Photon production from the vacuum close to the super-radiant transition: When Casimir meets Kibble-Zurek

The dynamical Casimir effect (DCE) predicts the generation of photons from the vacuum due to the parametric amplification of the quantum fluctuation of an electromagnetic field\cite{casimir1,casimir2}. The verification of such effect is still elusive in optical systems due to the very demanding requirements of its experimental implementation. This typically requires very fast changes of the boundary conditions of the problem, such as the high-frequency driving of the positions of the mirrors of a cavity accommodating the field. Here, we show that an ensemble of two-level atoms collectively coupled to the electromagnetic field of a cavity (thus embodying the quantum Dicke model\cite{dicke}), driven at low frequencies and close to a quantum phase transition, stimulates the production of photons from the vacuum. This paves the way to an effective simulation of the DCE through a mechanism that has recently found an outstanding experimental demonstration\cite{esslinger}. The spectral properties of the emitted radiation reflect the critical nature of the system and allow us to link the detection of DCE to the Kibble-Zurek mechanism for the production of defects when crossing a continuous phase transition\cite{KZ1,KZ2}. We illustrate the features of our proposal by addressing a simple cavity quantum-electrodynamics (cQED) setting of immediate experimental realisation.Comment: 4+1 pages, major changes in the second part of the paper. To appear in Physical Review Letter

Dynamical control of quantum state transfer within hybrid open systems

We analyze quantum state-transfer optimization within hybrid open systems, from a "noisy" (write-in) qubit to its "quiet" counterpart (storage qubit). Intriguing interplay is revealed between our ability to avoid bath-induced errors that profoundly depend on the bath-memory time and the limitations imposed by leakage out of the operational subspace. Counterintuitively, under no circumstances is the fastest transfer optimal (for a given transfer energy)

Dissipation in adiabatic quantum computers: lessons from an exactly solvable model

We introduce and study the adiabatic dynamics of free-fermion models subject to a local Lindblad bath and in the presence of a time-dependent Hamiltonian. The merit of these models is that they can be solved exactly, and will help us to study the interplay between nonadiabatic transitions and dissipation in many-body quantum systems. After the adiabatic evolution, we evaluate the excess energy (the average value of the Hamiltonian) as a measure of the deviation from reaching the final target ground state. We compute the excess energy in a variety of different situations, where the nature of the bath and the Hamiltonian is modified. We find robust evidence of the fact that an optimal working time for the quantum annealing protocol emerges as a result of the competition between the nonadiabatic effects and the dissipative processes. We compare these results with the matrix-product-operator simulations of an Ising system and show that the phenomenology we found also applies for this more realistic case

Geometric measure of quantum discord and total quantum correlations in a N-partite quantum state

Quantum discord, as introduced by Olliver and Zurek [Phys. Rev. Lett. \textbf{88}, 017901 (2001)], is a measure of the discrepancy between quantum versions of two classically equivalent expressions for mutual information and is found to be useful in quantification and application of quantum correlations in mixed states. It is viewed as a key resource present in certain quantum communication tasks and quantum computational models without containing much entanglement. An early step toward the quantification of quantum discord in a quantum state was by Dakic, Vedral, and Brukner [Phys. Rev. Lett. 105,190502 (2010)] who introduced a geometric measure of quantum discord and derived an explicit formula for any two-qubit state. Recently, Luo and Fu [Phys. Rev. A \textbf{82}, 034302 (2010)] introduced a generic form of the geometric measure of quantum discord for a bipartite quantum state. We extend these results and find generic forms of the geometric measure of quantum discord and total quantum correlations in a general N-partite quantum state. Further, we obtain computable exact formulas for the geometric measure of quantum discord and total quantum correlations in a N-qubit quantum state. The exact formulas for the $N$-qubit quantum state are experimentally implementable.Comment: 18 pages, 3 figure

Changes in Culture Expanded Human Amniotic Epithelial Cells: Implications for Potential Therapeutic Applications

