The human health effects of Florida Red Tide (FRT) blooms : an expanded analysis

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Environment International 68 (2014): 144-153, doi:10.1016/j.envint.2014.03.016.Human respiratory and digestive illnesses can be caused by exposures to brevetoxins from blooms of the marine alga Karenia brevis, also known as Florida red tide (FRT). K. brevis requires macro-nutrients to grow; although the sources of these nutrients have not been resolved completely, they are thought to originate both naturally and anthropogenically. The latter sources comprise atmospheric depositions, industrial effluents, land runoffs, or submerged groundwater discharges. To date, there has been only limited research on the extent of human health risks and economic impacts due to FRT. We hypothesized that FRT blooms were associated with increases in the numbers of emergency room visits and hospital inpatient admissions for both respiratory and digestive illnesses. We sought to estimate these relationships and to calculate the costs of associated adverse health impacts. We developed environmental exposure-response models to test the effects of FRT blooms on human health, using data from diverse sources. We estimated the FRT bloom-associated illness costs, using extant data and parameters from the literature. When controlling for resident population, a proxy for tourism, and seasonal and annual effects, we found that increases in respiratory and digestive illnesses can be explained by FRT blooms. Specifically, FRT blooms were associated with human health and economic effects in older cohorts (≥ 55 years of age) in six southwest Florida counties. Annual costs of illness ranged from $60,000 to$700,000 annually, but these costs could exceed $1.0 million per year for severe, long-lasting FRT blooms, such as the one that occurred during 2005. Assuming that the average annual illness costs of FRT blooms persist into the future, using a discount rate of 3$2-24 million.This research was sponsored by the National Science Foundation under NSF/CNH Grant No. 1009106.L.E. Fleming acknowledges support from the European Regional Development Fund and the European Social Fund Convergence Programme for Cornwall and the Isles of Scilly

Research Evidence on the Use of Learning Analytics: Implications for Education Policy

The evidence shows that the use of learning analytics to improve and to innovate learning and teaching in Europe is still in its infancy. The high expectations have not yet been realised. Though early adopters are already taking a lead in research and development, the evidence on practice and successful implementation is still scarce. Furthermore, though the work across Europe on learning analytics is promising, it is currently fragmented. This underlines the need for a careful build-up of research and experimentation, with both practice and policies that have a unified European vision. Therefore, the study suggests that work is needed to make links between learning analytics, the beliefs and values that underpin this field, and European priority areas for education and training 2020. As a way of guiding the discussion about further development in this area, the Action List for Learning Analytics is proposed. The Action List for Learning Analytics focuses on seven areas of activity. It outlines a set of actions for educators, researchers, developers and policymakers in which learning analytics are used to drive work in Europe’s priority areas for education and training. Strategic work should take place to ensure that each area is covered, that there is no duplication of effort, that teams are working on all actions and that their work proceeds in parallel. Policy leadership and governance practices •Develop common visions of learning analytics that address strategic objectives and priorities •Develop a roadmap for learning analytics within Europe •Align learning analytics work with different sectors of education •Develop frameworks that enable the development of analytics •Assign responsibility for the development of learning analytics within Europe •Continuously work on reaching common understanding and developing new priorities Institutional leadership and governance practices •Create organisational structures to support the use of learning analytics and help educational leaders to implement these changes •Develop practices that are appropriate to different contexts •Develop and employ ethical standards, including data protection Collaboration and networking •Identify and build on work in related areas and other countries •Engage stakeholders throughout the process to create learning analytics that have useful features •Support collaboration with commercial organisations Teaching and learning practices •Develop learning analytics that makes good use of pedagogy •Align analytics with assessment practices Quality assessment and assurance practices •Develop a robust quality assurance process to ensure the validity and reliability of tools •Develop evaluation checklists for learning analytics tools Capacity building •Identify the skills required in different areas •Train and support researchers and developers to work in this field •Train and support educators to use analytics to support achievement Infrastructure •Develop technologies that enable development of analytics •Adapt and employ interoperability standard

