53 research outputs found

    Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma

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    Craniopharyngiomas are locally aggressive tumors which typically are focused in the sellar and suprasellar region near a number of critical neural and vascular structures mediating endocrinologic, behavioral, and visual functions. The present study aims to summarize and compare the published literature regarding morbidity resulting from treatment of craniopharyngioma. We performed a comprehensive search of the published English language literature to identify studies publishing outcome data of patients undergoing surgery for craniopharyngioma. Comparisons of the rates of endocrine, vascular, neurological, and visual complications were performed using Pearson’s chi-squared test, and covariates of interest were fitted into a multivariate logistic regression model. In our data set, 540 patients underwent surgical resection of their tumor. 138 patients received biopsy alone followed by some form of radiotherapy. Mean overall follow-up for all patients in these studies was 54 ± 1.8 months. The overall rate of new endocrinopathy for all patients undergoing surgical resection of their mass was 37% (95% CI = 33–41). Patients receiving GTR had over 2.5 times the rate of developing at least one endocrinopathy compared to patients receiving STR alone or STR + XRT (52 vs. 19 vs. 20%, χ2P < 0.00001). On multivariate analysis, GTR conferred a significant increase in the risk of endocrinopathy compared to STR + XRT (OR = 3.45, 95% CI = 2.05–5.81, P < 0.00001), after controlling for study size and the presence of significant hypothalamic involvement. There was a statistical trend towards worse visual outcomes in patients receiving XRT after STR compared to GTR or STR alone (GTR = 3.5% vs. STR 2.1% vs. STR + XRT 6.4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available

    Stacked-Wires FETs for advanced CMOS scaling

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    International audienceWe present recent progress on vertically stacked-wires MOSFETs with a replacement metal gate process for CMOS scaling beyond FinFET technology. Key technological challenges (such as 3D integration process including inner spacer, mobility, and strain engineering) will be discussed in relation to recent research results

    The beam combiners of GRAVITY VLTI instrument: concept, development, and performance in laboratory

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    Gravity is one of the second-generation instruments of the Very Large Telescope Interferometer that operates in the near infrared range and that is designed for precision narrow-angle astrometry and interferometric imaging. With its infrared wavefront sensors, pupil stabilization, fringe tracker, and metrology, the instrument is tailored to provide a high sensitivity, imaging with 4-millisecond resolution, and astrometry with a 10”arcsec precision. It will probe physics close to the event horizon of the Galactic Centre black hole, and allow to study mass accretion and jets in young stellar objects and active galactic nuclei, planet formation in circumstellar discs, or detect and measure the masses of black holes in massive star clusters throughout the Milky Way. As the instrument required an outstanding level of precision and stability, integrated optics has been chosen to collect and combine the four VLTI beams in the K band. A dedicated integrated optics chip glued to a fiber array has been developed. Technology breakthroughs have been mandatory to fulfill all the specifications. This paper is focused on the interferometric beam combination system of Gravity. Once the combiner concept described, the paper details the developments that have been led, the integration and the performance of the assemblies
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