5,865 research outputs found
Exercise and progressive supranuclear palsy : the need for explicit exercise reporting
Background
Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercises in PSP, the quality of reporting of exercise therapies appears mixed. The current investigation aims to evaluate the comprehensiveness of reporting of exercise and physical activity interventions in the PSP literature.
Methods
Two independent reviewers used the Consensus on Exercise Reporting Template (CERT) to extract all exercise intervention data from 11 studies included in a systematic review. CERT items covered: ‘what’ (materials), ‘who’ (instructor qualifications), ‘how’ (delivery), ‘where’ (location), ‘when’, ‘how much’ (dosage), ‘tailoring’ (what, how), and ‘how well’ (fidelity) exercise delivery complied with the protocol. Each exercise item was scored ‘1’ (adequately reported) or ‘0’ (not adequately reported or unclear). The CERT score was calculated, as well as the percentage of studies that reported each CERT item.
Results
The CERT scores ranged from 3 to 12 out of 19. No PSP studies adequately described exercise elements that would allow exact replication of the interventions. Well-described items included exercise equipment, exercise settings, exercise therapy scheduling, frequency and duration. Poorly described items included decision rules for exercise progression, instructor qualifications, exercise adherence, motivation strategies, safety and adverse events associated with exercise therapies.
Discussion
The results revealed variability in the reporting of physical therapies for people living with PSP. Future exercise trials need to more comprehensively describe equipment, instructor qualifications, exercise and physical activity type, dosage, setting, individual tailoring of exercises, supervision, adherence, motivation strategies, progression decisions, safety and adverse events.
Conclusion
Although beneficial for people living with PSP, exercise and physical therapy interventions have been inadequately reported. It is recommended that evidence-based reporting templates be utilised to comprehensively document therapeutic exercise design, delivery and evaluation
Space Trajectory Error Analysis Program (STEAP) for halo orbit missions. Volume 2: Programmer's manual
The six month effort was responsible for the development, test, conversion, and documentation of computer software for the mission analysis of missions to halo orbits about libration points in the earth-sun system. The software consisting of two programs called NOMNAL and ERRAN is part of the Space Trajectories Error Analysis Programs. The program NOMNAL targets a transfer trajectory from earth on a given launch date to a specified halo orbit on a required arrival date. Either impulsive or finite thrust insertion maneuvers into halo orbit are permitted by the program. The transfer trajectory is consistent with a realistic launch profile input by the user. The second program ERRAN conducts error analyses of the targeted transfer trajectory. Measurements including range, doppler, star-planet angles, and apparent planet diameter are processed in a Kalman-Schmidt filter to determine the trajectory knowledge uncertainty
Imaging Photon Lattice States by Scanning Defect Microscopy
Microwave photons inside lattices of coupled resonators and superconducting
qubits can exhibit surprising matter-like behavior. Realizing such open-system
quantum simulators presents an experimental challenge and requires new tools
and measurement techniques. Here, we introduce Scanning Defect Microscopy as
one such tool and illustrate its use in mapping the normal-mode structure of
microwave photons inside a 49-site Kagome lattice of coplanar waveguide
resonators. Scanning is accomplished by moving a probe equipped with a sapphire
tip across the lattice. This locally perturbs resonator frequencies and induces
shifts of the lattice resonance frequencies which we determine by measuring the
transmission spectrum. From the magnitude of mode shifts we can reconstruct
photon field amplitudes at each lattice site and thus create spatial images of
the photon-lattice normal modes
Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Streptococcus
Background:
A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was
associated with a six month upsurge in invasive GAS disease in the UK. The epidemic lineage
(Lineage C) had lost two typical emm3 prophages, Φ315.1 and Φ315.2 associated with the
superantigen ssa, but gained a different prophage (ΦUK-M3.1) associated with a different
superantigen, speC and a DNAse spd1.
Methods and Results:
The presence of speC and spd1 in Lineage C ST15 strains enhanced both in vitro mitogenic
and DNAse activities over non-Lineage C ST15 strains. Invasive disease models in Galleria
mellonella and SPEC-sensitive transgenic mice, revealed no difference in overall invasiveness
of Lineage C ST15 strains compared to non-Lineage C ST15 strains, consistent with clinical
and epidemiological analysis. Lineage C strains did however markedly prolong murine nasal
infection with enhanced nasal and airborne shedding compared to non-Lineage C strains.
Deletion of speC or spd1 in two Lineage C strains identified a possible role for spd1 in airborne
shedding from the murine nasopharynx.
Conclusions:
Nasopharyngeal infection and shedding of Lineage C strains was enhanced compared to nonLineage
C strains and this was, in part, mediated by the gain of the DNase spd1 through prophage acquisition
Advanced Interval Management (IM) Concepts of Operations
This document provides a high-level description of several advanced IM operations that NASA is considering for future research and development. It covers two versions of IM-CSPO and IM with Wake Mitigation. These are preliminary descriptions to support an initial benefits analysi
Low Voltage Electrical Stimulation of Beef Carcasses Slows Carcass Chilling Rate and Improves Steak Color
The objective of this study was to evaluate the influence of two levels of low voltage electrical stimulation (ES) on temperature decline, pH, and meat quality
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