201 research outputs found
Neurotic states at students with a hypodynamia
Mental health of the person depends on his physical state. Need of sports exists throughout human life. Restriction of motor activity of a body, lack of physical exercises negatively influences both physical health, and the mental healthΠΡΠΈΡ
ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ Π΅Π³ΠΎ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ. ΠΠ΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π·Π°Π½ΡΡΠΈΡ ΡΠΏΠΎΡΡΠΎΠΌ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ ΠΆΠΈΠ·Π½ΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅Π»Π°, Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΠΊ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΏΡΠ°ΠΆΠ½Π΅Π½ΠΈΠΉ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΠ΅Ρ ΠΊΠ°ΠΊ Π½Π° ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅, ΡΠ°ΠΊ ΠΈ Π½Π° ΠΏΡΠΈΡ
ΠΈΡΠ΅ΡΠΊΠΎ
A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves
The transcription factor ZENK is an immediate early gene that has been employed as a surrogate marker to map neuronal activity in the brain. It has been used in a wide variety of species, however, commercially available antibodies have limited immunoreactivity in birds. To address this issue we generated a new mouse monoclonal antibody, 7B7-A3, raised against ZENK from the rock pigeon (Columba livia). We show that 7B7-A3 labels clZENK in both immunoblots and histological stainings with high sensitivity and selectivity for its target. Using a sound stimulation paradigm we demonstrate that 7B7-A3 can detect activity-dependent ZENK expression at key stations of the central auditory pathway of the pigeon. Finally, we compare staining efficiency across three avian species and confirm that 7B7-A3 is compatible with immunohistochemical detection of ZENK in the rock pigeon, zebra finch, and domestic chicken. Taken together, 7B7-A3 represents a useful tool for the avian neuroscience community to map functional activity in the brain
Nanodomain structure evolution investigation during polarization reversal of lithium niobate monocrystals with modified surface layers by proton exchange with different thicknesses
Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ ΡΠΎΡΠΌΡ ΠΌΠΈΠΊΡΠΎΠ΄ΠΎΠΌΠ΅Π½ΠΎΠ² ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π°Π½ΠΎΠ΄ΠΎΠΌΠ΅Π½Π½ΡΡ
ΡΡΡΡΠΊΡΡΡ Π² Π½ΠΈΠΎΠ±Π°ΡΠ΅ Π»ΠΈΡΠΈΡ Ρ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΠΌ ΡΠ»ΠΎΠ΅ΠΌ, ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΡΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΠΎΠ»ΡΠΈΠ½Ρ.
Π Π°Π±ΠΎΡΠ° Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π° Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΡΠΈΠ·ΠΈΠΊΠΈ ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΠΊΠΎΠ². Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎ- ΠΈ Π½Π°Π½ΠΎΠ΄ΠΎΠΌΠ΅Π½Π½ΡΡ
ΡΡΡΡΠΊΡΡΡ Π² Π½Π΅ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΡ
Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΡΠΊΡΠ°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π΄Π΅ΠΏΠΎΠ»ΡΡΠΈΠ·ΡΡΡΠΈΡ
ΠΏΠΎΠ»Π΅ΠΉ, ΡΠ΅Π°Π»ΠΈΠ·ΡΠ΅ΠΌΡΡ
ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΈ Π² ΠΌΠΎΠ½ΠΎΠΊΡΠΈΡΡΠ°Π»Π»Π°Ρ
Π½ΠΈΠΎΠ±Π°ΡΠ° Π»ΠΈΡΠΈΡ Ρ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΠΌ ΡΠ»ΠΎΠ΅ΠΌ, ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΡΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π°.
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
Π΄ΠΈΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ»ΠΎΠ΅Π² Π½Π° ΠΊΠΈΠ½Π΅ΡΠΈΠΊΡ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΈ ΠΈΠΌΠ΅Π΅Ρ Π²Π°ΠΆΠ½ΠΎΠ΅ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈ ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π΄ΠΈΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ»ΠΎΠ΅Π² Π²Π°ΠΆΠ½ΠΎ Π΄Π»Ρ Π²ΡΡΡΠ½Π΅Π½ΠΈΡ ΡΠΎΠ»ΠΈ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ»ΠΎΡ Π² Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΡΡ
Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΡΡ
Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ². Π‘ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»ΠΎΠ΅Π² Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΠΎΡΠΊΡΡΠ²Π°Π΅Ρ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ Π΄Π»Ρ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΎΠΉ ΠΈ Π³Π΅ΠΎΠΌΠ΅ΡΡΠΈΠ΅ΠΉ Π΄ΠΎΠΌΠ΅Π½Π½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½ΠΎΠ²ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
, Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎ-ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎ-ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΡΠΎΠΉΡΡΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π΄ΠΎΠΌΠ΅Π½Π½ΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ.
Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΠ±ΡΠ΅ΠΊΡΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π² Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ Π½ΠΈΠΎΠ±Π°Ρ Π»ΠΈΡΠΈΡ LiNbO3, ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΡΠ²Π»ΡΡΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΠΎΡΡΡΠ΅Π±ΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°ΠΌΠΈ Π΄Π»Ρ ΠΏΠΎΡΡΡΠΎΠ΅Π½ΠΈΡ Π±ΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° ΡΡΡΡΠΎΠΉΡΡΠ² Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΎΠΏΡΠΈΠΊΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² Π΄ΠΎΠΌΠ΅Π½Π½ΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ. Π ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ΄Π΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ Π½ΠΈΠΎΠ±Π°Ρ Π»ΠΈΡΠΈΡ ΠΊΠΎΠ½Π³ΡΡΡΠ½ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° (CLN). Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ Π‘LN ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Ρ
Π½ΠΈΠΊΠ° ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π²ΠΎΠ»Π½ΠΎΠ²ΠΎΠ΄ΠΎΠ² β ΠΏΡΠΎΡΠΎΠ½Π½ΡΠΉ ΠΎΠ±ΠΌΠ΅Π½ (PE), ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠΎΠ·Π΄Π°Π²Π°ΡΡ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ Π΄ΠΈΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ»ΠΎΠΈ Ρ Ρ
ΠΎΡΠΎΡΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΡΠΌΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ (Π³Π»ΡΠ±ΠΈΠ½ΠΎΠΉ, ΡΠΎΡΠΌΠΎΠΉ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡΡ). Π‘ΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ Π²Π°ΠΆΠ½ΠΎΠ³ΠΎ Π΄Π»Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»ΠΈΠ²Π°Π΅Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ.
ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π² Ρ
ΠΎΡΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΡΠ°Π±ΠΎΡΡ:
β’ Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΠΎΠ³ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ ΠΏΡΠΎΠΏΠΎΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ ΡΠΎΠ»ΡΠΈΠ½Π΅ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ.
β’ ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΈ Π² ΡΠ°ΡΡΡΡΠ΅ΠΌ ΠΏΠΎΠ»Π΅ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎ ΠΎΡ ΡΠΎΠ»ΡΠΈΠ½Ρ PE-ΡΠ»ΠΎΡ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° Π΄ΠΎΠΌΠ΅Π½Π½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ Π½Π°ΡΠΈΠ½Π°Π΅ΡΡΡ Ρ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΈ ΡΠΎΡΡΠ° ΡΠ΅ΡΡΠΈΡΠ³ΠΎΠ»ΡΠ½ΡΡ
Π΄ΠΎΠΌΠ΅Π½ΠΎΠ²;
β’ Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π² ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
Ρ ΡΠΎΠ»ΡΠΈΠ½ΠΎΠΉ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ 1,7 ΠΈ 3,4 ΠΌΠΊΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π΄Π²Π° ΡΠΈΠΏΠ° ΡΠ²ΠΎΠ»ΡΡΠΈΠΈ Π΄ΠΎΠΌΠ΅Π½Π½ΡΡ
ΡΡΡΡΠΊΡΡΡ: 1) ΡΠΎΡΡ Β«ΡΠΈΡΠΎΠΊΠΎΠΉ Π΄ΠΎΠΌΠ΅Π½Π½ΠΎΠΉ Π³ΡΠ°Π½ΠΈΡΡΒ» (wide domain boundary - WDB) Π² ΡΠ»Π°Π±ΠΎΠΌ ΠΈ ΡΡΠ΅Π΄Π½Π΅ΠΌ ΠΏΠΎΠ»Π΅ ΠΈ
2) ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΈΠΊΡΠΎ- ΠΈ Π½Π°Π½ΠΎΠ΄ΠΎΠΌΠ΅Π½Π½ΡΡ
Π°Π½ΡΠ°ΠΌΠ±Π»Π΅ΠΉ Π² ΡΠΈΠ»ΡΠ½ΠΎΠΌ ΠΏΠΎΠ»Π΅.
