10 research outputs found
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe
Characterization and 3D reservoir modelling of fluvial sandstones of the Williams Fork Formation, Rulison Field, Piceance Basin, Colorado, USA
Influence of meandering river sandstone architecture on waterflooding mechanisms: a case study of the M-I layer in the Kumkol Oilfield, Kazakhstan
Sequence stratigraphic controls on reservoir characterization and architecture: case study of the Messinian Abu Madi incised-valley fill, Egypt
Study of sedimentary characteristic in Denglouku formation, southern Songliao basin, Northeast China
A field experimental investigation of managerially facilitated consumer-to-consumer interaction
Positive social interactions among consumers are considered increasingly important elements in corporate relationship marketing efforts. There is scant empirical research, however, demonstrating the effect of consumer interactions facilitated by service industry managers on consumer evaluations and behavioral intentions. This study employs a field experimental methodology utilizing four half-day cultural heritage tours (n=156) to examine consumer-to-consumer (C-to-C) interactions within the group travel context. Research findings demonstrate that managerially facilitated C-to-C interactions significantly increase tour member satisfaction and enjoyment. Theoretical and managerial implications are discussed, and calls are made for more field experimental methodologies to be used in tourism research