Human responses to Florida red tides : policy awareness and adherence to local fertilizer ordinances

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Science of The Total Environment 493 (2014): 898-909, doi:10.1016/j.scitotenv.2014.06.083.To mitigate the damages of natural hazards, policy responses can be beneficial only if they are effective. Using a self-administered survey approach, this paper focuses on the adherence to local fertilizer ordinances (i.e., county or municipal rules regulating the application of fertilizer to private lawns or facilities such as golf courses) implemented in jurisdictions along the southwest Florida coast in response to hazardous blooms of Florida red tides (Karenia brevis). These ordinances play a role in the context of evolving programs of water pollution control at federal, state, water basin, and local levels. With respect to policy effectiveness, while the strength of physical linkages is of critical importance, the extent to which humans affected are aware of and adhere to the relevant rules, is equally critical. We sought to understand the public’s depth of understanding about the rationales for local fertilizer ordinances. Respondents in Sarasota, Florida, were asked about their fertilizer practices in an area that has experienced several major blooms of Florida red tides over the past two decades. A highly educated, older population of 305 residents and “snowbirds” reported relatively little knowledge about a local fertilizer ordinance, its purpose, or whether it would change the frequency, size, or duration of red tides. This finding held true even among subpopulations that were expected to have more interest in or to be more knowledgeable about harmful algal blooms. In the face of uncertain science and environmental outcomes, and with individual motivations at odds with evolving public policies, the effectiveness of local community efforts to decrease the impacts of red tides may be compromised. Targeted social-science research on human perceptions about the risks of Florida red tides and education about the rationales for potential policy responses is warranted.This work was funded under sponsorship of the National Science Foundation (NSF), awards #1009106 and #1004181and the National Institute for Environmental Health Sciences (NIEHS), award # R21ES017413-01A2. Fleming received support from the European Regional Development Fund and European Social Fund (European Centre for Environment and Human Health, University of Exeter Medical School)

Treatment of invasive fungal infections in clinical practice: a multi-centre survey on customary dosing, treatment indications, efficacy and safety of voriconazole

Invasive fungal infections are frequent and often deadly complications in patients with malignant hematological diseases. Voriconazole is a third generation triazole antifungal with broad activity against most clinically relevant fungal pathogens. Clinical practice often deviates from insights gained from controlled randomized trials. We conducted a multi-centre survey to evaluate efficacy, safety, treatment indications and dosing of voriconazole outside clinical trials. Patients receiving voriconazole were documented via electronic data capturing. An analysis was conducted after submission of 100 episodes from September 2004 to November 2005. Voriconazole was administered for suspected or proven invasive fungal infection (IFI) (57%), as empirical treatment in patients with fever of unknown origin (21%) and secondary (19%) as well as primary (3%) prophylaxis of IFI. Investigators’ assessment of fungal infection often diverted from EORTC/MSG 2002 criteria. A favorable response was reported in 61.4% for suspected or proven IFI and 52.4% for empirical treatment. Mortality was 15%, 26.7% of which was attributable to IFI. Breakthrough fungal infections occurred in four (21.1%) patients with voriconazole as secondary prophylaxis. Toxicity and adverse events comprised elevated liver enzymes and visual disturbances. Although indications frequently deviated from clinical evidence and legal approval, voriconazole showed efficacy and safety, comparable to major controlled clinical trials. Data from this survey demonstrate the difficulty of putting drugs to their approved use in IFI

