Modelling the impacts of policy interventions for food systems transformation in Indonesia – Governance and policy support: Report.

The Government of Indonesia and FAO have recognized the need for thorough analysis and modelling of Indonesia’s food systems to support food systems transformation efforts in the country. This is needed to provide a better understanding of the governance context in food systems, including the political economy dynamics influencing performance, as well as to identify synergies and trade-offs across different policy goals and optimal policy mixes for achieving multiple policy objectives. In this regard, FAO facilitated a project to pilot an innovative approach to modelling for food systems transformation. This modelling approach was developed and implemented by a team of researchers from IFPRI, IIASA, IISD and Christian-Albrechts-University of Kiel. It makes use of three different economic models to generate insights that can assist Indonesian policymakers in developing technically sound and politically feasible policy interventions for food systems transformation. This report provides context for food systems transformation in Indonesia and describes the overall modelling approach before synthesizing the results of the individual modelling activities and distilling these into the overall findings of the modelling. It concludes with implications from these findings for policymaking for food systems transformation in Indonesia and some suggestions for next steps. The results of this modelling and the insights drawn from these results are expected to support efforts to translate Indonesia’s commitments on food systems transformation into concrete policy interventions and to inform medium- and long-term development planning by the Indonesian Government

Water Consumption by Livestock Systems from 2002–2020 and Predictions for 2030–2050 under Climate Changes in the Czech Republic

The livestock system in Europe relies on a complex holistic equilibrium that is the outcome of an interplay of demand, market, crop production, livestock production, land use, water availability, and other factors. When modeling future scenarios of water consumption by livestock systems, the most suitable tools result from the interconnectivity of growth models, economic models, and climate models. We integrated the Environmental Policy Integrated Climate growth model (EPIC), animal-level model (RUMINANT), economic model (Global Biosphere Management Model, GLOBIOM), EURO-CORDEX climate models, and regression models. This study developed novel livestock production scenarios for individual regions of the Czech Republic with estimations of the categories of livestock that have been bred during the last 20 years and will be bred in the future and what their water consumption will be, both throughout the year and in particular seasons. First, the numbers of farm animals, namely, cattle, pigs, sheep, horses, goats, and poultry in 2002–2020 were evaluated, and their numbers were predicted for the following years until 2050. Second, livestock water consumption per region was determined based on the number of livestock individuals. Third, changes in the amount of water consumed by livestock per year in individual regions in 2050 compared to 2005 were estimated

Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting

We aimed to provide comprehensive protocols and promote effective management of pregnant women with gynecological cancers. New insights and more experience have been gained since the previous guidelines were published in 2014. Members of the International Network on Cancer, Infertility and Pregnancy (INCIP), in collaboration with other international experts, reviewed existing literature on their respective areas of expertise. Summaries were subsequently merged into a manuscript that served as a basis for discussion during the consensus meeting. Treatment of gynecological cancers during pregnancy is attainable if management is achieved by collaboration of a multidisciplinary team of health care providers. This allows further optimization of maternal treatment, while considering fetal development and providing psychological support and long-term follow-up of the infants. Nonionizing imaging procedures are preferred diagnostic procedures, but limited ionizing imaging methods can be allowed if indispensable for treatment plans. In contrast to other cancers, standard surgery for gynecological cancers often needs to be adapted according to cancer type and gestational age. Most standard regimens of chemotherapy can be administered after 14 weeks gestational age but are not recommended beyond 35 weeks. C-section is recommended for most cervical and vulvar cancers, whereas vaginal delivery is allowed in most ovarian cancers. Breast-feeding should be avoided with ongoing chemotherapeutic, endocrine or targeted treatment. More studies that focus on the long-term toxic effects of gynecologic cancer treatments are needed to provide a full understanding of their fetal impact. In particular, data on targeted therapies that are becoming standard of care in certain gynecological malignancies is still limited. Furthermore, more studies aimed at the definition of the exact prognosis of patients after antenatal cancer treatment are warranted. Participation in existing registries (www.cancerinpregnancy.org) and the creation of national tumor boards with multidisciplinary teams of care providers (supplementary Box S1, available at Annals of Oncology online) is encouraged

Symptomatic asymmetry in the first six months of life: differential diagnosis

Asymmetry in infancy is a clinical condition with a wide variation in appearances (shape, posture, and movement), etiology, localization, and severity. The prevalence of an asymmetric positional preference is 12% of all newborns during the first six months of life. The asymmetry is either idiopathic or symptomatic. Pediatricians and physiotherapists have to distinguish symptomatic asymmetry (SA) from idiopathic asymmetry (IA) when examining young infants with a positional preference to determine the prognosis and the intervention strategy. The majority of cases will be idiopathic, but the initial presentation of a positional preference might be a symptom of a more serious underlying disorder. The purpose of this review is to synthesize the current information on the incidence of SA, as well as the possible causes and the accompanying signs that differentiate SA from IA. This review presents an overview of the nine most prevalent disorders in infants in their first six months of life leading to SA. We have discovered that the literature does not provide a comprehensive analysis of the incidence, characteristics, signs, and symptoms of SA. Knowledge of the presented clues is important in the clinical decision making with regard to young infants with asymmetry. We recommend to design a valid and useful screening instrument

