376 research outputs found
Do prestigious Spanish scholarly book publishers have more teaching impact?
Purpose
The purpose of this paper is to assess the educational value of prestigious and productive Spanish scholarly publishers based on mentions of their books in online scholarly syllabi.
Design/methodology/approach
Syllabus mentions of 15,117 books from 27 publishers were searched for, manually checked and compared with Microsoft Academic (MA) citations.
Findings
Most books published by Ariel, SĂntesis, Tecnos and Cátedra have been mentioned in at least one online syllabus, indicating that their books have consistently high educational value. In contrast, few books published by the most productive publishers were mentioned in online syllabi. Prestigious publishers have both the highest educational impact based on syllabus mentions and the highest research impact based on MA citations.
Research limitations/implications
The results might be different for other publishers. The online syllabus mentions found may be a small fraction of the syllabus mentions of the sampled books.
Practical implications
Authors of Spanish-language social sciences and humanities books should consider general prestige when selecting a publisher if they want educational uptake for their work.
Originality/value
This is the first study assessing book publishers based on syllabus mentions
Recommended from our members
Baroclinic Interleaving Instability: A Second-Moment Closure Approach
Interleaving motions on a wide, baroclinic front are modeled using a second-moment closure to represent unresolved fluxes by turbulence and salt fingering. A linear perturbation analysis reveals two broad classes of unstable modes. First are scale-selective modes comparable with interleaving as observed in oceanic fronts. These correspond well with observations in some respects but grow by a very different mechanism, which ought to be easily distinguished in hydrographic profiles. The second mode type is the so-called ultraviolet catastrophe, which is expected to lead to steppy profiles even in the absence of interleaving. Both modes are driven by positive feedbacks between interleaving and the underlying small-scale mixing processes. Contrary to expectations, use of the second-moment closure in place of earlier empirical mixing models does not lead to improved agreement with observations.Keywords: Mixing, Diapycnal mixing, Instabilit
MicroRNAs in Tumor Endothelial Cells: Regulation, Function and Therapeutic Applications
Tumor endothelial cells (TECs) are key stromal components of the tumor microenvironment,
and are essential for tumor angiogenesis, growth and metastasis. Accumulating evidence has
shown that small single-stranded non-coding microRNAs (miRNAs) act as powerful endogenous
regulators of TEC function and blood vessel formation. This systematic review provides an upto-date overview of these endothelial miRNAs. Their expression is mainly regulated by hypoxia,
pro-angiogenic factors, gap junctions and extracellular vesicles, as well as long non-coding RNAs
and circular RNAs. In preclinical studies, they have been shown to modulate diverse fundamental
angiogenesis-related signaling pathways and proteins, including the vascular endothelial growth
factor (VEGF)/VEGF receptor (VEGFR) pathway; the rat sarcoma virus (Ras)/rapidly accelerated
fibrosarcoma (Raf)/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated
kinase (ERK) pathway; the phosphoinositide 3-kinase (PI3K)/AKT pathway; and the transforming
growth factor (TGF)-β/TGF-β receptor (TGFBR) pathway, as well as krüppel-like factors (KLFs),
suppressor of cytokine signaling (SOCS) and metalloproteinases (MMPs). Accordingly, endothelial
miRNAs represent promising targets for future anti-angiogenic cancer therapy. To achieve this, it will
be necessary to further unravel the regulatory and functional networks of endothelial miRNAs and
to develop safe and efficient TEC-specific miRNA delivery technologies
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Energetics of Bottom Ekman Layers during Buoyancy Arrest
Turbulent bottom Ekman layers are among the most important energy conversion sites in the ocean. Their energetics are notoriously complex, in particular near sloping topography, where the feedback between cross-slope Ekman transports, buoyancy forcing, and mixing affects the energy budget in ways that are not well understood. Here, the authors attempt to clarify the energy pathways and different routes to mixing, using a combined theoretical and modeling approach. The analysis is based on a newly developed energy flux diagram for turbulent Ekman layers near sloping topography that allows for an exact definition of the different energy reservoirs and energy pathways. Using a second-moment turbulence model, it is shown that mixing efficiencies increase for increasing slope angle and interior stratification, but do not exceed the threshold of 5% except for very steep slopes, where the canonical value of 20% may be reached. Available potential energy generated by cross-slope advection may equal up to 70% of the energy lost to dissipation for upwelling-favorable flow, and up to 40% for downwelling-favorable flow.Keywords: Diapycnal mixing, Upwelling/downwelling, Mass fluxes/transport, Bottom currents, Circulation/Dynamics, Topographic effects, Ekman pumping/transpor
