El valor de la razón y su relación con la fe. John Henry Newman y C. S. Lewis: una mirada.

Through a comparison of texts by Newman and Lewis, the author shows the relationship between the two in their analysis of the relationship between faith and reason. The paper points out the parallelism in the three natural ways of religious knowledge: human intelligence, experience in life, and the witness of Tradition. It shows how both Newman and Lewis attempted to understand their own “intelligence of faith” in relation to their understanding of reality in such a way that faith would have a real impact on life.Sobre la base de la comparación de textos de Newman y Lewis, la autora muestra la coincidencia de planteamiento entre ambos en la consideración de la relación entre la fe y la razón. El ensayo señala el paralelismo en las tres vías naturales de conocimiento religioso del hombre: la inteligencia humana, la experiencia de la vida y el testimonio de la tradición. Sobre esas tres vías se analiza cómo tanto Newman como Lewis se esforzaron por comprender su propia inteligencia de la fe en relación con su inteligencia de la realidad de modo que tuviera incidencia real en la vida

Three-dimensional dielectric crystalline waveguide beam splitters in mid-infrared band by direct femtosecond laser writing

We report on the fabrication of three-dimensional waveguide beam splitters in a dielectric Bi4Ge3O12 (BGO) crystal by direct femtosecond laser writing. In the laser written tracks of BGO crystal, positive refractive index is induced, resulting in so-called Type I configuration waveguiding cores. The “multiscan” technique is utilized to shape cores with designed cross-sectional geometry in order to achieve guidance at mid-infrared wavelength of 4 μm. The fundamental mode guidance along both TE and TM polarizations has been obtained in the waveguide structures. With this feature, we implement beam splitters from 2D to 3D geometries, and realize 1 × 2, 1 × 3, and 1 × 4 power splitting at 4μm.This work was supported by the National Natural Science Foundation of China (No. 11274203), Junta de Castilla y León under project (SA086A12-2), and Ministerio de Economía y Competitividad under project (FIS2013-44174-P), Spain

Self-Regulation in Children with Neurodevelopmental Disorders “SR-MRehab: Un Colegio Emocionante”: A Protocol Study

Self-regulation refers to the ability to control and modulate behavior, and it can include both emotional and cognitive modulation. Children with neurodevelopmental disorders may show difficulties in self-regulation. The main objective of this study is to improve self-regulation skills in children between 6 and 11 years of age with neurodevelopmental disorders. Methodology: A randomized controlled trial will be conducted with the use of “SR-MRehab: Un colegio emocionante”, based on a non-immersive virtual reality system where virtual objects can be managed by children in a natural way using their hands. Children will be recruited from several schools of Granada (Spain) and they will be randomly allocated to two groups. An assessment will be conducted before and after the intervention and 24 weeks after the end of the intervention process. The experimental group will receive the intervention using virtual reality. The control group will receive a standard self-regulation program. Both interventions will be performed once a week for a total of 10 sessions. Changes in self-regulation, as well as the acceptability of technology with the use of SR-MRehab, will be evaluated. The results will be published and will provide evidence regarding the use of this type of intervention in children with neurodevelopmental disorders. Trial registration: Registered with code NCT04418921.Programa Estatal de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I+D+i y del Programa Estatal de I+D+i Orientada a los Retos de la Sociedad, del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2017 PID2019-108915RB-I00Teaching innovation project of the Degree in Occupational Therapy of the University of Granada about Emotional Skills 19-7

Aplicación de técnicas de detección de anomalías a escenarios de ciudades inteligentes

[ES] Una de las grandes preocupaciones en la actualidad de las empresas es la detección y prevención temprana de ataques de ciberseguridad. Para ello, existen los Sistemas de Detección de Intrusiones, herramientas que cuentan con sensores virtuales y que basan su detección en el análisis del tráfico de red. El problema surge cuando se dan ataques que estos sistemas no detectan. Una de las soluciones existentes a esta problemática es acudir a la minería de datos e intentar detectar anomalías en grandes volúmenes de datos, no pertenecientes únicamente al tráfico de red sino datos que puedan provenir de diversas fuentes. En este artículo se propone una solución enmarcada en el proyecto DHARMA haciendo uso de la técnica de agrupamiento, dentro de la disciplina de la minería de datos, en concreto del algoritmo DBSCAN.Este trabajo ha sido financiado en parte con el apoyo del MINECO español (proyecto DHARMA, Dynamic Heterogeneous Threats Risk Management and Assessment, con código TIN2014-59023-C2-2-R) y por la Comisión Europea (FEDER/ERDF).Romero, I.; Alonso, C.; Villagrá, V.; Vázquez, L.; Holgado, P. (2018). Aplicación de técnicas de detección de anomalías a escenarios de ciudades inteligentes. En XIII Jornadas de Ingeniería telemática (JITEL 2017). Libro de actas. Editorial Universitat Politècnica de València. 182-188. https://doi.org/10.4995/JITEL2017.2017.6574OCS18218

