Antioxidant and Antipyretic Studies on Methanolic Extraction of Flaveria Trinervia Leaves

Abstract

The aim of the present study was to perform antipyretic and antioxidant activity of Flaveria trinervia Methanolic leaves extract by different in-vivo and in-vitro models. The different pharmacognostical parameters were evaluated as per standard procedure. Finally, antipyretic (Brewer's Yeast Pyrexia model) and antioxidant activity (Hydroxyl Radaical scavenging activity, determination of Reducing Power, Metal chelating activity, Carbon tetrachloride (ccl4) induced lipid peroxidation, Inhibitory Test on Protein Oxidative Modification, Lipid peroxidation assay, Catalase assay and Reduced glutathione assay) was evaluated by adopting different methods. The extracts showed a marked antipyretic effect by causing a reduction in yeast-induced fever. Methanolic extract (200 and 400 mg/kg) showed the effect to the same degree as paracetamol (50mg/kg, i.p.). The experimentally induced laboratory model was employed in evaluating the antipyretic activities of Methanolic extracts of Flaveria trinervia. The extract caused a better hypothermal activity against yeast-induced pyrexia in rats. Free radical scavenging activity of Flaveria trinervia. was found because polyphenolic compounds present in plant contribute significantly to the total antioxidant capacity of the leaves. Flavonoids play some important pharmacological roles against diseases, such as cardiovascular diseases, cancer, inflammation and allergy.&nbsp