Negatif duygusallık, bağlamsal performans ve iş sosyal destekleri arasındaki ilişkilerin belirlenmesine yönelik bir araştırma

Bu çalışmada iş sosyal desteklerinin negatif duygusallığın bağlamsal performans üzerinde negatif etkilerini azaltabileceği savının test edilmesi amaçlanmaktadır

Kişilik özelliklerinin hasta iken işe gelme (presenteizm) davranışı üzerindeki etkileri: imalat sanayiinde bir araştırma

Kişilik özellikleri ile devamsızlık arasındaki ilişkileri inceleyen çok sayıda çalışma olmasına karşın, kişilik özellikleri ile presenteizm ilişkisini irdeleyen az sayıda çalışma mevcuttur. Bu çalışma, örgütsel davranış literatüründe bu konudaki ampirik araştırma eksikliğini ortadan kaldırmayı amaçlamaktadır. Bu çalışmanın amacı, kişilik özelliklerinin (veya Beş Büyük Kişilik Faktörünün) presenteizm üzerindeki etkilerini incelemektir. Araştırmanın örneklemini, Türkiye’de Mersin ilindeki bir büyük ölçekli imalat sanayi işletmesinin işgörenleri oluşturmaktadır. Araştırma bulgularına göre, kişilik özelliklerinden dışadönüklük boyutunun, presenteizm üzerinde pozitif ama anlamlı olmayan bir etkiye sahip olduğu tespit edilirken, kişiliğin uyumluluk boyutunun presenteizm üzerinde negatif ama anlamlı olmayan bir etkiye sahip olduğu saptanmıştır. Buna karşın beş kişilik özelliğinden deneyime açıklık, sorumluluk ve duygusal denge boyutlarının presenteizm üzerinde pozitif ve anlamlı etkiye sahip olduğu tespit edilmiştir. Son olarak araştırmanın bazı kısıtları olduğu belirtilmiş ve ve gelecekte presenteizm konusunda araştırma yapacaklara bazı önerilerde bulunulmuştur.Although numerous studies have investigated the relations between personality characteristics and absenteeism, few studies have focused on the effects of personality characteristics on presenteeism. This study aims to eliminate the lack of empirical research on this subject in organizational behavior literature. The goal of the study is to examine the effects of the personality characteristics (or Big Five Personality Factor) on presenteeism. The sampling consists of employees of a large enterprise in manufacturing industry in the Mersin Province, Turkey. According to the findings of the research, it showed that while extraversion dimension of personality had a positive, but not signifaicant effect on presenteeism, agreeableness dimension of personality had a negative, but not significant effect on presesenteeism. However, it indicated that openness to experience; conscientiousness and neuroticism dimensions of personality had a significant positive effect on presenteeism. Lastly, it is stressed that this study has some limitations and suggestions that contributed to the research to be done related to presenteeism in the future

Toward the integration of biosimilars into pediatric rheumatology: adalimumab ABP 501 experience of PeRA research group.

Optimization of hydrolysis conditions of lignocellulosic biomass is crucial to able to produce value-added products by fermentation. This study not only determines optimal dilute sulfuric acid (H2SO4) hydrolysis conditions of wheat bran (WB) and rye bran (RB) by using one-factor-at-a-time method and subsequently Box-Behnken design but also elucidates chemical composition of hydrolysates yielded under optimal hydrolysis conditions. Based on the results, optimal hydrolysis conditions of WB and RB were 121 and 130 degrees C of temperature, 1/8 and 1/8 w/v of solid to liquid ratio, 2.66 and 1.58% v/v of dilute H2SO4 ratio, and 30 and 16 min of implementation time, respectively. Hydrolysates obtained from WB and RB at these conditions contained 72.7 (0.58 g sugar/g biomass) and 89.4 g/L (0.72 g sugar/g biomass) of reducing sugar concentration, respectively. Hydrolysis rates of WB and RB were 87.79 and 91.33%, respectively. Main reducing sugar in RB hydrolysate was glucose with 31.17 g/L (0.25 g glucose/g biomass) while glucose and xylose were the main monosaccharides with 20.90 (0.17 g glucose/g biomass) and 18.69 g/L (0.15 g xylose/g biomass) in WB hydrolysate, respectively. With acidic hydrolysis of WB and RB, inhibitors such as phenolics, 5-Hydroxymethylfurfural, 2-Furaldehyde (not for RB), acetic acid, and formic acid (not for WB) formed. Catalytic efficiency values of H2SO4 for WB and RB were 15.2 and 24.4 g /g, respectively, indicating that inhibitor concentration in WB hydrolysate was higher than that of RB. These results indicated that WB and RB have a high potential in production of value-added products by fermentation

The Multifaceted Presentation of the Multisystem Inflammatory Syndrome in Children: Data from a Cluster Analysis.

