The Approaches to Improvement of Development Management of Hotel Industry of Region

The article is aimed at researching the existing approaches to development management of hotel industry of region. The article substantiates the financial-economic feasibility of the introduction of outsourcing, adaptive room inventory, and provision of residential premises for rent in the activities of large, medium and small hotels together with similar means of accommodation in the Eastern, Western, Southern, Northern, and Central regions of Ukraine. It has been identified that the development of special methodical recommendations concerning the use of one or another form of work organization is a prerequisite for improving the development management of the hotel industry in a particular region taking into consideration possible risks and specificity of hotel services. For this purpose the sequence of actions on choice of the necessary form of organization of activity of hotel activity has been formed, which is based on expert-statistical method and confirms necessity of adaptation of hotel enterprises to contemporary conditions in terms of services for hotel consumers

Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes

Автоматизована система розрахунку коригувальних мас і прогнозування залишкової вібрації при динамічному балансуванні турбоагрегатів

In Ukraine, 47,7 % of electricity production falls on nuclear power plants. An important and time-consuming process in the NPP is the monitoring of the level of vibration and dynamic balancing of turbines. Nowadays in our country we have only a partial automation of it. Therefore, solving of technical problems in power engineering based on modern information technologies is actual and in demand. Analysis of existing solutions shows that there is practically no single algorithm for dynamic balancing and the method of selecting one optimal load for a set of bearings to eliminate the calculated vibration. The goal of the work is to create unified software that could not only compute the corrective loads, but also immediately offer an engineer the most optimal solution how to eliminate the vibration. Actually, to create such functionality, it is necessary to combine the numerical and vector methods of determining the vibration and to improve them for the possibility of choosing the best value. Our main tasks: to find the optimal mass of test load and optimal place to put it; find the optimum mass and the optimal location of the correcting load during repair and under load in order to get the minimum values of vibration at all monitored points, without exceeding their normal values; to analyze and predict how the direction of the vibration vector would change; to visualize the results on the selected direction; to improve a technology of calculation corrective load for each bearing to obtain more accurate and quick results. Sometimes the calculated values of the expected vibration do not coincide with real values when a turbine unit is operating at high power. Therefore, one of the solutions to the problem is to create a knowledge base for the system and an algorithm to select corrective loads based on conclusions and attempts that system made earlier.Проанализирована технология динамической балансировки турбоагрегатов. Создана автоматизированная система, выполняющая анализ уровня вибрации и подбор груза для ее устранения. Усовершенствована технология расчетов корректирующего груза для каждого подшипника с целью получения более точных и быстрых результатов.Проаналізовано технологію динамічного балансування турбоагрегатів. Створено автоматизовану систему, що виконує аналіз рівня вібрації і підбір вантажу для її усунення. Удосконалено технологію розрахунків коригувального вантажу для кожного підшипника з метою отримання більш точних і швидких результатів

A novel biocompatibility test for disperse materials

Introduction. Development of novel biocompatibility tests represents an urgent problem. Use of chicken embryos minimizes the effect of exogenous factors on the experimental course (as the chicken embryo develops in medium it is almost completely isolated from external effects), enables the observation of physiological and pathological processes in the dynamics and assessment of the response of the body response to various materials in many cell populations. Objective. We aimed to show the possibility of using chicken embryo as a test system for evaluation of the biological effects of powdered materials. Materials and methods. In this study, we applied developing chicken embryos produced by incubation of Highline white eggs. Test and control groups (200 embryos in total) were used. Powdered materials were introduced into the embryo yolk sac in the form of suspension in biocompatible dextran (rheopolyglucine).The material was sterilized for 60 min at 120 °С. Two disperse materials, activated charcoal and asbestos powders, were selected to assess the capabilities of the method. Morphological (review, selective histochemical, and electron microscopy) examination methods were applied in testing, which produced the following results. Results. Model efficacy was confirmed by testing certain substances, such as activated charcoal and asbestos. Faster growth and accelerated development of chicken embryos, the absence of tissue pathological reactions, was indicative of the biocompatibility of activated charcoal. Poor biocompatibility of asbestos was concluded from its multiple teratogenic effects detected for the first time for this material. Conclusions.The paper contains motivation and experimental data regarding the usability of chicken embryos in integrated testing of disperse material biocompatibility

CHARACTERISTICS OF THE VARIETIES AND LINES OF WINTER WHEAT OBTAINED IN ARRIGC NAMED AFTER I.G. KALINENKO ON RESISTANCE TO A COMPLEX OF PATHOGENS OF ECONOMICALLY VALUABLE DISEASES

The article considers the varieties and selection lines of winter wheat developed in ARRIGC named after I.G. Kalinenko and the results of long-term study of their immunology to the North-Caucasus populations of the pathogens of leaf, yellow, stem (black) rusts, yellow leaf blotch, septoriosis, obtained on artificially infected plots of ARRIGP. During the years of 2007-2015 we studied the types of winter wheat resistance to the pathogens of epiphytotic dangerous diseases, i.e. 29 – to leaf septoriosis, 57 – to stem (black) rust, 59 – to leaf rust and yellow leaf blotch and 64 – to yellow rust. Using the method of phyto pathologic testing we found out, that 43 varieties developed in ARRIGC named after I.G. Kalinenko possessed 21 Lr genes (1, 2c, 3, 3ka, 3bg, 10, 11, 14a, 14в, 16, 17, 21, 23, 28, 30, 32, 33, 34, 40, B, Exch) during sprouting and 8 Yr genes and their combinations (2+6, 7, 7+22+23, 8+19, 9, 10, 21, 39+Alp). It has been established that the genes of resistance are inefficient in protection from original populations of the pathogens of leaf and yellow rust because of the high content of fungus isolates with complementary genes of virulence. But during the study of the varieties, selected as the sources of resistance we identified the efficient gene Lr17 in ‘Aksiniya’, ‘Izuminka’,‘Kapitan’ and the efficient gene Yr8+19 in ‘Lilit’. The characteristics of the varieties and breeding lines of winter wheat according to their types and genes of resistance have been given in the paper. It allows using them in the breeding practice and in agricultural production more efficient

The renin-angiotensin system: a possible new target for depression

Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin-angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin-angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment