CLINICAL EVALUATION OF SHASHILEKHA VATI IN THE MANAGEMENT OF SHVITRA WITH SPECIAL REFERENCE TO VITILIGO

In Ayurveda, it is described that Viruddha aahar is the main etiological factor for so many diseases. Shvitra is one of them. This study focuses to develop evidence based support for efficacy of textual reference of Yogaratnakara regarding Shvitraghna property of Shashilekha Vati with Bakuchi tail and Madhu as Anupana with special reference to vitiligo. Shashilekha Vati was prepared according to the method mentioned in the classical text of Yogaratnakara. The trial was conducted on a sample size of 60 divided in two groups. In the criteria of assessment, measurement of area of lesion, nature of regimentation and degree of regimentation were taken. It is observed that there is significant regimentation in the treated lesion and reduction in total area of lesions. Shashilekha Vati with Anupana enters to all Sukshmastrotasas and it acts on dash, Dhatu by properties of Sukshma, Tikshna guna and Ushna virya. Thus it does Diana, patina and acts as Tayca, Varna. Oil of Bakunin acts on arterioles of sub capillary plexus due to which they dilate and increase the plasma in this area. At the same time copper acts on enzyme tyrosines. Due to which melanoblasts are stimulated. They further exude and diffuse into the decolourised area and pigmentation takes place in that area. It is observed that out of 30 patients in Drug Group i.e. taking Shashilekha Vati, 19 patients had marked to complete (76-100%) regimentation, 7 patients had marked (51-75%) regimentation, 3 patients had moderate (26-50%) regimentation and only one patient had minimal (below 25%) regimentation. The Drug in Group A-Shashilekha Vati showed significant regimentation and reduction in area of lesions as compared to Group B

Nutritional considerations in geriatrics

To lead healthy and active life, human beings need a broad range of nutrients. The nutrients required for different physiological age groups can be derived only from a well-balanced diet. One of the major challenges for the success of health sciences in the present scenario is increasing elderly population in the society. Nutritional deficiency, particularly of proteins is very common in elderly people. Over 60% of elderly people are malnourished, and there are many causes for this malnutrition and it is not always easy to differentiate the age-related from the pathological. We always need to remind the phrase that “it is of great importance to add life to years and not years to life.” Here is article reviewing the basics of nutrition in elderly people and the role of prosthodontist in the same

Real Time Protection System for Four Wheeler

The rapid development of electronics provides secured environment to the human in present day of life. Using this development in the branch of electronics is designed to reduce the risk involved in accidents due to drunken driving which will reduce the rate of deaths. Instead of having the single application in a system it is better to have multiple applications such that the user can run the vehicle safely and can avoid the accident. Here in this paper we are using a combination of different technologies such as GPS, GSM technology. The main reason for driving drunk is that the police are not able to check each and every car. So we need an effective system which checks whether the driving person has drunken or not. Vehicle will be automatically off when the system senses alcohol. The car is embedded with all the above technologies. DOI: 10.17762/ijritcc2321-8169.150311

Role of imaging in the management of thyroglossal duct cyst carcinomas (TGC-TIRADS): a single centre retrospective study over 16 years