Background: The aim of this study was to evaluate the outcomes of patients with the multisystem inflammatory syndrome in children (MIS-C) according to phenotypes of disease and define the prognostic factors for the severe course. Methods: This cross-sectional study included 293 patients with MIS-C from seven pediatric rheumatology centers. A two-step cluster analysis was performed to define the spectrum of disease and their outcomes were compared between each group. Results: Four subgroups were identified as follows: cluster I, predominantly Kawasaki-like features (n = 100); cluster II, predominantly MAS-like features (n = 34); cluster III, predominantly LV dysfunction (n = 47); cluster IV, other presentations (n = 112). The duration of fever was longer in cluster II and the length of hospitalization was longer in both clusters II and III. Laboratory findings revealed lower lymphocyte and platelet counts and higher acute phase reactants (APRs) in cluster II, while patients in cluster IV showed less inflammation with lower APRs. The resolution of abnormal laboratory findings was longer in clusters II and III, while it was shortest in cluster IV. Seven patients died. Among them, four belonged to cluster II, while three were labeled as cluster III. Patients with severe course had higher levels of neutrophil-lymphocyte ratio, mean platelet volume, procalcitonin, ferritin, interleukin-6, fibrinogen, D-Dimer, BNP, and troponin-I, and lower levels of lymphocyte and platelet counts. Conclusion: As shown, MIS-C is not a single disease presenting with various clinical features and outcomes. Understanding the disease spectrum will provide individualized management

Clinical characteristics and predictors for recurrence in chronic nonbacterial osteomyelitis: a retrospective multicenter analysis

Background/aim: Chronic nonbacterial osteomyelitis (CNO) is a rare disease of unknown etiology and most commonly occurs during childhood or adolescence. The purpose of this study is to collect data on the clinical features, outcomes, and management of the disease and to identify the factors affecting recurrence. Materials and methods: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study. Results: The study included 87 patients (38 girls, 49 boys; median age: 12.5 years). The median follow-up time was 20 months (IQR: 8.5–40). The median time of diagnostic delay was 9.9 months (IQR: 3–24). Arthralgia and bone pain were the most common presenting symptoms. Multifocal involvement was detected in 86.2% of the cases and a recurrent course was reported in one-third of those included in the study. The most commonly involved bones were the femur and tibia. Vertebrae and clavicles were affected in 19.5% and 20.6% of cases, respectively. The erythrocyte sedimentation rate (ESR) values of 60.9% of the patients were above 20 mm/h and the C-reactive protein values of 44.8% were above 5 mg/L. The remission rate was 13.3% in patients using nonsteroidal antiinflammatory drugs and 75.0% in those using biological drugs. Vertebral and mandibular involvement and high ESR values at the time of diagnosis were associated with recurrence. Conclusion: In this multicenter study, CNO with vertebral and mandibular involvement and high ESR at diagnosis were associated with recurrence

The clinical course of SARS-CoV-2 infection among children with rheumatic disease under biologic therapy: a retrospective and multicenter study.

The effects of biological disease-modifying antirheumatic drugs (bDMARDs) in the clinical course of COVID-19 on children with underlying rheumatologic diseases have not been fully demonstrated. To evaluate the course of COVID-19 infection in patients with rheumatic disease receiving bDMARD treatment. This was a retrospective, multicenter study conducted in pediatric patients infected by SARS-CoV-2 and under bDMARDs therapy. The study population consisted of 113 patients (72 female/41 male). The mean age of the patients was 12.87 +/- 4.69 years. The primary diagnosis of the cohort was as follows: 63 juvenile idiopathic arthritis, 35 systemic autoinflammatory diseases, 10 vasculitides, and five cases of connective tissue diseases. The mean duration of the primary disease was 4.62 +/- 3.65 years. A total of 19 patients had additional comorbid diseases. Thirty-five patients were treated with canakinumab, 25 with adalimumab, 18 with etanercept, 10 with infliximab, nine with tocilizumab, six with rituximab, four with anakinra, three with tofacitinib, and one with abatacept. The median exposure time of the biological drug was 13.5 months. Seventy-one patients had symptomatic COVID-19, while 42 were asymptomatic. Twenty-four patients required hospitalization. Five patients presented with MIS-C. The hospitalized patients were younger and had a shorter duration of rheumatic disease compared to ambulatory patients, although the difference was not statistically significant. Steroid usage, presence of fever, and dyspnea were more common among the hospitalized patients. A worsening in the course of both COVID-19 and current disease was not noticed under bDMARDs, however, to end with a strong conclusion multicentric international studies are required

