143 research outputs found
Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range: Great Potential for Solid-state Cooling
Solid-state cooling based on caloric effects is considered a viable
alternative to replace the conventional vapor-compression refrigeration
systems. Regarding barocaloric materials, recent results show that elastomers
are promising candidates for cooling applications around room-temperature. In
the present paper, we report supergiant barocaloric effects observed in acetoxy
silicone rubber - a very popular, low-cost and environmentally friendly
elastomer. Huge values of adiabatic temperature change and reversible
isothermal entropy change were obtained upon moderate applied pressures and
relatively low strains. These huge barocaloric changes are associated both to
the polymer chains rearrangements induced by confined compression and to the
first-order structural transition. The results are comparable to the best
barocaloric materials reported so far, opening encouraging prospects for the
application of elastomers in near future solid-state cooling devices.Comment: 19 pages, 7 figures, 2 table
Orbital characterization of GJ1108A system, and comparison of dynamical mass with model-derived mass for resolved binaries
We report an orbital characterization of GJ1108Aab that is a low-mass binary
system in pre-main-sequence phase. Via the combination of astrometry using
adaptive optics and radial velocity measurements, an eccentric orbital solution
of =0.63 is obtained, which might be induced by the Kozai-Lidov mechanism
with a widely separated GJ1108B system. Combined with several observed
properties, we confirm the system is indeed young. Columba is the most probable
moving group, to which the GJ1108A system belongs, although its membership to
the group has not been established. If the age of Columba is assumed for
GJ1108A, the dynamical masses of both GJ1108Aa and GJ1108Ab ( and ) are more massive than what an
evolutionary model predicts based on the age and luminosities. We consider the
discrepancy in mass comparison can attribute to an age uncertainty; the system
is likely older than stars in Columba, and effects that are not implemented in
classical models such as accretion history and magnetic activity are not
preferred to explain the mass discrepancy. We also discuss the performance of
the evolutionary model by compiling similar low-mass objects in evolutionary
state based on the literature. Consequently, it is suggested that the current
model on average reproduces the mass of resolved low-mass binaries without any
significant offsets.Comment: Accepted in Ap
Subaru Imaging of Asymmetric Features in a Transitional Disk in Upper Scorpius
We report high-resolution (0.07 arcsec) near-infrared polarized intensity
images of the circumstellar disk around the star 2MASS J16042165-2130284
obtained with HiCIAO mounted on the Subaru 8.2 m telescope. We present our
-band data, which clearly exhibits a resolved, face-on disk with a large
inner hole for the first time at infrared wavelengths. We detect the
centrosymmetric polarization pattern in the circumstellar material as has been
observed in other disks. Elliptical fitting gives the semimajor axis, semiminor
axis, and position angle (P.A.) of the disk as 63 AU, 62 AU, and -14
, respectively. The disk is asymmetric, with one dip located at P.A.s
of . Our observed disk size agrees well with a previous study
of dust and CO emission at submillimeter wavelength with Submillimeter Array.
Hence, the near-infrared light is interpreted as scattered light reflected from
the inner edge of the disk. Our observations also detect an elongated arc (50
AU) extending over the disk inner hole. It emanates at the inner edge of the
western side of the disk, extending inward first, then curving to the
northeast. We discuss the possibility that the inner hole, the dip, and the arc
that we have observed may be related to the existence of unseen bodies within
the disk.Comment: 21 pages, 3 figures, published 2012 November 7 by ApJL, typo
correcte
SEEDS direct imaging of the RV-detected companion to V450 Andromedae, and characterization of the system
We report the direct imaging detection of a low-mass companion to a young,
moderately active star V450 And, that was previously identified with the radial
velocity method. The companion was found in high-contrast images obtained with
the Subaru Telescope equipped with the HiCIAO camera and AO188 adaptive optics
system. From the public ELODIE and SOPHIE archives we extracted available
high-resolution spectra and radial velocity (RV) measurements, along with RVs
from the Lick planet search program. We combined our multi-epoch astrometry
with these archival, partially unpublished RVs, and found that the companion is
a low-mass star, not a brown dwarf, as previously suggested. We found the
best-fitting dynamical masses to be and
M. We also performed spectral analysis of
the SOPHIE spectra with the iSpec code. The Hipparcos time-series photometry
shows a periodicity of d, which is also seen in SOPHIE spectra as an
RV modulation of the star A. We interpret it as being caused by spots on the
stellar surface, and the star to be rotating with the given period. From the
rotation and level of activity, we found that the system is
Myr old, consistent with an isochrone analysis ( Myr). This
work may serve as a test case for future studies of low-mass stars, brown