Human amniotic epithelial cells (hAEC) isolated from term placenta have stem cell-like properties, differentiate into tissue specific cells and reduce lung and liver inflammation and fibrosis following transplantation into disease models established in mice. These features together with their low immunogenicity and immunosuppressive properties make hAEC an attractive source of cells for potential therapeutic applications. However, generation of large cell numbers required for therapies through serial expansion in xenobiotic-free media may be a limiting factor. We investigated if hAEC could be expanded in xenobiotic-free media and if expansion altered their differentiation capacity, immunophenotype, immunosuppressive properties and production of immunomodulatory factors. Serial expansion in xenobiotic-free media was limited with cumulative cell numbers and population doubling times significantly lower than controls maintained in fetal calf serum. The epithelial morphology of primary hAEC changed into mesenchymal-stromal like cells by passage 4–5 (P4–P5) with down regulation of epithelial markers CK7, CD49f, EpCAM and E-cadherin and elevation of mesenchymal-stromal markers CD44, CD105, CD146 and vimentin. The P5 hAEC expanded in xenobiotic-free medium differentiated into osteocyte and alveolar epithelium-like cells, but not chondrocyte, hepatocyte, α- and β-pancreatic-like cells. Expression of HLA Class IA, Class II and co-stimulatory molecules CD80, CD86 and CD40 remained unaltered. The P5 hAEC suppressed mitogen stimulated T cell proliferation, but were less suppressive compared with primary hAEC at higher splenocyte ratios. Primary and P5 hAEC did not secrete the immunosuppressive factors IL-10 and HGF, whereas TGF-β1 and HLA-G were reduced and IL-6 elevated in P5 hAEC. These findings suggest that primary and expanded hAEC may be suitable for different cellular therapeutic applications

The technical performance of the HEGRA system of imaging air Cherenkov telescopes

Between early 1997 and late 2002, the HEGRA collaboration operated a stereoscopic system of 4 (later 5) imaging atmospheric Cherenkov telescopes. In this paper we present the calibration schemes which were developed for the system, and report on the performance of the detector over the years. In general, the telescope system was very well understood, regarding both the absolute calibration and the slight changes in performance over the years. The system had an energy threshold of 500 GeV for observations at zenith and under optimum detector conditions. With the corresponding calibration schemes, a systematic accuracy of 15 percent on the absolute energy scale has been achieved. The continuous sensitivity monitoring provided a relative accuracy of a few percent, and showed that the threshold did not exceed 600 GeV throughout the entire operation time. The readout electronics and the imaging quality of the dishes were well monitored and stable. The absolute pointing had an accuracy of at least 25 arcsec; this number was guaranteed throughout the whole lifetime of the experiment.G. Puhlhofer ... G. P. Rowell.. and W. Wittek...et al., the HEGRA Collaboratio

Derivation of Chondrogenically-Committed Cells from Human Embryonic Cells for Cartilage Tissue Regeneration

Background: Heterogeneous and uncontrolled differentiation of human embryonic stem cells (hESCs) in embryoid bodies (EBs) limits the potential use of hESCs for cell-based therapies. More efficient strategies are needed for the commitment and differentiation of hESCs to produce a homogeneous population of specific cell types for tissue regeneration applications. Methodology/Principal Findings: We report here that significant chondrocytic commitment of feeder-free cultured human embryonic stem cells (FF-hESCs), as determined by gene expression and immunostaining analysis, was induced by coculture with primary chondrocytes. Furthermore, a dynamic expression profile of chondrocyte-specific genes was observed during monolayer expansion of the chondrogenically-committed cells. Chondrogenically-committed cells synergistically responded to transforming growth factor-b1 (TGF-b1) and b1-integrin activating antibody by increasing tissue mass in pellet culture. In addition, when encapsulated in hydrogels, these cells formed cartilage tissue both in vitro and in vivo. In contrast, the absence of chondrocyte co-culture did not result in an expandable cell population from FF-hESCs. Conclusions/Significance: The direct chondrocytic commitment of FF-hESCs can be induced by morphogenetic factor

Calcified Algae for Tissue Engineering.

This book presents the latest advances in marine structures and related biomaterials for applications in both soft- and hard-tissue engineering, as well as controlled drug delivery