Differences and similarities of multisystem inflammatory syndrome in children, Kawasaki disease and macrophage activating syndrome due to systemic juvenile idiopathic arthritis: a comparative study

To compare the clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C), patients with Kawasaki disease (KD) and with macrophage activating syndrome due to systemic juvenile idiopathic arthritis (sJIA-MAS) on real-life data. Patients diagnosed with MIS-C, KD, and sJIA-MAS from 12 different centers in Turkey who were followed for at least 6 months were included in the study. Demographic, clinical, and laboratory findings of all patients were analyzed. A total of 154 MIS-C, 59 KD, and 31 sJIA-MAS patients were included. The median age of patients with MIS-C were higher than those with KD while lower than those with sJIA-MAS (8.2, 3, 12 years, respectively). Myalgia (39.6%), cardiac (50.6%), gastrointestinal (72.7%), and neurological (22.1%) involvements were more common in patients with MIS-C compared to others. MIS-C patients had lower levels of lymphocyte (950 vs 1700 cells/mu l) and thrombocyte (173,000 vs 355,000 cells/mu l) counts and higher pro-BNP (1108 vs 55 pg/ml) levels than KD. Ferritin levels were higher in patients with MIS-C compared to patients with KD while they were lower than patients with sJIA-MAS (440, 170, 10,442 ng/ml, respectively). Patients with MIS-C had a shorter duration of hospitalization than sJIA-MAS (p = 0.02) while they required intensive care unit admission more frequently (55 vs 8 patients, p < 0.001). The median MAS/sJIA score of MIS-C patients was - 1.64 (- 5.23 to 9.68) and the median MAS/sJIA score of sJIA-MAS patients was -2.81 ([- 3.79] to [- 1.27]). MIS-C patients displayed certain differences in clinical and laboratory features when compared to KD and sJIA-MAS. Definition of the differences and similarities between MIS-C and the other intense inflammatory syndromes of childhood such as KD and MAS will help the clinicians while making timely diagnosis

Pregnancy and its outcomes in hemodialysis patients in Turkey

Background/aim: This study aimed to investigate pregnancy frequency and evaluate the factors affecting live births in hemodialysis (HD) patients. Materials and methods: Female HD patients whose pregnancy was retrospectively reported between January 1, 2014, and December 31, 2019. The duration of HD, primary disease, and the information on whether the pregnancy resulted in abortion, stillbirth, or live birth, whether the HD duration was prolonged after diagnosing the pregnancy and whether it accompanied preeclampsia were recorded. Results: In this study, we reached 9038 HD female patients' data in the study. A total of 235 pregnancies were detected in 145 patients. The mean age was 35.42 (35 +/- 7.4) years. The mean age at first gestation was 30.8 +/- 6.5 years. The average birth week was 32 (28 -36) weeks. A total of 53.8% (no = 78) of the patients had live birth, 51.7% (no = 70) had at least one abortion in the first 20 weeks, and 13.1% (no = 19) had at least one stillbirth after 20 weeks. The rate of patients' increased numbers of dialysis sessions during pregnancy was 71.7%. The abortion rate was 22.4% in those with increased HD sessions, whereas 79.3% in those not increased HD sessions (p < 0.001). Live birth frequency was 67.2% in the increased HD sessions group and 3.4% in those who did not differ in HD sessions (p < 0.001). Conclusion: For the first time, we reported pregnancy outcomes in HD female patients, covering all regions of Turkey. It has been observed that; increasing the number of HD sessions in dialysis patients will decrease fetal and maternal complications and increase live birth rates