Plasma accelerator-based ultrabright x-ray beams from ultrabright electron beams

We provide a pathway to compact ultrabright light sources, based on ultrabright, high energy electron beams emerging from a combination of plasma Wakefield acceleration and plasma photocathodes. While plasma acceleration is known to produce accelerating fields three or four orders of magnitude larger than conventional accelerators, the plasma photocathode allows production of electron beams three or four orders of magnitude brighter than conventional, and thus is suitable to unleash the full potential of plasma accelerators. In particular, this is the case for various types of light sources, which profit enormously from an increased electron beam brightness. Building on the recent first experimental demonstration of the plasma photocathode, in this work we discuss the prospects of plasma photocathodes for key photon source approaches such as x-ray free-electron lasers, betatron radiation, ion-channel lasers and inverse Compton scattering

Observation-based modeling of ozone chemistry in the Seoul metropolitan area during the Korea-United States Air Quality Study (KORUS-AQ)

The Seoul Metropolitan Area (SMA) has a population of 24 million and frequently experiences unhealthy levels of ozone (O3). In this work, measurements taken during the Korea-United States Air Quality Study (KORUS-AQ, 2016) are used to explore regional gradients in O3 and its chemical precursors, and an observationally-constrained 0-D photochemical box model is used to quantify key aspects of O3 production including its sensitivity to precursor gases. Box model performance was evaluated by comparing modeled concentrations of select secondary species to airborne measurements. These comparisons indicate that the steady state assumption used in 0-D box models cannot describe select intermediate species, highlighting the importance of having a broad suite of trace gases as model constraints. When fully constrained, aggregated statistics of modeled O3 production rates agreed with observed changes in O3, indicating that the box model was able to represent the majority of O3 chemistry. Comparison of airborne observations between urban Seoul and a downwind receptor site reveal a positive gradient in O3 coinciding with a negative gradient in NOx, no gradient in CH2O, and a slight positive gradient in modeled rates of O3 production. Together, these observations indicate a radical-limited (VOC-limited) O3 production environment in the SMA. Zero-out simulations identified C7+ aromatics as the dominant VOC contributors to O3 production, with isoprene and anthropogenic alkenes making smaller but appreciable contributions. Simulations of model sensitivity to decreases in NOx produced results that were not spatially uniform, with large increases in O3 production predicted for urban Seoul and decreases in O3 production predicted for far-outlying areas. The policy implications of this work are clear: Effective O3 mitigation strategies in the SMA must focus on reducing local emissions of C7+ aromatics, while reductions in NOx emissions may increase O3 in some areas but generally decrease the regional extent of O3 exposure

MRI atlas of a lizard brain

Magnetic resonance imaging (MRI) is an established technique for neuroanatomical analysis, being particularly useful in the medical sciences. However, the application of MRI to evolutionary neuroscience is still in its infancy. Few magnetic resonance brain atlases exist outside the standard model organisms in neuroscience and no magnetic resonance atlas has been produced for any reptile brain. A detailed understanding of reptilian brain anatomy is necessary to elucidate the evolutionary origin of enigmatic brain structures such as the cerebral cortex. Here, we present a magnetic resonance atlas for the brain of a representative squamate reptile, the Australian tawny dragon (Agamidae: Ctenophorus decresii), which has been the subject of numerous ecological and behavioral studies. We used a high-field 11.74T magnet, a paramagnetic contrasting-enhancing agent and minimum-deformation modeling of the brains of thirteen adult male individuals. From this, we created a high-resolution three-dimensional model of a lizard brain. The 3D-MRI model can be freely downloaded and allows a better comprehension of brain areas, nuclei, and fiber tracts, facilitating comparison with other species and setting the basis for future comparative evolution imaging studies. The MRI model and atlas of a tawny dragon brain (Ctenophorus decresii) can be viewed online and downloaded using the Wiley Biolucida Server at wiley.biolucida.net.Government of Australia, Grant/Award Numbers: APA#31/2011, IPRS#1182/2010; National Science and Engineering Research Council of Canada, Grant/Award Number: PGSD3-415253-2012; Quebec Nature and Technology Research Fund, Grant/AwardNumber: 208332; National Imaging Facility of Australia; Spanish Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional, Grant/Award Number:BFU2015-68537-