X-Ray Emission from the Warm Hot Intergalactic Medium

The number of detected baryons in the Universe at z<0.5 is much smaller than predicted by standard big bang nucleosynthesis and by the detailed observation of the Lyman alpha forest at red-shift z=2. Hydrodynamical simulations indicate that a large fraction of the baryons today is expected to be in a ``warm-hot'' (10^5-10^7K) filamentary gas, distributed in the intergalactic medium. This gas, if it exists, should be observable only in the soft X-ray and UV bands. Using the predictions of a particular hydrodynamic model, we simulated the expected X-ray flux as a function of energy in the 0.1-2 keV band due to the Warm-Hot Intergalactic Medium (WHIM), and compared it with the flux from local and high red-shift diffuse components. Our results show that as much as 20% of the total diffuse X-ray background (DXB) in the energy range 0.37-0.925keV could be due to X-ray flux from the WHIM, 70% of which comes from filaments at redshift z between 0.1 and 0.6. Simulations done using a FOV of 3', comparable with that of Suzaku and Constellation-X, show that in more than 20% of the observations we expect the WHIM flux to contribute to more than 20% of the DXB. These simulations also show that in about 10% of all the observations a single bright filament in the FOV accounts, alone, for more than 20% of the DXB flux. Red-shifted oxygen lines should be clearly visible in these observations.Comment: 19 pages, 6 figure

Measuring and modeling water-related soil-vegetation feedbacks in a fallow plot

Abstract. Land fallowing is one possible response to shortage of water for irrigation. Leaving the soil unseeded implies a change of the soil functioning that has an impact on the water cycle. The development of a soil crust in the open spaces between the patterns of grass weed affects the soil properties and the field-scale water balance. The objectives of this study are to test the potential of integrated non-invasive geophysical methods and ground-image analysis and to quantify the effect of the soil–vegetation interaction on the water balance of fallow land at the local- and plot scale. We measured repeatedly in space and time local soil saturation and vegetation cover over two small plots located in southern Sardinia, Italy, during a controlled irrigation experiment. One plot was left unseeded and the other was cultivated. The comparative analysis of ERT maps of soil moisture evidenced a considerably different hydrologic response to irrigation of the two plots. Local measurements of soil saturation and vegetation cover were repeated in space to evidence a positive feedback between weed growth and infiltration at the fallow plot. A simple bucket model captured the different soil moisture dynamics at the two plots during the infiltration experiment and was used to estimate the impact of the soil vegetation feedback on the yearly water balance at the fallow site

dfpk : An R-package for Bayesian dose-finding designs using Pharmacokinetics (PK) for phase I clinical trials

Background and objective Dose-finding, aiming at finding the maximum tolerated dose, and pharmacokinetics studies are the first in human studies in the development process of a new pharmacological treatment. In the literature, to date only few attempts have been made to combine pharmacokinetics and dose-finding and to our knowledge no software implementation is generally available. In previous papers, we proposed several Bayesian adaptive pharmacokinetics-based dose-finding designs in small populations. The objective of this work is to implement these dose-finding methods in an R package, called dfpk. Methods All methods were developed in a sequential Bayesian setting and Bayesian parameter estimation is carried out using the rstan package. All available pharmacokinetics and toxicity data are used to suggest the dose of the next cohort with a constraint regarding the probability of toxicity. Stopping rules are also considered for each method. The ggplot2 package is used to create summary plots of toxicities or concentration curves. Results For all implemented methods, dfpk provides a function (nextDose) to estimate the probability of efficacy and to suggest the dose to give to the next cohort, and a function to run trial simulations to design a trial (nsim). The sim.data function generates at each dose the toxicity value related to a pharmacokinetic measure of exposure, the AUC, with an underlying pharmacokinetic one compartmental model with linear absorption. It is included as an example since similar data-frames can be generated directly by the user and passed to nsim. Conclusion The developed user-friendly R package dfpk, available on the CRAN repository, supports the design of innovative dose-finding studies using PK information

A galaxy overdensity at z=0.401 associated with an X-ray emitting structure of Warm-Hot Intergalactic Medium

We present the results of spectroscopic observations of galaxies associated with the diffuse X-ray emitting structure discovered by Zappacosta et al. (2002). After measuring the redshifts of 161 galaxies, we confirm an overdensity of galaxies with projected dimensions of at least 2 Mpc, determine its spectroscopic redshift in z=0.401+/-0.002, and show that it is spatially coincident with the diffuse X-ray emission. This confirms the original claim that this X-ray emission has an extragalactic nature and is due to the Warm-Hot Intergalactic Medium (WHIM). We used this value of the redshift to compute the temperature of the emitting gas. The resulting value depends on the metallicity that is assumed for the IGM, and is constrained to be between 0.3 and 0.6 keV for metallicities between 0.05 and 0.3 solar, in good agreement with the expectations from the WHIM.Comment: 9 pages, A&A, in press, minor language change