Sleep analysis for elderly care using a low-resolution visual sensor network
Nearly half of the senior citizens report difficulty initiating and maintaining sleep. Frequent visits to the bathroom in the middle of the night is considered as one of the major reasons for sleep disorder. This leads to serious diseases such as depression and diabetes. In this paper, we propose to use a network of cheap low-resolution visual sensors (30 x 30 pixels) for long-term activity analysis of a senior citizen in a service flat. The main focus of our research is on elderly behaviour analysis to detect health deterioration. Specifically, this paper treats the analysis of sleep patterns. Firstly, motion patterns are detected. Then, a rule-based approach on the motion patterns is proposed to determine the wake up time and sleep time. The nightly bathroom visit is identified using a classification-based model. In our evaluation, we performed experiments on 10 months of real-life data. The ground truth is collected from the diaries in which the senior citizen wrote down his sleep time and wake up time. The results show accurate extraction of the sleep durations with an overall Mean Absolute Error (MAE) of 22.91 min and Spearman correlation coefficient of 0.69. Finally, the nightly bathroom visits analysis indicate sleep disorder in several nights
On the structure of maximal solvable extensions and of Levi extensions of nilpotent algebras
We establish an improved upper estimate on dimension of any solvable algebra
s with its nilradical isomorphic to a given nilpotent Lie algebra n. Next we
consider Levi decomposable algebras with a given nilradical n and investigate
restrictions on possible Levi factors originating from the structure of
characteristic ideals of n. We present a new perspective on Turkowski's
classification of Levi decomposable algebras up to dimension 9.Comment: 21 pages; major revision - one section added, another erased;
author's version of the published pape
FVCOM validation experiments : comparisons with ROMS for three idealized barotropic test problems
Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 113 (2008): C07042, doi:10.1029/2007JC004557.The unstructured-grid Finite-Volume Coastal Ocean Model (FVCOM) is evaluated using three idealized benchmark test problems: the Rossby equatorial soliton, the hydraulic jump, and the three-dimensional barotropic wind-driven basin. These test cases examine the properties of numerical dispersion and damping, the performance of the nonlinear advection scheme for supercritical flow conditions, and the accuracy of the implicit vertical viscosity scheme in barotropic settings, respectively. It is demonstrated that FVCOM provides overall a second-order spatial accuracy for the vertically averaged equations (i.e., external mode), and with increasing grid resolution the model-computed solutions show a fast convergence toward the analytic solutions regardless of the particular triangulation method. Examples are provided to illustrate the ability of FVCOM to facilitate local grid refinement and speed up computation. Comparisons are also made between FVCOM and the structured-grid Regional Ocean Modeling System (ROMS) for these test cases. For the linear problem in a simple rectangular domain, i.e., the wind-driven basin case, the performance of the two models is quite similar. For the nonlinear case, such as the Rossby equatorial soliton, the second-order advection scheme used in FVCOM is almost as accurate as the fourth-order advection scheme implemented in ROMS if the horizontal resolution is relatively high. FVCOM has taken advantage of the new development in computational fluid dynamics in resolving flow problems containing discontinuities. One salient feature illustrated by the three-dimensional barotropic wind-driven basin case is that FVCOM and ROMS simulations show different responses to the refinement of grid size in the horizontal and in the vertical.For this work, H. Huang and G. Cowles
were supported by the Massachusetts Marine Fisheries Institute (MFI)
through NOAA grants DOC/NOAA/NA04NMF4720332 and DOC/
NOAA/NA05NMF472113; C. Chen was supported by NSF grants
(OCE0234545, OCE0606928, OCE0712903, OCE0732084, and
OCE0726851), NOAA grants (NA160P2323, NA06RG0029, and
NA960P0113), MIT Sea grant (2006-RC-103), and Georgia Sea grant
(NA26RG0373 and NA66RG0282); C. Winant was supported through
NSF grant OCE-0726673; R. Beardsley was supported through NSF
OCE—0227679 and the WHOI Smith Chair; K. Hedstrom was supported
through NASA grant NAG13– 03021 and the Arctic Region Supercomputing
Center; and D. Haidvogel was supported through grants ONR N00014-
03-1-0683 and NSF OCE 043557
A Genome-Wide Analysis of FRT-Like Sequences in the Human Genome
Efficient and precise genome manipulations can be achieved by the
Flp/FRT system of site-specific DNA recombination.
