Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Molecular Factors Influencing the Affinity of Flavonoid Compounds on PGlycoprotein Efflux Transporter

The most common mechanism of the so-called multidrug resistance (MDR), is mainly associated with an over expression of P-glycoprotein (Pgp). It is an ATP-dependent transport protein that limits the intracellular accumulation of a variety of structurally unrelated compounds within various organs and normal tissues such as kidney, small intestine and the blood brain barrier. Thus, the expression of Pgp has a major impact on the pharmacokinetic profile of many therapeutic agents and therefore, overcoming Pgp-mediated efflux constitutes an attractive means of potentially enhancing their therapeutic efficacy. The flavonoids comprise a large group of polyphenolic compounds that occur in plants and vegetables, and they have been shown to display a wide variety of biological activities. For example, anti-inflammatory, antioxidant, ntiallergic, hepatoprotective, antithrombotic, antiviral, and anticarcinogenic activities. The interactions between flavonoids and Pgp have also been extensively studied and some quantitative structure-activity relationships (QSAR) have been reported. In the present work, we have employed 2D-QSAR analysis to evaluate the interactions between Pgp and several flavonoid compounds with the aim of dentifying the molecular factors responsible for the Pgp-binding affinity evidenced by these compounds. Thus, the reported data for dissociation constants (KD) between Pgp and 62 flavonoid compounds were modeled by mean of multiple regression analysis (MLR), and structures of the compounds under study were characterized by means of calculated physicochemical properties and several topological and constitutional descriptors, as well as geometrical and quantum chemical indexes. The obtained results suggest that the hydrophobic and especially geometric factors are of prime importance for binding, whereas in the case of flavonoid derivatives with flavone (flavonols), flavanone and isoflavone nuclei, the electronic factors are also involved in electron donor/acceptor interactions. In addition, in the case of chalcones, the results suggest that the affinity toward P-gp of such compounds is mainly governed by intermolecular dispersive interactions at the binding site.Fil: Vázquez, Rodolfo Nieto. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Camargo, Alejandra Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Marchevsky, Eduardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Luco, Juan Maria. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentin

A quantum-stabilized mirror for atoms

Peer reviewe

A high-reflectivity atom-focusing mirror stable at room temperature

It is shown that the Pb(√3x√3)R30/Si(111) ordered layer is an excellent mirror for neutral He atoms. It focuses more than 15% of the incoming He atoms into the specular peak, and is stable up to 450 K. Moreover, the reflectivity remains almost unchanged in a time scale of several weeks in ultrahigh vacuum. As a consequence, this system is a very good candidate to be used as a mirror in the next generation of the scanning helium atom microscope.This work was supported by the Ministerio de Ciencia y Tecnología through projects FIS2007-61114 and CONSOLIDER “Nanociencia Molecular” CSD2007-00010 and the Comunidad de Madrid through program NANOMAGNET S0505/MAT/0194.Peer reviewe