Role of perfusion CT in the evaluation of metastatic nodal tumor response after radiochemotherapy in head and neck cancer: preliminary findings

OBJECTIVE: To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence. PATIENTS AND METHODS: Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated. PET/CT examination was also performed at baseline and 3 months after treatment for metabolic assessment. RESULTS: Between July 2012 and May 2016, 27 patients were evaluated. Overall, only 3 patients (11%) experienced tumor persistence in the largest metastatic lymph node. A significant reduction of all PCTp values (p<0.0001), except MTT (from 6.3 to 5.7 s; p=0.089), was observed at 3 weeks post-RT-CT compared to baseline. All PCTp values including MTT were significantly lower at 3-month follow-up compared to baseline (p<0.05). Moreover, a statistical significant association was observed between nodal tumor persistence and high BF values (p=0.045) at 3 months after treatment that did not occur for the other parameters. CONCLUSIONS: Our preliminary findings show that all PCTp except MTT are significantly reduced after RT-CT. High BF values at 3 months post-RTCT are predictive of nodal tumor persistence

Xmm-Newton Observations of the Diffuse X-ray Background

We analyzed two XMM-Newton observations in the direction of the high density, high latitude, neutral hydrogen cloud MBM20 and of a nearby low density region that we called the Eridanus hole. The cloud MBM20 is at a distance evaluated between 100 and 200 pc from the Sun and its density is sufficiently high to shield about 75% of the foreground emission in the 3/4 keV energy band.The combination of the two observations makes possible an evaluation of the OVII and OVIII emission both for the foreground component due to the Local Bubble,and the background one, due primary to the galactic halo.The two observations are in good agreement with each other and with ROSAT observations of the same part of the sky and the OVII and OVIII fluxes are OVII=3.89+/-0.56 photons cm^-2 s^-1 sr^-1, OVIII=0.68+/-0.24 photons cm^-2 s^-1 sr^-1 for MBM20 and OVII=7.26+/-0.34 photons cm^-2 s^-1 sr^-1,OVIII=1.63+/-0.17 photons cm^-2 s^-1 sr^-1 for the Eridanus hole. The spectra are in agreement with a simple three component model, one unabsorbed and one absorbed plasma component, and a power law, without evidence for any strong contamination from ion exchange in the solar system. Assuming that the two plasma components are in thermal equilibrium we obtain a temperature of 0.096 keV for the foreground component and 0.197 keV for the background one. Assuming the foreground component is due solely to Local Bubble emission we obtain a lower and upper limit for the plasma density of 0.0079 cm^-3 and 0.0095 cm^-3 and limits of 16,200 cm^-3 K and 19,500 cm^-3 K for the plasma pressure, in good agreement with theoretical predictions. Similarly, assuming that the absorbed plasma component is due to Galactic halo emission, we obtain a plasma density ranging from 0.0009 cm^-3 to 0.0016 cm^-3, and a pressure ranging from 3.0*10^3 to 6.7*10^3 cm^-3 K.Comment: 31 pages, 5 figures, Accepted for publication in Ap

A preliminary census of engineering activities located in Sicily (Southern Italy) which may “potentially” induce seismicity

The seismic events caused by human engineering activities are commonly termed as “triggered” and “induced”. This class of earthquakes, though characterized by low-to-moderate magnitude, have significant social and eco- nomical implications since they occur close to the engineering activity responsible for triggering/inducing them and can be felt by the inhabitants living nearby, and may even produce damage. One of the first well-documented examples of induced seismicity was observed in 1932 in Algeria, when a shallow magnitude 3.0 earthquake occurred close to the Oued Fodda Dam. By the continuous global improvement of seismic monitoring networks, numerous other examples of human-induced earthquakes have been identified. Induced earthquakes occur at shallow depths and are related to a number of human activities, such as fluid injection under high pressure (e.g. waste-water disposal in deep wells, hydrofracturing activities in enhanced geothermal systems and oil recovery, shale-gas fracking, natural and CO2 gas storage), hydrocarbon exploitation, groundwater extraction, deep underground mining, large water impoundments and underground nuclear tests. In Italy, induced/triggered seismicity is suspected to have contributed to the disaster of the Vajont dam in 1963. Despite this suspected case and the presence in the Italian territory of a large amount of engineering activities “capable” of inducing seismicity, no extensive researches on this topic have been conducted to date. Hence, in order to improve knowledge and correctly assess the potential hazard at a specific location in the future, here we started a preliminary study on the entire range of engineering activities currently located in Sicily (Southern Italy) which may “potentially” induce seismicity. To this end, we performed: • a preliminary census of all engineering activities located in the study area by collecting all the useful information coming from available on-line catalogues; • a detailed compilation of instrumental and historical seismicity, focal mechanisms solutions, multidisciplinary stress indicators, GPS-based ground deformation field, mapped faults, etc by merging data from on-line catalogues with those reported in literature. Finally, for each individual site, we analysed: i) long-term statistic behaviour of instrumental seismicity (mag- nitude of completeness, seismic release above a threshold magnitude, depth distribution, focal plane solutions); ii) long-term statistic behaviour of historical seismicity (maximum magnitude estimation, recurrence time inter- val, etc); iii) properties and orientation of faults (length, estimated geological slip, kinematics, etc); iv) regional stress (from borehole, seismological and geological observations) and strain (from GPS-based observations) fields.UnpublishedVienna (Austria)6T. Sismicità indotta e caratterizzazione sismica dei sistemi naturaliope

