The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population

The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified

Correlation of subway turnstile entries and COVID-19 incidence and deaths in New York City

In this paper, we show a strong correlation between turnstile entries data of the New York City (NYC) subway provided by NYC Metropolitan Transport Authority and COVID-19 deaths and cases reported by the NYC Department of Health from March to May 2020. This correlation is obtained through linear regression and confirmed by the prediction of the number of deaths by a Long Short-Term Memory neural network. The correlation is more significant after considering incubation and symptomatic phases of this disease as experienced by people who died from it. We extend the analysis to each individual NYC borough. We also estimate the dates when the number of COVID-19 deaths and cases would approach zero by using the Auto-Regressive Integrated Moving Average model on the reported deaths and cases. We also backward forecast the dates when the first cases and deaths might have occurred

Ambulatory Blood Pressure Monitoring in Lean, Obese and Diabetic Children and Adolescents.

AIM: To determine if children and adolescents who have obesity (Ob) or type 2 diabetes (T2DM) of relatively short duration have impaired cardiovascular function compared with lean subjects using 24-hour ambulatory blood pressure as a surrogate measure of evaluation. METHODS: We enrolled 100 African-Caribbean subjects (45 males/55 females), mean ages 14.4-15.2 years (range 11.8-18.5 years) and Tanner stage 4.2-4.8. Mean BMI for the Ob (n = 40), T2DM (n = 39) and lean (n = 21) groups were 40.3, 34.2 and 20.8, respectively (p \u3c 0.01, Ob and T2DM vs. lean). Mean hemoglobin A1c in lean and Ob was 5.4 and 5.5% compared to 8.8% in T2DM (p \u3c 0.001, T2DM vs. lean and Ob). Ambulatory blood pressure was recorded every 20 min over 24 h using Spacelabs 70207. RESULTS: Mean 24-hour, daytime and nighttime systolic blood pressure was significantly higher in Ob and T2DM compared with lean subjects (mean 24-hour 117 and 120 vs. 109 mm Hg; daytime 121 and 123 vs. 113 mm Hg; and nighttime 109 and 115 vs. 101 mm Hg; p \u3c 0.01 for all time periods). The nocturnal systolic dip in Ob and T2DM did not differ from that of lean, whereas nocturnal diastolic dip decreased significantly in Ob and T2DM compared to lean (11.5 and 10.4 vs. 20.6 mm Hg; p \u3c 0.01). Mean pulse pressure was significantly increased in the Ob and T2DM groups compared to lean subjects (51 and 54 vs. 45 mm Hg; p \u3c 0.01). CONCLUSION: Adolescent Ob and T2DM groups share adverse risk factors, which may be harbingers of adult cardiovascular events