β’ ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ Π² ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
Ρ ΡΠΎΠ»ΡΠΈΠ½ΠΎΠΉ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ 4,6 ΠΌΠΊΠΌ ΡΠ΅Π°Π»ΠΈΠ·ΡΠ΅ΡΡΡ Π΄ΠΈΡΠΊΡΠ΅ΡΠ½ΠΎΠ΅ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅, ΠΈ ΡΠΎΡΠΌΠΈΡΡΡΡΡΡ ΠΏΠ°ΡΡΠΈΠ½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠ΅ Π΄ΠΎΠΌΠ΅Π½Π½ΡΠ΅ ΡΡΡΡΠΊΡΡΡΡ, ΡΠΎΡΡΠΎΡΡΠΈΠ΅ ΠΈΠ· ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π΄ΠΎΠΌΠ΅Π½ΠΎΠ².
β’ ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠΎΠ»Π΅Π²ΡΠ΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΡΠΊΠΎΡΠΎΡΡΠΈ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΡΡΠΎΠ½ΡΠ° Π½Π°Π½ΠΎΠ΄ΠΎΠΌΠ΅Π½ΠΎΠ² ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π°ΠΏΠΏΡΠΎΠΊΡΠΈΠΌΠΈΡΠΎΠ²Π°Π½Ρ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡΡ Ρ ΠΏΠΎΠ»Π΅ΠΌ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Ea = 3,3 Β± 0,1 ΠΊΠ/ΠΌΠΌ.
ΠΠ΅ΡΡΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΡΠ°Π±ΠΎΡΡ. Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΠΊΠΎΠ² ΠΠΠ ΡΠΈΠ·ΠΈΠΊΠΈ ΠΈ ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΠΎΠΉ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΠΊΠΈ ΠΠ½ΡΡΠΈΡΡΡΠ° Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½Π°ΡΠΊ Π£ΡΠ°Π»ΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° ΠΈΠΌΠ΅Π½ΠΈ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΠΡΠ΅Π·ΠΈΠ΄Π΅Π½ΡΠ° Π ΠΎΡΡΠΈΠΈ Π.Π.ΠΠ»ΡΡΠΈΠ½Π° Π½Π° ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΠΈ Π£ΡΠ°Π»ΡΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΡΡΠ° ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Β«Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈΒ» ΠΠΠ Π£ΡΠ€Π£.ΠΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π£ΡΠ€Π£ Π½Π° 2013 Π³ΠΎΠ΄ (ΠΏ.2.1.2.1
On a snow cover composition in the vicinity of the Verkhnekamsky Salt Deposit
The snow cover chemical composition was investigated on the territory of the Verkhnekamskiy potash-magnesium salt deposit in the zone of influence of atmospheric emissions of Berezniki Potash Mining Complex (Perm Region). The object of researches was the snow in this area. Features of specific pollutants contained in the emissions of these mine groups and their relationship with the air intake and following atmospheric deposition were examined. With regard for specific character of pollutants in the emissions, studies of melt water included determination of the following chemical components β SO42-, Cl-, NO3-, NO2-, ΠCO3-, Ca2+, Mg2+, Na+, K+, of the pH value as well as suspended solid substances, and total mineralization. An analysis of snow composition was performed on two sites from which one was the surrounding background territory, while another area was the urban territory of city Berezniki, i.e. area of operating mine group. To assess the results the indicator of specific stock macro component was used. Increased specific stock relative to the background snowpack is clearly indicative of components directly related to the extraction and processing of salts Cl-, Na+, K+. The revealed anomalies have a local character and, as a rule, do not extend beyond boundaries of sanitary protection zones of the enterprises. Maps of distribution of values of the specific reserves for the analyzed list of components in the melt water were constructed. Our results obtained for the Verkhnekamskiy Deposit area were compared with similar published data on the territories of cities in the zone influenced by motor roads, reserves, and coastal zones of the Russian Arctic seas
The expression, localisation and interactome of pigeon CRY2
Cryptochromes (CRY) are highly conserved signalling molecules that regulate circadian rhythms and are candidate radical pair based magnetoreceptors. Birds have at least four cryptochromes (CRY1a, CRY1b, CRY2, and CRY4), but few studies have interrogated their function. Here we investigate the expression, localisation and interactome of clCRY2 in the pigeon retina. We report that clCRY2 has two distinct transcript variants, clCRY2a, and a previously unreported splice isoform, clCRY2b which is larger in size. We show that clCRY2a mRNA is expressed in all retinal layers and clCRY2b is enriched in the inner and outer nuclear layer. To define the localisation and interaction