Influenza d virus infection in herd of cattle, Japan

Citation: Murakami, S., Endoh, M., Kobayashi, T., Takenaka-Uema, A., Chambers, J. K., Uchida, K., . . . Horimoto, T. (2016). Influenza d virus infection in herd of cattle, Japan. Emerging Infectious Diseases, 22(8), 1517-1519. doi:10.3201/eid2208.160362Although the provisionally named influenza D virus was first isolated as an influenza C–like virus from pigs with respiratory illness in Oklahoma in 2011 (1,2), epidemiologic analyses suggested that cattle are major reservoirs of this virus (3) and the virus is potentially involved in the bovine respiratory disease complex. The high rates of illness and death related to this disease in feedlot cattle are caused by multiple factors, including several viral and bacterial co-infections. Influenza D viruses were detected in cattle and pigs with respiratory diseases (and in some healthy cattle) in China (4), France (5), Italy (6), among other countries, indicating their wide global geographic distribution. Although the influenza D virus, like the human influenza C virus, is known to use 9-O-acetylated sialic acids as the cell receptor (2,7), its zoonotic potential is undefined because of limited research (1,8). We report influenza D virus infection in a herd of cattle in Japan

Imagen profesional de farmacias comunitarias: causas y estrategias de mejora aplicando técnicas de investigación cualitativa

Objetivo Conocer las opiniones de los farmacéuticos con relación a los factores que explican la falta de visibilidad de la farmacia comunitaria como establecimiento sanitario y proponer estrategias de desarrollo profesional a fin de lograr mejorar la accesibilidad a los servicios profesionales mediante técnicas de investigación cualitativa.Material y métodos Se utilizó una Técnica de Grupo Nominal (TGN) en 2 rondas sucesivas, respondiendo a 2 consignas guía sobre factores y estrategias. Posteriormente se realizó un Framework analysis.Resultados Se aportaron 34 ideas referidas a factores y 32 a estrategias. Las estrategias fueron agrupadas en 14 temas, destacándose las vinculadas a la priorización de los servicios profesionales orientados a los pacientes, al cumplimiento de la ética y a la formación continua del farmacéutico.Discusión Las técnicas utilizadas permitieron evidenciar situaciones percibidas por los farmacéuticos que no están formalmente descriptas en la literatura. Aumentar la visibilidad de los servicios profesionales en las farmacias comunitarias implica acordar y abordar estrategias que deben sustentarse en la participación conjunta de los propios farmacéuticos, las asociaciones profesionales y las universidades

Good drug promotion practices of prescription medicines in drug promotional materials collected at health facilities

En Argentina, las "Buenas Prácticas de Promoción de Medicamentos de Venta Bajo Receta" (Resolución 627/2007 MSyA) regulan la promoción destinada a los profesionales que prescriben o dispensan. Ambos actos deben ser consecuencia de una actitud profesional, basada en evidencia científica. El objetivo de este trabajo fue valorar el cumplimiento de la normativa en el material promocional impreso recibido y/o recolectado en establecimientos asistenciales públicos y privados de la provincia de Córdoba. El diseño del estudio fue cuali-cuantitativo descriptivo y transversal, en establecimientos de Córdoba Capital (muestra 2007) y un hospital de la ciudad de Alta Gracia (muestra 2008). Para su análisis, se organizó el material recolectado teniendo en cuenta el cumplimiento de la normativa y sus características generales. El cumplimiento de todos los ítems analizados de la normativa fue de 0% (n = 66) en la muestra 2007 y de 3,8% (n = 26), en 2008. El mayor incumplimiento fue en "composición cuali-cuantitativa" y más del 25% de los impresos eran ilegibles.In Argentina, the "Good Drug Promotion Practices of Prescription Medicines" (627/2007 MSyA resolution) rules the promotion focused on health care professionals who prescribe or dispense medication. Both acts should be a consequence of a professional attitude, based on scientific evidence. The objective of the present study was to assess the compliance of the regulation in printed promotional materials collected at public and private inpatient health care facilities in the province of Córdoba. The design was a quali-quantitative descriptive and cross-section study in health facilities of Córdoba City (2007 sample) and in a hospital of Alta Gracia City (2008 sample). To analize the collected materials, they were organized in order to their compliance of the regulation and general characteristics. The compliance of all items analized was 0% (n = 66) in the 2007 sample, and 3.8% (n = 26) in 2008. The highest non-compliance was in "quali-quantitative drug composition", and more than 25% of printed materials were illegible.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Good drug promotion practices of prescription medicines in drug promotional materials collected at health facilities

