707 research outputs found
Quantum teleportation and entanglement swapping with linear optics logic gates
We report on the usage of a linear optics phase gate for distinguishing all
four Bell states simultaneously in a quantum teleportation and entanglement
swapping protocol. This is demonstrated by full state tomography of the one and
two qubit output states of the two protocols, yielding average state fidelities
of about 0.83 and 0.77, respectively. In addition, the performance of the
teleportation channel is characterised by quantum process tomography. The non
classical properties of the entanglement swapping output states are further
confirmed by the violation of a CHSH-type Bell inequality of 2.14 on average.Comment: 11 pages, 3 figure
High-fidelity transmission of entanglement over a high-loss freespace channel
Quantum entanglement enables tasks not possible in classical physics. Many
quantum communication protocols require the distribution of entangled states
between distant parties. Here we experimentally demonstrate the successful
transmission of an entangled photon pair over a 144 km free-space link. The
received entangled states have excellent, noise-limited fidelity, even though
they are exposed to extreme attenuation dominated by turbulent atmospheric
effects. The total channel loss of 64 dB corresponds to the estimated
attenuation regime for a two-photon satellite quantum communication scenario.
We confirm that the received two-photon states are still highly entangled by
violating the CHSH inequality by more than 5 standard deviations. From a
fundamental point of view, our results show that the photons are virtually not
subject to decoherence during their 0.5 ms long flight through air, which is
encouraging for future world-wide quantum communication scenarios.Comment: 5 pages, 3 figures, replaced paper with published version, added
journal referenc
Attacks on quantum key distribution protocols that employ non-ITS authentication
We demonstrate how adversaries with unbounded computing resources can break
Quantum Key Distribution (QKD) protocols which employ a particular message
authentication code suggested previously. This authentication code, featuring
low key consumption, is not Information-Theoretically Secure (ITS) since for
each message the eavesdropper has intercepted she is able to send a different
message from a set of messages that she can calculate by finding collisions of
a cryptographic hash function. However, when this authentication code was
introduced it was shown to prevent straightforward Man-In-The-Middle (MITM)
attacks against QKD protocols.
In this paper, we prove that the set of messages that collide with any given
message under this authentication code contains with high probability a message
that has small Hamming distance to any other given message. Based on this fact
we present extended MITM attacks against different versions of BB84 QKD
protocols using the addressed authentication code; for three protocols we
describe every single action taken by the adversary. For all protocols the
adversary can obtain complete knowledge of the key, and for most protocols her
success probability in doing so approaches unity.
Since the attacks work against all authentication methods which allow to
calculate colliding messages, the underlying building blocks of the presented
attacks expose the potential pitfalls arising as a consequence of non-ITS
authentication in QKD-postprocessing. We propose countermeasures, increasing
the eavesdroppers demand for computational power, and also prove necessary and
sufficient conditions for upgrading the discussed authentication code to the
ITS level.Comment: 34 page
Positive association between mammographic breast density and bone mineral density in the Postmenopausal Estrogen/Progestin Interventions Study
INTRODUCTION: Mammographic breast density is a strong independent risk factor for breast cancer. We hypothesized that demonstration of an association between mammographic breast density and bone mineral density (BMD) would suggest a unifying underlying mechanism influencing both breast density and BMD. METHODS: In a cross-sectional analysis of baseline data from the Postmenopausal Estrogen/Progestin Interventions Study (PEPI), participants were aged 45 to 64 years and were at least 1 year postmenopausal. Mammographic breast density (percentage of the breast composed of dense tissue), the outcome, was assessed with a computer-assisted percentage-density method. BMD, the primary predictor, was measured with dual-energy X-ray absorptiometry. Women quitting menopausal hormone therapy to join PEPI were designated recent hormone users. RESULTS: The mean age of the 594 women was 56 years. The average time since menopause was 5.6 years. After adjustment for age, body mass index, and cigarette smoking, in women who were not recent hormone users before trial enrollment (n = 415), mammographic density was positively associated with total hip (P = 0.04) and lumbar (P = 0.08) BMD. Mammographic density of recent hormone users (n = 171) was not significantly related to either total hip (P = 0.51) or lumbar (P = 0.44) BMD. In participants who were not recent hormone users, mammographic density was 4% greater in the highest quartile of total hip BMD than in the lowest. In participants who were not recent hormone users, mammographic density was 5% greater in the highest quartile of lumbar spine BMD than in the lowest. CONCLUSION: Mammographic density and BMD are positively associated in women who have not recently used postmenopausal hormones. A unifying biological mechanism may link mammographic density and BMD. Recent exogenous postmenopausal hormone use may obscure the association between mammographic density and BMD by having a persistent effect on breast tissue
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
Introduction
Mammographic density (MD), as assessed from film screen mammograms, is determined by the relative content of adipose, connective and epithelial tissue in the female breast. In epidemiological studies, a high percentage of MD confers a four to six fold risk elevation of developing breast cancer, even after adjustment for other known breast cancer risk factors. However, the biologic correlates of density are little known.
Methods
Gene expression analysis using whole genome arrays was performed on breast biopsies from 143 women; 79 women with no malignancy (healthy women) and 64 newly diagnosed breast cancer patients, both included from mammographic centres. Percent MD was determined using a previously validated, computerized method on scanned mammograms. Significance analysis of microarrays (SAM) was performed to identify genes influencing MD and a linear regression model was used to assess the independent contribution from different variables to MD.
Results
SAM-analysis identified 24 genes differentially expressed between samples from breasts with high and low MD. These genes included three uridine 5'-diphospho-glucuronosyltransferase (UGT) genes and the oestrogen receptor gene (ESR1). These genes were down-regulated in samples with high MD compared to those with low MD. The UGT gene products, which are known to inactivate oestrogen metabolites, were also down-regulated in tumour samples compared to samples from healthy individuals. Several single nucleotide polymorphisms (SNPs) in the UGT genes associated with the expression of UGT and other genes in their vicinity were identified.
Conclusions
Three UGT enzymes were lower expressed both in breast tissue biopsies from healthy women with high MD and in biopsies from newly diagnosed breast cancers. The association was strongest amongst young women and women using hormonal therapy. UGT2B10 predicts MD independently of age, hormone therapy and parity. Our results indicate that down-regulation of UGT genes in women exposed to female sex hormones is associated with high MD and might increase the risk of breast cancer
De Broglie Wavelength of a Nonlocal Four-Photon
Superposition is one of the most distinct features of quantum theory and has
been demonstrated in numerous realizations of Young's classical double-slit
interference experiment and its analogues. However, quantum entanglement - a
significant coherent superposition in multiparticle systems - yields phenomena
that are much richer and more interesting than anything that can be seen in a
one-particle system. Among them, one important type of multi-particle
experiments uses path-entangled number-states, which exhibit pure higher-order
interference and allow novel applications in metrology and imaging such as
quantum interferometry and spectroscopy with phase sensitivity at the
Heisenberg limit or quantum lithography beyond the classical diffraction limit.
Up to now, in optical implementations of such schemes lower-order interference
effects would always decrease the overall performance at higher particle
numbers. They have thus been limited to two photons. We overcome this
limitation and demonstrate a linear-optics-based four-photon interferometer.
Observation of a four-particle mode-entangled state is confirmed by
interference fringes with a periodicity of one quarter of the single-photon
wavelength. This scheme can readily be extended to arbitrary photon numbers and
thus represents an important step towards realizable applications with
entanglement-enhanced performance.Comment: 19 pages, 4 figures, submitted on November 18, 200
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