High precision determination of the Q2Q^2-evolution of the Bjorken Sum

We present a significantly improved determination of the Bjorken Sum for 0.6$\leq Q^{2}\leq$4.8 GeV$^{2}$ using precise new $g_{1}^{p}$ and $g_{1}^{d}$ data taken with the CLAS detector at Jefferson Lab. A higher-twist analysis of the $Q^{2}$-dependence of the Bjorken Sum yields the twist-4 coefficient $f_{2}^{p-n}=-0.064 \pm0.009\pm_{0.036}^{0.032}$. This leads to the color polarizabilities $\chi_{E}^{p-n}=-0.032\pm0.024$ and $\chi_{B}^{p-n}=0.032\pm0.013$. The strong force coupling is determined to be \alpha_{s}^{\overline{\mbox{ MS}}}(M_{Z}^{2})=0.1124\pm0.0061, which has an uncertainty a factor of 1.5 smaller than earlier estimates using polarized DIS data. This improvement makes the comparison between $\alpha_{s}$ extracted from polarized DIS and other techniques a valuable test of QCD.Comment: Published in Phys. Rev. D. V1: 8 pages, 3 figures. V2: Updated references; Included threshold matching in \alpha_s evolution. Corrected a typo on the uncertainty for \Lambda_QCD. V3: Published versio

CALPHAD formalism for Portland clinker: thermodynamic models and databases

International audienceThe so-called CALPHAD method is widely used in metallurgy to predict phase diagrams of multi-component systems. The application of the method to oxide systems is much more recent, because of the difficulty of modelling the ionic liquid phase. Since the 1980s, several models have been proposed by various communities. Thermodynamic databases for oxides are available and still under development. The purpose of this article is to discuss the distinct approaches of the method for the calculation of multi-component systems for Portland cement elaboration. The article gives a state of the art of the most recent experimental data and the various calculations for the CaO-Al2O3-SiO2 phase diagram. A literature review of the three binary sub-systems leads to main conclusions: (i) discrepancies are found in the literature for the selected experimental data, (ii) the phase diagram data in the reference books are not complete and up to date and (iii) the two-sublattices model and the modified quasichemical model can be equally used for the modelling of the aluminates liquid. The predictive feature of the CALPHAD method is illustrated using the CaO-Al2O3-SiO2 system with the two-sublattices model: extrapolated (predicted) and fully-assessed phase diagrams are compared in the clinkering zone of interest. The recent application of the predictive method for the calculations of high-order systems (taking into account Fe2O3, SO3, CaF2, P2O5) shows that the databases developed with the two-sublattices model and the modified quasichemical model are no longer equivalent

Visualising the past – an evaluation of processes and sequences for fingermark recovery from old documents

This study aimed to collect data on the effectiveness of most of the fingermark visualisation reagents currently used on porous surfaces on fingermarks aged for up to 90 years, significantly extending the timescales for which such information exists. A limited subset of the variables associated with processing of old fingermarks was explored, with a focus on the use of 1,8 diazafluoren-9-one (DFO), 1,2-indandione, ninhydrin, and physical developer. These techniques were used in sequence on batches of cheques between 11 and 32 years old, and on documents dating from the 1920s and 1940s. The potential for applying a physical developer enhancement process (blue toning) as the final step in the sequence was also explored. The benefits of using processing sequences on porous items were clearly demonstrated, with all processes in the sequence adding value in terms of additional marks found on the cheques up to 32 years old. In addition, physical developer was found to be capable of developing fingermarks up to 90 years old, whereas the amino acid reagents appear less effective on documents of 70 years and older. An experimental physical developer formulation with reduced environmental impact was found to be as effective as the existing process in these experiments. Blue toning was found to visualise an additional 10-25% of marks, and its wider use after silver-based deposition processes is recommended based on the evidence from this study.Peer reviewedFinal Accepted Versio

Transient vitamin B5 starving improves mammalian cell homeostasis and protein production.

