Borderline Ovarian Malignancies : A Single Institute Retrospective Study.

Background: Borderline ovarian tumors are histologically characterized as epithelial tumors with a stratified growth pattern but without destructive stromal invasion. Little is known about the histological subtypes and outcome, role of fertility sparing surgery and role of postoperative therapy in advanced stage in Indian scenario. While there is ample data in the world literature about this disease, prognosis in Indian patients is largely unknown due to dearth of studies in our setting. Objective: To study the demographic profile, clinical features, imaging, treatment and outcome of borderline ovarian tumors. Methods: This is a retrospective study of eighty seven patients with pathologically proven diagnosis of borderline ovarian tumor, diagnosed and treated from January 2006 to October 2011 at our institution. Most patients underwent surgical staging which incuded total abdominal hysterectomy and bilateral salphingo-oophorectomy, infracolic omentectomy, bilateral pelvic and para aortic lymphadenectomy. Young patients who had not completed their family underwent fertility sparing surgery. Patients with invasive metastatic implants received adjuvant chemotherapy. The outcome of these patients was correlated with stage, type of peritoneal implant, type of surgical procedure and with histological subtype. Results: At a median follow-up of 48 months, 100 percent survival was noted. One patient with stage III disease had recurrence. Conclusions: Borderline ovarian tumors occur at a younger age compared to invasive tumors. In patients with early stage disease who wish to preserve fertility, hysterectomy and contralateral oophorectomy are not necessary. Serous tumors occur at a younger age. They can be associated with invasive peritoneal implants and raised CA125 values. Majority of the serous tumors are bilateral and smaller in size compared to mucinous and endometroid tumors. Raised CA125 values did not correlate with the stage of disease. These patients have an excellent prognosis even in Indian scenario where majority of patients present with big ovarian masses

A study on medication adherence, medication related challenges faced and coping strategies adopted by visually impaired subjects in a tertiary care hospital

Background: Visual impairment poses a significant threat to proper medication practice leading to medication related challenges and some adopted self coping strategies with substantial impact on medication adherence. Visually impaired are potentially more likely to have unsafe medicine related practice which by itself is more rampant in general population. Studies related to them are largely unexplored and can provide data to improve disease management and health related quality of life. Objectives was to study the level of medication adherence, medication related challenges and self adopted coping strategies in visually impaired people.Methods: A cross sectional descriptive study enrolling 204 subjects with VI was done. Medication adherence was assessed using MMAS. Medication related challenges and self-adopted coping strategies was assessed by using pre-validated semi-structured questionnaire.Results: Majority of the subjects showed medium medication adherence with forgetfulness to take medicine as the main reason for non adherence. Difficulty in remembering the instructions, spilling of liquid medicine, taking wrong dose, difficulty in using topical medications were the most common challenges faced by them in daily drug administration. To overcome challenges locating the drugs at different places, finger felt volume for liquid medication, textural feeling of the drug or container, time tracking were the major self adopted coping strategies by the visually impaired subjects.Conclusions: Creating awareness of the medication related problem faced by visually impaired helps to provide adequate assistance to medication use and improve proper health care services in them

Subclasses of Multivalent Meromorphic Functions with a Pole of Order p at the Origin

In this paper, we carry out a systematic study to discover the properties of a subclass of meromorphic starlike functions defined using the Mittag–Leffler three-parameter function. Differential operators involving special functions have been very useful in extracting information about the various properties of functions belonging to geometrically defined function classes. Here, we choose the Prabhakar function (or a three parameter Mittag–Leffler function) for our study, since it has several applications in science and engineering problems. To provide our study with more versatility, we define our class by employing a certain pseudo-starlike type analytic characterization quasi-subordinate to a more general function. We provide the conditions to obtain sufficient conditions for meromorphic starlikeness involving quasi-subordination. Our other main results include the solution to the Fekete–Szegő problem and inclusion relationships for functions belonging to the defined function classes. Several consequences of our main results are pointed out

A Mathematical Model for Micropolar Fluid Flow Through an Artery with the effect of Stenosis and Post Stenotic Dilatation

The effects of both stenosis and post stenotic dilatation have been studied on steady flow of micropolar fluid through an artery. Assuming the stenosis to be mild, the equations governing the flow of the proposed model are solved. Closed form expressions for the flow characteristics such as velocity, pressure drop, and volumetric flow rate, resistance to the flow and wall shear stress are derived. The effects of various parameters on resistance to the flow and wall shear stress have been analyzed through the graphs. It is found that the resistance to the flow increases with the height and length of the stenosis, but the resistance to the flow decreases with stenotic dilatation. With the increase of the coupling number the resistance to the flow increases. However, the effect of coupling number is not very significant. The resistance to the flow decreases with the micropolar fluid parameter. The wall shear stress increases with coupling number and stenosis height, but it decreases with micropolar fluid parameter and stenotic dilatation