Optical ridge waveguides in Yb:YAG laser crystal produced by combination of swift carbon ion irradiation and femtosecond laser ablation

We report on the fabrication of optical ridge waveguides in ytterbium-doped yttrium aluminum garnet (Yb:YAG) single crystal by applying swift C5+ ion irradiation and the followed femtosecond laser ablation. The planar waveguide layer is first produced by C5+ ion irradiation and the laser ablation is used to microstructure the planar waveguide surface to construct ridge structures. The lowest propagation loss of the ridge waveguide has been determined to be ~2.1 dB/cm. From the confocal micro-fluorescence and micro-Raman spectra obtained from the waveguide regions, the intensities, positions and widths of the emission-line peaks had no obvious changes with respect to those from the bulks, which indicate that C5+ ion irradiation does not affect the bulk-related properties of the Yb:YAG crystal significantly in the waveguide regions. The results obtained in this work suggest potential applications of the Yb:YAG ridge waveguides as integrated laser sources.The work is supported by the National Natural Science Foundation of China (No. U1332121) and Ministerio de Economía y Competitividad of Spain (FIS2013-44174-P). S.Z. acknowledges the funding by the Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF-VH-NG-713). This work was partially carried out in CLPU facility (Lab. 2) in the framework of the access agreement concerning USAL staff

Synthesis of water-soluble hemicoronenediimides by photocyclization of perylenediimides: Turn-on fluorescent probes in water by complexation with Cucurbit[7]uril or binding to G-quadruplex Motifs

A new series of perylene and hemicoronene diimides, obtained by visible light photocyclization, are presented, between them some remarkable examples that are soluble in only water, and give nanoparticles by selfassociation. Those compounds work as new fluorescent materials in water by complexation with cucurbit[7] uril, as well as selective G-quadruplex binding ligands with remarkable cytotoxic activity when the interaction with G4 was sufficiently strong.We acknowledge the Ministerio de Ciencia, Innovación y Universidades-FEDER (Grants PID2019-111215RB-100 and RTI2018- 102040-B-100), the Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Grants BU263P18 and BU305P18), “la Caixa” Foundation (LCF/PR/PR12/11070003) for financial support. A. R.C. thanks Secretaría General de Universidades for a FPU18/03225 Grant. This research has made use of the high-performance computing resources of the Castilla y León Supercomputing Center (SCAYLE, htt ps://www.scayle.es), financed by FEDER (Fondo Europeo de Desarrollo Regional). We thank Ms. Ma del Pilar Castroviejo-Fernández, from PCT, UBU, for assistance in AFM studies and Mr. Javier Gutierrez-Reguera from LTI, UVA, for assistance in DLS studies

Self-Assembly Hydrosoluble Coronenes: A Rich Source of Supramolecular Turn-On Fluorogenic Sensing Materials in Aqueous Media

Water-soluble coronenes, that form nanoparticles by self-association, work as new fluorescent materials by complexation with cucurbit[7]uril, as well as selective turn-on fluorogenic sensors for nitroaromatic explosives with remarkable selectivity, by using only water as solvent.NATO Science for Peace and Security Programme (SPS G5536), Ministerio de Ciencia, Innovación y Universidades-FEDER (PID2019-111215RB-100 and RTI2018-102040-B-100), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (BU263P18) and “la Caixa” Foundation (LCF/PR/PR12/11070003) for financial support. A.R.C. thanks Secretaría General de Universidades (FPU18/03225)

References Values of Soluble alpha-Klotho Serum Levels Using an Enzyme-Linked Immunosorbent Assay in Healthy Adults Aged 18-85 Years