dwarfs and exoplanets by combination of RV and direct imaging data.Comment: 15 pages, 9 figures, 7 tables, to appear in Ap
Direct Imaging of Fine Structures in Giant Planet Forming Regions of the Protoplanetary Disk around AB Aurigae
We report high-resolution 1.6 \micron polarized intensity () images of
the circumstellar disk around the Herbig Ae star AB Aur at a radial distance of
22 AU () up to 554 AU (3.85), which have been obtained by the
high-contrast instrument HiCIAO with the dual-beam polarimetry. We revealed
complicated and asymmetrical structures in the inner part (140 AU) of
the disk, while confirming the previously reported outer ( 200 AU)
spiral structure. We have imaged a double ring structure at 40 and
100 AU and a ring-like gap between the two. We found a significant
discrepancy of inclination angles between two rings, which may indicate that
the disk of AB Aur is warped. Furthermore, we found seven dips (the typical
size is 45 AU or less) within two rings as well as three prominent
peaks at 40 AU. The observed structures, including a bumpy double ring, a
ring-like gap, and a warped disk in the innermost regions, provide essential
information for understanding the formation mechanism of recently detected
wide-orbit ( 20 AU) planets.Comment: 12 pages, 3 figure
Imaging of a Transitional Disk Gap in Reflected Light: Indications of Planet Formation Around the Young Solar Analog LkCa 15
We present H- and Ks-band imaging data resolving the gap in the transitional
disk around LkCa 15, revealing the surrounding nebulosity. We detect sharp
elliptical contours delimiting the nebulosity on the inside as well as the
outside, consistent with the shape, size, ellipticity, and orientation of
starlight reflected from the far-side disk wall, whereas the near-side wall is
shielded from view by the disk's optically thick bulk. We note that
forward-scattering of starlight on the near-side disk surface could provide an
alternate interpretation of the nebulosity. In either case, this discovery
provides confirmation of the disk geometry that has been proposed to explain
the spectral energy distributions (SED) of such systems, comprising an
optically thick outer disk with an inner truncation radius of ~46 AU enclosing
a largely evacuated gap. Our data show an offset of the nebulosity contours
along the major axis, likely corresponding to a physical pericenter offset of
the disk gap. This reinforces the leading theory that dynamical clearing by at
least one orbiting body is the cause of the gap. Based on evolutionary models,
our high-contrast imagery imposes an upper limit of 21 Jupiter masses on
companions at separations outside of 0.1" and of 13 Jupiter masses outside of
0.2". Thus, we find that a planetary system around LkCa 15 is the most likely
explanation for the disk architecture.Comment: 5 pages, 4 figures, accepted for publication in ApJ Letters. Minor
change to Figure
Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases
Aims
The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge. We aimed to identify pathogenic or likely pathogenic variants in CCSD patients by using WES and 2015 American College of Medical Genetics and Genomics (ACMG) standards and guidelines as well as evaluating the usefulness of functional studies for determining them.
Methods and Results
We performed WES of 23 probands diagnosed with early-onset (<65 years) CCSD and analyzed 117 genes linked to arrhythmogenic diseases or cardiomyopathies. We focused on rare variants (minor allele frequency < 0.1%) that were absent from population databases. Five probands had protein truncating variants in EMD and LMNA which were classified as “pathogenic” by 2015 ACMG standards and guidelines. To evaluate the functional changes brought about by these variants, we generated a knock-out zebrafish with CRISPR-mediated insertions or deletions of the EMD or LMNA homologs in zebrafish. The mean heart rate and conduction velocities in the CRISPR/Cas9-injected embryos and F2 generation embryos with homozygous deletions were significantly decreased. Twenty-one variants of uncertain significance were identified in 11 probands. Cellular electrophysiological study and in vivo zebrafish cardiac assay showed that 2 variants in KCNH2 and SCN5A, 4 variants in SCN10A, and 1 variant in MYH6 damaged each gene, which resulted in the change of the clinical significance of them from “Uncertain significance” to “Likely pathogenic” in 6 probands.
Conclusions
Of 23 CCSD probands, we successfully identified pathogenic or likely pathogenic variants in 11 probands (48%). Functional analyses of a cellular electrophysiological study and in vivo zebrafish cardiac assay might be useful for determining the pathogenicity of rare variants in patients with CCSD. SCN10A may be one of the major genes responsible for CCSD.
Translational Perspective
Whole-exome sequencing (WES) may be helpful in determining the causes of cardiac conduction system disease (CCSD), however, the identification of pathogenic variants remains a challenge. We performed WES of 23 probands diagnosed with early-onset CCSD, and identified 12 pathogenic or likely pathogenic variants in 11 of these probands (48%) according to the 2015 ACMG standards and guidelines. In this context, functional analyses of a cellular electrophysiological study and in vivo zebrafish cardiac assay might be useful for determining the pathogenicity of rare variants, and SCN10A may be one of the major development factors in CCSD
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