Trapping dust particles in the outer regions of protoplanetary disks

Aims. We attempt to explain grain growth to mm sized particles and their retention in the outer regions of protoplanetary disks, as observed at sub-mm and mm wavelengths, by investigating whether strong inhomogeneities in the gas density profiles can decelerate excessive radial drift and help the dust particles to grow. Methods. We use coagulation/fragmentation and disk-structure models, to simulate the evolution of dust in a bumpy surface density profile, which we mimic with a sinusoidal disturbance. For different values of the amplitude and length scale of the bumps, we investigate the ability of this model to produce and retain large particles on million-year timescales. In addition, we compare the pressure inhomogeneities considered in this work with the pressure profiles that come from magnetorotational instability. Using the Common Astronomy Software Applications ALMA simulator, we study whether there are observational signatures of these pressure inhomogeneities that can be seen with ALMA. Results. We present the conditions required to trap dust particles and the corresponding calculations predicting the spectral slope in the mm-wavelength range, to compare with current observations. Finally, we present simulated images using different antenna configurations of ALMA at different frequencies, to show that the ring structures will be detectable at the distances of either the Taurus Auriga or Ophiucus star-forming regions

Tracing planet-induced structures in circumstellar disks using molecular lines

Circumstellar disks are considered to be the birthplace of planets. Specific structures like spiral arms, gaps, and cavities are characteristic indicators of planet-disk interaction. Investigating these structures can provide insights into the growth of protoplanets and the physical properties of the disk. We investigate the feasibility of using molecular lines to trace planet-induced structures in circumstellar disks. Based on 3D hydrodynamic simulations of planet-disk interactions, we perform self-consistent temperature calculations and produce N-LTE molecular line velocity-channel maps and spectra of these disks using our new N-LTE line radiative transfer code Mol3D. Subsequently, we simulate ALMA observations using the CASA simulator. We consider two nearly face-on inclinations, 5 disk masses, 7 disk radii, and 2 different typical pre-main-sequence host stars (T Tauri, Herbig Ae). We calculate up to 141 individual velocity-channel maps for five molecules/isotopoloques in a total of 32 rotational transitions to investigate the frequency dependence of the structures indicated above. We find that the majority of protoplanetary disks in our parameter space could be detected in the molecular lines considered. However, unlike the continuum case, gap detection is not straightforward in lines. For example, gaps are not seen in symmetric rings but are masked by the pattern caused by the global (Keplerian) velocity field. We identify specific regions in the velocity-channel maps that are characteristic of planet-induced structures. Simulations of high angular resolution molecular line observations demonstrate the potential of ALMA to provide complementary information about the planet-disk interaction as compared to continuum observations. In particular, the detection of planet-induced gaps is possible under certain conditions.(abridged)Comment: 19 pages, 19 figures, accepted for publication in A&

Boundedness of Pseudodifferential Operators on Banach Function Spaces

We show that if the Hardy-Littlewood maximal operator is bounded on a separable Banach function space $X(\mathbb{R}^n)$ and on its associate space $X'(\mathbb{R}^n)$, then a pseudodifferential operator $\operatorname{Op}(a)$ is bounded on $X(\mathbb{R}^n)$ whenever the symbol $a$ belongs to the H\"ormander class $S_{\rho,\delta}^{n(\rho-1)}$ with $0<\rho\le 1$, $0\le\delta<1$ or to the the Miyachi class $S_{\rho,\delta}^{n(\rho-1)}(\varkappa,n)$ with $0\le\delta\le\rho\le 1$, $0\le\delta0$. This result is applied to the case of variable Lebesgue spaces $L^{p(\cdot)}(\mathbb{R}^n)$.Comment: To appear in a special volume of Operator Theory: Advances and Applications dedicated to Ant\'onio Ferreira dos Santo

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.

A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of the ZAP-70 protein tyrosine kinase with the TCR complex. Human T cell leukemia virus type I-transformed CD4+ T cell lines were established from ZAP-70-deficient patients and normal controls. ZAP-70 was expressed and appropriately phosphorylated in normal T cell lines after TCR engagement, but was not detected in T cell lines from ZAP-70-deficient patients. To determine whether signaling could be reconstituted, wild-type ZAP-70 was introduced into deficient cells with a ZAP-70 retroviral vector. High titer producer clones expressing ZAP-70 were generated in the Gibbon ape leukemia virus packaging line PG13. After transduction, ZAP-70 was detected at levels equivalent to those observed in normal cells, and was appropriately phosphorylated on tyrosine after receptor engagement. The kinase activity of ZAP-70 in the reconstituted cells was also appropriately upregulated by receptor aggregation. Moreover, normal and transduced cells, but not ZAP-70-deficient cells, were able to mobilize calcium after receptor ligation, indicating that proximal TCR signaling was reconstituted. These results indicate that this form of SCID may be corrected by gene therapy

An efficient and robust procedure to calculate absorption spectra of aqueous charged species applied to NO2−

Accurate calculation of absorption spectra of aqueous NO2−requires rigorously sampling the quantum potential energy surfaces for microsolvation of NO2−with at least five explicit water molecules and embedding the resulting clusters in a continuum solvent accounting for the statistical weighted contributions of individual isomers. This method, which we address as ASCEC + PCM, introduces several desired features when compared against MD simulations derived QM/MM spectra: comparatively fewer explicit solvent molecules to be treated with expensive QM methods, the identification of equilibrium structures in the quantum PES to be used in further vibrational spectroscopy, and the unequivocal identification of cluster orbitals undergoing electronic transitions and charge transfer that originate the spectral bands