network of clCRY2 we generated and validated a monoclonal antibody that detects both clCRY2 isoforms. Immunohistochemical studies revealed that clCRY2a/b is present in all retinal layers and is enriched in the outer limiting membrane and outer plexiform layer. Proteomic analysis showed clCRY2a/b interacts with typical circadian molecules (PER2, CLOCK, ARTNL), cell junction proteins (CTNNA1, CTNNA2) and components associated with the microtubule motor dynein (DYNC1LI2, DCTN1, DCTN2, DCTN3) within the retina. Collectively these data show that clCRY2 is a component of the avian circadian clock and unexpectedly associates with the microtubule cytoskeleton
Immunotropic effects of vitamin D3 in original rectal suppositories in experimental ulcerative colitis
Increased incidence of ulcerative colitis (UC) is a prerequisite for searching new therapeutic approaches, primarily with an opportunity of site-directed impact on the colon lesion. UC pathogenesis is associated with dysregulated immune response, and limited effectiveness of basic therapy for the disorder. Vitamin D3 exhibits antioxidant, anti-inflammatory, immunomodulatory and other properties, it has been shown to be effective in some autoimmune diseases, thus prompting us to study its effect on immune status in UC. We aimed for studying the effect of vitamin D3, as a component of original rectal suppositories, upon clinical course and indexes of immune status in experimental UC. UC in rats was modeled with 3% oxazolone solution. The vitamin D3-containing suppositories (1500 IU) weighing 300 mg were administered per rectum every 12 hours for 6 days. On days 2, 4 and 6 of UC, the clinical features were assessed as well as blood leukocyte counts, numbers of CD3+, CD45RA+; absorbing and NBT-reducing abilities of blood neutrophils were determined; IgM, IgG, IL-6 and IL-8 concentrations in serum were also studied.The DAI index increased in non-treated UC, along with raised neutrophil numbers in blood, their absorption and NBT-reducing activity was also increased, the total number of lymphocytes, including CD3+, CD45RA+ became higher, serum concentrations of IgM, IgG, IL-6, IL-8 increased. Local use of vitamin D3 in UC reduces DAI parameters, causes decrease in blood neutrophil counts, reducing and partially restoring absorptive and NBT-reducing abilities of neutrophils, decline of total lymphocyte counts in blood, partially restoring the CD3+ and CD45RA+ numbers, causing decline and partial restoration of serum IgM, IgG, IL-6, IL-8 concentrations. An association between clinical signs and indexes of immune status in UC was established under the conditions of vitamin D3 use. Conclusions: The protective effect of vitamin D3 in UC can be mediated by its antioxidant effect, changes in production of immunoregulatory cytokines, modulation of Th1-, Th2-, Th17-dependent reactions and Treg activity, being a pre-requisite for further studies to clarify the mechanism of vitamin D3 immunotropic action in UC,with an opportunity of using it in clinical practice
ΠΠΊΠΎΠ³Π΅ΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈ Π±ΠΈΠΎΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΠΎΡΠ΅Π½ΠΊΠ° Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ ΠΌΠ°Π»ΡΡ ΡΠ΅ΠΊ Π³ΠΎΡΠΎΠ΄Π° ΠΠ΅ΡΠ΅Π·Π½ΠΈΠΊΠΈ
This paper presents an assessment of the state of the rivers Tolych, Zyryanka and Bygel, flowing within the area with a high technogenic impact (Berezniki, Perm krai). Water quality was evaluated using the integrated geochemical parameters. The characteristics of the macrozoobenthos have been studied as a bioindicator of the ecological state of the reservoir. The formation of the trace element composition and, consequently, water quality is associated with both natural and anthropogenic factors. The obtained metal pollution index (MI) demonstrates the unsuitability of water from rivers Tolych, Zyryanka, and Bygel for domestic purposes.Π Π΄Π°Π½Π½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠ΅ΠΊ Π’ΠΎΠ»ΡΡ, ΠΡΡΡΠ½ΠΊΠ° ΠΈ ΠΡΠ³Π΅Π»Ρ, ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠΈΡ
Π² Π·ΠΎΠ½Π΅ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ³Π΅Π½Π½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΎΠΉ (Π³. ΠΠ΅ΡΠ΅Π·Π½ΠΈΠΊΠΈ, ΠΠ΅ΡΠΌΡΠΊΠΈΠΉ ΠΊΡΠ°ΠΉ). ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° ΠΊΠ°ΡΠ΅ΡΡΠ²Π° Π²ΠΎΠ΄Ρ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½ΡΡ
