Production of Dispersion Alloys with the Aid of Ultrasonics Final Report

Dispersion of inerts in molten matrix by ultrasonic energy, and ultrasonic treatment of alloys to produce dispersion strengthenin

Gold Nanoparticles Decorated with Sialic Acid Terminated Bi-antennary N-Glycans for the Detection of Influenza Virus at Nanomolar Concentrations

Gold nanoparticles decorated with full-length sialic acid terminated complex bi-antennary N-glycans, synthesized with glycans isolated from egg yolk, were used as a sensor for the detection of both recombinant hemagglutinin (HA) and whole influenza A virus particles of the H1N1 subtype. Nanoparticle aggregation was induced by interaction between the sialic acid termini of the glycans attached to gold and the multivalent sialic acid binding sites of HA. Both dynamic light scattering (DLS) and UV/Vis spectroscopy demonstrated the efficiency of the sensor, which could detect viral HA at nanomolar concentrations and revealed a linear relationship between the extent of nanoparticle aggregation and the concentration of HA. UV/ Vis studies also showed that these nanoparticles can selectively detect an influenza A virus strain that preferentially binds sialic acid terminated glycans with a(2!6) linkages over a strain that prefers glycans with terminal a(2!3)-linked sialic acids

The prevalence of polypharmacy in elderly attenders to an emergency department - a problem with a need for an effective solution

We studied the prevalence of polypharmacy in attenders aged 75 years and over to an emergency department (ED) in North London over a period of 1 month. We identified 467 patients in this age group. Analysis of medications being prescribed revealed at least 82 patients on medication with the potential for adverse interaction. There is a need for ED-initiated strategies to identify interactions and for pathways to allow for medication review

Empirical Determination of Bang-Bang Operations

Strong and fast "bang-bang" (BB) pulses have been recently proposed as a means for reducing decoherence in a quantum system. So far theoretical analysis of the BB technique relied on model Hamiltonians. Here we introduce a method for empirically determining the set of required BB pulses, that relies on quantum process tomography. In this manner an experimenter may tailor his or her BB pulses to the quantum system at hand, without having to assume a model Hamiltonian.Comment: 14 pages, 2 eps figures, ReVTeX4 two-colum

A ruthenium(II) polypyridyl complex disrupts actin cytoskeleton assembly and blocks cytokinesis

The dinuclear Ru(II) complex [(Ru(phen) 2 ) 2 (tpphz)] 4+ (phen = 1,10-phenanthroline, tpphz = tetrapyridophenazine) “RuRuPhen” blocks the transformation of G-actin to F-actin filaments with no disassembly of pre-formed F-actin. Molecular docking studies indicate multiple RuRuPhen molecules bind to the surface of G-actin but not the binding pockets of established actin polymerisation inhibitors. In cells, addition of RuRuPhen causes rapid disruption to actin stress fibre organisation, compromising actomyosin contractility and cell motility, due to this effect RuRuPhen interferes with late-stage cytokinesis. Immunofluorescent microscopy reveals that RuRuPhen causes cytokinetic abscission failure by interfering with ESCRT complex recruitmen

BioModels—15 years of sharing computational models in life science

Computational modelling has become increasingly common in life science research. To provide a platform to support universal sharing, easy accessibility and model reproducibility, BioModels (https://www.ebi.ac.uk/biomodels/), a repository for mathematical models, was established in 2005. The current BioModels platform allows submission of models encoded in diverse modelling formats, including SBML, CellML, PharmML, COMBINE archive, MATLAB, Mathematica, R, Python or C++. The models submitted to BioModels are curated to verify the computational representation of the biological process and the reproducibility of the simulation results in the reference publication. The curation also involves encoding models in standard formats and annotation with controlled vocabularies following MIRIAM (minimal information required in the annotation of biochemical models) guidelines. BioModels now accepts large-scale submission of auto-generated computational models. With gradual growth in content over 15 years, BioModels currently hosts about 2000 models from the published literature. With about 800 curated models, BioModels has become the world’s largest repository of curated models and emerged as the third most used data resource after PubMed and Google Scholar among the scientists who use modelling in their research. Thus, BioModels benefits modellers by providing access to reliable and semantically enriched curated models in standard formats that are easy to share, reproduce and reuse

Integrated Late Eocene-Oligocene Stratigraphy of the Alabama Coastal Plain: Correlation of Hiatuses and Stratal Surfaces to Glacioeustatic Lowerings

We integrated strontium and oxygen isotopic, biostratigraphic, and magnetostratigraphic studies of two upper Eocene-Oligocene boreholes drilled near Bay Minette and St. Stephens Quarry (SSQ), Alabama. Continuous coring provided fresh, unweathered material for magnetostratigraphic studies, minimizing problems reported from nearby outcrops. Difficulties with each technique were encountered because of diagenesis, absence of marker fossils, and the presence of unconformities; however, by integrating results from isotopic stratigraphy, biostratigraphy, and magnetostratigraphy, we correlated these relatively shallow-water deposits to the geomagnetic polarity time scale (GPTS). At the SSQ borehole, the upper Eocene to lower Oligocene section is apparently complete within our stratigraphic resolution (0.2-0.5 m.y.), allowing us to estimate the ages of several stratal surfaces. Late Eocene Sr isotope age estimates are as expected at the SSQ borehole, but Oligocene ages are ~1 m.y. older than expected due to diagenesis. At the Bay Minette borehole, a latest Eocene-earliest Oligocene and a late early Oligocene hiatus were detected. We correlate these two hiatuses and stratal surfaces at SSQ with global δ^18O increases inferred to represent glacioeustatic lowerings and with evidence for hiatuses on other continental margins: (1) a distinct disconformity at the base of the Chickasawhay Limestone at both boreholes and a hiatus at Bay Minette correlates with a global δ^18O increase; we revise the age of this surface (equivalent to the TB 1.1 sequence boundary) making it ~2 m.y. older than previously reported; and (2) a surface at the top of the Shubuta Member (lowermost Oligocene) has been interpreted both as a condensed section and a disconformity; this surface at SSQ and a hiatus at Bay Minette correlate with a sharp global δ^18O increase and with hiatuses on the New Jersey and Irish margins. The timing of the hiatuses and stratal surfaces correlates with the inflection of the δ^18O increases and not with the maximum values, supporting models that indicate that unconformities form during the maximum rates of sea level fall