Strategic delegation in a sequential model with multiple stages

We analyze strategic delegation in a Stackelberg model with an arbitrary number, n, of firms. We show that the n-1 last movers delegate their production decisions to managers whereas the first mover does not. Equilibrium incentive rates are increasing in the order with which managers select quantities. Letting u_i^* denote the equilibrium payoff of the firm whose manager moves in the i-th place, we show that u_n^*>u_{n-1}^*>...>u_2^*>u_1^*. We also compare the delegation outcome of our game with that of a Cournot oligopoly and show that the late (early) moving firms choose higher (lower) incentive rates than the Cournot firms.Comment: To appear in International Game Theory Review (IGTR), Vol. 13, No. 3 (2011) 1-1

Development of n-DoF Preloaded structures for impact mitigation in cobots

A core issue in collaborative robotics is that of impact mitigation, especially when collisions happen with operators. Passively compliant structures can be used as the frame of the cobot, although, usually, they are implemented by means of a single-degree-offreedom (DoF). However, n-DoF preloaded structures offer a number of advantages in terms of flexibility in designing their behavior. In this work, we propose a comprehensive framework for classifying n-DoF preloaded structures, including one-, two-, and threedimensional arrays. Furthermore, we investigate the implications of the peculiar behavior of these structures-which present sharp stiff-to-compliant transitions at designdetermined load thresholds-on impact mitigation. To this regard, an analytical n-DoF dynamic model was developed and numerically implemented. A prototype of a 10DoF structure was tested under static and impact loads, showing a very good agreement with the model. Future developments will see the application of n-DoF preloaded structures to impact-mitigation on cobots and in the field of mobile robots, as well as to the field of novel architected materials

A Kohonen SOM architecture for intrusion detection on in-vehicle communication networks

The diffusion of connected devices in modern vehicles involves a lack in security of the in-vehicle communication networks such as the controller area network (CAN) bus. The CAN bus protocol does not provide security systems to counter cyber and physical attacks. Thus, an intrusion-detection system to identify attacks and anomalies on the CAN bus is desirable. In the present work, we propose a distance-based intrusion-detection network aimed at identifying attack messages injected on a CAN bus using a Kohonen self-organizing map (SOM) network. It is a power classifier that can be trained both as supervised and unsupervised learning. SOM found broad application in security issues, but was never performed on in-vehicle communication networks. We performed two approaches, first using a supervised X-Y fused Kohonen network (XYF) and then combining the XYF network with a K-means clustering algorithm (XYF-K) in order to improve the efficiency of the network. The models were tested on an open source dataset concerning data messages sent on a CAN bus 2.0B and containing large traffic volume with a low number of features and more than 2000 different attack types, sent totally at random. Despite the complex structure of the CAN bus dataset, the proposed architectures showed a high performance in the accuracy of the detection of attack messages

Intrusion detection for in-vehicle communication networks: An unsupervised kohonen SOM approach

The diffusion of embedded and portable communication devices on modern vehicles entails new security risks since in-vehicle communication protocols are still insecure and vulnerable to attacks. Increasing interest is being given to the implementation of automotive cybersecurity systems. In this work we propose an efficient and high-performing intrusion detection system based on an unsupervised Kohonen Self-Organizing Map (SOM) network, to identify attack messages sent on a Controller Area Network (CAN) bus. The SOM network found a wide range of applications in intrusion detection because of its features of high detection rate, short training time, and high versatility. We propose to extend the SOM network to intrusion detection on in-vehicle CAN buses. Many hybrid approaches were proposed to combine the SOM network with other clustering methods, such as the k-means algorithm, in order to improve the accuracy of the model. We introduced a novel distance-based procedure to integrate the SOM network with the K-means algorithm and compared it with the traditional procedure. The models were tested on a car hacking dataset concerning traffic data messages sent on a CAN bus, characterized by a large volume of traffic with a low number of features and highly imbalanced data distribution. The experimentation showed that the proposed method greatly improved detection accuracy over the traditional approach

Cognitive processess and cognitive reserve in multiple sclerosis

Multiple Sclerosis (MS) is characterized by motor, cognitive, and neuropsychiatric symptoms, which can occur independently. While MS is traditionally considered an inflammatory disease of the white matter, degeneration of gray matter is increasingly recognized as an important contributor to the progressive cognitive decline. A protective factor against the progression of cognitive dysfunction in MS could be the cognitive reserve, defined as resistance to brain dysfunction. Aim of the present study is to evaluate the role of cognitive reserve for different aspects of cognitive dysfunction of patients with MS. We found that patients with MS and lower cognitive reserve have poorer neuropsychological performance and slower information speed processing. These findings support the notion that intellectual reserve may protect some aspects of cognitive function in patients with MS

The role of invasive alien species in the emergence and spread of zoonoses

The role of invasive alien species in the transmission dynamics of zoonotic pathogens is often overlooked, despite the rapid escalation in biological invasions globally. Here we synthesise available information on the influence of invasive alien species on zoonotic pathogen dynamics in invaded ranges, focussing on Europe, and identify key associated knowledge gaps. We identified 272 documented interactions between alien species and zoonotic pathogens within invaded ranges. The majority of these involved invasive alien mammals followed by birds with only a few occurrences of other taxa documented. A wide range of potential interactions between invasive alien species and zoonotic pathogens were identified but few studies considered transmission to humans and so there was limited evidence of actual impacts on human health. However, there is an urgent need to raise awareness of the potential risks posed to human health by the transmission of zoonotic diseases by invasive alien species; the role of invasive alien species in zoonotic disease transmission may exceed that of native wildlife and occur in a relatively short period following the arrival of an invasive alien species within a new region. Ecological and social mechanisms govern the dynamics of zoonotic disease transmission but wildlife diseases are not consistently included within animal, plant and human policies. Rapid advances in the development of systems frameworks that integrate the ecological, economic and social processes promoting spillover in rapidly changing environments will increase understanding to inform decision-making

Generation of the Rubinstein-Taybi syndrome type 2 patient-derived induced pluripotent stem cell line (IAIi001-A) carrying the EP300 exon 23 stop mutation c.3829A > T, p.(Lys1277*)

Rubinstein-Taybi syndrome (RSTS) is a neurodevelopmental disorder characterized by growth retardation, skeletal anomalies and intellectual disability, caused by heterozygous mutation in either the CREBBP (RSTS1) or EP300 (RSTS2) genes. We generated an induced pluripotent stem cell line from an RSTS2 patient's blood mononuclear cells by Sendai virus non integrative reprogramming method. The iPSC line (IAIi001RSTS2-65-A) displayed iPSC morphology, expressed pluripotency markers, possessed trilineage differentiation potential and was stable by karyotyping. Mutation and western blot analyses demonstrated in IAIi001RSTS2-65-A the patient's specific non sense mutation in exon 23 c.3829A > T, p.(Lys 1277*) and showed reduced quantity of wild type p300 protein