A glimpse at Ethology in Latin America

The state of the art of Ethology in five Latin America countries is briefly presented here. The overall outlook regarding research laboratories and themes is promising: the community is numerous, active and there are topics addressing all aspects of animal behavior, especially in large countries like Brazil and Argentina. Ethology as an undergraduate discipline is generally a subcategory of Biology, being taught mainly at Zoology/ Psychology/ Ecology/ Agriculture Courses and at Medical Veterinary Schools, often as an eligible discipline. Ethology as a formal major Graduate Program is rare and mainly restricted to Brazil.Facultad de Ciencias Naturales y Muse

MESSAGEix-GLOBIOM nexus module: integrating water sector and climate impacts

The integrated assessment model (IAM) MESSAGEix-GLOBIOM developed by IIASA is widely used to analyze global change and socioeconomic development scenarios within energy and land systems across different scales. However, to date, the representation of impacts from climate effects and water systems in the IAM has been limited. We present a new nexus module for MESSAGEix-GLOBIOM that improves the representation of climate impacts and enables the analysis of interactions between population, economic growth, energy, land, and water resources in a dynamic system. The module uses a spatially resolved representation of water systems to retain hydrological information without compromising computational feasibility. It maps simplified water availability and key infrastructure assumptions with the energy and land systems. The results of this study inform on the transformation pathways required under climate change impacts and mitigation scenarios. The pathways include multi-sectoral indicators highlighting the importance of water as a constraint in energy and land-use decisions and the implications of global responses to limited water availability from different sources, suggesting possible shifts in the energy and land sectors

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened 230 new mouse anti-CHIKV monoclonal antibodies (MAbs) for their ability to inhibit infection of all three CHIKV genotypes. Four of 36 neutralizing MAbs (CHK-102, CHK-152, CHK-166, and CHK-263) provided complete protection against lethality as prophylaxis in highly susceptible immunocompromised mice lacking the type I IFN receptor (Ifnar−/−) and mapped to distinct epitopes on the E1 and E2 structural proteins. CHK-152, the most protective MAb, was humanized, shown to block viral fusion, and require Fc effector function for optimal activity in vivo. In post-exposure therapeutic trials, administration of a single dose of a combination of two neutralizing MAbs (CHK-102+CHK-152 or CHK-166+CHK-152) limited the development of resistance and protected immunocompromised mice against disease when given 24 to 36 hours before CHIKV-induced death. Selected pairs of highly neutralizing MAbs may be a promising treatment option for CHIKV in humans

Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering

Novel, injectable hydrogels were developed that solidify through a dual-gelation, physical and chemical, mechanism upon preparation and elevation of temperature to 37°C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolyticallydegradable polyamidoamine-based diamine crosslinker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxyamine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine crosslinker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant post-formation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability

Eukaryotic richness in the abyss: insights from pyrotag sequencing

Background: The deep sea floor is considered one of the most diverse ecosystems on Earth. Recent environmental DNA surveys based on clone libraries of rRNA genes confirm this observation and reveal a high diversity of eukaryotes present in deep-sea sediment samples. However, environmental clone-library surveys yield only a modest number of sequences with which to evaluate the diversity of abyssal eukaryotes. Methodology/Principal Findings: Here, we examined the richness of eukaryotic DNA in deep Arctic and Southern Ocean samples using massively parallel sequencing of the 18S ribosomal RNA (rRNA) V9 hypervariable region. In very small volumes of sediments, ranging from 0.35 to 0.7 g, we recovered up to 7,499 unique sequences per sample. By clustering sequences having up to 3 differences, we observed from 942 to 1756 Operational Taxonomic Units (OTUs) per sample. Taxonomic analyses of these OTUs showed that DNA of all major groups of eukaryotes is represented at the deep-sea floor. The dinoflagellates, cercozoans, ciliates, and euglenozoans predominate, contributing to 17%, 16%, 10%, and 8% of all assigned OTUs, respectively. Interestingly, many sequences represent photosynthetic taxa or are similar to those reported from the environmental surveys of surface waters. Moreover, each sample contained from 31 to 71 different metazoan OTUs despite the small sample volume collected. This indicates that a significant faction of the eukaryotic DNA sequences likely do not belong to living organisms, but represent either free, extracellular DNA or remains and resting stages of planktonic species. Conclusions/Significance: In view of our study, the deep-sea floor appears as a global DNA repository, which preserves genetic information about organisms living in the sediment, as well as in the water column above it. This information can be used for future monitoring of past and present environmental changes.French ANR Aquaparadox; ANR DeepOases; Swiss National Science Foundation [31003A-125372]; WM Keck foundationinfo:eu-repo/semantics/publishedVersio