Analysis of complications of pyelolithotomy in treatment of kidney stones

Secţia Urologie, IMSP Spitalul Clinic RepublicanIntroducere. Clasificarea Clavien a complicațiilor chirurgicale a fost introdusă în practica medicală acum 20 de ani. În 2004 acest sistem a fost reevaluat și modificat cu scopul de a crește acuratețea și aplicabilitatea sa în practica chirurgicală. Odată cu introducerea metodelor minim invazive de tratament s-a modificat structura și frecvența complicațiilor postoperatorii, devenind astfel mai dificilă compararea și evaluarea lor, în special atunci când sunt utilizate și metodele clasice de tratament chirurgical. Studiul retrospectiv, a fost efectuat pe 217 pacienți cu litiază bazinetală, tratați prin pielolitotomie în perioada 2007-2012, în cadrul Clinicii de Urologie şi Nefrologie Chirurgicală a Spitalului Clinic Republican. Postoperator au fost determinate complicații la 125 (57,6%) pacienți, inclusiv în 89 (41,01%) cazuri minore și în 26 (12,0%) cazuri majore. Valoarea medie a scorului Clavien în acest lot de pacienți a constituit 2,06±0,02. Pielolitotomia este o metodă efectivă de tratament a calculilor renali. Rata complicațiilor postoperatorii depinde de dimensiunea, durata persistenței calculilor, prezența infecției urinare și nu în ultimul rând, de măiestria chirurgului. Utilizarea Clasificației Clavien permite standartizarea complicațiilor postoperatorii, aprecierea gradului de severitate a complicațiilor și elaborarea unei tactici de tratament corecte și prompte la pacienții cu litiază bazinetală. Introduction. Clavien Classification of surgical complications has been introduced in medical practice for 20 years now. In 2004 this system has been revised and amended in order to increase its accuracy and applicability in surgical practice. The introduction of minim invasive methods of treatment changed the structure and frequency of postoperative complications, making more difficult to compare and evaluate them, especially when there are used classical surgical methods of treatment. The retrospective study was performed on 217 patients with kidney stones treated by pyelolithotomy in 2007-2012, in the Clinic of Urology and Surgical Nephrology, Republican Clinical Hospital. Postoperative complications were determined in 125 (57,6%) patients, including 89 (41,01%) minor and 26 (12,0%) major complications. Mean score Clavien in this group of patients was 2,06 ± 0,02. Pyelolithotomy is an effective method for the treatment of kidney stones. The rate of postoperative complications depends on the size, disease duration, urinary infection and, not least, the skills of the surgeon. The Usage of Clavien classification allows to standardize postoperative complications, to assess the severity of complications and to develop tactics of a fair and prompt treatment in patients with kidney stones

БИОЛОГИЧЕСКИЕ ОСОБЕННОСТИ И ПОСЕВНЫЕ КАЧЕСТВА НЕСТРЕЛКУЮЩЕГОСЯ ЧЕСНОКА В ЗАВИСИМОСТИ ОТ МЕСТОПОЛОЖЕНИЯ ЗУБКА В ЛУКОВИЦЕ

Research conducted at the Institute of Genetics, Physiology and Plant Protection found that when using the peripheral and internal cloves of garlic for planting in comparison with the use of them of different locations without calibrating them by mass, during the growth between the variants differences in the area of the leaf surface of plants were observed. Indicator of the foliage also depends on of the location of the garlic cloves in the bulb. The location of garlic cloves, peripheral and internal, as a planting material, also affects the growth of vegetative mass formation and bulb weight. In the bulb structure the peripheral cloves of garlic have some increase in their quality over internals (the ratio is in the range of 60:40%). Analysis of the obtained productivity data makes it possible to note that in the formation of high yields of non-clotting garlic, the location of the clove of garlic in the bulb is of the leading importance. Differences in gross and commodity yields, between variants (B3) and (B2) are not so great, but the advantage of the first one is everywhere traced. Studies have also found that the use of all garlic cloves for planting at different locations without calibrating them by weight, leads to differently bulbs maturing time, which makes the harvesting process more difficult and leads to additional labor costs, in which case when harvesting - 24% of it consist of small noncommodity bulbs. The use of the same mass garlic cloves of different locations for planting ensures the simultaneous of ripening, a greater proportion of standard bulbs and a high quality of planting material.Исследованиями, проведенными в Институте Генетики, Физиологии и Защиты Растений Республики Молдова, установлено, что при использовании на посадку периферийного и внутреннего зубка в сравнении с использованием зубков разного местоположения без калибровки их по массе, в процессе роста между вариантами обнаружились различия по площади листовой поверхности растений. От места расположения зубков в луковице зависит и показатель их облиственности. Местоположение зубков, периферийные и внутренние, как посадочный материал влияет также на рост образования вегетативной массы и массы луковицы. В структуре луковицы периферийные зубки обладают некоторым повышением их качества над внутренними (соотношение находится в пределах 60:40%.) Анализ полученных данных продуктивности позволяет отметить, что в формирование высоких урожаев нестрелкующегося чеснока местоположение зубка в луковице имеет ведущее значение. Различия в валовом и товарном урожае между вариантами (B3) и (B2) не столь велики, однако всюду прослеживается преимущество первого. Исследованиями также установлено, что использование на посадку всех зубков разного местоположения без калибровки их по массе, приводит к разновременности созревания луковиц, что затрудняет процесс уборки и приводит к дополнительным затратам труда, и в таком случае при уборке урожая 24% его приходится на мелкие нетоварные луковицы. Использование на посадку одинаковых по массе зубков разного местоположения обеспечивает дружность созревания, большую долю стандартных луковиц и высокое качество посадочного материала

