112 research outputs found

    The Librarian’s Role in the Procurement of IPDN Electronic Library Materials During the Covid-19 Pandemic

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    Abstract  Background: Electronic library materials are more effective and efficient than printed books. Therefore, they are popular with millennials, especially when library services are only open online during the Covid-19 pandemic and the new normal era. Librarians are required to maximize e-resources services when the budget is fully refocused on handling the Covid-19 outbreak. Purpose: This research aims to analyze the librarian’s role in procuring electronic library materials during the Covid-19 pandemic. Method: The method used is qualitative with a descriptive analysis design. Results: The results show that librarians act as administrators in selecting and procuring electronic library materials through the digital library applications “Digilib Praja” and “Smartlib IPDN.” In the policy dimension, they serve as an advisory board to the head of the library in making policies, selecting information technology-based service tools, and implementing digital book fundraising policies. In the Service Object Achievement dimension, librarians play a role in gathering information needs and ensuring electronic book purchases are based on guidelines for the IPDN Library. Conclusion: In conclusion, the role of librarians in procuring electronic library materials was sufficiently performed. They can procure IPDN e-resources through a digital book fundraising policy, which can be applied to another university as a form of innovation.  Keywords: Librarian Role; Procurement of Electronic Library Materials; E-Resources; Fundraising  Abstrak  Latar Belakang: Bahan pustaka elektronik dinilai lebih efektif dan efisien ketimbang buku cetak, oleh karenanya lebih digemari kaum milenial terutama pada saat layanan perpustakaan hanya dibuka secara daring di masa pandemic covid-19 atau pada normal baru. Sementara itu pustakawan dituntut untuk dapat memaksimalkan layanan e-resources di saat anggaran pembelian eresources seluruhnya dialihkan (refocusing) untuk penanganan wabah covid-19. Tujuan: Penelitian ini bertujuan untuk menganalisa bagaimana peran pustakawan dalam pengadaan bahan pustaka elektronik di masa pandemic Covid-19. Metode: Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan desain analisis deskriptif. Hasil: Temuan penelitian menunjukkan bahwa pada dimensi Aksesibilitas Teknologi Informasi, pustakawan berperan sebagai administrator sekaligus actor utama proses seleksi dan pengadaan bahan pustaka elektronik (eresources), yakni melalui aplikasi perpustakaan digital “Digilib Praja” dan “Smartlib IPDN”. Pada dimensi Kebijakan, pustakawan berperan sebagai dewan penasihat kepala perpustakaan dalam membuat kebijakan, memilih tools layanan berbasis teknologi informasi, sekaligus sebagai pelaksana kebijakan fundrising buku digital.  Pada dimensi Ketercapaian Objek Layanan, pustakawan berperan dalam kegiatan menghimpun kebutuhan informasi dan memastikan pembelanjaan buku elektronik diimplementasikan berdasarkan pedoman pengembangan bahan pustaka Perpustakaan IPDN. Kesimpulan: Penelitian ini menyimpulkan bahwa peran pustakawan dalam pengadaan bahan pustaka elektronik di masa pandemic Covid-19 berjalan sangat baik. Problem utama pengadaan eresources IPDN di masa pandemic dapat diatasi oleh pustakawan melalui kebijakan fundrising buku digital, dimana hal ini dapat diterapkan juga di perpustakaan perguruan tinggi lain di Indonesia sebagai bentuk inovasi perpustakaan sekaligus mengatasi problem keterbatasan anggaran.  Kata kunci: Peran Pustakawan; Pengadaan Bahan Pustaka Elektronik; e-Resources; Fundrisin

    Coastal Trade in Awa, Akwa Ibom State of Nigeria 1900–1970

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    This paper examines the contributions of communities in Awa clan to the success of the international trade in commodities from the 1900s to the end of the Nigerian Civil War in 1970. It analyses how these hinterland dwellers were railroaded into trade relations with European merchant ships and the impact of such trade on the development of settlement patterns, skills acquisition. It also critically accesses the Awa communities more than 100 years after. Keywords: creeks, waterways, trading vessels, palm oil, kernel, rubbe

