Realization of a classical counterpart of a scalable design for adiabatic quantum computation

We implement a classical counterpart of a scalable design for adiabatic quantum computation. The key element of this design is a coupler providing controllable coupling between two bistable elements (in our case superconducting rings with a single Josephson junction playing the role of a classical counterpart of superconducting flux qubits) The coupler is also a superconducting ring with a single Josephson junction that operates in the non-hysteretic mode. The flux coupling between two bistable rings can be controlled by changing the magnetic flux through the coupler. Thereby, the coupling can be tuned from ferromagnetic trough zero to to anti-ferromagnetic.Comment: 3 pages, 3 figures v2: extended discussion experimental result

Knowledge, Food and Place: a way of producing a way of knowing

The article examines the dynamics of knowledge in the valorisation of local food, drawing on the results from the CORASON project (A cognitive approach to rural sustainable development: the dynamics of expert and lay knowledge), funded by the EU under its Framework Programme 6. It is based on the analysis of several in-depth case studies on food relocalisation carried out in 10 European countries

Groundwater Flow Patterns of the Ames Aquifer

Extensive field studies have indicated that the Ames aquifer (at Ames, Iowa) approximates a confined horizontal aquifer of uniform thickness and height. The aquifer is partly fed through the channel beds of two surface streams, the Skunk River and Squaw Creek. Part of the boundary of the Ames Aquifer is formed by a till layer that can be considered impervious. Pumping tests have indicated that the Skunk River and Squaw Creek maintain nearly a constant head distribution along the boundaries of the aquifer while the aquifer is pumped. A theoretical solution is presented that yields the well discharge, the hydraulic head at every point in the flow region, and the stream function when the aquifer is pumped by one completely penetrating well

An evaluation of the SWATRER and, CERES-Millet models for southwest Niger

The SWATKER (Dierckx el aL, 1986) soil water and CERES-Millet (Godwin el ol.. 1984; Jones el al. 1984) growth models wcre evaluated for millet (PennisNwn arnuicmun) during the 1989 growing season at Tara, Niger (300 km, south of Niamey). The required minimum data sets for the plant and soil components of each modcl were either f~ld determined or obtained from the literature. A field experiment was carried out in order to validate the soil water balance and plant growth subroutine6 Soil water content. leaf area and dry matter (DM) were measured weekly. Good agreement between simulated and measured soil water content was obtained with SWATRER. The CERES-Millet modcl overestimated leaf area index (LAI). DM and yield by 46%, 40% and 101% respectively. The CERES-Millet modcl consistently overestimated soil water content by 5% throughout the growing season. The SWATRER model showed good promise for evaluating waterilertilizcr management strategies. Once the CERES-Millet modcl is calibrated. it can be utilized to evaluate new production zonq new cultivara and numerous cultural practices

Elevated urinary excretion of free pyridinoline in Friesian horses suggests a breed-specific increase in collagen degradation

Background: Friesian horses are known for their high inbreeding rate resulting in several genetic diseases such as hydrocephaly and dwarfism. This last decade, several studies focused on two other presumed hereditary traits in Friesian horses: megaoesophagus and aortic rupture. The pathogenesis of these diseases remains obscure but an important role of collagen has been hypothesized. The purpose of this study was to examine possible breed-related differences in collagen catabolism. Urinary specimens from Friesian (n = 17, median age 10 years old) and Warmblood horses (n = 17, median age 10 years old) were assessed for mature collagen cross-links, i.e. pyridinoline (PYD) (=hydroxylysylpyridinoline/HP) and deoxypyridinoline (DPD) (lysylpyridinoline /LP). Solid-phase extraction was performed, followed by reversed-phase ion-paired liquid chromatography prior to tandem mass spectrometry (MS/MS) detection. Results: Mean urinary concentrations of free PYD, expressed as fPYD/creatinine ratio, were significantly higher in Friesian horses compared to Warmblood horses (28.5 ± 5.2 versus 22.2 ± 9.6 nmol/mmol, p = 0.02) while mean fDPD/creatinine ratios were similar in both horse breeds (3.0 ± 0.7 versus 4.6 ± 3.7 nmol/mmol, p = 0.09). Conclusions: Since DPD is considered a specific bone degradation marker and PYD is more widely distributed in connective tissues, the significant elevation in the mean PYD/DPD ratio in Friesian versus Warmblood horses (9.6 ± 1.6 versus 5.7 ± 1.8, p < 0.0001) suggests a soft tissue origin for the increased fPYD levels. Considering that a previous study found no differences in total collagen content between Friesian and Warmblood horses for tendon and aortic tissue, this indicates a higher rate of collagen degradation. The latter might, at least in part, explain the predisposition of Friesians to connective tissue disorders

A pilot evaluation of the Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) program

Background: Despite increased annual mortality in long-term care (LTC) homes, research has shown that care of dying residents and their families is currently suboptimal in these settings. The purpose of this study was to evaluate resident and family outcomes associated with the Strengthening a Palliative Approach in LTC (SPA-LTC) program, developed to help encourage meaningful end of life discussions and planning. Methods: The study employs a mixed method design in four LTC homes across Southern Ontario. Data were collected from residents and families of the LTC homes through chart reviews, interviews, and focus groups. Interviews with family who attended a Palliative Care Conference included both closed-ended and open-ended questions. Results: In total, 39 residents/families agreed to participate in the study. Positive intervention outcomes included a reduction in the proportion of emergency department use at end of life and hospital deaths for those participating in SPA-LTC, improved support for families, and increased family involvement in the care of residents. For families who attended a Palliative Care Conference, both quantitative and qualitative findings revealed that families benefited from attending them. Residents stated that they appreciated learning about a palliative approach to care and being informed about their current status. Conclusions: The benefits of SPA-LTC for residents and families justify its continued use within LTC. Study results also suggest that certain enhancements of the program could further promote future integration of best practices within a palliative approach to care within the LTC context. However, the generalizability of these results across LTC homes in different regions and countries is limited given the small sample size

Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls

The stable incidence of new leprosy cases suggests that transmission of infection continues despite worldwide implementation of MDT. Thus, specific tools are needed to diagnose early stage Mycobacterium leprae infection, the likely sources of transmission. M. leprae antigens that induce T-cell responses in M. leprae exposed and/or infected individuals thus are major targets for new diagnostic tools. Previously, we showed that ML1601c was immunogenic in patients and healthy household contacts (HHC). However, some endemic controls (EC) also recognized this protein. To improve the diagnostic potential, IFN-γ responses to ML1601c peptides were assessed using PBMC from Brazilian leprosy patients and EC. Five ML1601c peptides only induced IFN-γ in patients and HHC. Moreover, 24-hour whole-blood assay (WBA), two ML1601c peptides could assess the level of M. leprae exposure in Ethiopian EC. Beside IFN-γ, also IP-10, IL-6, IL-1β, TNF-α, and MCP-1 were increased in EC from areas with high leprosy prevalence in response to these ML1601c peptides. Thus, ML1601c peptides may be useful for differentiating M. leprae exposed or infected individuals and can also be used to indicate the magnitude of M. leprae transmission even in the context of various HLA alleles as present in these different genetic backgrounds