STUDY ON NUTRITIONAL AND ELEMENTAL ANALYSIS OF THE SEAWEEDS OF NORTHERN SAMAR, PHILIPINES

The purpose of the study: In this work, the nutritional and elemental analysis of seaweeds in Northern Samar is analyzed. Methodology: The seaweeds of Northern Samar are collected from the intertidal zone, and it was brought back to the College of Science for taxonomic identity.   The nutritional and elemental content of the seaweeds were determined. Main findings: Based on the results obtained a total of 39 species belonging to eighteen (18) families of seaweeds were recorded from different coastal towns in Northern Samar, Philippines.  The results revealed that for seaweeds with the economic value the nutritional and elemental content is comparable to the unknown seaweeds with no economic value.     Implications: The results of the bioavailability of nutrients of this study might be the basis that unknown seaweeds with no economic value can be used directly in the diet and promote health advantage. Originality/Novelty of study: The seaweeds of Northern Samar are not properly documented in comparison with other marine flora.  The results demonstrated that some species of seaweeds collected in Northern Samar with no economic value could also accumulate non-essential elements.  Further studies would surely be a great contribution to our local food and pharmaceutical industries.&nbsp

The subchondral bone in articular cartilage repair: current problems in the surgical management

As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the articular surface only. It is becoming apparent that without support from an intact subchondral bed, any treatment of the surface chondral lesion is likely to fail. This article reviews issues affecting the entire osteochondral unit, such as subchondral changes after marrow-stimulation techniques and meniscectomy or large osteochondral defects created by prosthetic resurfacing techniques. Also discussed are surgical techniques designed to address these issues, including the use of osteochondral allografts, autologous bone grafting, next generation cell-based implants, as well as strategies after failed subchondral repair and problems specific to the ankle joint. Lastly, since this area remains in constant evolution, the requirements for prospective studies needed to evaluate these emerging technologies will be reviewed

Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders

Purpose: This study aims to comprehensively delineate the phenotypic spectrum of ACTL6B-related disorders, previously associated with both autosomal recessive and autosomal dominant neurodevelopmental disorders. Molecularly, the role of the nucleolar protein ACTL6B in contributing to the disease has remained unclear. Methods: We identified 105 affected individuals, including 39 previously reported cases, and systematically analyzed detailed clinical and genetic data for all individuals. Additionally, we conducted knockdown experiments in neuronal cells to investigate the role of ACTL6B in ribosome biogenesis. Results: Biallelic variants in ACTL6B are associated with severe-to-profound global developmental delay/intellectual disability, infantile intractable seizures, absent speech, autistic features, dystonia, and increased lethality. De novo monoallelic variants result in moderate-to-severe global developmental delay/intellectual disability, absent speech, and autistic features, whereas seizures and dystonia were less frequently observed. Dysmorphic facial features and brain abnormalities, including hypoplastic corpus callosum, and parenchymal volume loss/atrophy, are common findings in both groups. We reveal that in the nucleolus, ACTL6B plays a crucial role in ribosome biogenesis, particularly in pre-rRNA processing. Conclusion: This study provides a comprehensive characterization of the clinical spectrum of both autosomal recessive and dominant forms of ACTL6B-associated disorders. It offers a comparative analysis of their respective phenotypes provides a plausible molecular explanation and suggests their inclusion within the expanding category of “ribosomopathies.”<p/

Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders.

PURPOSE: This study aims to comprehensively delineate the phenotypic spectrum of ACTL6B-related disorders, previously associated with both autosomal recessive and autosomal dominant neurodevelopmental disorders. Molecularly, the role of the nucleolar protein ACTL6B in contributing to the disease has remained unclear. METHODS: We identified 105 affected individuals, including 39 previously reported cases, and systematically analysed detailed clinical and genetic data for all individuals. Additionally, we conducted knockdown experiments in neuronal cells to investigate the role of ACTL6B in ribosome biogenesis. RESULTS: Biallelic variants in ACTL6B are associated with severe-to-profound global developmental delay/intellectual disability (GDD/ID), infantile intractable seizures, absent speech, autistic features, dystonia, and increased lethality. De novo monoallelic variants result in moderate-to-severe GDD/ID, absent speech, and autistic features, while seizures and dystonia were less frequently observed. Dysmorphic facial features and brain abnormalities, including hypoplastic corpus callosum, parenchymal volume loss/atrophy, are common findings in both groups. We reveal that in the nucleolus, ACTL6B plays a crucial role in ribosome biogenesis, in particular in pre-rRNA processing. CONCLUSION: This study provides a comprehensive characterization of the clinical spectrum of both autosomal recessive and dominant forms of ACTL6B-associated disorders. It offers a comparative analysis of their respective phenotypes provides a plausible molecular explanation and suggests their inclusion within the expanding category of 'ribosomopathies'

Small mammals and Foraminifera from the Anatolian (Central Taurus) Early Miocene

The age of the terrestrial clastics of the Derincay Formation that outcrop widely in the Mut region is controversial. In an attempt to resolve their age, small mammals have been collected at the locality Yapinti from the lacustrine mudstones in this formation. This assemblage contains Enginia cf. E. gertcheki, Cricetodon cf. C. kasapligili, Cricetodon aff. C. aliveriensis, Megacricetodon collongensis, Democricetodon sp., Karydomys n.sp., Eumyarion sp., Tamias sp. Gliridae gen. et sp. indet, Sayimys sp., Albertona n.sp., Galerix uenayae, Talpidae gen. et sp. indet, Oligosorex sp., Soricidae gen. et sp. indet. This association suggests an Early Miocene Age (MN3 to early MN4) which roughly correlates with the middle Burdigalian (+/-18 Ma). The Yapinti assemblage is of special interest because the continental deposits of the Derincay Formation that yielded the rodents are disconformably overlain by the marine Mut and Koselerli formations assigned to the late Burdigalian on the basis of planktonic Foraminifera, which is a first order correlation between continental and marine deposits

The rodent fauna from the Adapazari pull-apart basin (NW Anatolia): its bearings on the age of the North Anatolian fault

3rd International Turkish Geology Symposium -- AUG 31-SEP 04, 1998 -- MIDDLE EAST TECHN UNIV, ANKARA, TURKEYTo the east of the Sea of Marmara, the North Anatolian fault (NAF) branches into two strands, namely the northern and the southern strands. The Adapazari pull-apart basin is located in the overlapping zone of the Dokurcun and the Izmit-Adapazari segments of the northern strand. The combined temporal ranges of the arvicolids from the Karapurcek formation (the first unit of the basin fill), deposited in the primary morphology of the Adapazari pull-apart basin, cover the latest Villanyian (latest Pliocene) and the Biharian (Early Pleistocene) time interval. The Degirmendere fauna collected from the lowermost sediments of this formation suggests that the Adapazari pull-apart basin started to form in the latest Pliocene. This, in turn, suggests that the dextral movement along the northern strand of the NAF commenced during the latest Pliocene. A new species, Tibericola sakaryaensis is also described. (C) 2001 Editions scientifiques et medicales Elsevier. SAS.Middle East Techn Univ, Sci & Res Council Turkey, Amer Assoc Petr Geol, Turkish Petr Corp, BP Explorat, Etibank, Perenko, Rio Tur Madencilil A S Rio Tinto Petroleum, Cominco & Arc