En Argentina, las "Buenas Prácticas de Promoción de Medicamentos de Venta Bajo Receta" (Resolución 627/2007 MSyA) regulan la promoción destinada a los profesionales que prescriben o dispensan. Ambos actos deben ser consecuencia de una actitud profesional, basada en evidencia científica. El objetivo de este trabajo fue valorar el cumplimiento de la normativa en el material promocional impreso recibido y/o recolectado en establecimientos asistenciales públicos y privados de la provincia de Córdoba. El diseño del estudio fue cuali-cuantitativo descriptivo y transversal, en establecimientos de Córdoba Capital (muestra 2007) y un hospital de la ciudad de Alta Gracia (muestra 2008). Para su análisis, se organizó el material recolectado teniendo en cuenta el cumplimiento de la normativa y sus características generales. El cumplimiento de todos los ítems analizados de la normativa fue de 0% (n = 66) en la muestra 2007 y de 3,8% (n = 26), en 2008. El mayor incumplimiento fue en "composición cuali-cuantitativa" y más del 25% de los impresos eran ilegibles.In Argentina, the "Good Drug Promotion Practices of Prescription Medicines" (627/2007 MSyA resolution) rules the promotion focused on health care professionals who prescribe or dispense medication. Both acts should be a consequence of a professional attitude, based on scientific evidence. The objective of the present study was to assess the compliance of the regulation in printed promotional materials collected at public and private inpatient health care facilities in the province of Córdoba. The design was a quali-quantitative descriptive and cross-section study in health facilities of Córdoba City (2007 sample) and in a hospital of Alta Gracia City (2008 sample). To analize the collected materials, they were organized in order to their compliance of the regulation and general characteristics. The compliance of all items analized was 0% (n = 66) in the 2007 sample, and 3.8% (n = 26) in 2008. The highest non-compliance was in "quali-quantitative drug composition", and more than 25% of printed materials were illegible.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Good drug promotion practices of prescription medicines in drug promotional materials collected at health facilities

En Argentina, las "Buenas Prácticas de Promoción de Medicamentos de Venta Bajo Receta" (Resolución 627/2007 MSyA) regulan la promoción destinada a los profesionales que prescriben o dispensan. Ambos actos deben ser consecuencia de una actitud profesional, basada en evidencia científica. El objetivo de este trabajo fue valorar el cumplimiento de la normativa en el material promocional impreso recibido y/o recolectado en establecimientos asistenciales públicos y privados de la provincia de Córdoba. El diseño del estudio fue cuali-cuantitativo descriptivo y transversal, en establecimientos de Córdoba Capital (muestra 2007) y un hospital de la ciudad de Alta Gracia (muestra 2008). Para su análisis, se organizó el material recolectado teniendo en cuenta el cumplimiento de la normativa y sus características generales. El cumplimiento de todos los ítems analizados de la normativa fue de 0% (n = 66) en la muestra 2007 y de 3,8% (n = 26), en 2008. El mayor incumplimiento fue en "composición cuali-cuantitativa" y más del 25% de los impresos eran ilegibles.In Argentina, the "Good Drug Promotion Practices of Prescription Medicines" (627/2007 MSyA resolution) rules the promotion focused on health care professionals who prescribe or dispense medication. Both acts should be a consequence of a professional attitude, based on scientific evidence. The objective of the present study was to assess the compliance of the regulation in printed promotional materials collected at public and private inpatient health care facilities in the province of Córdoba. The design was a quali-quantitative descriptive and cross-section study in health facilities of Córdoba City (2007 sample) and in a hospital of Alta Gracia City (2008 sample). To analize the collected materials, they were organized in order to their compliance of the regulation and general characteristics. The compliance of all items analized was 0% (n = 66) in the 2007 sample, and 3.8% (n = 26) in 2008. The highest non-compliance was in "quali-quantitative drug composition", and more than 25% of printed materials were illegible.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Feline immunodeficiency virus subtype C is prevalent in northern part of Taiwan