Prostamol®Uno in treatment of the patients with benign prostatic hyperplasia (experience of 10 years)

Catedra Urologie şi Nefrologie Chirurgicală USMF „N. Testemiţanu”, Spitalul Raional Edineţ; Secţia Urologie IMSP Spitalul Clinic Republican, Al V-lea Congres de Urologie, Dializă şi Transplant Renal din Republica Moldova cu participare internaţională (1-13 iunie 2011)Summary. During 10 years, between 2001-2011, 760 patients with BPH were treated with Prostamol®Uno, 320mg, daily. In this trial patients were assessed pre- and post- treatment with International Prostate Symptom Score (IPSS), the Quality of Life (QOL), values of PSA and volume of residual urine appreciated ecographically. The analysis of our data shows decrease in IPSS score, QOL and volume of residual urine with in 53,4 %, 57,5% and 48,7% respectively. Prostamol®Uno is one of election drug in conservative treatment of BPH

Direct magnetic and surface relief patterning using carbazole-based azopolymer

The results on using of carbazole-based azopolymer layers (Polyepoxypropylcarbazole:Methyl Red with magnetic particles of Fe2SO4) for the recording of 1-D and 2-D surface relief gratings are presented in this report. Morphology study using AFM and MFM of obtained structures has shown their good quality. Surface relief gratings with profile height up to 1.2 µm were obtained during the holographic recording using blue laser. Along with surface relief grating it was shown the direct formation of magnetic relief. Possibility of simultaneous direct fabrication of surface and magnetic relief by optical holographic recording using azopolymer thin films as recording media was shown

Breeding progress and preparedness for mass‐scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar

UK: The UK‐led miscanthus research and breeding was mainly supported by the Biotechnology and Biological Sciences Research Council (BBSRC), Department for Environment, Food and Rural Affairs (Defra), the BBSRC CSP strategic funding grant BB/CSP1730/1, Innovate UK/BBSRC “MUST” BB/N016149/1, CERES Inc. and Terravesta Ltd. through the GIANT‐LINK project (LK0863). Genomic selection and genomewide association study activities were supported by BBSRC grant BB/K01711X/1, the BBSRC strategic programme grant on Energy Grasses & Bio‐refining BBS/E/W/10963A01. The UK‐led willow R&D work reported here was supported by BBSRC (BBS/E/C/00005199, BBS/E/C/00005201, BB/G016216/1, BB/E006833/1, BB/G00580X/1 and BBS/E/C/000I0410), Defra (NF0424) and the Department of Trade and Industry (DTI) (B/W6/00599/00/00). IT: The Brain Gain Program (Rientro dei cervelli) of the Italian Ministry of Education, University, and Research supports Antoine Harfouche. US: Contributions by Gerald Tuskan to this manuscript were supported by the Center for Bioenergy Innovation, a US Department of Energy Bioenergy Research Center supported by the Office of Biological and Environmental Research in the DOE Office of Science, under contract number DE‐AC05‐00OR22725. Willow breeding efforts at Cornell University have been supported by grants from the US Department of Agriculture National Institute of Food and Agriculture. Contributions by the University of Illinois were supported primarily by the DOE Office of Science; Office of Biological and Environmental Research (BER); grant nos. DE‐SC0006634, DE‐SC0012379 and DE‐SC0018420 (Center for Advanced Bioenergy and Bioproducts Innovation); and the Energy Biosciences Institute. EU: We would like to further acknowledge contributions from the EU projects “OPTIMISC” FP7‐289159 on miscanthus and “WATBIO” FP7‐311929 on poplar and miscanthus as well as “GRACE” H2020‐EU.3.2.6. Bio‐based Industries Joint Technology Initiative (BBI‐JTI) Project ID 745012 on miscanthus.Peer reviewedPostprintPublisher PD