Hector Vazquez-Lorente (FPU18/03655) and Lucas Jurado-Fasoli (FPU19/01609) are under an FPU fellowship from the Spanish Ministry of Education. This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. The APC was funded by San Cecilio University Hospital, FIBAO, IBS-Granada, Spain.alpha-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered circulating soluble alpha-Klotho levels have been observed in aged non-healthy individuals, no specific reference values across a wide range of ages and sex using an enzyme-linked immunosorbent assay (ELISA) are available for larger cohorts of healthy individuals. The present analytical cross-sectional study was aimed to establish the reference values of soluble alpha-Klotho serum levels in healthy adults by age and sex groups. A total of 346 (59% women) healthy individuals aged from 18 to 85 years were recruited. Subjects were divided by sex and age as: (i) young (18-34.9 years), (ii) middle-aged (35-54.9 years), and (iii) senior (55-85 years) individuals. The soluble alpha-Klotho levels were measured in serum using ELISA. Senior adults were the age-group that presented the lowest soluble alpha-Klotho serum levels (p < 0.01), with age showing a negative association with soluble alpha-Klotho serum levels (p < 0.001). No differences between sexes were observed. Therefore, soluble alpha-Klotho levels were especially decreased-regardless of sex-in our cohort of healthy individuals because of the physiological decline derived from the aging process. We recommend routine assessments of soluble alpha-Klotho levels using ELISA as a simple and cheap detectable marker of aging that improves quality of life in the elderly.Spanish Government FPU18/03655 FPU19/01609San Cecilio University Hospital, FIBAO, IBS-Granada, Spai

Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART): study protocol

Congenital heart disease; Neurodevelopment; Predictive markersCardiopatía congénita; Desarrollo neurológico; Marcadores predictivosCardiopaties congènites; Neurodesenvolupament; Marcadors predictiusBackground: Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances in early diagnosis and postnatal management have increased survival in CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, have emerged as a key prognostic factor in the counseling of these pregnancies. Methods: Eligible participants are women presenting at 20 to < 37 weeks of gestation carrying a fetus with CHD. Maternal/neonatal recordings are performed at regular intervals, from the fetal period to 24 months of age, and include: placental and fetal hemodynamics, fetal brain magnetic resonance imaging (MRI), functional echocardiography, cerebral oxymetry, electroencephalography and serum neurological and cardiac biomarkers. Neurodevelopmental assessment is planned at 12 months of age using the ages and stages questionnaire (ASQ) and at 24months of age with the Bayley-III test. Target recruitment is at least 150 cases classified in three groups according to three main severe CHD groups: transposition of great arteries (TGA), Tetralogy of Fallot (TOF) and Left Ventricular Outflow Tract Obstruction (LVOTO). Discussion: The results of NEURO-HEART study will provide themost comprehensive knowledge until date of children’s neurologic prognosis in CHD and will have the potential for developing future clinical decisive tools and improving preventive strategies in CHD.RETICS funded by the PN 2018-2021 (Spain), ISCIII- Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (FEDER), reference RD16/002

Proteomic analysis of synovial fibroblasts and articular chondrocytes co-cultures reveals valuable VIP-modulated inflammatory and degradative proteins in osteoarthritis

Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release innate-derived immune mediators that initiate and perpetuate inflammation, inducing cartilage extracellular matrix (ECM) degradation. Given the lack of therapies for the treatment of OA, in this study, we explore biomarkers that enable the development of new therapeutical approaches. We analyze the set of secreted proteins in AC and SF co-cultures by stable isotope labeling with amino acids (SILAC). We describe, for the first time, 115 proteins detected in SF-AC co-cultures stimulated by fibronectin fragments (Fn-fs). We also study the role of the vasoactive intestinal peptide (VIP) in this secretome, providing new proteins involved in the main events of OA, confirmed by ELISA and multiplex analyses. VIP decreases proteins involved in the inflammatory process (CHI3L1, PTX3), complement activation (C1r, C3), and cartilage ECM degradation (DCN, CTSB and MMP2), key events in the initiation and progression of OA. Our results support the anti-inflammatory and anti-catabolic properties of VIP in rheumatic diseases and provide potential new targets for OA treatment