The seroepidemiological survey of cats conducted in northern part of Taiwan in 1998 revealed that the positive rate of feline immunodeficiency virus (FIV)-infection was 21.9% (7/32) and the rate was much higher than those of previous reports. We succeeded in isolation of three strains of FIV from peripheral blood mononuclear cells of the blood samples. Nucleotide sequences of the env variable V3 to V5 region of the strains revealed that the isolates from distinct areas belong to subtype C. These data together with our previous report (Inada et al. 1997. Arch. Virol., 142: 1459-1467) indicate that FIV subtype C is prevalent in northern part of Taiwan

Aportes a la caracterización de la problemática del uso terapéutico del aceite de Cannabis en Córdoba, Argentina

Informe CIMEFil: Bustos Fierro, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Uema, Sonia Andrea Naeko. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Nuñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Nuñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil : Bertotto, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Eynard, M. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil : Armando, Pedro D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.Fil : Manzo, Pablo Gabriel Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; Argentina.El uso terapéutico del aceite de “cannabis" (AC) es una problemática social que pone en tensión aspectos legales, sanitarios, científicos y culturales. En nuestra legislación nacional, el “cannabis” está clasificado como estupefaciente. Esta situación se traduce, en drogas de uso prohibido y presupuestas de peligrosidad para la salud. En Argentina, no se produce formalmente AC de manufactura de calidad, que asegure la pureza, uniformidad y un contenido estándar de cannabinoides. Sin embargo, una importante cantidad de personas lo emplean para el tratamiento de diversas patologías, los cuales son realizados en un contexto de informalidad terapéutica y donde la provisión del mismo se realiza por canales externos al sistema de salud, desconociendo su composición química, las dosificaciones a utilizar y la forma de realizar el seguimiento clínico de la evolución de la patología abordada.info:eu-repo/semantics/publishedVersionFil: Bustos Fierro, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.Fil: Uema, Sonia Andrea Naeko. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Nuñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Ciencias Farmacéuticas; Argentina.Fil: Nuñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil : Bertotto, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Eynard, M. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Fil : Armando, Pedro D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.Fil : Manzo, Pablo Gabriel Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; Argentina

Radium-223 in women with hormone receptor-positive bone-metastatic breast cancer receiving endocrine therapy: pooled analysis of two international, phase 2, randomized, double-blind, placebo-controlled trials