Comparison of consumer preference on meat from broiler and village chicken and processed chicken meat products in Batticaloa district of Sri Lanka

The demand for chicken meat is increases in Batticaloa district as the chicken is the major protein source next to fish in this district However, the availability of chicken meat is lower and the prices for meat have also increased. The major sources of chicken meat in the market are village chicken, broiler chicken, cross-bred chicken and processed products. Consumers believe that meat form village chicken is healthier. This poses a particular challenge for the organization of safe marketing chains. Consumer preferences affect the production and marketing systems for poultry products, therefore knowledge and understanding of these preferences is required for the design of appropriate new interventions. In this context, a survey based study was carried out during December, 2009 to May 2010. Two hundred respondents were randomly selected to gather information on the availability of meat and meat products, consumer preference and consumption pattern. The sample was comprised of equal numbers of male and female respondents having education from primary level to graduation in Batticaloa district The results of the study revealed that the availability of broiler meat was significantly higher (P>0.05) in urban areas (66%) while in rural areas the availability of village chicken meat (88%) was significantly higher (P>0.05) than broiler, cross-bred and chicken meat products. Consumers showed significantly higher (P>0.05) preference for village chicken meat (68%) while lowest preference was for processed products (13%). Among processed meat products the consumers showed significantly higher (P>0.05) preference for meat balls (58%). Furthermore, the majority of respondents (73%) liked to purchase meat up to 1kg weekly. Around 76% of the respondents consume meat once a week. Sixty two percent of the consumers were willing consume fish as the substituted for chicken meat and meat products than other substitutes (mutton, beef, pork and crustacean). Farmshed was the major sales point for meat (67%). The respondents were asked to express consumption of meat in case of increased prices and 64% of the respondents had positive response and rest showed negative response to this aspect From the study it was concluded that the consumer preference of chicken meat and meat products showed the positive trend. However, low purchasing power resulted weaker purchasing frequency in rural areas. Government organizations should take efforts for enhance the production and marketing according to the farmers' perception. Results will be much useful in planning the location specific and species based poultry farming and will be beneficial to policy makers also. Key words: Village Chicken, Broiler, Consumer Preference

Some Properties of Bazilevič Functions Involving Srivastava–Tomovski Operator

We introduce a new class of Bazilevič functions involving the Srivastava–Tomovski generalization of the Mittag-Leffler function. The family of functions introduced here is superordinated by a conic domain, which is impacted by the Janowski function. We obtain coefficient estimates and subordination conditions for starlikeness and Fekete–Szegö functional for functions belonging to the class

The Effect of Particle Drag and Wall Absorption on Mass Transfer in Concentric Annulus Flows

The effects of the irreversible boundary reaction and the particle drag on mass transfer are studied analytically in concentric annulus flows. The solution of mathematical model, based on the generalized dispersion model brings out the mass transport following by the insertion of catheter on an artery in terms of the three effective transport coefficients, viz., the exchange, convection and diffusion coefficient. A general expression is derived which shows clearly the time dependent nature of the coefficients in the dispersive model. The complete time dependent expression for the exchange coefficient is obtained explicitly and independent of velocity distribution in the flow; however it does depend on the initial solute distribution. Because of the complexity of the problem only asymptotic large time evaluations are made for the convective and diffusion coefficients, but these are sufficient to give the physical insight into the nature of the problem of the effects of drag and absorption parameters. It is found that as absorption parameter increases exchange and convection coefficients will be enhanced, but diffusion coefficient will be reduced. After certain period of time exchange coefficient will be constant for different values annular gap. As the drag parameter increases convection and diffusion coefficients will be reduced. With the enhancement of catheter radius i.e., the annular gap will be reduced then the convection and diffusion coefficients will be decreased

GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations

Modern DNA sequencing technologies enable geneticists to rapidly identify genetic variation among many human genomes. However, isolating the minority of variants underlying disease remains an important, yet formidable challenge for medical genetics. We have developed GEMINI (GEnome MINIng), a flexible software package for exploring all forms of human genetic variation. Unlike existing tools, GEMINI integrates genetic variation with a diverse and adaptable set of genome annotations (e.g., dbSNP, ENCODE, UCSC, ClinVar, KEGG) into a unified database to facilitate interpretation and data exploration. Whereas other methods provide an inflexible set of variant filters or prioritization methods, GEMINI allows researchers to compose complex queries based on sample genotypes, inheritance patterns, and both pre-installed and custom genome annotations. GEMINI also provides methods for ad hoc queries and data exploration, a simple programming interface for custom analyses that leverage the underlying database, and both command line and graphical tools for common analyses. We demonstrate GEMINI's utility for exploring variation in personal genomes and family based genetic studies, and illustrate its ability to scale to studies involving thousands of human samples. GEMINI is designed for reproducibility and flexibility and our goal is to provide researchers with a standard framework for medical genomics