Evidence for spin-triplet superconducting correlations in metal-oxide heterostructures with non-collinear magnetization

Heterostructures composed of ferromagnetic La0.7Sr0.3MnO3, ferromagnetic SrRuO3, and superconducting YBa2Cu3Ox were studied experimentally. Structures of composition Au/La0.7Sr0.3MnO3/SrRuO3/YBa2Cu3Ox were prepared by pulsed laser deposition, and their high quality was confirmed by X-ray diffraction and reflectometry. A non-collinear magnetic state of the heterostructures was revealed by means of SQUID magnetometry and polarized neutron reflectometry. We have further observed superconducting currents in mesa-structures fabricated by deposition of a second superconducting Nb layer on top of the heterostructure, followed by patterning with photolithography and ion-beam etching. Josephson effects observed in these mesa-structures can be explained by the penetration of a triplet component of the superconducting order parameter into the magnetic layers.Comment: 10 pages, 6 figure

Micromachined Oblique Incidence Refleciometry (OIR) Probe for Skin Cancer Detection

We present the design, fabrication and in-vivo testing of a new micromachined probe for skin cancer detection based on oblique incidence reflectometry (OIR). The device miniaturization and fabrication precision provided by micromachining ensure reliable and repeatable high performance of the probe. The developed probe has been tested in a pre-clinical condition. An overall sensitivity of 100% and specificity of 93% haven been achieved in the classification of malignant and benign skin lesions

Legendrian Distributions with Applications to Poincar\'e Series

Let $X$ be a compact Kahler manifold and $L\to X$ a quantizing holomorphic Hermitian line bundle. To immersed Lagrangian submanifolds $\Lambda$ of $X$ satisfying a Bohr-Sommerfeld condition we associate sequences $\{ |\Lambda, k\rangle \}_{k=1}^\infty$, where $\forall k$ $|\Lambda, k\rangle$ is a holomorphic section of $L^{\otimes k}$. The terms in each sequence concentrate on $\Lambda$, and a sequence itself has a symbol which is a half-form, $\sigma$, on $\Lambda$. We prove estimates, as $k\to\infty$, of the norm squares $\langle \Lambda, k|\Lambda, k\rangle$ in terms of $\int_\Lambda \sigma\overline{\sigma}$. More generally, we show that if $\Lambda_1$ and $\Lambda_2$ are two Bohr-Sommerfeld Lagrangian submanifolds intersecting cleanly, the inner products $\langle\Lambda_1, k|\Lambda_2, k\rangle$ have an asymptotic expansion as $k\to\infty$, the leading coefficient being an integral over the intersection $\Lambda_1\cap\Lambda_2$. Our construction is a quantization scheme of Bohr-Sommerfeld Lagrangian submanifolds of $X$. We prove that the Poincar\'e series on hyperbolic surfaces are a particular case, and therefore obtain estimates of their norms and inner products.Comment: 41 pages, LaTe

A Double Fragmentation Approach for Improving Virtual Primary Key-Based Watermark Synchronization

Relational data watermarking techniques using virtual primary key schemes try to avoid compromising watermark detection due to the deletion or replacement of the relation's primary key. Nevertheless, these techniques face the limitations that bring high redundancy of the generated set of virtual primary keys, which often compromises the quality of the embedded watermark. As a solution to this problem, this paper proposes double fragmentation of the watermark by using the existing redundancy in the set of virtual primary keys. This way, we guarantee the right identification of the watermark despite the deletion of any of the attributes of the relation. The experiments carried out to validate our proposal show an increment between 81.04% and 99.05% of detected marks with respect to previous solutions found in the literature. Furthermore, we found out that our approach takes advantage of the redundancy present in the set of virtual primary keys. Concerning the computational complexity of the solution, we performed a set of scalability tests that show the linear behavior of our approach with respect to the processes runtime and the number of tuples involved, making it feasible to use no matter the amount of data to be protected

HQR-Scheme: A High Quality and resilient virtual primary key generation approach for watermarking relational data

Most of the watermarking techniques designed to protect relational data often use the Primary Key (PK) of relations to perform the watermark synchronization. Despite offering high confidence to the watermark detection, these approaches become useless if the PK can be erased or updated. A typical example is when an attacker wishes to use a stolen relation, unlinked to the rest of the database. In that case, the original values of the PK lose relevance, since they are not employed to check the referential integrity. Then, it is possible to erase or replace the PK, compromising the watermark detection with no need to perform the slightest modification on the rest of the data. To avoid the problems caused by the PK-dependency some schemes have been proposed to generate Virtual Primary Keys (VPK) used instead. Nevertheless, the quality of the watermark synchronized using VPKs is compromised due to the presence of duplicate values in the set of VPKs and the fragility of the VPK schemes against the elimination of attributes. In this paper, we introduce the metrics to allow precise measuring of the quality of the VPKs generated by any scheme without requiring to perform the watermark embedding. This way, time waste can be avoided in case of low-quality detection. We also analyze the main aspects to design the ideal VPK scheme, seeking the generation of high-quality VPK sets adding robustness to the process. Finally, a new scheme is presented along with the experiments carried out to validate and compare the results with the rest of the schemes proposed in the literature