Integración latinoamericana: hegemonía, Estado y populismo

Este libro es resultado de la compilación de las ponencias más destacadas del II Congreso de Pensamiento Político Latinoamericano, al cual se presentaron ciento veintidós trabajos. La publicación tiene como objetivo difundir el trabajo de investigadores comprometidos con la necesidad de afirmar un discurso propiamente latinoamericano, definiendo en ese mismo recorrido el concepto mismo de americanidad.-La comunicación popular para la batalla cultural por Josefina Adrover. -El cuento de la ley. Relaciones entre derecho y literatura por Arabia Federico & Boco Gastón. -O surgimento tardio da comissão da verdade no brasil e a predominância militar na política brasileira de direitos humanos por Msc. Camila Tribess & Msc. Sandra Avi Dos Santos. -La muerte y la mordaza. El doble silenciamiento de las Intelectuales desaparecidas: el caso de Alicia Eguren por Graciela Barbieri. -La influencia de la revolución bolivariana en América Latina y el Caribe por Alejando Beade. -Baldosas de la memoria como intervención político subjetiva por Diego Benegas Loyo, Ayelén Colosimo & Antonella Dalessio. -Ciudadanía del consumidor por Julián Bertachi. -Constitucionalismo latinoamericano y d.e.s.c. por Pablo Blanco. -Empresas estatales en el proceso de reforma neoliberal: los casos de YPF y Petrobrás por Cachés Javier & Garibaldi Pablo. -Tecnología y movimientos sociales: el caso del movimiento #yosoy132 en México por Juan José Carrillo Nieto. -Judicialização e questão social: as ações do estadona garantia de direitos por Hellen Soares Santana Carneiro. -Una lectura fanoniana de los conflictos de subjetividad en el siglo xxi por Juan Pablo Cedriani. -El pensamiento filosófico, político y pedagógico de Arturo Andrés Roig por Mónica Cerruti. -El discurso socio-político en torno a la construcción de memoria colectiva e identidad política de víctimas en el Cono Sur a partir del contexto de implementación de la doctrina de seguridad nacional por Marcos Cruz Ladino & Martha Isabel Gómez. -Claves de interpretación de la iglesia disidente frente a la dictadura en España (1970-1978). Las concomitancias con la teología de liberación y su proyección de los derechos humanos por Juan Antonio Delgado de la Rosa & Gredos San Diego. -As comunidades eclesiais de base e o movimento popular em volta redonda: o espaço urbano como lugar de luta por direitos sociais por Camila Faria. -Sindicalismo e força de trabalho no período desenvolvimentista em volta redonda (1940-1950)por Camila Faria. -Algunas consideraciones acerca de las brechas de género en la universidad: La UNRC. por Lilian Fernández del Moral, colaboradores: Diego Benegas Loyo & Nicolás Valverde. -Discursos y prácticas de resistencia del feminismo indígena: desafíos para el feminismo académico y aportes para un diálogo intercultural por Martín Forciniti & Mercedes Palumbo. -De los derechos humanos a los derechos posimperiales: La interpelacion de los pueblos originarios a la universalidad juridica por Martín Forciniti & Soledad Ramati. -La forja de un puente entre dos movimientos nacionales. La fuerza de orientación radical de la joven argentina (forja), eje entre el yrigoyenismo y peronismo por Juan Godoy. -Arte y política: semejanzas y diferencias por Elina Ibarra. -¿La investigación como práctica política? por Silvia María Kelly , Ruth Rajchenberg & Carolina Wajnerman. -¿Posneoliberalismo en América latina? transformaciones políticas y económicas en la última década por Agustín Lewit & Luis Wainer. -Descolonizando el desarrollo: aportes del MST y del MO.CA.SE.- VC.por Gabriel Rodrigues Lopes -El federalismo alternativo por Martín López & Pedro Ferré. -Ottobah Cugoano: pensar la libertad y la igualdad desde las víctimas por Juan Francisco Martinez Peria -Los poderes innominados del constitucionalismo latinoamericano. La necesidad de un nuevo marco de comprensión y comparación crítico situado por Alejandro Medici. -La falta de vocación exportadora en el productor PYME argentino y la colonización de actitudes empresariales por Ana María Mendoza. -El marxismo español contemporáneo: Francisco Fernández Buey in memoriam por Marta Nogueroles Jové -Del crisol de razas a la olla popular notas para este bicentenario de la patria por Juan José Olivera. -La conflictiva relación entre hambre y libertad por Rodolfo Enrique Peláez. -Deslocamento populacional brasileiro frente á hegemonia do capital, uma questão social por Vilma Pereira da Silva. -El rol de los sonidos en el funcionamiento de los centros clandestinos de detención por Facundo Petit de Murat. -¿Qué ignora el maestro ignorante de Ranciere? una lectura en clave descolonial por Ezequiel Pinacchio. -La construcción de identidades políticas durante el proceso de provincialización del territorio nacional de Chubut (1954-1955): reconfiguración de un discurso sobre el status político-institucional de los territorios nacionales por Anaclara Raffaele. -Arte terapia y decolonialización: una práctica para la liberación por Ruth Alejandra Rajchenberg -La política de los barrios ciudad en la provincia de Córdoba: territorio, política y poder por Saccucci, Erika Ave Oria. -Sexo, gênero e sexualidade: encontros e desencontros Benevento por Claudia Toffano. -Abrir la agenda e integrar otras voces: debates y compromisos del feminismo contemporáneo en América latina por Vanesa Vázquez Laba. -Polémicas culturales, política y poder en cuba: el caso de la creación y cierre de la revista Pensamiento Crítico por Vergara María Ximena. -¿Integración vs. crecimiento? algunas notas para la integración de Argentina en el MERCOSUR por MG. Juan Von Zeschau. -Aportes para (re) pensar el uso de la cuestión nacional en los discursos de la argentina kirchnerista por María Virginia Quiroga & Aarón Attias -Arte y participación: una relación estratégica y del buen vivir. Alcances y dimensiones del arte transformador por Carolina Wajnerman

Immobilized artificial membrane chromatography : quantitative structure-retention relationships of structurally diverse drugs

The chromatographic capacity factors (log k‘) for 32 structurally diverse drugs were determined by high performance liquid chromatography (HPLC) on a stationary phase composed of phospholipids, the so-called immobilized artificial membrane (IAM). In addition, quantitative structure-retention relationships (QSRR) were developed in order to explain the dependence of retention on the chemical structure of the neutral, acidic, and basic drugs considered in this study. The obtained retention data were modeled by means of multiple regression analysis (MLR) and partial least squares (PLS) techniques. The structures of the compounds under study were characterized by means of calculated physicochemical properties and several nonempirical descriptors. For the carboxylic compounds included in the analysis, the obtained results suggest that the IAM-retention is governed by hydrophobicity factors followed by electronic effects due to polarizability in second place. Further, from the analysis of the results obtained of two developed quantitative structure-permeability studies for 20 miscellaneous carboxylic compounds, it may be concluded that the balance between polarizability and hydrophobic effects is not the same toward IAM phases and biological membranes. These results suggest that the IAM phases could not be a suitable model in assessing the acid-membrane interactions. However, it is not possible to generalize this observation, and further work in this area needs to be done to obtain a full understanding of the partitioning of carboxylic compounds in biological membranes. For the non-carboxylic compounds included in the analysis, this work shows that the hydrophobic factors are of prime importance for the IAM-retention of these compounds, while the specific polar interactions, such as electron pair donor−acceptor interactions and electrostatic interactions, are also involved, but they are not dominant

Compilación de Proyectos de Investigacion de 1984-2002

Instituto Politecnico Nacional. UPIICS