IntroductionThyroglossal duct cyst (TGDC) is the most frequently encountered developmental anomaly in thyroid genesis with a reported incidence of 7% in the adult population. The cyst is known to develop anywhere along the pathway of thyroid descent but is more frequently seen in the infrahyoid neck in the midline. The incidence of malignancy in a TGDC is approximately 1%; a majority of these are papillary carcinomas. This study was conducted at a single tertiary care centre which spanned over a decade which adds practice changing evidence-based knowledge to existing literature on this rare entity. A comprehensive study which conclusively establishes the imaging features predictive of malignancy in TGDC carcinomas (TGDCa), the protocol for optimal management, clinical outcome and long-term survival of these patients is not available. Although TGDC carcinoma is thought to have an excellent prognosis, there is not enough data available on the long-term survival of these patients. The aim of this study was to identify whether neck ultrasound (US) can serve as an accurate imaging tool for the preoperative diagnosis of TGDC carcinomas.MethodsWe accessed the electronic medical records of 86 patients with TGDC between January 2005 to December 2021. Of these, 22 patients were detected with TGDC papillary carcinoma on histopathologic examination. Relevant imaging, treatment and follow up information for all cases of TGDC carcinoma were retrospectively reviewed. We compared US characteristics predictive of malignancy across outcomes groups; malignant vs benign using the Chi-square test. Based on the results, a TGC-TIRADS classification was proposed with calculation of the percentage likelihood of malignancy for each category.ResultsCompared to benign TGDCs, malignant TGDCs were more likely to present with following US characteristics: irregular or lobulated margins (90.40 vs. 38.10%), solid-cystic composition (61.90 vs. 17.07%), internal vascularity (47.62 vs. 4.88 %), internal calcification (76.19 vs. 7.32 %) (each p value < 0.005). Calcifications and internal vascularity were the most specific while irregular/lobulated margins were the most sensitive feature for malignancy. AUC under the ROC curve was 0.88. Allpatients were operated and were disease free at the end of 5 years or till the recent follow up.DiscussionUS is the imaging modality of choice for pre-operative diagnosis of TGDC carcinoma. Thepre-operative diagnosis and risk stratification of thyroglossal lesions will be aided by the application of the proposed TGC-TIRADS classification, for which the percentage likelihood of malignancy correlated well with the results in our study. Sistrunk procedure is adequate for isolated TGDC carcinoma; suspicious neck nodes on imaging also necessitates selective nodal dissection. Papillary carcinomas have an excellent prognosis with low incidence of disease recurrence

Optimal production of alkaline protease from solvent-tolerant alkalophilic <i style="">Pseudomonas aeruginosa</i> MTCC 7926

329-339A new organic solvent-tolerant bacterial strain UD-5 was isolated from industrial solvent effluent-sediment stream, collected from Ankleshwar (India) and documented for the production of solvent-tolerant alkaline protease. Based on phylogenetic analysis of the 16S rRNA gene sequence and phenotypic analysis, as well as biochemical analyses, this strain was identified as Pseudomonas aeruginosa MTCC 7926. It secreted an extracellular, thermostable; alkaline protease in a casamino acid-rich salt medium (pH 9) at 40°C, in static condition. The solvent-tolerance of bacterium in the presence of n-hexane, dodecane, cyclohexane and DMSO, xylene and tolune was analyzed. Effect of pH, temperature, agitation, carbon and nitrogen sources and various salts on the growth and protease production by strain UD-5 of solvent-tolerant P. aeruginosa MTCC 7926 from-manmade ecological habitat was studied. It provided an alternative source of alkaline protease with additional attributes of industrial applications compared to proteases reported earlier. Its ability to grow in organic solvents especially in water-miscible solvents (DMF and DMSO) proves its potential for applications in non-aqueous reactions in addition to usage in detergent, laundry additives and leather finishing

Antioxidant and antipyretic studies on methanolic extraction of flaveria trinervia leaves

The aim of the present study was to perform antipyretic and antioxidant activity of Flaveria trinervia Methanolic leaves extract by different in-vivo and in-vitro models. The different pharmacognostical parameters were evaluated as per standard procedure. Finally, antipyretic (Brewer’s Yeast Pyrexia model) and antioxidant activity (Hydroxyl Radaical scavenging activity, determination of Reducing Power, Metal chelating activity, Carbon tetrachloride (ccl4) induced lipid peroxidation, Inhibitory Test on Protein Oxidative Modification, Lipid peroxidation assay, Catalase assay and Reduced glutathione assay) was evaluated by adopting different methods. The extracts showed a marked antipyretic effect by causing a reduction in yeast-induced fever. Methanolic extract (200 and 400 mg/kg) showed the effect to the same degree as paracetamol (50mg/kg, i.p.). The experimentally induced laboratory model was employed in evaluating the antipyretic activities of Methanolic extracts of Flaveria trinervia. The extract caused a better hypothermal activity against yeast-induced pyrexia in rats. Free radical scavenging activity of Flaveria trinervia. was found because polyphenolic compounds present in plant contribute significantly to the total antioxidant capacity of the leaves. Flavonoids play some important pharmacological roles against diseases, such as cardiovascular diseases, cancer, inflammation and allergy.&nbsp