    “Saccharomyces cerevisiae G protein Coupled Receptor, Ste2p Interactions with its Ligand, α-factor and Cognate Gα protein, Gpa1p

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    The Saccharomyces cerevisiae alpha-factor receptor, Ste2p, belongs to the G proteincoupled receptors (GPCRs), a class of integral membrane proteins that are characterized by seven-transmembrane (TM) domains. Ste2p-alpha-factor pair has been used extensively as a paradigm for investigating GPCRs structure and function. Upon binding of alpha-factor to Ste2p, a signal is transduced via an associated guanine-nucleotide binding protein, Gpa1p, initiating a cascade of events similar to those for mammalian GPCRs signal transduction. GPCRs are essential in many physiological processes associated with human diseases. Many aspects of structure and function are highly conserved across GPCRs, irrespective of primary amino acid sequence. This dissertation investigated the interactions of Ste2p with alpha-factor and Gpa1p. An overview of GPCRs in general with specific emphasis on Ste2p interactions with alpha-factor and Gpa1p are discussed in part I. Cross-linking studies of alpha-factor analogs containing 3,4-dihydroxylphenylalanine (DOPA) at positions 1 and 13 indicated that Trp1 and Tyr13 of α-factor are in close proximity to Lys269 and Cys59 of Ste2p, respectively when alphafactor is bound to Ste2p. An alpha-factor synergist lacking the last two amino acids required for binding could only inhibit the cross-linking of DOPA at position 1 suggesting that the alphafactor synergist interacts with the N-terminus of alpha-factor (described in part II). Part III describes the first report of an unnatural amino acid, p-benzoyl-L-phenylalanine (Bpa), replacement in a GPCR expressed in its native environment, and the use these receptors to photocapture a peptide ligand. Many of the Bpa-substituted Ste2p receptors exhibited biological activity and two of them, Phe55-Bpa and Tyr193-Bpa, were able to selectively capture alphafactor in the ligand binding site after photoactivation; indicating that these residues may be in direct contact or in close proximity to alpha-factor when bound to Ste2p. Part IV reports for the first time the involvement of the third intracellular loop (IL3) in Ste2p homo-dimer formation, and also conformational changes at the cytoplasmic ends of TM5-TM6 of Ste2p induced by alpha-factor binding. Conformational changes in the C-terminus of Gpa1p occurring during Ste2p and Gpa1p activation are also discussed for the first time in part V. Variants of Ste2p- Gpa1p fusion proteins that displayed activities similar to Ste2p and Gpa1p are described in part VI. The final part of this dissertation discusses the overall conclusions and contains suggestions for future studies. The results obtained during this study should provide very important information about the mechanisms underlying the activation of GPCRs and G proteins

    Intracystic papillary carcinoma of the breast in a 21-year old premenopausal Nigerian woman: a case report

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    We report the case of a 21-year-old Nigerian woman who presented to us with features of intracystic papillary carcinoma, a rare form of breast cancer usually seen in postmenopausal women in their sixth to eighth decades of life. To the best of our knowledge, there has been only one other case report of this lesion occurring in women in their second decade of life

    Prevalence of artificially created maxillary midline diastema and its complications in a selected nigerian population

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    Background: Maxillary midline diastema (MMD) is generally regarded as a symbol of beauty in Nigeria. The desperation to look beautiful has caused many individuals to seek the creation of artificial midline diastema and that comes often with undesirable side effects.Aim: To determine the prevalence of artificially created maxillary midline diastema (MMD) and its complications in a selected Nigerian population.Method: A cross-sectional study using a semi-structured questionnaire as the instrument for data collection was done among patients attending a private clinic in Owerri the capital of Imo state in Nigeria over a period of 18 months. The data were retrieved from the questionnaires and analyzed using the SPSS version 20.Results: There were 141 respondents comprising 58(41.1%) males and 83(58.9%) females, giving a male to female ratio of 1:1.4. The prevalence of artificially created MMD was 34.0% with increased frequency in: the 21-30 years age group; among the females and in respondents with tertiary level of education. Majority of the respondents (69.5%) desire MMD and 20.8% of those without it wanted it created through cosmetic dentistry. Twenty of the 48 respondents with artificial MMD had it done to enhance personal beauty and aesthetics. The commonest complication was tooth sensitivity (44.8%), followed by toothache (41.4%).Conclusion: The prevalence of artificially created MMD was 34.0% in this study; and it is commoner in females and younger age group .The commonest complication was tooth sensitivity. Enhancement of personal beauty and aesthetic was the major reason for having it done.Keywords: Artificially created, Maxillary Midline Diastema, Complication

