Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet`s disease

Behçet’s disease (BD) is an autoimmune multisystemic disease. The precise etiology of BD is not fully understood; however, it is thought that interactions between genetic and environmental factors play an essential role in its pathogenesis. The nuclear receptor coactivator-5 (NCOA5) gene encodes a coregulator for nuclear receptor sub- family 1 group D member 2 (NR1D2) and estrogen receptor 1 and 2 (ESR1 and ESR2). Also, the NCOA5 gene insufficiency leads to an elevated expression of IL-6, and increased levels of IL-6 were found to be related to the pathogenesis of BD. In this study, we aimed to clarify the impact of the NCOA5 rs2903908 polymorphism on susceptibility and clinical findings of BD. This study included 671 participants (300 BD patients and 371 healthy controls). The analyses of NCOA5 rs2903908 polymorphism was performed by using the TaqMan allelic discrim- ination assay. The frequency of TT genotype of the NCOA5 rs2903908 polymorphism was found significantly higher in BD patients compared to those in healthy controls (p=0.016, OR=1.46, 95 % CI=1.08–1.99). Also, the frequencies of CT genotype was observed significantly higher in BD patients with genital ulceration and uveitis than without genital ulceration and uveitis (p=0.002 and p=0.005, respectively). The most significant association was found between C allele frequencies of BD patients with and without uveitis (p=0.0001). Our study represents e first time that the NCOA5 rs2903908 polymorphism seemed to be linked to BD susceptibility and clinical findings

Validity and reliability of the Turkish Version of DSM-5 Level 2 Somatic Symptom Scale (Child Form for 11-17 years and Parent Form for 6-17 years)

Objective: This study aimed to assess the validity and reliability of the Turkish Version of DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) Level 2 Somatic Symptom Scale's Child and Parent Forms. Methods: The study group consisted of a community and clinical sample. The scale was applied to 120 parents and 186 adolescents that represented the clinical and community sample. During the assessment process, Child Somatization Inventory was also used. Results: Reliability analyses indicated a high internal consistency regarding DSM-5 Level 2 Somatic Symptom Scales, for parent forms and acceptable internal consistency for child forms. In the meantime, it was shown that both child and parents form for DSM-5 Level 2 Somatization Symptom Scale were significantly correlated with Child Somatization Inventory. As for the content validity, five factors for child forms and three factors for parent forms were obtained and was observed to be consistent with the original construct of the scale. Conclusion: It was concluded that Turkish version of DSM-V Level 2 Somatic Symptom Scale was a valid and reliable tool to be utilized both for clinical practice and research purposes

Vascular Complications in Le Fort I Osteotomy: Incidence, Reasons, and Management of the Intraoperative Hemorrhage

Purpose: The aim of this study was to investigate the incidence, types, and reasons for the intraoperative hemorrhage during Le Fort I osteotomy

High Performance 15-μm Pitch 640x512 MWIR InAs/GaSb Type-II Superlattice Sensors

IEEEWe report the high performance of Mid-wave Infrared Region (MWIR) InAs/GaSb Type-II Superlattice (T2SL) sensors with 640 x 512 format and 15-μm pixel pitch at both Focal Plane Array (FPA) and pixel level. The p-intrinsic-Barrier-n epilayer structure is adopted for this study, which is grown on 620 ± 30 μm thick GaSb substrate and highly-doped GaSb cap layer at the top structure. The mesa type pixels with sizes of 220 μm x 220 μm have dark currents 7.8 x 10-12 A at 77 K both of which are equivalent to state-of-the-art values for Type-II Superlattice sensors. The various passivation techniques to lower the dark current are applied and the results are given in terms of dark current. Electro-optical measurements yielded comparable results to literature. After gathering data and optimizing the fabrication conditions, the FPA of 15-μm pitch having 4.92 μm cut-off wavelength (λc) shows 1.6 A/W peak responsivity, Noise Equivalent Temperature Difference (NETD) of 22.6 mK with optics of f/2.3, quantum efficiency larger than 65% and 99.75% operability. The acquired images by using aforementioned FPA device is presented in this paper. With the reduction of dark current, an encouraging imaging performance is obtained which shows the potential of the Type-II Superlattice detectors in 3rd generation infrared sensors

Near-Fault Earthquake Ground Motion and Seismic Isolation Design

Seismic isolation is one of the most reliable passive structural control techniques with adequately established standards for the earthquake protection of structures from earthquakes. However, it has been shown that the seismic isolation systems may not function the best for the near-fault ground motions, since in the proximity of a capable fault, the ground motions are significantly affected by the rupture mechanism and may generate high demands on the isolation system and the structure. In fact, several earthquake resistant design codes state that the seismically isolated structures located at near-fault sites should be designed by considering larger seismic demands than the demand on structures at far-field sites. When the fault ruptures in forward direction to the site most of the seismic energy arrives in coherent long-period ground velocity pulses. The ground-motion prediction equations (GMPEs) typically cannot account for such effects with limited distance metrics and lack adequate data at large magnitudes and near distances. For the reliable earthquake design of the isolated structure in near fault conditions that meets the performance objectives, the 3D design basis ground motion(s) need to be appropriately assessed. Measures in the design of the isolation system, such as modifications in the stiffness and damping characteristics, as well as in the limitation of vertical effects are needed. The behavior of the base-isolated buildings under near-fault (NF) ground motions with fling-step and forward-directivity characteristics are investigated with a rational assessment of design-basis near-fault ground motion, are investigated in a parametric format. The parametric study includes several variables, including the structural system flexibility; number of stories; isolation system characteristic (yield) strength, and the isolation periods related to the post-elastic stiffness. Furthermore, the effect of additional damping by viscous dampers were tested for some selected cases. Important findings observed from the parametric performance results and the overall conclusions of the study are provided.Politecnico TorinoWOS:0009635759000092-s2.0-85148693217Conference Proceedings Citation Index – ScienceProceedings PaperUluslararası işbirliği ile yapılmayan - HAYIRNisan2023YÖK - 2022-2

Spatial control of a smart beam

This study presents the design and implementation of a spatial H(infinity) controller for the active vibration control of a smart beam. The smart beam was modeled by assumed-modes method that results in a model including large number of resonant modes. The order of the model was reduced by direct model truncation and the model correction technique was applied to compensate the effect of the contribution of the out of range modes to the dynamics of the system. Additionally, spatial identification of the beam was performed, by comparing the analytical and experimental system models, in order to determine the modal damping ratios of the smart beam. Then, the spatial H(infinity) controller was designed and implemented to suppress the first two flexural vibrations of the smart beam

Smart structures and their applications on active vibration control: Studies in the Department of Aerospace Engineering, METU

This work presents the theoretical and experimental studies conducted in Aerospace Engineering Department of Middle East Technical University on smart structures with particular attention given to the structural modelling characteristics and active suppression of in-vacuo vibrations. The smart structures considered in these analyses are finite and flat aluminium cantilever beam-like (called as smart beam) and plate-like (called as smart fin) structures with surface bonded lead-zirconate-titanate patches. Finite element models of smart beam and smart fin are obtained. Then the experimental studies regarding open loop behaviour of the structures are performed by using strain gauges and laser displacement sensor to determine the system models. Further studies are carried out to obtain H(infinity) and mu-synthesis controllers which are intended to be used in the suppression of free and forced vibrations of the smart structures. It is observed that satisfactory attenuation levels are achieved and robust performance of the systems in the presence of uncertainties is ensured. In that respect a comparative study involving H(infinity) and sliding mode controls is also conducted. Recently, the studies involving aerodynamic loading are also gathering pace