Breeding progress and preparedness for mass-scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar

Genetic improvement through breeding is one of the key approaches to increasing biomass supply. This paper documents the breeding progress to date for four perennial biomass crops (PBCs) that have high output–input energy ratios: namely Panicum virgatum (switchgrass), species of the genera Miscanthus (miscanthus), Salix (willow) and Populus (poplar). For each crop, we report on the size of germplasm collections, the efforts to date to phenotype and genotype, the diversity available for breeding and on the scale of breeding work as indicated by number of attempted crosses. We also report on the development of faster and more precise breeding using molecular breeding techniques. Poplar is the model tree for genetic studies and is furthest ahead in terms of biological knowledge and genetic resources. Linkage maps, transgenesis and genome editing methods are now being used in commercially focused poplar breeding. These are in development in switchgrass, miscanthus and willow generating large genetic and phenotypic data sets requiring concomitant efforts in informatics to create summaries that can be accessed and used by practical breeders. Cultivars of switchgrass and miscanthus can be seed-based synthetic populations, semihybrids or clones. Willow and poplar cultivars are commercially deployed as clones. At local and regional level, the most advanced cultivars in each crop are at technology readiness levels which could be scaled to planting rates of thousands of hectares per year in about 5 years with existing commercial developers. Investment in further development of better cultivars is subject to current market failure and the long breeding cycles. We conclude that sustained public investment in breeding plays a key role in delivering future mass-scale deployment of PBCs

BIOLOGICAL FEATURES AND SOWING QUALITIES OF NON-CLOTTING GARLIC, DEPENDING ON THE LOCATION OF THE GARLIC CLOVES IN THE BULB

Research conducted at the Institute of Genetics, Physiology and Plant Protection found that when using the peripheral and internal cloves of garlic for planting in comparison with the use of them of different locations without calibrating them by mass, during the growth between the variants differences in the area of the leaf surface of plants were observed. Indicator of the foliage also depends on of the location of the garlic cloves in the bulb. The location of garlic cloves, peripheral and internal, as a planting material, also affects the growth of vegetative mass formation and bulb weight. In the bulb structure the peripheral cloves of garlic have some increase in their quality over internals (the ratio is in the range of 60:40%). Analysis of the obtained productivity data makes it possible to note that in the formation of high yields of non-clotting garlic, the location of the clove of garlic in the bulb is of the leading importance. Differences in gross and commodity yields, between variants (B3) and (B2) are not so great, but the advantage of the first one is everywhere traced. Studies have also found that the use of all garlic cloves for planting at different locations without calibrating them by weight, leads to differently bulbs maturing time, which makes the harvesting process more difficult and leads to additional labor costs, in which case when harvesting - 24% of it consist of small noncommodity bulbs. The use of the same mass garlic cloves of different locations for planting ensures the simultaneous of ripening, a greater proportion of standard bulbs and a high quality of planting material

Oxidative stress and antioxidant status in patients with complicated urolithiasis

In recent years, intense efforts have been made to clarify the pathogenesis of urolithiasis, which affects more than 10% of the population of developed countries. Currently, a number of studies have assumed a key role in the pathogenesis of oxalate urolithiasis, which is the most common one that belongs to the active forms of oxygen generated in the kidney, as a result of the activation of free radical oxidation that occurs in the interaction of calcium oxalate crystals with renal tubular epithelial cells. In the current work, oxidant and antioxidant status were assessed in the blood of patients with complicated urolithiasis pre – and post surgery. The surgical treatment of complicated urolithiasis leads a decrease of the oxidative stress and an increase in the potential of antiradical and antiperoxidative protection

Agronomical biofortification of garlic plant (Allium sativum L.) in aspect of increasing selenium content and antioxidant properties

ABSTRACT The paper presents results of studying the effect of garlic plant (Allium sativum L.) foliar treatment with gibberellins and potassium selenate on the yield, selenium content and antioxidant protection capacity of the leaves and bulbs. It has been found that biological fortification of the garlic plant by treating the leaves with the solution of potassium selenate increases the selenium content in leaves and bulbs, the capacity of the antioxidant protection of cells, the content of the proline, pigment assimilation and, reduces lipid peroxidation. Potassium selenate amplifies the adaptive potential of plants, reduces the negative impact of moisture deficit, enhances the accumulation of the substances that increase the water retention capacity in the leaves, and optimizes the processes of growth and productivity

The peculiarities of chemical composition of kidney stones in patients with recurrent urolithiasis in Republic of Moldova

Catedra Urologie și nefrologie chirurgicală, Universitatea de Stat de Medicină și Farmacie “Nicolae Testemițanu”, Chișinău, Republica Moldova, Secția Urologie, Spitalul Clinic Republican, Chișinău, Republica Moldov