Applications of this system are limited, however, to cases when target sites for
Flp recombinase, FRT sites, are pre-introduced into a genome
locale of interest. To expand use of the Flp/FRT system in
genome engineering, variants of Flp recombinase can be evolved to recognize
pre-existing genomic sequences that resemble FRT and thus can
serve as recombination sites. To understand the distribution and sequence
properties of genomic FRT-like sites, we performed a
genome-wide analysis of FRT-like sites in the human genome
using the experimentally-derived parameters. Out of 642,151 identified
FRT-like sequences, 581,157 sequences were unique and
12,452 sequences had at least one exact duplicate. Duplicated
FRT-like sequences are located mostly within LINE1, but
also within LTRs of endogenous retroviruses, Alu repeats and other repetitive
DNA sequences. The unique FRT-like sequences were classified
based on the number of matches to FRT within the first four
proximal bases pairs of the Flp binding elements of FRT and the
nature of mismatched base pairs in the same region. The data obtained will be
useful for the emerging field of genome engineering
Evaluation of Field Sobriety Tests for Identifying Drivers Under the Influence of Cannabis: A Randomized Clinical Trial
IMPORTANCE: With increasing medicinal and recreational cannabis legalization, there is a public health need for effective and unbiased evaluations for determining whether a driver is impaired due to Δ9-tetrahydrocannabinol (THC) exposure. Field sobriety tests (FSTs) are a key component of the gold standard law enforcement officer-based evaluations, yet controlled studies are inconclusive regarding their efficacy in detecting whether a person is under the influence of THC.
OBJECTIVE: To examine the classification accuracy of FSTs with respect to cannabis exposure and driving impairment (as determined via a driving simulation).
DESIGN, SETTING, AND PARTICIPANTS: This double-blind, placebo-controlled parallel randomized clinical trial was conducted from February 2017 to June 2019 at the Center for Medicinal Cannabis Research, University of California, San Diego. Participants were aged 21 to 55 years and had used cannabis in the past month. Data were analyzed from August 2021 to April 2023.
INTERVENTION: Participants were randomized 1:1:1 to placebo (0.02% THC), 5.9% THC cannabis, or 13.4% THC cannabis smoked ad libitum.
MAIN OUTCOME AND MEASURES: The primary end point was law enforcement officer determination of FST impairment at 4 time points after smoking. Additional measures included officer estimation as to whether participants were in the THC or placebo group as well as driving simulator data. Officers did not observe driving performance.
RESULTS: The study included 184 participants (117 [63.6%] male; mean [SD] age, 30 [8.3] years) who had used cannabis a mean (SD) of 16.7 (9.8) days in the past 30 days; 121 received THC and 63, placebo. Officers classified 98 participants (81.0%) in the THC group and 31 (49.2%) in the placebo group as FST impaired (difference, 31.8 percentage points; 95% CI, 16.4-47.2 percentage points; P \u3c .001) at 70 minutes after smoking. The THC group performed significantly worse than the placebo group on 8 of 27 individual FST components (29.6%) and all FST summary scores. However, the placebo group did not complete a median of 8 (IQR, 5-11) FST components as instructed. Of 128 participants classified as FST impaired, officers suspected 127 (99.2%) as having received THC. Driving simulator performance was significantly associated with results of select FSTs (eg, ≥2 clues on One Leg Stand was associated with impairment on the simulator: odds ratio, 3.09; 95% CI, 1.63-5.88; P \u3c .001).
CONCLUSIONS AND RELEVANCE: This randomized clinical trial found that when administered by highly trained officers, FSTs differentiated between individuals receiving THC vs placebo and driving abilities were associated with results of some FSTs. However, the high rate at which the participants receiving placebo failed to adequately perform FSTs and the high frequency that poor FST performance was suspected to be due to THC-related impairment suggest that FSTs, absent other indicators, may be insufficient to denote THC-specific impairment in drivers.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02849587
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