<span style="font-size:13.0pt;mso-bidi-font-size: 15.0pt" lang="EN-US">Biotransformation of low cost lignocellulosic substrates into vanillin by white rot fungus, <i>Phanerochaete chrysosporium</i> NCIM 1197 </span>

281-283Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling aromatic compound, occurs naturally in vanilla beans. It is widely used as a flavouring additive for beverages and aromatic additive for candles, fragrances, and perfumes. It is also noted as nutraceutical. Efforts have been made to obtain aromatic compounds produced by means of biological process, which employ microorganisms. White rot fungus, Phanerochaete chrysosporium NCIM 1197 was used to transform lignocellulosic substrates like rice husk, groundnut shell, etc. Further, detection and quantification of vanillin were carried out by TLC and spectrophotometrically. The maximum vanillin production (up to 55 µg/mL) was observed within 72 h using groundnut shell as a substrate. The use of various carbon sources, viz., glucose and starch, along with groundnut shell, affected vanillin production. Supplementation of glucose along with groundnut shell showed more increase in vanillin production (37 µg/mL within 96 h) in comparison to the supplementation of starch (up to 21 µg/mL within 96 h). </span

A facile microwave assisted synthesis and antimicrobial activities of naturally occurring (E)-cinnamyl (E)-cinnamates and (E)-aryl cinnamates

1459-1465Benzaldehydes 1a-e on reaction with phosphorane 3 and aldehydes 2a-e with phosphorane 4 under microwave irradiation provide the (E)-cinnamyl (E)-cinnamates 5a-e and (E)-aryl cinnamates 6a-e respectively in high yield. Cinnamates 5a-e and 6a-e exhibit antibacterial and antifungal activity

Antioxidant and Antipyretic Studies on Methanolic Extraction of Flaveria Trinervia Leaves

The aim of the present study was to perform antipyretic and antioxidant activity of Flaveria trinervia Methanolic leaves extract by different in-vivo and in-vitro models. The different pharmacognostical parameters were evaluated as per standard procedure. Finally, antipyretic (Brewer's Yeast Pyrexia model) and antioxidant activity (Hydroxyl Radaical scavenging activity, determination of Reducing Power, Metal chelating activity, Carbon tetrachloride (ccl4) induced lipid peroxidation, Inhibitory Test on Protein Oxidative Modification, Lipid peroxidation assay, Catalase assay and Reduced glutathione assay) was evaluated by adopting different methods. The extracts showed a marked antipyretic effect by causing a reduction in yeast-induced fever. Methanolic extract (200 and 400 mg/kg) showed the effect to the same degree as paracetamol (50mg/kg, i.p.). The experimentally induced laboratory model was employed in evaluating the antipyretic activities of Methanolic extracts of Flaveria trinervia. The extract caused a better hypothermal activity against yeast-induced pyrexia in rats. Free radical scavenging activity of Flaveria trinervia. was found because polyphenolic compounds present in plant contribute significantly to the total antioxidant capacity of the leaves. Flavonoids play some important pharmacological roles against diseases, such as cardiovascular diseases, cancer, inflammation and allergy.&nbsp

Short and efficient process for the synthesis of trans-4-aminocyclohexanecarboxylic acid derivatives

This contribution relates to an industrially feasible process for the preparation of isomerically pure trans-4-amino-1-cyclohexanecarboxylic acid derivatives that are useful building blocks in the synthesis of several pharmacologically active compounds such as glimepiride, L-370518