Increasing Therapy Related Myeloid Neoplasms in Multiple Myeloma

© 2018 Stichting European Society for Clinical Investigation Journal Foundation. This document is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc /4.0/ This document is the submitted version of a published work that appeared in final form in European Journal of Clinical Investigation.Background: Despite the longer survival achieved in multiple myeloma (MM) patients due to new therapy strategies, a concern is emerging regarding an increased risk of secondary primary malignancies (SPMs) and how to characterize those patients at risk. We performed a retrospective study covering a 28‐year follow‐ up period (1991‐2018) in a tertiary single institution. Material and Methods: Data of 403 MM patients were recorded and compared with the epidemiologic register of the population area covered by our centre, calculating the standardize incidence ratio (SIR) for the different types of SPMs diagnosed in the MM cohort. Fine and Gray regression models were used to identify risk factors for SPMs. Results: Out of the 403 MM patients, 23 (5.7%) developed SPMs: 13 therapyrelated myeloid (TRM) malignancies (10 of them (77%) myelodysplastic syndrome (MDS), 1 acute lymphoid leukaemia and 9 solid neoplasms. In the MM cohort, the relative risk of MDS was significantly higher than in the general population. Survival of patients with TRM malignancies was poor with a median of 4 months from the diagnosis, and most of them showed complex karyotype. Within the MM subset, multivariable analysis showed a higher risk of TRM malignancies in patients that previously received prolonged treatment with lenalidomide (>18 months). Conclusions: Though the improvement in MM outcome during the last decades is an unprecedented achievement, it has been accompanied by the rise in TRM malignancies with complex cytogenetic profile and poor prognosis that are in the need of an improved biologic and therapeutic approach

The alhambra survey: evolution of galaxy spectral segregation

We study the clustering of galaxies as a function of spectral type and redshift in the range 0.35 <z <1.1 using data from the Advanced Large Homogeneous Area Medium Band Redshift Astronomical (ALHAMBRA) survey. The data cover 2.381 deg2 in 7 fields, after applying a detailed angular selection mask, with accurate photometric redshifts down to IAB <24. From this catalog we draw five fixed number density redshift-limited bins. We estimate the clustering evolution for two different spectral populations selected using the ALHAMBRA-based photometric templates: quiescent and star-forming galaxies. For each sample we measure the real-space clustering using the projected correlation function. Our calculations are performed over the range [0.03, 10.0] h-1 Mpc, allowing us to find a steeper trend for Mpc, which is especially clear for star-forming galaxies. Our analysis also shows a clear early differentiation in the clustering properties of both populations: star-forming galaxies show weaker clustering with evolution in the correlation length over the analyzed redshift range, while quiescent galaxies show stronger clustering already at high redshifts and no appreciable evolution. We also perform the bias calculation where similar segregation is found, but now it is among the quiescent galaxies where a growing evolution with redshift is clearer (abrigatted). These findings clearly corroborate the well-known color-density relation, confirming that quiescent galaxies are mainly located in dark matter halos that are more massive than those typically populated by star-forming galaxies.Ministerio de Economía y Competitividad y FEDER AYA2010-22111-C03-02 AYA2013-48623-C2-2 AYA2012-39620 AYA2013-40611-P AYA2013-42227-P AYA2013-43188-P AYA2013-48623-C2-1 ESP2013-48274 AYA2014-58861-C3-1Junta de Andalucía TIC114 JA2828 P10-FQM-644

The ALHAMBRA survey: evolution of galaxy spectral segregation

We study the clustering of galaxies as a function of spectral type and redshift in the range $0.35 < z < 1.1$ using data from the Advanced Large Homogeneous Area Medium Band Redshift Astronomical (ALHAMBRA) survey. The data cover 2.381 deg$^2$ in 7 fields, after applying a detailed angular selection mask, with accurate photometric redshifts [$\sigma_z < 0.014(1+z)$] down to $I_{AB} < 24$. From this catalog we draw five fixed number density, redshift-limited bins. We estimate the clustering evolution for two different spectral populations selected using the ALHAMBRA-based photometric templates: quiescent and star-forming galaxies. For each sample, we measure the real-space clustering using the projected correlation function. Our calculations are performed over the range $[0.03,10.0] h^{-1}$ Mpc, allowing us to find a steeper trend for $r_p \lesssim 0.2 h^{-1}$ Mpc, which is especially clear for star-forming galaxies. Our analysis also shows a clear early differentiation in the clustering properties of both populations: star-forming galaxies show weaker clustering with evolution in the correlation length over the analysed redshift range, while quiescent galaxies show stronger clustering already at high redshifts, and no appreciable evolution. We also perform the bias calculation where similar segregation is found, but now it is among the quiescent galaxies where a growing evolution with redshift is clearer. These findings clearly corroborate the well known colour-density relation, confirming that quiescent galaxies are mainly located in dark matter halos that are more massive than those typically populated by star-forming galaxies.Comment: 14 pages, 9 figures, accepted by Ap

