Efeito do consórcio cultural no manejo ecológico de insetos em tomateiro.

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"Mapping the Discourse. Architecture Periodicals in/for the Teaching of Architecture History/ Une cartographie du discours. Périodiques d’architecture dans/pour l’enseignement de l’histoire de l’architecture".

The article reflects on a pedagogical project conducted in the framework of the History and Theory course at Politecnico di Milano and questions the value of architectural journals as sources, instruments, methods, and narrative devices for the teaching of architectural history, probing their role as mediators with multifaceted networks of professional, intellectual, and institutional milieux involved in the production of architectural knowledge. The study was conducted on a corpus of around fifty periodicals addressed as a “system of knowledge”, crossing diverse genres and generations of journals, and questioning their character of “complex social objects” to be investigated in their material, economic, cultural, and visual dimensions. On the one hand, the method combining “journal biographies” with the decoding of the issues through the analysis of all their structuring parts allows questioning the changing notion of milieu that magazines contribute to creating over time, revealing the interrelations between a constellation of agents - editors, owners, institutions, and audience – with their divergent agendas, rationalities, and editorial strategies. On the other hand, the paper reflects on the significance of analyzing journals in their interconnections, as cross-cultural and comparative readings offer a more nuanced understanding of the times and forms of production of architectural culture as a transnational practice, challenging the canonical interpretations and time frames of a 20th-century architectural history still centered on the European and North American editorial scene

Palladium(II)-η3-Allyl Complexes Bearing N-Trifluoromethyl N-Heterocyclic Carbenes: A New Generation of Anticancer Agents that Restrain the Growth of High-Grade Serous Ovarian Cancer Tumoroids

The first palladium organometallic compounds bearing N-trifluoromethyl N-heterocyclic carbenes have been synthesized. These η3-allyl complexes are potent antiproliferative agents against different cancer lines (for the most part, IC50 values fall in the range 0.02–0.5 μm). By choosing 1,3,5-triaza-7-phosphaadamantane (PTA) as co-ligand, we can improve the selectivity toward tumor cells, whereas the introduction of 2-methyl substituents generally reduces the antitumor activity slightly. A series of biochemical assays, aimed at defining the cellular targets of these palladium complexes, has shown that mitochondria are damaged before DNA, thus revealing a behavior substantially different from that of cisplatin and its derivatives. We assume that the specific mechanism of action of these organometallic compounds involves nucleophilic attack on the η3-allyl fragment. The effectiveness of a representative complex, 4 c, was verified on ovarian cancer tumoroids derived from patients. The results are promising: unlike carboplatin, our compound turned out to be very active and showed a low toxicity toward normal liver organoids

NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: A report from the AIEOP-AML group.

In the last years, collaborative studies have joined to link the degree of genetic heterogeneity of acute myeloid leukemia (AML) to clinical outcome,1, 2 allowing risk stratification before therapy and guiding post-induction treatment of children with AML. So far, still half of these patients, whose disease is usually characterized by a grim prognosis, lack a known biomarker offering opportunities of targeted treatment

Princípios e práticas ecológicas para o manejo de insetos-praga na agricultura.

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School self-efficacy is affected by gender and motor skills: findings from an Italian study

Background: Perceived school self-efficacy (SE) is an important variable in students' activities as it affects their motivation and learning. Further, self-efficacy might represent a good predictor of performance, persistence and perseverance. Motor skills and other physical health determinants are extensively debated and linked to cognitive function in children of developmental age. However, inconclusive evidence supports a definitive relationship between perceived school SE and motor skills among schoolchildren. We conducted a cross-sectional study on 6-11-year-old schoolchildren to evaluate the extent by which perceived school SE and physical health determinants were related. Methods: A SE questionnaire and motor performance battery tests were administered to primary school pupils recruited from 154 sampled schools of northwest Italy. Perceived SE at school was assessed via 12 items from the Caprara's questionnaire. Motor performance scores were obtained from motor skill tests: 4 × 10 m shuttle run test, SRT; standing broad jump, SBJ; six-minute walking test, 6MWT. Results: A total of 3,962 children (M = 2,019; F = 1943) were studied and 68% were normal weight. Overall, a 58% of the sample perceived a high SE, while, as to gender differences, a greater percentage of females perceived high levels of school SE with respect to any other level (χ2 = 38.93, p < 0.0001). Results from multinomial logistic regression analysis revealed that: (i) females perceived higher SE compared to males; (ii) children who performed better in SRT and 6MWT showed higher levels of perceived school SE; (iii) no significant effect was registered for the body weight. Alternative strategies are encouraged to enhance SE through physical education: structured interventions might enhance both complex motor skills and high-order cognitive skills, like SE, in young children

Field evaluation of Bt cotton crop impact on nontarget pests: cotton aphid and boll weevil.

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