    Effects of timing of the antiretroviral therapy initiation on multidrug-resistant tuberculosis outcomes in HIV co-infected patients in Sizwe tropical disease hospital, Johannesburg, South Africa, 2007-2010

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    Multidrug-resistant tuberculosis (MDR-TB) is a threat to global tuberculosis (TB) control. Its management in human immunodeficiency virus (HIV) co-infected patients has been a challenging experience. There is however paucity of data on the effects of antiretroviral treatment (ART) before or after starting MDR-TB treatment. Therefore the objectives of this study were to describe the clinical characteristics and outcomes of MDR-TB treatment; and determine the predictors of mortality, cure and failure in HIV-TB co-infected patients who were started on ART before and after commencement of MDR-TB treatment

    AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

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    The regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internalization of AMPARs from the synaptic membrane. Here, we show that N-methyl-d-aspartate receptor (NMDAR) activation leads to increased S-nitrosylation of Thorase and N-ethylmaleimide-sensitive factor (NSF). S-nitrosylation of Thorase stabilizes Thorase-AMPAR complexes and enhances the internalization of AMPAR and interaction with protein-interacting C kinase 1 (PICK1). S-nitrosylated NSF is dependent on the S-nitrosylation of Thorase via trans-nitrosylation, which modulates the surface insertion of AMPARs. In the presence of the S-nitrosylation-deficient C137L Thorase mutant, AMPAR trafficking, long-term potentiation, and long-term depression are impaired. Overall, our data suggest that both S-nitrosylation and interactions of Thorase and NSF/PICK1 are required to modulate AMPAR-mediated synaptic plasticity. This study provides critical information that elucidates the mechanism underlying Thorase and NSF-mediated trafficking of AMPAR complexes

    Pengaruh Kompensasi Bonus, Leverage dan Ukuran Perusahaan Terhadap Manajemen Laba (Studi Empiri pada Perusahaan yang Terdaftar di Bursa Efek Indonesia periode 2018 – 2020)

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    Penelitian ini bertujuan untuk mengetahui Pengaruh Kompensasi Bonus, Leverage, dan Ukuran Perusahaan Terhadap Manajemen Laba pada Perusahaan yang terdaftar di Bursa Efek Indonesia 2018 – 2020. Metode penelitian yang digunakan adalah random sampling dari perusahaan yang terdaftar di Bursa Efek Indonesia periode 2018 – 2020. Metode penarikan sampel sebanyak 45 perusahaan dan harus dieliminasi dengan Tehnik Pengumpulan data yaitu menggunakan laporan keuangan / tahunan yang tercatat pada Bursa Efek Indonesia periode 2018 – 2020. Hasil pengujian hipotesis dilakukan dengan uji regresi linear berganda. Hasil penelitian menunjukkan bahwa : (1) Kompensasi Bonus tidak berpengaruh positif dan tidak signifikan terhadap Manajemen Laba. Yang ditunjukkan dengan hasil t hitung > t tabel, dengan nilai t hitung yang dimiliki variabel kompensasi bonus 1,001 (1,001 < 2,0141). (2) Leverage tidak berpengaruh positif dan tidaksignifikan terhadap Manajemen Laba. Yang ditunjukkan dengan hasil t hitung > t tabel, Karena nilai t hitung yang dimiliki variabel leverage 1,251 (1,251 < 2,0141). (3) Ukuran perusahaan berpengaruh negatif dan signifikan terhadap Manajemen Laba. Yang ditunjukkan dengan hasil t hitung > t tabel, Karena nilai t hitung yang dimiliki variabel ukuran perusahaan -2,506 (-2,506 > 2,0141)
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