Background Most women with advanced breast cancer have skeletal metastases. Radium-223 is an alpha-emitting radionuclide that selectively targets areas of bone metastases. Methods Two double-blind, placebo-controlled studies of radium-223 were conducted in women with hormone receptor-positive (HR+), bone-predominant metastatic breast cancer. All patients received endocrine therapy (ET), as a single agent of the investigator’s choice (Study A) or exemestane + everolimus (Study B). Patients were randomized to receive radium-223 (55 kBq/kg) or placebo intravenously every 4 weeks for six doses. Accrual was halted following unblinded interim analyses per protocol amendments, and both studies were terminated. We report pooled analyses of symptomatic skeletal event-free survival (SSE-FS; primary endpoint), radiologic progression-free survival (rPFS) and overall survival (OS; secondary), and time to bone alkaline phosphatase (ALP) progression (exploratory). Results In total, 382 patients were enrolled, and 196 SSE-FS events (70% planned total) were recorded. Hazard ratios (95% confidence intervals) and nominal p values for radium-223 + ET versus placebo + ET were: SSE-FS 0.809 (0.610–1.072), p = 0.1389; rPFS 0.956 (0.759–1.205), p = 0.7039; OS 0.889 (0.660–1.199), p = 0.4410; and time to bone ALP progression 0.593 (0.379–0.926), p = 0.0195. Radium-223- or placebo-related treatment-emergent adverse events were reported in 50.3% versus 35.1% of patients (grade 3/4: 25.7% vs. 8.5%), with fractures/bone-associated events in 23.5% versus 23.9%. Conclusions In patients with HR+ bone-metastatic breast cancer, numeric differences favoring radium-223 + ET over placebo + ET for the primary SSE-FS endpoint were suggestive of efficacy, in line with the primary outcome measure used in the underlying phase 2 studies. No similar evidence of efficacy was observed for secondary progression or survival endpoints. Adverse events were more frequent with radium-223 + ET versus placebo + ET, but the safety profile of the combination was consistent with the safety profiles of the component drugs

Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

<p>Abstract</p> <p>Background</p> <p>The aim of the study was to investigate the effect of acupuncture on wound healing after soft tissue or orthopaedic surgery in dogs.</p> <p>Methods</p> <p>29 dogs were submitted to soft tissue and/or orthopaedic surgeries. Five dogs had two surgical wounds each, so there were totally 34 wounds in the study. All owners received instructions for post operative care as well as antibiotic and pain treatment. The dogs were randomly assigned to treatment or control groups. Treated dogs received one dry needle acupuncture treatment right after surgery and the control group received no such treatment. A veterinary surgeon that was blinded to the treatment, evaluated the wounds at three and seven days after surgery in regard to oedema (scale 0-3), scabs (yes/no), exudate (yes/no), hematoma (yes/no), dermatitis (yes/no), and aspect of the wound (dry/humid).</p> <p>Results</p> <p>There was no significant difference between the treatment and control groups in the variables evaluated three and seven days after surgery. However, oedema reduced significantly in the group treated with acupuncture at seven days compared to three days after surgery, possibly due the fact that there was more oedema in the treatment group at day three (although this difference was nor significant between groups).</p> <p>Conclusions</p> <p>The use of a single acupuncture treatment right after surgery in dogs did not appear to have any beneficial effects in surgical wound healing.</p

Condições e relações de trabalho no serviço público: o caso do governo Lula

Este artigo tem por objetivo inventariar as diversas iniciativas do governo Lula (2003-2010) no que diz respeito à formatação de uma política de recursos humanos e, dessa forma, verificar se houve melhoria das condições e relações de trabalho no setor público brasileiro. A partir dos anos 1990 e na contramão do grande crescimento do emprego público nas seis décadas anteriores, a adesão dos governos brasileiros aos princípios do "Consenso de Washington" destaca o funcionalismo como ponto fundamental na agenda das reformas necessárias à retomada do crescimento econômico. Os tais governos tenderam a tratar o emprego público como um problema fiscal e atuaram no sentido de restringir sua dimensão. Em simultâneo, as condições e relações de trabalho apresentaram-se mais precarizadas (evidenciadas pela ausência de reajuste salarial; o crescimento de formas variáveis de remuneração; ampliação do quadro de temporários e terceirizados e com a postura autoritária diante da representação sindical). Por meio de pesquisa documental e bibliográfica, poder-se-á perceber que a reestruturação de várias carreiras, a retomada dos concursos, a criação da Mesa Nacional de Negociação Permanente, a reforma previdenciária e os reajustes seletivos das remunerações manifestam a ambigüidade como marca fundamental das políticas de recursos humanos. Isto porque, a um só tempo, os avanços nas condições de trabalho do servidor público foram sempre acompanhados pela manutenção de parte da agenda conservadora dos anos 1990, sobretudo no que diz respeito à reprodução de limites fiscais rigorosos