The ALHAMBRA survey : Estimation of the clustering signal encoded in the cosmic variance

The relative cosmic variance ($\sigma_v$) is a fundamental source of uncertainty in pencil-beam surveys and, as a particular case of count-in-cell statistics, can be used to estimate the bias between galaxies and their underlying dark-matter distribution. Our goal is to test the significance of the clustering information encoded in the $\sigma_v$ measured in the ALHAMBRA survey. We measure the cosmic variance of several galaxy populations selected with $B-$band luminosity at $0.35 \leq z < 1.05$ as the intrinsic dispersion in the number density distribution derived from the 48 ALHAMBRA subfields. We compare the observational $\sigma_v$ with the cosmic variance of the dark matter expected from the theory, $\sigma_{v,{\rm dm}}$. This provides an estimation of the galaxy bias $b$. The galaxy bias from the cosmic variance is in excellent agreement with the bias estimated by two-point correlation function analysis in ALHAMBRA. This holds for different redshift bins, for red and blue subsamples, and for several $B-$band luminosity selections. We find that $b$ increases with the $B-$band luminosity and the redshift, as expected from previous work. Moreover, red galaxies have a larger bias than blue galaxies, with a relative bias of $b_{\rm rel} = 1.4 \pm 0.2$. Our results demonstrate that the cosmic variance measured in ALHAMBRA is due to the clustering of galaxies and can be used to characterise the $\sigma_v$ affecting pencil-beam surveys. In addition, it can also be used to estimate the galaxy bias $b$ from a method independent of correlation functions.Comment: Astronomy and Astrophysics, in press. 9 pages, 4 figures, 3 table

The ALHAMBRA survey : B−B-band luminosity function of quiescent and star-forming galaxies at 0.2≤z<10.2 \leq z < 1 by PDF analysis

Our goal is to study the evolution of the $B-$band luminosity function (LF) since $z=1$ using ALHAMBRA data. We used the photometric redshift and the $I-$band selection magnitude probability distribution functions (PDFs) of those ALHAMBRA galaxies with $I\leq24$ mag to compute the posterior LF. We statistically studied quiescent and star-forming galaxies using the template information encoded in the PDFs. The LF covariance matrix in redshift-magnitude-galaxy type space was computed, including the cosmic variance. That was estimated from the intrinsic dispersion of the LF measurements in the 48 ALHAMBRA sub-fields. The uncertainty due to the photometric redshift prior is also included in our analysis. We modelled the LF with a redshift-dependent Schechter function affected by the same selection effects than the data. The measured ALHAMBRA LF at $0.2\leq z<1$ and the evolving Schechter parameters both for quiescent and star-forming galaxies agree with previous results in the literature. The estimated redshift evolution of $M_B^* \propto Qz$ is $Q_{\rm SF}=-1.03\pm0.08$ and $Q_{\rm Q}=-0.80\pm0.08$, and of $\log \phi^* \propto Pz$ is $P_{\rm SF}=-0.01\pm0.03$ and $P_{\rm Q}=-0.41\pm0.05$. The measured faint-end slopes are $\alpha_{\rm SF}=-1.29\pm0.02$ and $\alpha_{\rm Q}=-0.53\pm0.04$. We find a significant population of faint quiescent galaxies, modelled by a second Schechter function with slope $\beta=-1.31\pm0.11$. We find a factor $2.55\pm0.14$ decrease in the luminosity density $j_B$ of star-forming galaxies, and a factor $1.25\pm0.16$ increase in the $j_B$ of quiescent ones since $z=1$, confirming the continuous build-up of the quiescent population with cosmic time. The contribution of the faint quiescent population to $j_B$ increases from 3% at $z=1$ to 6% at $z=0$. The developed methodology will be applied to future multi-filter surveys such as J-PAS.Comment: Accepted for publication in Astronomy and Astrophysics. 25 pages, 20 figures, 7 table

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum