fit by an absorbed blackbody (${N}_{{\rm{H}}}$ = (1.13 ± 0.03) × 1023 cm−2 and kT = 1.16 ± 0.03 keV) plus a power law (Γ = 0.0 ± 1.3) in the 1–20 keV band, with a luminosity of ~8 × 1034 erg s−1, dominated by the blackbody emission. From our timing analysis, we derive a dipolar magnetic field B ~ 7 × 1014 G, spin-down luminosity ${\dot{E}}_{\mathrm{rot}}\sim 1.4\times {10}^{36}$ erg s−1, and characteristic age of 240 yr, the shortest currently known. Archival observations led to an upper limit on the quiescent luminosity <5.5 × 1033 erg s−1, lower than the value expected from magnetar cooling models at the source characteristic age. A 1 hr radio observation with the Sardinia Radio Telescope taken about 1 week after the X-ray burst detected a number of strong and short radio pulses at 1.5 GHz, in addition to regular pulsed emission; they were emitted at an average rate 0.9 min−1 and accounted for ~50% of the total pulsed radio fluence. We conclude that Swift J1818.0–1607 is a peculiar magnetar belonging to the small, diverse group of young neutron stars with properties straddling those of rotationally and magnetically powered pulsars. Future observations will make a better estimation of the age possible by measuring the spin-down rate in quiescence

About curvature, conformal metrics and warped products

We consider the curvature of a family of warped products of two pseduo-Riemannian manifolds $(B,g_B)$ and $(F,g_F)$ furnished with metrics of the form $c^{2}g_B \oplus w^2 g_F$ and, in particular, of the type $w^{2 \mu}g_B \oplus w^2 g_F$, where $c, w \colon B \to (0,\infty)$ are smooth functions and $\mu$ is a real parameter. We obtain suitable expressions for the Ricci tensor and scalar curvature of such products that allow us to establish results about the existence of Einstein or constant scalar curvature structures in these categories. If $(B,g_B)$ is Riemannian, the latter question involves nonlinear elliptic partial differential equations with concave-convex nonlinearities and singular partial differential equations of the Lichnerowicz-York type among others.Comment: 32 pages, 3 figure

Deep X-ray and radio observations of the first outburst of the young magnetar Swift J1818.0-1607

Swift J1818.0-1607 is a radio-loud magnetar with a spin period of 1.36 s and a dipolar magnetic field strength of B~3E14 G, which is very young compared to the Galactic pulsar population. We report here on the long-term X-ray monitoring campaign of this young magnetar using XMM-Newton, NuSTAR, and Swift from the activation of its first outburst in March 2020 until October 2021, as well as INTEGRAL upper limits on its hard X-ray emission. The 1-10 keV magnetar spectrum is well modeled by an absorbed blackbody with a temperature of kT_BB~1.1 keV, and apparent reduction in the radius of the emitting region from ~0.6 to ~0.2 km. We also confirm the bright diffuse X-ray emission around the source extending between ~50'' and ~110''. A timing analysis revealed large torque variability, with an average spin-down rate nudot~-2.3E-11 Hz^2 that appears to decrease in magnitude over time. We also observed Swift J1818.0-1607 with the Karl G. Jansky Very Large Array (VLA) on 2021 March 22. We detected the radio counterpart to Swift J1818.0-1607 measuring a flux density of S_v = 4.38+/-0.05 mJy at 3 GHz, and a half ring-like structure of bright diffuse radio emission located at ~90'' to the west of the magnetar. We tentatively suggest that the diffuse X-ray emission is due to a dust scattering halo and that the radio structure may be associated with the supernova remnant of this young pulsar, based on its morphology.Comment: 19 pages, 8 figures, accepted for publication on Ap

Strongly magnetized pulsars: explosive events and evolution

Well before the radio discovery of pulsars offered the first observational confirmation for their existence (Hewish et al., 1968), it had been suggested that neutron stars might be endowed with very strong magnetic fields of $10^{10}$-$10^{14}$G (Hoyle et al., 1964; Pacini, 1967). It is because of their magnetic fields that these otherwise small ed inert, cooling dead stars emit radio pulses and shine in various part of the electromagnetic spectrum. But the presence of a strong magnetic field has more subtle and sometimes dramatic consequences: In the last decades of observations indeed, evidence mounted that it is likely the magnetic field that makes of an isolated neutron star what it is among the different observational manifestations in which they come. The contribution of the magnetic field to the energy budget of the neutron star can be comparable or even exceed the available kinetic energy. The most magnetised neutron stars in particular, the magnetars, exhibit an amazing assortment of explosive events, underlining the importance of their magnetic field in their lives. In this chapter we review the recent observational and theoretical achievements, which not only confirmed the importance of the magnetic field in the evolution of neutron stars, but also provide a promising unification scheme for the different observational manifestations in which they appear. We focus on the role of their magnetic field as an energy source behind their persistent emission, but also its critical role in explosive events.Comment: Review commissioned for publication in the White Book of "NewCompStar" European COST Action MP1304, 43 pages, 8 figure

The INTEGRAL view of the pulsating hard X-ray sky: from accreting and transitional millisecond pulsars to rotation-powered pulsars and magnetars

In the last 25 years, a new generation of X-ray satellites imparted a significant leap forward in our knowledge of X-ray pulsars. The discovery of accreting and transitional millisecond pulsars proved that disk accretion can spin up a neutron star to a very high rotation speed. The detection of MeV-GeV pulsed emission from a few hundreds of rotation-powered pulsars probed particle acceleration in the outer magnetosphere, or even beyond. Also, a population of two dozens of magnetars has emerged. INTEGRAL played a central role to achieve these results by providing instruments with high temporal resolution up to the hard X-ray/soft gamma-ray band and a large field of view imager with good angular resolution to spot hard X-ray transients. In this article, we review the main contributions by INTEGRAL to our understanding of the pulsating hard X-ray sky, such as the discovery and characterization of several accreting and transitional millisecond pulsars, the generation of the first catalog of hard X-ray/soft gamma-ray rotation-powered pulsars, the detection of polarization in the hard X-ray emission from the Crab pulsar, and the discovery of persistent hard X-ray emission from several magnetars.</p