Π³Π΅ΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΌΠ°ΠΊΡΠΎΠ·ΠΎΠΎΠ±Π΅Π½ΡΠΎΡΠ° ΠΈΠ·ΡΡΠ΅Π½Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±ΠΈΠΎΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ° ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π²ΠΎΠ΄ΠΎΡΠΎΠΊΠΎΠ². Π€ΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΈΠΊΡΠΎΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΠΈ, ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅, ΠΊΠ°ΡΠ΅ΡΡΠ²Π° Π²ΠΎΠ΄ ΡΠ²ΡΠ·Π°Π½ΠΎ ΠΊΠ°ΠΊ Ρ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ, ΡΠ°ΠΊ ΠΈ Ρ Π°Π½ΡΡΠΎΠΏΠΎΠ³Π΅Π½Π½ΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ. Π Π΄Π°Π½Π½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½Π° Π²Π°ΠΆΠ½ΠΎΡΡΡ Π²ΡΠ±ΠΎΡΠ° ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΊ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° Π²ΠΎΠ΄. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°ΡΡΠ΅ΡΠ° ΠΈΠ½Π΄Π΅ΠΊΡΠ° Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΌΠ΅ΡΠ°Π»Π»Π°ΠΌΠΈ (MI) Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ Π½Π΅ΠΏΡΠΈΠ³ΠΎΠ΄Π½ΠΎΡΡΡ Π²ΠΎΠ΄Π½ΡΡ
Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΡΡΡΠΎΠ² ΡΠ΅ΠΊ Π’ΠΎΠ»ΡΡ, ΠΡΡΡΠ½ΠΊΠ° ΠΈ ΠΡΠ³Π΅Π»Ρ Π΄Π»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΠΈΡΠ°Π½ΠΈΠΈ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
From colloidal CdSe quantum dots to microscale optically anisotropic supercrystals through bottom-up self-assembly
This is the author accepted manuscript. The final version is available on open access from Royal Society of Chemistry via the DOI in this recordThe development of fabrication techniques for novel nanostructured materials is one of the key tasks of modern materials science. One pathway to successfully complete this task is the bottom-up assembly of colloidal nanoparticles into ordered superstructures, possessing both the properties of individual nanoparticles and further novel properties resulting from their interactions. However, nanoparticle self-assembly depends on a variety of parameters, which makes the precise control of this process a complicated problem. Here, the time course of quantum dot (QD) self-assembly into ordered superstructures has been analyzed, along with the evolution of their morphological and optical properties. QD self-assembly occurs through two distinct stages (homo- and hetero-geneous), leading to the formation of supercrystals with a layered morphology. Analysis of the optical properties throughout the superstructuresβ growth has shown that the absorption and photoluminescence (PL) bands are blue shifted, retaining almost the same PL lifetimes as in the initial QD solution. The supercrystals formed possess a further unique optical property caused by their layered morphology; namely, a four-fold symmetry characterized by strong birefringence. Such supercrystals may be used for the fabrication of microscale optical paths with high extinction coefficients and specific polarization properties for novel optoelectronic devices.This study was supported by the Ministry of Education and
Science of the Russian Federation through the grant No.
14.584.21.0032 (ID RFMEFI58417X0032), the Engineering
and Physical Sciences Research Council (EPSRC) of the United
Kingdom via the EPSRC Centre for Doctoral Training in Electromagnetic
Metamaterials (Grant No. EP/L015331/1) and
via EP/N035569/1, and the Royal Society via International
Exchange Grant No. 2016/R1
Psychological features of the people subject to ASMR-to effect
In article, we considered a phenomenon of ASMR and its interrelation with the leading representative system, suggestibility degree, field dependence and field independence and touch sensitivity.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ ΡΠ΅Π½ΠΎΠΌΠ΅Π½ ΠΠ‘ΠΠ ΠΈ Π΅Π³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Ρ Π²Π΅Π΄ΡΡΠ΅ΠΉ ΡΠ΅ΠΏΡΠ΅Π·Π΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠΎΠΉ, ΡΡΠ΅ΠΏΠ΅Π½ΡΡ Π²Π½ΡΡΠ°Π΅ΠΌΠΎΡΡΠΈ, ΠΏΠΎΠ»Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡΡ-ΠΏΠΎΠ»Π΅Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡΡ ΠΈ ΡΠ΅Π½ΡΠΎΡΠ½ΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ
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