Maintaining a metabolic steady state is essential for an organism's fitness and survival when confronted with environmental stress, and metabolic imbalance can be reversed by exposing the organism to fasting. Here, we attempted to apply this physiological principle to mammalian cell cultures to improve cellular fitness and consequently their ability to express recombinant proteins. We showed that transient vitamin B5 deprivation, an essential cofactor of central cellular metabolism, can quickly and irreversibly affect mammalian cell growth and division. A selection method was designed that relies on mammalian cell dependence on vitamin B5 for energy production, using the co-expression of the B5 transporter SLC5A6 and a gene of interest. We demonstrated that vitamin B5 selection persistently activates peroxisome proliferator-activated receptors (PPAR), a family of transcription factors involved in energy homeostasis, thereby altering lipid metabolism, improving cell fitness and therapeutic protein production. Thus, stable PPAR activation may constitute a cellular memory of past deprivation state, providing increased resistance to further potential fasting events. In other words, our results imply that cultured cells, once exposed to metabolic starvation, may display an improved metabolic fitness as compared to non-exposed cells, allowing increased resistance to cellular stress

Colloquium: Gravitational Form Factors of the Proton

The physics of the gravitational form factors of the proton, and their understanding within quantum chromodynamics, has advanced significantly in the past two decades through both theory and experiment. This Colloquium provides an overview of this progress, highlights the physical insights unveiled by studies of gravitational form factors, and reviews their interpretation in terms of the mechanical properties of the proton.Comment: 22 pages, 15 figure

Case Report: Coronary-Pulmonary Fistula Closure by Percutaneous Approach: Learning From Mistakes.

Coronary-pulmonary artery fistulas (CPAF) are congenital vascular anomalies detected incidentally in most cases. When a significant left-right shunt exists, surgical, or percutaneous treatment is indicated. We describe a challenging case of CPAF closure, by percutaneous approach, in a patient symptomatic for dyspnea and evidence of a significant left-right shunt. A first attempt to close the fistula was performed implanting a vascular plug but it quickly embolized. The plug was successfully retrieved. In a second attempt, we deployed several coils before implanting the vascular plug with total closure of the fistula. The combination of plugs and coils is associated with a higher success rate of closure

Design of beam optics and radiation protection concept for NA60+ heavy-ion experiment at CERN

NA60+ is a fixed target experiment proposed in the framework of the Physics Beyond Colliders programme at CERN. It aims to precisely measure the hard and electromagnetic probes in nuclear collisions. Initially proposed for the underground cavern ECN3 with very high beam intensities, the experiment now foresees a location in the EHN1 surface hall which was shown to have a limited impact on the physics performance in spite of a significant reduction of beam intensity and detector size. The potential installation and operation of the experiment with the ion beams from the Super Proton Synchrotron (SPS) has been examined regarding detector integration, beam physics, radiation protection and shielding requirements. The integration of the experiment is considered feasible, but would require a significant reconfiguration of the existing hall infrastructure with regards to shielding and layout

Predicting dengue fever outbreaks in French Guiana using climate indicators

Background Dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. Associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. In French Guiana, climate-based models are not available to assist in developing an early warning system. This study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue fever outbreaks in French Guiana. Methodology/Principal Findings Lagged correlations and composite analyses were performed to identify the climatic conditions that characterized a typical epidemic year and to define the best indices for predicting dengue fever outbreaks during the period 1991-2013. A logistic regression was then performed to build a forecast model. We demonstrate that a model based on summer Equatorial Pacific Ocean sea surface temperatures and Azores High sea-level pressure had predictive value and was able to predict 80% of the outbreaks while incorrectly predicting only 15% of the non-epidemic years. Predictions for 2014-2015 were consistent with the observed non-epidemic conditions, and an outbreak in early 2016 was predicted. Conclusions/Significance These findings indicate that outbreak resurgence can be modeled using a simple combination of climate indicators. This might be useful for anticipating public health actions to mitigate the effects of major outbreaks, particularly in areas where resources are limited and medical infrastructures are generally insufficient

Magnetic Moment of the Fragmentation Aligned 61Fe(9/2)+ Isomer

We report on the g factor measurement of the isomer in $^{61}Fe$ ($E^{*}=861 keV$). The isomer was produced and spin-aligned via a projectile-fragmentation reaction at intermediate energy, the Time Dependent Perturbed Angular Distribution (TDPAD) method being used for the measurement of the g factor. For the first time, due to significant improvements of the experimental technique, an appreciable residual alignment of the isomer has been observed, allowing a precise determination of its g factor: $g=-0.229(2)$. Comparison of the experimental g factor with shell-model and mean field calculations confirms the $9/2^+$ spin and parity assignments and suggests the onset of deformation due to the intrusion of Nilsson orbitals emerging from the $\nu g_{9/2}$.Comment: 4 figures. Submitted to Phys. Rev. Let