Incorporating dose–volume histogram parameters of swallowing organs at risk in a videofluoroscopy-based predictive model of radiation-induced dysphagia after head and neck cancer intensity-modulated radiation therapy

Purpose: To develop a&nbsp;videofluoroscopy-based predictive model of radiation-induced dysphagia (RID) by incorporating DVH parameters of swallowing organs at risk (SWOARs) in a&nbsp;machine learning analysis. Methods: Videofluoroscopy (VF) was performed to assess the penetration-aspiration score&nbsp;(P/A) at baseline and at 6 and 12&nbsp;months after RT. An RID predictive model was developed using dose to nine SWOARs and P/A-VF data at 6&nbsp;and 12 months after treatment. A&nbsp;total of 72&nbsp;dosimetric features for each patient were extracted from DVH and analyzed with linear support vector machine classification (SVC), logistic regression classification (LRC), and random forest classification (RFC). Results: 38&nbsp;patients were evaluable. The relevance of SWOARs DVH features emerged both at 6 months (AUC 0.82 with SVC; 0.80 with LRC; and 0.83 with RFC) and at 12 months (AUC 0.85 with SVC; 0.82 with LRC; and 0.94 with RFC). The SWOARs and the corresponding features with the highest relevance at 6 months resulted as the base of tongue (V65 and Dmean), the superior (Dmean) and medium constrictor muscle (V45, V55; V65; Dmp; Dmean; Dmax and Dmin), and the parotid glands (Dmean and Dmp). On the contrary, the features with the highest relevance at 12 months were the medium (V55; Dmin and Dmean) and inferior constrictor muscles (V55, V65 Dmin and Dmax), the glottis (V55 and Dmax), the cricopharyngeal muscle (Dmax), and the cervical esophagus (Dmax). Conclusion: We trained and cross-validated an&nbsp;RID predictive model with high discriminative ability at both 6&nbsp;and 12 months after RT. We expect to improve the predictive power of this model by enlarging the number of training datasets

The role of clinicopathologic and molecular prognostic factors in the post-mastectomy radiotherapy (PMRT): a retrospective analysis of 912 patients

OBJECTIVE: To assess the association of clinicopathologic and molecular features with loco-regional recurrence (LRR) in post-mastectomy breast cancer patients with or without adjuvant radiotherapy (PMRT). PATIENTS AND METHODS: We retrospectively reviewed data of patients undergone to mastectomy followed or not by PMRT between January 2004 and June 2013. The patients were divided according to clinicopathologic and molecular sub-classification features. LRR and Cancer Specific Survival (CSS) were calculated using the Kaplan-Meier method; the prognostic factors were compared using long-rank tests and Cox regression model. RESULTS: A total of 912 patients underwent to mastectomy of whom 269 (29.5%) followed by PMRT and 643 (70.5%) not; among the PMRT group, 77 underwent to the chest wall (CW) and 202 to the chest wall and lymphatic drainage (CWLD) irradiation. The median follow-up was 54 months (range, 3-118). No significant difference in terms of LRR and CSS was found between non-PMRT and PMRT group (p=0.175; and p=0.628). The multivariate analysis of LRR for patients who did not undergo PMRT showed a significant correlation with the presence of extracapsular extension (ECE) (p=0.049), Ki-67>30% (p=0.048) and triple negative status (p=0.001). In the PMRT group, triple negative status resulted as the only variable significantly correlated to LRR (p=0.006) at the multivariate analysis and T-stage also showed a trend to significance (p=0.073). Finally, no difference in LRR control was shown between CW and CWLD-PMRT (p=0.078). CONCLUSIONS: After mastectomy ECE, a cut off of Ki-67>30% and triple negative status werestrictly correlated with LRR regardless of clinicopathologic stage. PMRT has a positive impact in decreasing LRR in patients with this molecular profile. Besides, CW might represent a valid option for patients with one to three positive nodes