Systemic immune inflammation index may be a new powerful marker for the accurate early prediction of complications in patients with acute appendicitis

To investigate the relationship between the systemic immune-inflammatory index (SII) and acute appendicitis (AA). Materials and Methods: We retrospectively evaluated patients aged over 18 years who were diagnosed with AA and underwent surgery at our clinic from January 1, 2019, through July 31, 2022. The patients were divided into three groups: complicated acute appendicitis (CAA), uncomplicated acute appendicitis (UAA), and control. The clinical and laboratory characteristics of the patients evaluated at the emergency department were recorded. The neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and SII (neutrophil count x platelet count/lymphocyte count) were calculated.Results: The study included a total of 1,456 patients, of whom 628 had UAA, 104 had CAA, and 714 were controls. The NLR, PLR, and SII values were statistically significantly higher in the CAA group than in the control group and the UAA group. The multivariate logistic regression analysis revealed that SII was an independent predictor of CAA development (odds ratio [OR]: 4.65; 95% confidence interval [CI]: 2.31-10.17). The predictive power of SII in the prediction of CAA (area under the curve [AUC]: 0.809) was much higher than that of NLR (AUC: 0.729), neutrophil count (AUC: 0.696), and C -reactive protein (AUC: 0.732) alone. It was determined that an SII value greater than 1,989.2 had a sensitivity of 78.4% and a specificity of 88.5% in predicting CAA development.Conclusion: SII is a simple, inexpensive, and promising marker that could predict both the diagnosis and severity of appendicitis

THE EFFECT OF CURCUMIN AGAINST FLUORIDE AND MERCURY INDUCED NEURODEGENERATION AND OXIDATIVE INJURY

OBJECTIVES:The aim of this study was to investigate the effect ofcurcumin(10μM) on neurotoxicity and oxidative stress caused by theapplication of sodium fluoride(10mM) and mercuric chloride(5μM) on rat brainsynaptosomes obtained in vitro to prevent degenerative damage on synaptosomes.MATERIALS and METHODS:In our study, sinapotosomes were preparedusing brain obtained from 5 Wistar Albino rats. A Control, B 10 mM SodiumFluoride, C 5 μM Mercury Chloride, D 5 μM Mercury Chloride+10 μMCurcumin, E 10 mM Sodium Fluoride+10 μM Curcumin, F 10 mM SodiumFluoride+5 μM Mercury Chloride+10 μM Curcumin six groups were formed.DNA fragmation, Adenosine Deaminase(ADA), Malondialdehyde(MDA)and Superoxide Dismutase(SOD) levels were measured on the synaptosomes.RESULTS:MDA and DNA fragmentation levels significant increased,SOD and ADA levels decreased in the B and C groups compared to theA group(p&lt;0.01). In curcumin-treated groups D and E, MDA and DNAfragmentation levels decreased, SOD and ADA levels increased statisticallywhen compared with A, B and C groups(p&lt;0.01). The levels of MDA andDNA fragmentation in the F group were statistically decreased comparedto A, B and C groups, whereas levels of SOD and ADA statisticallyincreased(p&lt;0.01). There was no statistically difference in the levels of MDA,SOD, ADA and DNA fragments in group F compared to group D and E(p&gt; 0.01).CONCLUSIONS:In our study, it was observed that administration ofsodium fluoride and mercury chloride increased oxidative stress andneurotoxicity and damaged the antioxidant system. It has been observedthat Curcumin may reduce increased oxidative stress and neurotoxicityKeywords: Brain, Neurotoxicity, Free Radicals, Antioxidant</p

ACID BLUE 121 BOYAR MADDESİNİN MUZ KABUĞUNA KESİKLİ SİSTEMDE ADSORBSİYONUNUN ARAŞTIRILMASI

Bu çalışmada, Acid Blue 121 (AB 121)’in tarımsal bir atık olan muz kabuğu (MK)’na adsorbsiyonuna başlangıç pH’sı, sıcaklık, başlangıç boyar madde derişimi ve adsorbent derişiminin etkisi kesikli bir sistemde araştırılmıştır. AB 121’in MK’na adsorbsiyonu denge verilerinin Langmuir izoterm modeline çok iyi uyduğu; MK’nun maksimum tek tabaka adsorpsiyon kapasitesinin 141 mg/g olduğu saptanmıştır. AB 121’nin MK’na adsorbsiyonu kinetiğinin yalancı ikinci mertebe kinetik modeli ile temsil edilebileceği ayrıca giderimde tanecik içi ve tanecik dışı difüzyonunun etkili olduğu sonucuna varılmıştır. AB 121’in MK’na adsorbsiyonuna ait termodinamik parametreler belirlenmiş; çalışılan adsorpsiyon sisteminin ekzotermik ve kendiliğinden gerçekleştiği gözlenmiştir. MK’nun FTIR, SEM ve EDX analizleri ile karakterizasyonu çalışmaları da gerçekleştirilmiştir

Performance of the systemic immune-inflammation index in predicting survival to discharge in out-of-hospital cardiac arrest

Objective: To investigate whether the systemic immune-inflammatory index (SII) could be used as a prognostic marker of out-of-hospital cardiac arrest (OHCA). Methods: We evaluated patients aged 18 years and older, who presented to the emergency department (ED) due to OHCA between January 2019 and December 2021 and achieved the return of spontaneous circulation after successful resuscitation. Routine laboratory tests were obtained from the first blood samples measured following the patients’ admission to ED. The neutrophil–lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were calculated by dividing the neutrophil and platelet counts by the lymphocyte count. SII was calculated as platelets × neutrophils / lymphocytes. Results: Among the 237 patients with OHCA included in the study, the in-hospital mortality rate was 82.7%. The SII, NLR, and PLR values were statistically significantly lower in the surviving group than in the deceased group. The multivariate logistic regression analysis revealed that SII [odds ratio (OR): 0.68, 95% confidence interval (CI): 0.56–0.84, p = 0.004] was an independent predictor of survival to discharge. In the receiver operating characteristic analysis, the power of SII to predict survival to discharge [area under the curve (AUC): 0.798] was higher than either NLR (AUC: 0.739) or PLR (AUC: 0.632) alone. SII values below 700.8% predicted survival to discharge with 80.6% sensitivity and 70.7% specificity. Conclusion: Our findings showed that SII was more valuable than NLR and PLR in predicting survival to discharge and could be used as a predictive marker for this purpose

Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies

Schiff base derivatives were synthesized in this study via conventional, microwave irradiation and ultrasound sonication methods. Optimization conditions were examined for several parameter such as solvent, reaction time and yield. After determining the optimization conditions, the compounds were synthesized by using ultrasound sonication. The structures of the synthesized compounds were examined by spectral data, and the antiurease, antioxidant and antimicrobial activities of the Schiff bases derivatives were investigated due to the imine group (-C=N-) and promising results were obtained. The enzyme inhibitory potentials of these compounds were further validated through molecular docking studies. Also, In Silico ADME prediction studies were calculated for compounds